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The map label for this gene is 134299664

Identifier: 134299664

GI number: 134299664

Start: 1983200

End: 1984522

Strand: Reverse

Name: 134299664

Synonym: Dred_1810

Alternate gene names: NA

Gene position: 1984522-1983200 (Counterclockwise)

Preceding gene: 134299667

Following gene: 134299662

Centisome position: 55.0

GC content: 42.4

Gene sequence:

>1323_bases
GTGGGTAGACTAGCAAGAAAACTAAATCAGATTGAAAAGGATTTTTATCTATCCCTTGGCATGGTCAATGATATTGCACG
GAATTTTCGGGCGGAGATGGTTGCCGGCCAGTCTGGGGATAGTTCCCTCAAAATGCTACATACCTTTATAACACCCCCAA
CAGGCCAAGAAACGGGTGAATTTCTTGCAGTTGATTTCGGGGGAACAAATGTGCGAATTCAGTTGGTGGAACTTTTAGGA
AAAGGACGTTACAGAATTAGAAAAAACCATTCTGTTATGCTTTGTGACCCAGCTGGAAGTTACGACTATACTTTAGAATG
TACATCTGGGGAAGAATTATTTGATTTCATTGTTGAGCAAATTGTTAAGCTGATCGATAACAAAACACATTATTTTCTGG
GCCACACCTTTTCCTTTCCCACCAAACAAATCGACCCTGCCCGGGCGATTTTAATCAATTGGACAAAGGAATTTAAAACA
GCGGGGACGGAGGGGAAAGAGGTGACGTCTTTGCTGGAAAATGCTCTTAAAAGGAAATCGATAAGGAATGTTCAACCCTT
GTCAATTATCAATGATACCACAGCCACGCTTCTGACAGCTGCCTACGGGAATGACTGTGCCAATATAGGTTCCATTTGTG
GCACAGGACATAATACTTGTTACTTGGAGGCTGCGGCAGGTCCGGTGATTATAAATATGGAATCGGGTAATTTTAATAAA
TTTCCGCTGACAACCTTTGACCTGGTGTTAAATGAAGCCAGTGAACAGCCTAATCTGCAACAGCTTGAGAAAGCGGTATC
GGGTCGGTATGTTGGTGAGATTGTTCGCTTAATTATTTTGGATTTCGTAGCTGAAAAAATGCTTTTTTCAAGGGGTATTA
ATGGCATTGATGAGCCATTTTCCATCCAAGCGCCGGAGGTTTCATTAATGATCCGGGGTAACCACAAACCAGATGATCTG
TTGGATTTAGCCCATTGGGTTGGTGTAAAATGGTGTGTCAAAAGTCCTTCGGCGGATGAATTGATCGCCCTGCGGTGCAT
TGCACAAACGGTAATTTGCAGGGCATCCCGTTTAATTGCTGCAACCTTTTTAGGGGTATTGCAGCATATTGATCCAGAGC
TTAAGTCCCGACAGGTTATTGGTATTGATGGTTCAATGTTTCAAAACATGCCCTTTTTTTTGCAAGGCATCCTTGAAATC
TTTAGCAACATATATGAAGATAAAGCGGCTAATATAGTGTTGAAATATATAAGAGATGCTTCGGGTGTAGGGGCTGCCAT
TGCTGCAGCAAGAATGAAATCCCTGCAAGTCAAGGGCAACTAA

Upstream 100 bases:

>100_bases
TCCTAAGAGAGTATGTTTGTTAATTAGAGGTTTTTTGTATAATAGGGTTATTGGCATAAAGATTGAATAAATAATCTCTT
TCTGTAGTGGGGTGGTTTTT

Downstream 100 bases:

>100_bases
ATGATACGCTTGATAACAAAACTAAATTTCTCGGCCTGATTTATATCAGCTTCGGTCATCTCTGCCAATATATTATATCT
TTTCTGGTTTTTTAGCTTAA

Product: hexokinase

Products: ADP; D-hexose 6-phosphate

Alternate protein names: Hexokinase Type III; Hexokinase Family Protein

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MGRLARKLNQIEKDFYLSLGMVNDIARNFRAEMVAGQSGDSSLKMLHTFITPPTGQETGEFLAVDFGGTNVRIQLVELLG
KGRYRIRKNHSVMLCDPAGSYDYTLECTSGEELFDFIVEQIVKLIDNKTHYFLGHTFSFPTKQIDPARAILINWTKEFKT
AGTEGKEVTSLLENALKRKSIRNVQPLSIINDTTATLLTAAYGNDCANIGSICGTGHNTCYLEAAAGPVIINMESGNFNK
FPLTTFDLVLNEASEQPNLQQLEKAVSGRYVGEIVRLIILDFVAEKMLFSRGINGIDEPFSIQAPEVSLMIRGNHKPDDL
LDLAHWVGVKWCVKSPSADELIALRCIAQTVICRASRLIAATFLGVLQHIDPELKSRQVIGIDGSMFQNMPFFLQGILEI
FSNIYEDKAANIVLKYIRDASGVGAAIAAARMKSLQVKGN

Sequences:

>Translated_440_residues
MGRLARKLNQIEKDFYLSLGMVNDIARNFRAEMVAGQSGDSSLKMLHTFITPPTGQETGEFLAVDFGGTNVRIQLVELLG
KGRYRIRKNHSVMLCDPAGSYDYTLECTSGEELFDFIVEQIVKLIDNKTHYFLGHTFSFPTKQIDPARAILINWTKEFKT
AGTEGKEVTSLLENALKRKSIRNVQPLSIINDTTATLLTAAYGNDCANIGSICGTGHNTCYLEAAAGPVIINMESGNFNK
FPLTTFDLVLNEASEQPNLQQLEKAVSGRYVGEIVRLIILDFVAEKMLFSRGINGIDEPFSIQAPEVSLMIRGNHKPDDL
LDLAHWVGVKWCVKSPSADELIALRCIAQTVICRASRLIAATFLGVLQHIDPELKSRQVIGIDGSMFQNMPFFLQGILEI
FSNIYEDKAANIVLKYIRDASGVGAAIAAARMKSLQVKGN
>Mature_439_residues
GRLARKLNQIEKDFYLSLGMVNDIARNFRAEMVAGQSGDSSLKMLHTFITPPTGQETGEFLAVDFGGTNVRIQLVELLGK
GRYRIRKNHSVMLCDPAGSYDYTLECTSGEELFDFIVEQIVKLIDNKTHYFLGHTFSFPTKQIDPARAILINWTKEFKTA
GTEGKEVTSLLENALKRKSIRNVQPLSIINDTTATLLTAAYGNDCANIGSICGTGHNTCYLEAAAGPVIINMESGNFNKF
PLTTFDLVLNEASEQPNLQQLEKAVSGRYVGEIVRLIILDFVAEKMLFSRGINGIDEPFSIQAPEVSLMIRGNHKPDDLL
DLAHWVGVKWCVKSPSADELIALRCIAQTVICRASRLIAATFLGVLQHIDPELKSRQVIGIDGSMFQNMPFFLQGILEIF
SNIYEDKAANIVLKYIRDASGVGAAIAAARMKSLQVKGN

