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The map label for this gene is pyrH

Identifier: 134299823

GI number: 134299823

Start: 2170456

End: 2171184

Strand: Reverse

Name: pyrH

Synonym: Dred_1976

Alternate gene names: 134299823

Gene position: 2171184-2170456 (Counterclockwise)

Preceding gene: 134299824

Following gene: 134299822

Centisome position: 60.18

GC content: 44.58

Gene sequence:

>729_bases
ATGGTAACTCCCAAGTTTAGGCGGGTCATCCTTAAGTTAAGTGGCGAAGCACTGGCTGGACAAAAAGGATATGGTATTGA
CCCAGAAGTTGTATACTCAATAGCCAGTCAAATTAAGGATGTTCTTGAACATCGGGTACAACTGGCCATCGTAGTTGGTG
GTGGGAATATCTGGCGTGGAATATCCGGTAGCACAAAGGGGATGGATAGAGCTACGGCTGATTATATGGGTATGTTAGCT
ACTGTTATTAATTCCTTGGCTTTGCAAGATGCCCTGGAAAAAATAGAAGTAGATACTCGCGTACAAACCTCCTTTGAGAT
GCGAGCAGTGGCAGAGACTTACATCCGTCGTCGGGCAATTCGACATATGGAGAAAGGGCGGGTTGTCATTTTTGCTGCGG
GTACCGGGAACCCATATTTTTCAACCGATACCACCGCTGCATTACGTGCAGCAGAGGTAGAAGCTGAAATTATCTTGATG
GCAAAGCAGGTTGACGGTGTTTATGATGCGGATCCTTTGAAGCATCCTGGGGCCAAGCGGTTTGATGAACTGACCTATAT
AGATGTACTTAACCGAGGTCTACAGGTAATGGATTCCACAGCTGTTTCGCTTTGTATGGATAATAAAATCCCGCTATTGG
TGTTTGATTTAAATACCGAGGGTAATATTAAAAGAGCAATCTTAGGGGAACGTATAGGTACTTTTGTTGGGGGGGACTTA
AATGGTTAA

Upstream 100 bases:

>100_bases
AGCTGCACAAATTAAAGCATAATATTTATTTGATAACGTTTAAAAGGATTTTTTAAAAAGTTGTAGAATAACAGAACTAC
CAGACTGGAGGACACCCTTA

Downstream 100 bases:

>100_bases
AGAATTAATCTCTTCTGCGGAAGATCATATGAAGAAGAGTGTAGATGTTGTACGCAGGGAATTTGCTTCTTTGCGTGCCG
GTCGGGCAACCCCTTCTATT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MVTPKFRRVILKLSGEALAGQKGYGIDPEVVYSIASQIKDVLEHRVQLAIVVGGGNIWRGISGSTKGMDRATADYMGMLA
TVINSLALQDALEKIEVDTRVQTSFEMRAVAETYIRRRAIRHMEKGRVVIFAAGTGNPYFSTDTTAALRAAEVEAEIILM
AKQVDGVYDADPLKHPGAKRFDELTYIDVLNRGLQVMDSTAVSLCMDNKIPLLVFDLNTEGNIKRAILGERIGTFVGGDL
NG

Sequences:

>Translated_242_residues
MVTPKFRRVILKLSGEALAGQKGYGIDPEVVYSIASQIKDVLEHRVQLAIVVGGGNIWRGISGSTKGMDRATADYMGMLA
TVINSLALQDALEKIEVDTRVQTSFEMRAVAETYIRRRAIRHMEKGRVVIFAAGTGNPYFSTDTTAALRAAEVEAEIILM
AKQVDGVYDADPLKHPGAKRFDELTYIDVLNRGLQVMDSTAVSLCMDNKIPLLVFDLNTEGNIKRAILGERIGTFVGGDL
NG
>Mature_242_residues
MVTPKFRRVILKLSGEALAGQKGYGIDPEVVYSIASQIKDVLEHRVQLAIVVGGGNIWRGISGSTKGMDRATADYMGMLA
TVINSLALQDALEKIEVDTRVQTSFEMRAVAETYIRRRAIRHMEKGRVVIFAAGTGNPYFSTDTTAALRAAEVEAEIILM
AKQVDGVYDADPLKHPGAKRFDELTYIDVLNRGLQVMDSTAVSLCMDNKIPLLVFDLNTEGNIKRAILGERIGTFVGGDL
NG

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=44.6351931330472, Blast_Score=231, Evalue=4e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_DESRM (A4J5Z1)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113319.1
- ProteinModelPortal:   A4J5Z1
- SMR:   A4J5Z1
- STRING:   A4J5Z1
- GeneID:   4958387
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_1976
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   A4J5Z1
- ProtClustDB:   PRK00358
- BioCyc:   DRED349161:DRED_1976-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26420; Mature: 26420

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 163-163 BINDING 168-168 BINDING 171-171

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTPKFRRVILKLSGEALAGQKGYGIDPEVVYSIASQIKDVLEHRVQLAIVVGGGNIWRG
CCCHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCEECC
ISGSTKGMDRATADYMGMLATVINSLALQDALEKIEVDTRVQTSFEMRAVAETYIRRRAI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RHMEKGRVVIFAAGTGNPYFSTDTTAALRAAEVEAEIILMAKQVDGVYDADPLKHPGAKR
HHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEHHCCCCCCCCCCCCCCCHH
FDELTYIDVLNRGLQVMDSTAVSLCMDNKIPLLVFDLNTEGNIKRAILGERIGTFVGGDL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
NG
CC
>Mature Secondary Structure
MVTPKFRRVILKLSGEALAGQKGYGIDPEVVYSIASQIKDVLEHRVQLAIVVGGGNIWRG
CCCHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCEECC
ISGSTKGMDRATADYMGMLATVINSLALQDALEKIEVDTRVQTSFEMRAVAETYIRRRAI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
RHMEKGRVVIFAAGTGNPYFSTDTTAALRAAEVEAEIILMAKQVDGVYDADPLKHPGAKR
HHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEHHCCCCCCCCCCCCCCCHH
FDELTYIDVLNRGLQVMDSTAVSLCMDNKIPLLVFDLNTEGNIKRAILGERIGTFVGGDL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
NG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA