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The map label for this gene is frr

Identifier: 134299822

GI number: 134299822

Start: 2169909

End: 2170463

Strand: Reverse

Name: frr

Synonym: Dred_1975

Alternate gene names: 134299822

Gene position: 2170463-2169909 (Counterclockwise)

Preceding gene: 134299823

Following gene: 134299821

Centisome position: 60.16

GC content: 40.54

Gene sequence:

>555_bases
ATGGTTAAAGAATTAATCTCTTCTGCGGAAGATCATATGAAGAAGAGTGTAGATGTTGTACGCAGGGAATTTGCTTCTTT
GCGTGCCGGTCGGGCAACCCCTTCTATTTTGGATAAGGTAACGGTATCTTATTACGGAACGCCTACCCCTTTAAACCAGC
TTGCTAACATTTCTGTTCCGGAAGCACGCGTTTTAGTAATTCAGCCTTGGGATAAAAGTGTAATACCTGAAGTTGAAAAA
GCTATTTTAAAATCAGATGTTGGTATAACACCCAGCAGTGATGGAACTGTAATACGTTTAATAATTCCCCAGCTAACACA
GGAACGCCGTACTGAGCTAGTTAAAGTTATTAAGAAAAAGGCTGAGGAAGGTCGGGTAGCTGTTCGGAACATTCGCCGTG
ATACCAATGATAGTATTAAAGCCAAGCAAAAAGATGGTATTCCCGAAGATGAAGCCAAGCGGGGGCAGGACGAATTACAA
AAATTAACAGACAAATATGTTAAAGAAATCGACGAAATGGTAAAAGCCAAAGAACAGGAGATTATGCAAGTTTAG

Upstream 100 bases:

>100_bases
AATAAAATCCCGCTATTGGTGTTTGATTTAAATACCGAGGGTAATATTAAAAGAGCAATCTTAGGGGAACGTATAGGTAC
TTTTGTTGGGGGGGACTTAA

Downstream 100 bases:

>100_bases
GATGATGCCAGATGTACTGGGGTACGAACTAAACAATGCATTGTCCCTTCTTAGGAATTGCGGTTTCGATGTAACTGTTG
CCATTACCAGGCCACATCGA

Product: ribosome recycling factor

Products: NA

Alternate protein names: RRF; Ribosome-releasing factor

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MVKELISSAEDHMKKSVDVVRREFASLRAGRATPSILDKVTVSYYGTPTPLNQLANISVPEARVLVIQPWDKSVIPEVEK
AILKSDVGITPSSDGTVIRLIIPQLTQERRTELVKVIKKKAEEGRVAVRNIRRDTNDSIKAKQKDGIPEDEAKRGQDELQ
KLTDKYVKEIDEMVKAKEQEIMQV

Sequences:

>Translated_184_residues
MVKELISSAEDHMKKSVDVVRREFASLRAGRATPSILDKVTVSYYGTPTPLNQLANISVPEARVLVIQPWDKSVIPEVEK
AILKSDVGITPSSDGTVIRLIIPQLTQERRTELVKVIKKKAEEGRVAVRNIRRDTNDSIKAKQKDGIPEDEAKRGQDELQ
KLTDKYVKEIDEMVKAKEQEIMQV
>Mature_184_residues
MVKELISSAEDHMKKSVDVVRREFASLRAGRATPSILDKVTVSYYGTPTPLNQLANISVPEARVLVIQPWDKSVIPEVEK
AILKSDVGITPSSDGTVIRLIIPQLTQERRTELVKVIKKKAEEGRVAVRNIRRDTNDSIKAKQKDGIPEDEAKRGQDELQ
KLTDKYVKEIDEMVKAKEQEIMQV

Specific function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another

COG id: COG0233

COG function: function code J; Ribosome recycling factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RRF family

Homologues:

Organism=Homo sapiens, GI20270317, Length=188, Percent_Identity=27.6595744680851, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI291042689, Length=165, Percent_Identity=29.0909090909091, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786368, Length=185, Percent_Identity=48.1081081081081, Blast_Score=183, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24661488, Length=172, Percent_Identity=28.4883720930233, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): RRF_DESRM (A4J5Z0)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113318.1
- ProteinModelPortal:   A4J5Z0
- SMR:   A4J5Z0
- STRING:   A4J5Z0
- GeneID:   4957641
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_1975
- eggNOG:   COG0233
- HOGENOM:   HBG533975
- OMA:   YYGAETP
- PhylomeDB:   A4J5Z0
- ProtClustDB:   PRK00083
- BioCyc:   DRED349161:DRED_1975-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00040
- InterPro:   IPR002661
- InterPro:   IPR015998
- PANTHER:   PTHR20982
- PANTHER:   PTHR20982:SF3
- TIGRFAMs:   TIGR00496

Pfam domain/function: PF01765 RRF; SSF55194 Ribosome_recyc_fac

EC number: NA

Molecular weight: Translated: 20731; Mature: 20731

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKELISSAEDHMKKSVDVVRREFASLRAGRATPSILDKVTVSYYGTPTPLNQLANISVP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCC
EARVLVIQPWDKSVIPEVEKAILKSDVGITPSSDGTVIRLIIPQLTQERRTELVKVIKKK
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
AEEGRVAVRNIRRDTNDSIKAKQKDGIPEDEAKRGQDELQKLTDKYVKEIDEMVKAKEQE
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
IMQV
HHCC
>Mature Secondary Structure
MVKELISSAEDHMKKSVDVVRREFASLRAGRATPSILDKVTVSYYGTPTPLNQLANISVP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCC
EARVLVIQPWDKSVIPEVEKAILKSDVGITPSSDGTVIRLIIPQLTQERRTELVKVIKKK
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
AEEGRVAVRNIRRDTNDSIKAKQKDGIPEDEAKRGQDELQKLTDKYVKEIDEMVKAKEQE
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
IMQV
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA