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The map label for this gene is mutM

Identifier: 134299455

GI number: 134299455

Start: 1737057

End: 1737890

Strand: Reverse

Name: mutM

Synonym: Dred_1598

Alternate gene names: 134299455

Gene position: 1737890-1737057 (Counterclockwise)

Preceding gene: 134299456

Following gene: 134299454

Centisome position: 48.17

GC content: 44.96

Gene sequence:

>834_bases
ATGCCTGAACTACCGGAAGTAGAAACCATCGTTCGCTCCCTGGAAAAACATTTATCCGGCCTTGTCATAACCTCCGTTGA
TTTATTTAAACCAGAGGTTATCCGTACACCCAGGGTGGATATATTTACGGATCAAATTGTAGGAAGGCAATTTCAAAAAA
AACTGGGGCGTCGCGGCAAATACCTTTTACTCCACATGAGCGATGGCTTAACCCTGGTAATTCATCTTCGCATGACTGGA
AGACTGATTTATTGTGATGCTGACTTACCGCTGGAAAAACACACCCATGTGATTTTTCATTTGGATAATGGTAAACAACT
GCGCTTTGCCGATGTAAGGCGCTTTGGTCGTATGAGTCTGGTACCAACCAGAGAGGTACCCCATTTGCCCGGAATAAAAG
AAATGGGTCCAGAGCCCTTGGACACAGCCTTTAGCCGAGAATATTTAAAGAAAGAACTTCGTCGCAGACGAACCCGTATT
AAATCTTTATTGTTGGACCAGTGTTTTGTTGCCGGGTTAGGCAATATCTATGCTGACGAAGCACTGCACGAGGCTAAAAT
TCATCCCGAACGATTGGCACCGGATTTAACCAGCCGTGAAGCATCAGGGTTGCATAAAGCTATTATTGAAGTTATCTCCA
GTGGCATTAAACACAGAGGAACCACTTTTCGCGATTACGTAGACGGAGAAGGTCGTTCCGGCAGCTATCAACACCAATTA
AAGGTTTATAACCGCGAAGGTCTTCCCTGCCCCCACTGCGGAAAACCTATCCAACGCATAAAAGTAGCAGGCAGAAGTTC
TTATTACTGCTCCTCCTGTCAAAAAGCCAAATAG

Upstream 100 bases:

>100_bases
ACGCATTACAATTAGACGTACCACTAGTGGTGGACATTAAGCTTGGTCCCAATTGGTACGAAGCTAAGCCCATTTAATCC
GTCTTCTGAGAGGTGAAATC

Downstream 100 bases:

>100_bases
TAGCAAGCACCCCTTTCTCTCCCCCTTCATAGACTGTAGATGTAAACAACGTCGACTGGGGGGGAAGTCATGGAGTTGCT
CACATTGGTTGTCTTTGCCC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MPELPEVETIVRSLEKHLSGLVITSVDLFKPEVIRTPRVDIFTDQIVGRQFQKKLGRRGKYLLLHMSDGLTLVIHLRMTG
RLIYCDADLPLEKHTHVIFHLDNGKQLRFADVRRFGRMSLVPTREVPHLPGIKEMGPEPLDTAFSREYLKKELRRRRTRI
KSLLLDQCFVAGLGNIYADEALHEAKIHPERLAPDLTSREASGLHKAIIEVISSGIKHRGTTFRDYVDGEGRSGSYQHQL
KVYNREGLPCPHCGKPIQRIKVAGRSSYYCSSCQKAK

Sequences:

>Translated_277_residues
MPELPEVETIVRSLEKHLSGLVITSVDLFKPEVIRTPRVDIFTDQIVGRQFQKKLGRRGKYLLLHMSDGLTLVIHLRMTG
RLIYCDADLPLEKHTHVIFHLDNGKQLRFADVRRFGRMSLVPTREVPHLPGIKEMGPEPLDTAFSREYLKKELRRRRTRI
KSLLLDQCFVAGLGNIYADEALHEAKIHPERLAPDLTSREASGLHKAIIEVISSGIKHRGTTFRDYVDGEGRSGSYQHQL
KVYNREGLPCPHCGKPIQRIKVAGRSSYYCSSCQKAK
>Mature_276_residues
PELPEVETIVRSLEKHLSGLVITSVDLFKPEVIRTPRVDIFTDQIVGRQFQKKLGRRGKYLLLHMSDGLTLVIHLRMTGR
LIYCDADLPLEKHTHVIFHLDNGKQLRFADVRRFGRMSLVPTREVPHLPGIKEMGPEPLDTAFSREYLKKELRRRRTRIK
SLLLDQCFVAGLGNIYADEALHEAKIHPERLAPDLTSREASGLHKAIIEVISSGIKHRGTTFRDYVDGEGRSGSYQHQLK
VYNREGLPCPHCGKPIQRIKVAGRSSYYCSSCQKAK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=278, Percent_Identity=41.0071942446043, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1786932, Length=281, Percent_Identity=28.4697508896797, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_DESRM (A4J4X3)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001112951.1
- STRING:   A4J4X3
- GeneID:   4956392
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_1598
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   A4J4X3
- ProtClustDB:   CLSK843193
- BioCyc:   DRED349161:DRED_1598-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31598; Mature: 31467

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 265-265 BINDING 94-94 BINDING 113-113 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETIVRSLEKHLSGLVITSVDLFKPEVIRTPRVDIFTDQIVGRQFQKKLGRRGK
CCCCCHHHHHHHHHHHHHCCEEEEEHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
YLLLHMSDGLTLVIHLRMTGRLIYCDADLPLEKHTHVIFHLDNGKQLRFADVRRFGRMSL
EEEEEECCCCEEEEEEEECCEEEEECCCCCCCCCCEEEEEECCCCEEHHHHHHHHCCCCC
VPTREVPHLPGIKEMGPEPLDTAFSREYLKKELRRRRTRIKSLLLDQCFVAGLGNIYADE
CCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALHEAKIHPERLAPDLTSREASGLHKAIIEVISSGIKHRGTTFRDYVDGEGRSGSYQHQL
HHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEE
KVYNREGLPCPHCGKPIQRIKVAGRSSYYCSSCQKAK
EEECCCCCCCCCCCCHHHHHHHCCCCCHHHCCCCCCC
>Mature Secondary Structure 
PELPEVETIVRSLEKHLSGLVITSVDLFKPEVIRTPRVDIFTDQIVGRQFQKKLGRRGK
CCCCHHHHHHHHHHHHHCCEEEEEHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
YLLLHMSDGLTLVIHLRMTGRLIYCDADLPLEKHTHVIFHLDNGKQLRFADVRRFGRMSL
EEEEEECCCCEEEEEEEECCEEEEECCCCCCCCCCEEEEEECCCCEEHHHHHHHHCCCCC
VPTREVPHLPGIKEMGPEPLDTAFSREYLKKELRRRRTRIKSLLLDQCFVAGLGNIYADE
CCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ALHEAKIHPERLAPDLTSREASGLHKAIIEVISSGIKHRGTTFRDYVDGEGRSGSYQHQL
HHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEE
KVYNREGLPCPHCGKPIQRIKVAGRSSYYCSSCQKAK
EEECCCCCCCCCCCCHHHHHHHCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA