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The map label for this gene is rnc

Identifier: 134299915

GI number: 134299915

Start: 2267293

End: 2268033

Strand: Reverse

Name: rnc

Synonym: Dred_2069

Alternate gene names: 134299915

Gene position: 2268033-2267293 (Counterclockwise)

Preceding gene: 134299916

Following gene: 134299914

Centisome position: 62.86

GC content: 45.88

Gene sequence:

>741_bases
TTGTCTAAACAAGACGAGCAAGCTAATCGCCTGAAAACACGTTTGGGTTTTAAGTGGCATAATCCTACACTGCTGATACA
GGCACTAACGCATAGTTCTTGTGTTCATGAAAACAGGGGGCATGGTTTGTGTCATAATCAAAGATTAGAATTTTTAGGGG
ATGCAGTTTTAGAGCTGATTATCAGTGAACACTTATATAAAATGTTCCCAGATCGAACTGAAGGCGAGCTAACGAAAATG
AGGGCATCTTCAGTATGTGAGCCCTCCTTGGCAAAGGTAGCCCGGGGATTGGACCTGGGCCGTTGCCTGCGCATGGGGCG
TGGAGAAGAACGTTCCGGCGGCAGGGAGCGGCCATCCATCTTGGCTGATGCCTTTGAGGCATTACTGGGTGCTATTTATT
TGGATCAGGGGTTGGAAATTTCCAGACATTTTGTTTTAAACTGCCTCAGTTCTATTATCGACGATGTTGTGGCTGGAAGA
TTGGATAGGGATTATAAAACAGAATTACAAGAAATACTGCAACAATCATCTCCAGACCCCTTAACCTACACCATCATGGA
TGAATCCGGCCCCGATCATGACAAAACCTTTACAGCCGGGGTGATCTACAAAGGAAAGGTCATCGGTAAGGGGAGCGGTC
ACTCTAAAAAAGAAGCTGAACAACAGGCAGCAAAGGATGCCTTTCAGCATCTTGAAGGCATGGGAAAATCCGGCCATAAA
TCAGCTGGACCAATCCGATAA

Upstream 100 bases:

>100_bases
ATGAATGTCGATGTGGCACTTTCTAACTCCTTTGGCTTCGGGGGACATAACGTAACACTGGCCTTTAAAAAGTTTAATTT
TTAGAGCTGTGGTGATTCAT

Downstream 100 bases:

>100_bases
AGAAACGGACTACAGGGGGCAGAGCATTGGTTTTAAAAAGAATGGATATACAGGGCTTTAAGTCCTTTGGTGACCGTGTT
AAGTTAGAGTTGCATTCTGG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSKQDEQANRLKTRLGFKWHNPTLLIQALTHSSCVHENRGHGLCHNQRLEFLGDAVLELIISEHLYKMFPDRTEGELTKM
RASSVCEPSLAKVARGLDLGRCLRMGRGEERSGGRERPSILADAFEALLGAIYLDQGLEISRHFVLNCLSSIIDDVVAGR
LDRDYKTELQEILQQSSPDPLTYTIMDESGPDHDKTFTAGVIYKGKVIGKGSGHSKKEAEQQAAKDAFQHLEGMGKSGHK
SAGPIR

Sequences:

>Translated_246_residues
MSKQDEQANRLKTRLGFKWHNPTLLIQALTHSSCVHENRGHGLCHNQRLEFLGDAVLELIISEHLYKMFPDRTEGELTKM
RASSVCEPSLAKVARGLDLGRCLRMGRGEERSGGRERPSILADAFEALLGAIYLDQGLEISRHFVLNCLSSIIDDVVAGR
LDRDYKTELQEILQQSSPDPLTYTIMDESGPDHDKTFTAGVIYKGKVIGKGSGHSKKEAEQQAAKDAFQHLEGMGKSGHK
SAGPIR
>Mature_245_residues
SKQDEQANRLKTRLGFKWHNPTLLIQALTHSSCVHENRGHGLCHNQRLEFLGDAVLELIISEHLYKMFPDRTEGELTKMR
ASSVCEPSLAKVARGLDLGRCLRMGRGEERSGGRERPSILADAFEALLGAIYLDQGLEISRHFVLNCLSSIIDDVVAGRL
DRDYKTELQEILQQSSPDPLTYTIMDESGPDHDKTFTAGVIYKGKVIGKGSGHSKKEAEQQAAKDAFQHLEGMGKSGHKS
AGPIR

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=192, Percent_Identity=34.8958333333333, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI155030234, Length=192, Percent_Identity=34.8958333333333, Blast_Score=114, Evalue=7e-26,
Organism=Escherichia coli, GI1788920, Length=212, Percent_Identity=41.5094339622642, Blast_Score=153, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17506883, Length=239, Percent_Identity=31.3807531380753, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193202651, Length=239, Percent_Identity=31.3807531380753, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17137682, Length=236, Percent_Identity=30.9322033898305, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_DESRM (A4J683)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113411.1
- ProteinModelPortal:   A4J683
- SMR:   A4J683
- STRING:   A4J683
- GeneID:   4956699
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2069
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   A4J683
- ProtClustDB:   PRK00102
- BioCyc:   DRED349161:DRED_2069-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27279; Mature: 27148

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQDEQANRLKTRLGFKWHNPTLLIQALTHSSCVHENRGHGLCHNQRLEFLGDAVLELI
CCCCHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
ISEHLYKMFPDRTEGELTKMRASSVCEPSLAKVARGLDLGRCLRMGRGEERSGGRERPSI
HHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHH
LADAFEALLGAIYLDQGLEISRHFVLNCLSSIIDDVVAGRLDRDYKTELQEILQQSSPDP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
LTYTIMDESGPDHDKTFTAGVIYKGKVIGKGSGHSKKEAEQQAAKDAFQHLEGMGKSGHK
EEEEEECCCCCCCCCEEEECEEEECEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
SAGPIR
CCCCCC
>Mature Secondary Structure 
SKQDEQANRLKTRLGFKWHNPTLLIQALTHSSCVHENRGHGLCHNQRLEFLGDAVLELI
CCCHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
ISEHLYKMFPDRTEGELTKMRASSVCEPSLAKVARGLDLGRCLRMGRGEERSGGRERPSI
HHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHH
LADAFEALLGAIYLDQGLEISRHFVLNCLSSIIDDVVAGRLDRDYKTELQEILQQSSPDP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
LTYTIMDESGPDHDKTFTAGVIYKGKVIGKGSGHSKKEAEQQAAKDAFQHLEGMGKSGHK
EEEEEECCCCCCCCCEEEECEEEECEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
SAGPIR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA