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The map label for this gene is atoC [H]

Identifier: 134299369

GI number: 134299369

Start: 1638370

End: 1639716

Strand: Reverse

Name: atoC [H]

Synonym: Dred_1510

Alternate gene names: 134299369

Gene position: 1639716-1638370 (Counterclockwise)

Preceding gene: 134299370

Following gene: 134299368

Centisome position: 45.45

GC content: 41.5

Gene sequence:

>1347_bases
TTGATACCACGAATTCTGGTCATTGATGATGAAGAAAGAATGTGCTGGGCCCTTGAGAGGGCATTAGGCCATGAAGGATA
CCAAGTGATAACAGCTACCCGGGGTCTTCGGGGTATTGAGTTAGCCCATGAAACTGAACCTTCATTGGTAATTCTGGATT
TAAAGATGCCGGACATCACAGGTATTGAGGTATTAAAAAAGATTAAAAGTATCAACTCTAATATCCCTGTGATCATGATT
ACTGCTCACGGCACAATTGAAACCGCCATCGAAGCCATGAAATTCGGTGCCACTGATTATATCACCAAACCATTTAAGCT
GGATGAACTAAAAGTTCAAGTTAAACAGGCCCTCCATCTATCCAATTTAGAAAATCAGGTTGATTTTTTACGACAGGAAC
TGGGTAAAAAATATGGTAAAATGGTGGGTCAGAGTGATGCAATAAAAGAGGTTTCCCTGTTAATCCGACAGGTAGCCAAA
ACCAATGCCACTGTTCTTATTACCGGGGAAAGTGGTACTGGCAAAGAAGTGGCAGCGGTAGAAATACATAAATCCAGCAA
ACGAGCCGACAGGCCCTTTGTGGCAGTCAATTGCGCAGCTCTACCGGAACAACTTCTGGAAAGTGAATTGTTTGGGCATG
AAAAAGGGGCCTTTACTGGTGCCACAAGCAAAAAGAAAGGTCGCTTTGAAATTGCGGATAGGGGGACTATTTTTTTAGAT
GAGATTGGAGAAATGCCCATCAGCATGCAGGTTAAGTTGCTGCGGGTTCTGCAGGAAAGATGTTTTGAAAGACTGGGAGG
TACCGAGACCATTCAAGTGGATGTACGAGTAATTGCTGCCACCAACTCGGAGTTATCCTCTGCCATTGCCAAGGGAACCT
TTCGGGAGGATTTATATTATCGGTTAAACGTCATGCGAATTAACCTCCCTCCATTGCGTTCCCGCAAAGAAGACATCTCT
TTATTGGTAAATCATTTTCTAAGTAAGTTTGATCCTTCCCGAAGTAAAAAAATATCACCGGAGGCAATGAAGATTTTAAA
TAACTACCACTGGCCTGGTAATATTCGAGAACTTCAAAATGCCATTGAAAGAGCTCTGATTGTTTGTCAAGGTTCAGAAA
TCCAACCTGTACATCTGCCCAGGGAGTTATTGGATAGTTTAAAGGAAAATGCAGACCCCATTTTAAATCTCCCGGAAAGT
GGGTTCTCCCTTGAAGAGTTAGAAAAACATCTTATCATAAAAGCATTGGAAAAACATAACTATAATCAGACAAAGGCTGC
AAAATATTTGGGAATTTCTCGTCCTACGTTACTTTACCGAATGCAAAAATACGGTATTAAGTTATAG

Upstream 100 bases:

>100_bases
CATGAAGGAACCATTGAAGTGTCTAGTACCCGGAACAAAGGAACCACATTTACCATTCGGTTGCCAAGGAAAAAACATAT
CTCCGAGAGGAGGGATTGTC

Downstream 100 bases:

>100_bases
GTATTATAGAAAGGGTGGTATGAATGCTGCAGAGTTTAACTGCCCGTGATGTTATGATCCCGTTAAGTGATTACGCCACG
GTCTCAGCGGATGATTCTAT

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MIPRILVIDDEERMCWALERALGHEGYQVITATRGLRGIELAHETEPSLVILDLKMPDITGIEVLKKIKSINSNIPVIMI
TAHGTIETAIEAMKFGATDYITKPFKLDELKVQVKQALHLSNLENQVDFLRQELGKKYGKMVGQSDAIKEVSLLIRQVAK
TNATVLITGESGTGKEVAAVEIHKSSKRADRPFVAVNCAALPEQLLESELFGHEKGAFTGATSKKKGRFEIADRGTIFLD
EIGEMPISMQVKLLRVLQERCFERLGGTETIQVDVRVIAATNSELSSAIAKGTFREDLYYRLNVMRINLPPLRSRKEDIS
LLVNHFLSKFDPSRSKKISPEAMKILNNYHWPGNIRELQNAIERALIVCQGSEIQPVHLPRELLDSLKENADPILNLPES
GFSLEELEKHLIIKALEKHNYNQTKAAKYLGISRPTLLYRMQKYGIKL

Sequences:

>Translated_448_residues
MIPRILVIDDEERMCWALERALGHEGYQVITATRGLRGIELAHETEPSLVILDLKMPDITGIEVLKKIKSINSNIPVIMI
TAHGTIETAIEAMKFGATDYITKPFKLDELKVQVKQALHLSNLENQVDFLRQELGKKYGKMVGQSDAIKEVSLLIRQVAK
TNATVLITGESGTGKEVAAVEIHKSSKRADRPFVAVNCAALPEQLLESELFGHEKGAFTGATSKKKGRFEIADRGTIFLD
EIGEMPISMQVKLLRVLQERCFERLGGTETIQVDVRVIAATNSELSSAIAKGTFREDLYYRLNVMRINLPPLRSRKEDIS
LLVNHFLSKFDPSRSKKISPEAMKILNNYHWPGNIRELQNAIERALIVCQGSEIQPVHLPRELLDSLKENADPILNLPES
GFSLEELEKHLIIKALEKHNYNQTKAAKYLGISRPTLLYRMQKYGIKL
>Mature_448_residues
MIPRILVIDDEERMCWALERALGHEGYQVITATRGLRGIELAHETEPSLVILDLKMPDITGIEVLKKIKSINSNIPVIMI
TAHGTIETAIEAMKFGATDYITKPFKLDELKVQVKQALHLSNLENQVDFLRQELGKKYGKMVGQSDAIKEVSLLIRQVAK
TNATVLITGESGTGKEVAAVEIHKSSKRADRPFVAVNCAALPEQLLESELFGHEKGAFTGATSKKKGRFEIADRGTIFLD
EIGEMPISMQVKLLRVLQERCFERLGGTETIQVDVRVIAATNSELSSAIAKGTFREDLYYRLNVMRINLPPLRSRKEDIS
LLVNHFLSKFDPSRSKKISPEAMKILNNYHWPGNIRELQNAIERALIVCQGSEIQPVHLPRELLDSLKENADPILNLPES
GFSLEELEKHLIIKALEKHNYNQTKAAKYLGISRPTLLYRMQKYGIKL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=454, Percent_Identity=47.3568281938326, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1790437, Length=444, Percent_Identity=46.3963963963964, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1790299, Length=466, Percent_Identity=39.2703862660944, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1788905, Length=442, Percent_Identity=40.9502262443439, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI87082117, Length=327, Percent_Identity=48.0122324159021, Blast_Score=284, Evalue=9e-78,
Organism=Escherichia coli, GI1789087, Length=345, Percent_Identity=45.7971014492754, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1789233, Length=318, Percent_Identity=46.2264150943396, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1786524, Length=344, Percent_Identity=42.7325581395349, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87082152, Length=324, Percent_Identity=40.4320987654321, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI87081872, Length=307, Percent_Identity=40.3908794788274, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1787583, Length=317, Percent_Identity=40.0630914826498, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87081858, Length=293, Percent_Identity=33.1058020477816, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1789828, Length=255, Percent_Identity=32.9411764705882, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=34.4827586206897, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1786599, Length=124, Percent_Identity=36.2903225806452, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790552, Length=171, Percent_Identity=30.9941520467836, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789809, Length=116, Percent_Identity=33.6206896551724, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786911, Length=114, Percent_Identity=35.9649122807018, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082012, Length=133, Percent_Identity=29.3233082706767, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789402, Length=192, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790860, Length=114, Percent_Identity=29.8245614035088, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1787375, Length=119, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788394, Length=116, Percent_Identity=31.0344827586207, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790863, Length=116, Percent_Identity=30.1724137931034, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50383; Mature: 50383

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50030 UBA ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPRILVIDDEERMCWALERALGHEGYQVITATRGLRGIELAHETEPSLVILDLKMPDIT
CCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCCCCEEEEEECCCCCH
GIEVLKKIKSINSNIPVIMITAHGTIETAIEAMKFGATDYITKPFKLDELKVQVKQALHL
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHH
SNLENQVDFLRQELGKKYGKMVGQSDAIKEVSLLIRQVAKTNATVLITGESGTGKEVAAV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEE
EIHKSSKRADRPFVAVNCAALPEQLLESELFGHEKGAFTGATSKKKGRFEIADRGTIFLD
EEECCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCEEEEE
EIGEMPISMQVKLLRVLQERCFERLGGTETIQVDVRVIAATNSELSSAIAKGTFREDLYY
HHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHHHHCCHHHHHEE
RLNVMRINLPPLRSRKEDISLLVNHFLSKFDPSRSKKISPEAMKILNNYHWPGNIRELQN
EEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
AIERALIVCQGSEIQPVHLPRELLDSLKENADPILNLPESGFSLEELEKHLIIKALEKHN
HHHHHEEEECCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCC
YNQTKAAKYLGISRPTLLYRMQKYGIKL
CCHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MIPRILVIDDEERMCWALERALGHEGYQVITATRGLRGIELAHETEPSLVILDLKMPDIT
CCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCCCCEEEEEECCCCCH
GIEVLKKIKSINSNIPVIMITAHGTIETAIEAMKFGATDYITKPFKLDELKVQVKQALHL
HHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHH
SNLENQVDFLRQELGKKYGKMVGQSDAIKEVSLLIRQVAKTNATVLITGESGTGKEVAAV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEE
EIHKSSKRADRPFVAVNCAALPEQLLESELFGHEKGAFTGATSKKKGRFEIADRGTIFLD
EEECCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCEEEEE
EIGEMPISMQVKLLRVLQERCFERLGGTETIQVDVRVIAATNSELSSAIAKGTFREDLYY
HHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHHHHCCHHHHHEE
RLNVMRINLPPLRSRKEDISLLVNHFLSKFDPSRSKKISPEAMKILNNYHWPGNIRELQN
EEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
AIERALIVCQGSEIQPVHLPRELLDSLKENADPILNLPESGFSLEELEKHLIIKALEKHN
HHHHHEEEECCCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCC
YNQTKAAKYLGISRPTLLYRMQKYGIKL
CCHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]