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The map label for this gene is nuoF2 [H]

Identifier: 134299710

GI number: 134299710

Start: 2040142

End: 2041944

Strand: Reverse

Name: nuoF2 [H]

Synonym: Dred_1857

Alternate gene names: 134299710

Gene position: 2041944-2040142 (Counterclockwise)

Preceding gene: 134299711

Following gene: 134299709

Centisome position: 56.59

GC content: 44.59

Gene sequence:

>1803_bases
GTGAAAAACATTGATAATAATACTCCTAAAGTGGTTTGTATTTGCGCTGGTGGTTGCACTTCCTCCGGTTCCTTGAAAAT
ATTAGAACGTTTTCAAACTGAGATAGAACAAAGGGGACTGGCAGATAAAATTGTGGTTAAGCCTGTGGGGTGCCATGGCT
TTTGTGAACAGGGACCTATTGTTACGGTTGAACCAGAAAAATTATTTTATACCCGAGTTAGCGAGAATGATGTACCTGCC
CTTGTAGTATCTATAGCGAAAGGGTCACCAGTGGATCGGCTTTTATATATAAATCCGGAGAATAACCAAAGAGTCACCAA
TTATGAACGCGTTCCCTTTTATGCCCGCCAGCAGAAAATTGTCTTAGCAAAATGCGGTAAGATTAATCCGGAAAGGATTG
AGGACTATCTTGTCCTAGGAGGCTACCGGGCTATGAAAAAGGTATTAACAATCATGACACCACAAGCGGTGGTAGATGAA
GTGAAAAGCTCGGGTCTTCGGGGCCGCGGTGGTGCAGGATTTCCCACTGGTACAAAGTGGGAAGGTGCCCTTCATGCCAA
GATTAAAGATAAAAAATACGTGATTTGCAATGCAGATGAAGGTGACCCTGGTGCTTTTATGGATCGCAGCATATTAGAGG
GGAATCCCCATGAAGTCCTGGAAGGGATGATTATCTGTGGTTATGCCACTGGTTCGGATGAGGGATATATATATGTGCGG
GCGGAATACCCCATGGCCATTCGAAGATTAAAGATTGCTATTTCTCAGGCTGAAGCCGCAGGTTACCTAGGGAATAACAT
TCTTAATTCTGGCTTTAACTTTCACATTAAAATTAAAGCCGGTGCAGGGGCCTTTGTCTGTGGTGAGGGAACTGCCCTGA
TGGCTTCCATAGAAGGCAACCGGGGGATGCCACGATTCAAAGCAAGTCGATCCACCGAGAAGGGTCTTTGGGATAAACCA
ACAACAATGAATAATGTTGAAACCTTTGCCAACATTCCAACCATTATTGTCAAGGGAGCTTTATGGTATAGCTCCATCGG
TACGGATAATAGTAAAGGAACCAAAGTGTTTTCGTTAACTGGTAAAGTTGTTAATACAGGTTTAGTGGAAGTGCCGATGG
GAACTAGCCTCCGCCAAATTATATTTGATATCGGTGGTGGGATACCAAATAATAGAAAATTTAAAGCTGTACAATCCGGG
GGACCGTCTGGAGGATGTATTCCGGCAAAATACCTGGATTTGCCTGTGGACTATAATTCCCTGGGAAAGGTCGGAGCAAT
GATGGGCTCGGGCGGCCTTGTCGTTATGGATGATACCACCTGCATGGTGGATGTTGCACGGTTTTTCTTAAACTTTACCA
AGAATGAATCCTGCGGCAAATGTACGCCCTGTCGTGAAGGTACCCTGCGTATGTTGGAAATCCTTACTCGTATCTGTGAA
GGGAAAGGGGAACCCAAGGATATCGATGACCTAGAACGATTAGCAAAGGTTATCTGTGGTACATCACTGTGTGGACTTGG
CCAAAGTGCACCTTTCCCGGTCCTTAGCACTCTGCGCTACTTCCGGCATGAATATGAAGAGCATATTTACAATAAACGTT
GTCCAGCCGGTGTTTGTCCCAATCTACTGGTTTATACCATCGATAGGGAAAAATGCATTGGGTGTGGTATTTGTGCCCGC
TCCTGTCCTGTTGGAGCCATTGACGGGGAGAAAAAACAACCACATTCCATAGATATCAAAGCTTGCATAAAATGTGGCAA
TTGCCTGCAAAAATGTAAATTTGGTGCAGTTCAAAAGAGGTAG

Upstream 100 bases:

>100_bases
TAGCTCCCGCCATGATGATTAACGAAGATACTTACGGGCGCCTTACTCCGGTCAAAGCTTTAAATATTTTAAAACAGTAT
CAATAGACAGAGGTGTCATG

Downstream 100 bases:

>100_bases
ATGGCTTTTGGGAGAGTGAAGAGTTTGTCAAATGTTAACATAAATATAAATGGGCAGCAAATATTAGTTCCCGCTGGCAG
CACTATACTAGAGGCGGCTA

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MKNIDNNTPKVVCICAGGCTSSGSLKILERFQTEIEQRGLADKIVVKPVGCHGFCEQGPIVTVEPEKLFYTRVSENDVPA
LVVSIAKGSPVDRLLYINPENNQRVTNYERVPFYARQQKIVLAKCGKINPERIEDYLVLGGYRAMKKVLTIMTPQAVVDE
VKSSGLRGRGGAGFPTGTKWEGALHAKIKDKKYVICNADEGDPGAFMDRSILEGNPHEVLEGMIICGYATGSDEGYIYVR
AEYPMAIRRLKIAISQAEAAGYLGNNILNSGFNFHIKIKAGAGAFVCGEGTALMASIEGNRGMPRFKASRSTEKGLWDKP
TTMNNVETFANIPTIIVKGALWYSSIGTDNSKGTKVFSLTGKVVNTGLVEVPMGTSLRQIIFDIGGGIPNNRKFKAVQSG
GPSGGCIPAKYLDLPVDYNSLGKVGAMMGSGGLVVMDDTTCMVDVARFFLNFTKNESCGKCTPCREGTLRMLEILTRICE
GKGEPKDIDDLERLAKVICGTSLCGLGQSAPFPVLSTLRYFRHEYEEHIYNKRCPAGVCPNLLVYTIDREKCIGCGICAR
SCPVGAIDGEKKQPHSIDIKACIKCGNCLQKCKFGAVQKR

Sequences:

>Translated_600_residues
MKNIDNNTPKVVCICAGGCTSSGSLKILERFQTEIEQRGLADKIVVKPVGCHGFCEQGPIVTVEPEKLFYTRVSENDVPA
LVVSIAKGSPVDRLLYINPENNQRVTNYERVPFYARQQKIVLAKCGKINPERIEDYLVLGGYRAMKKVLTIMTPQAVVDE
VKSSGLRGRGGAGFPTGTKWEGALHAKIKDKKYVICNADEGDPGAFMDRSILEGNPHEVLEGMIICGYATGSDEGYIYVR
AEYPMAIRRLKIAISQAEAAGYLGNNILNSGFNFHIKIKAGAGAFVCGEGTALMASIEGNRGMPRFKASRSTEKGLWDKP
TTMNNVETFANIPTIIVKGALWYSSIGTDNSKGTKVFSLTGKVVNTGLVEVPMGTSLRQIIFDIGGGIPNNRKFKAVQSG
GPSGGCIPAKYLDLPVDYNSLGKVGAMMGSGGLVVMDDTTCMVDVARFFLNFTKNESCGKCTPCREGTLRMLEILTRICE
GKGEPKDIDDLERLAKVICGTSLCGLGQSAPFPVLSTLRYFRHEYEEHIYNKRCPAGVCPNLLVYTIDREKCIGCGICAR
SCPVGAIDGEKKQPHSIDIKACIKCGNCLQKCKFGAVQKR
>Mature_600_residues
MKNIDNNTPKVVCICAGGCTSSGSLKILERFQTEIEQRGLADKIVVKPVGCHGFCEQGPIVTVEPEKLFYTRVSENDVPA
LVVSIAKGSPVDRLLYINPENNQRVTNYERVPFYARQQKIVLAKCGKINPERIEDYLVLGGYRAMKKVLTIMTPQAVVDE
VKSSGLRGRGGAGFPTGTKWEGALHAKIKDKKYVICNADEGDPGAFMDRSILEGNPHEVLEGMIICGYATGSDEGYIYVR
AEYPMAIRRLKIAISQAEAAGYLGNNILNSGFNFHIKIKAGAGAFVCGEGTALMASIEGNRGMPRFKASRSTEKGLWDKP
TTMNNVETFANIPTIIVKGALWYSSIGTDNSKGTKVFSLTGKVVNTGLVEVPMGTSLRQIIFDIGGGIPNNRKFKAVQSG
GPSGGCIPAKYLDLPVDYNSLGKVGAMMGSGGLVVMDDTTCMVDVARFFLNFTKNESCGKCTPCREGTLRMLEILTRICE
GKGEPKDIDDLERLAKVICGTSLCGLGQSAPFPVLSTLRYFRHEYEEHIYNKRCPAGVCPNLLVYTIDREKCIGCGICAR
SCPVGAIDGEKKQPHSIDIKACIKCGNCLQKCKFGAVQKR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=400, Percent_Identity=39.25, Blast_Score=294, Evalue=2e-79,
Organism=Homo sapiens, GI260656005, Length=400, Percent_Identity=39.25, Blast_Score=294, Evalue=2e-79,
Organism=Escherichia coli, GI1788620, Length=420, Percent_Identity=40.4761904761905, Blast_Score=337, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17531727, Length=402, Percent_Identity=39.3034825870647, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI19920794, Length=400, Percent_Identity=38, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI45550452, Length=403, Percent_Identity=38.4615384615385, Blast_Score=278, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24653819, Length=380, Percent_Identity=32.6315789473684, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24653817, Length=355, Percent_Identity=30.7042253521127, Blast_Score=178, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 65161; Mature: 65161

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00645 COMPLEX1_51K_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIDNNTPKVVCICAGGCTSSGSLKILERFQTEIEQRGLADKIVVKPVGCHGFCEQGPI
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCE
VTVEPEKLFYTRVSENDVPALVVSIAKGSPVDRLLYINPENNQRVTNYERVPFYARQQKI
EEECCCCEEEEECCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCEECCCEECCCCEE
VLAKCGKINPERIEDYLVLGGYRAMKKVLTIMTPQAVVDEVKSSGLRGRGGAGFPTGTKW
EEEECCCCCHHHHHHEEEECCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
EGALHAKIKDKKYVICNADEGDPGAFMDRSILEGNPHEVLEGMIICGYATGSDEGYIYVR
CCEEEEEECCCEEEEEECCCCCCCCHHCCHHHCCCHHHHHCCEEEEEEECCCCCCEEEEE
AEYPMAIRRLKIAISQAEAAGYLGNNILNSGFNFHIKIKAGAGAFVCGEGTALMASIEGN
ECCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEECCCEEEECCCCEEEEEECCC
RGMPRFKASRSTEKGLWDKPTTMNNVETFANIPTIIVKGALWYSSIGTDNSKGTKVFSLT
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECHHHHHCCCCCCCCCCEEEEEE
GKVVNTGLVEVPMGTSLRQIIFDIGGGIPNNRKFKAVQSGGPSGGCIPAKYLDLPVDYNS
CHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHEEECCCCHHH
LGKVGAMMGSGGLVVMDDTTCMVDVARFFLNFTKNESCGKCTPCREGTLRMLEILTRICE
HHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GKGEPKDIDDLERLAKVICGTSLCGLGQSAPFPVLSTLRYFRHEYEEHIYNKRCPAGVCP
CCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NLLVYTIDREKCIGCGICARSCPVGAIDGEKKQPHSIDIKACIKCGNCLQKCKFGAVQKR
CEEEEEECCCHHCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKNIDNNTPKVVCICAGGCTSSGSLKILERFQTEIEQRGLADKIVVKPVGCHGFCEQGPI
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCE
VTVEPEKLFYTRVSENDVPALVVSIAKGSPVDRLLYINPENNQRVTNYERVPFYARQQKI
EEECCCCEEEEECCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCEECCCEECCCCEE
VLAKCGKINPERIEDYLVLGGYRAMKKVLTIMTPQAVVDEVKSSGLRGRGGAGFPTGTKW
EEEECCCCCHHHHHHEEEECCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
EGALHAKIKDKKYVICNADEGDPGAFMDRSILEGNPHEVLEGMIICGYATGSDEGYIYVR
CCEEEEEECCCEEEEEECCCCCCCCHHCCHHHCCCHHHHHCCEEEEEEECCCCCCEEEEE
AEYPMAIRRLKIAISQAEAAGYLGNNILNSGFNFHIKIKAGAGAFVCGEGTALMASIEGN
ECCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEECCCEEEECCCCEEEEEECCC
RGMPRFKASRSTEKGLWDKPTTMNNVETFANIPTIIVKGALWYSSIGTDNSKGTKVFSLT
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECHHHHHCCCCCCCCCCEEEEEE
GKVVNTGLVEVPMGTSLRQIIFDIGGGIPNNRKFKAVQSGGPSGGCIPAKYLDLPVDYNS
CHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHEEECCCCHHH
LGKVGAMMGSGGLVVMDDTTCMVDVARFFLNFTKNESCGKCTPCREGTLRMLEILTRICE
HHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GKGEPKDIDDLERLAKVICGTSLCGLGQSAPFPVLSTLRYFRHEYEEHIYNKRCPAGVCP
CCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NLLVYTIDREKCIGCGICARSCPVGAIDGEKKQPHSIDIKACIKCGNCLQKCKFGAVQKR
CEEEEEECCCHHCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]