Specific function: Unknown

COG id: COG5026

COG function: function code G; Hexokinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI15553127, Length=461, Percent_Identity=30.58568329718, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI188497754, Length=464, Percent_Identity=30.6034482758621, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI15991829, Length=462, Percent_Identity=30.7359307359307, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI15991831, Length=462, Percent_Identity=30.7359307359307, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI188497750, Length=466, Percent_Identity=30.4721030042918, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI15991827, Length=466, Percent_Identity=30.4721030042918, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI194097330, Length=452, Percent_Identity=31.858407079646, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI156151420, Length=468, Percent_Identity=29.0598290598291, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI4503951, Length=455, Percent_Identity=29.6703296703297, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI15967161, Length=455, Percent_Identity=29.4505494505495, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI15967159, Length=454, Percent_Identity=29.5154185022026, Blast_Score=168, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI71983713, Length=419, Percent_Identity=30.3102625298329, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71983705, Length=425, Percent_Identity=29.8823529411765, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17507937, Length=472, Percent_Identity=27.7542372881356, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17544236, Length=470, Percent_Identity=24.8936170212766, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321184, Length=433, Percent_Identity=26.5588914549654, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319809, Length=489, Percent_Identity=26.1758691206544, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321168, Length=457, Percent_Identity=27.1334792122538, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320724, Length=445, Percent_Identity=26.0674157303371, Blast_Score=126, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45551986, Length=450, Percent_Identity=29.3333333333333, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI17864242, Length=471, Percent_Identity=29.723991507431, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI18079297, Length=461, Percent_Identity=28.8503253796095, Blast_Score=161, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24640843, Length=433, Percent_Identity=29.7921478060046, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28571896, Length=400, Percent_Identity=28.75, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.1.1

Molecular weight: Translated: 48590; Mature: 48458

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLARKLNQIEKDFYLSLGMVNDIARNFRAEMVAGQSGDSSLKMLHTFITPPTGQETGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCC
FLAVDFGGTNVRIQLVELLGKGRYRIRKNHSVMLCDPAGSYDYTLECTSGEELFDFIVEQ
EEEEEECCCCEEEHHHHHHCCCCEEEECCCEEEEECCCCCCEEEEEECCCHHHHHHHHHH
IVKLIDNKTHYFLGHTFSFPTKQIDPARAILINWTKEFKTAGTEGKEVTSLLENALKRKS
HHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEECHHHHHCCCCCHHHHHHHHHHHHHHHH
IRNVQPLSIINDTTATLLTAAYGNDCANIGSICGTGHNTCYLEAAAGPVIINMESGNFNK
HCCCCCCHHCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCC
FPLTTFDLVLNEASEQPNLQQLEKAVSGRYVGEIVRLIILDFVAEKMLFSRGINGIDEPF
CCCHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SIQAPEVSLMIRGNHKPDDLLDLAHWVGVKWCVKSPSADELIALRCIAQTVICRASRLIA
EECCCCEEEEEECCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
ATFLGVLQHIDPELKSRQVIGIDGSMFQNMPFFLQGILEIFSNIYEDKAANIVLKYIRDA
HHHHHHHHHCCHHHHCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGVGAAIAAARMKSLQVKGN
CCCHHHHHHHHHHHEEECCC
>Mature Secondary Structure 
GRLARKLNQIEKDFYLSLGMVNDIARNFRAEMVAGQSGDSSLKMLHTFITPPTGQETGE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCC
FLAVDFGGTNVRIQLVELLGKGRYRIRKNHSVMLCDPAGSYDYTLECTSGEELFDFIVEQ
EEEEEECCCCEEEHHHHHHCCCCEEEECCCEEEEECCCCCCEEEEEECCCHHHHHHHHHH
IVKLIDNKTHYFLGHTFSFPTKQIDPARAILINWTKEFKTAGTEGKEVTSLLENALKRKS
HHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEECHHHHHCCCCCHHHHHHHHHHHHHHHH
IRNVQPLSIINDTTATLLTAAYGNDCANIGSICGTGHNTCYLEAAAGPVIINMESGNFNK
HCCCCCCHHCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCC
FPLTTFDLVLNEASEQPNLQQLEKAVSGRYVGEIVRLIILDFVAEKMLFSRGINGIDEPF
CCCHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SIQAPEVSLMIRGNHKPDDLLDLAHWVGVKWCVKSPSADELIALRCIAQTVICRASRLIA
EECCCCEEEEEECCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
ATFLGVLQHIDPELKSRQVIGIDGSMFQNMPFFLQGILEIFSNIYEDKAANIVLKYIRDA
HHHHHHHHHCCHHHHCCEEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SGVGAAIAAARMKSLQVKGN
CCCHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; D-hexose

Specific reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA