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The map label for this gene is zraS [H]

Identifier: 134299370

GI number: 134299370

Start: 1639691

End: 1641418

Strand: Reverse

Name: zraS [H]

Synonym: Dred_1511

Alternate gene names: 134299370

Gene position: 1641418-1639691 (Counterclockwise)

Preceding gene: 134299373

Following gene: 134299369

Centisome position: 45.49

GC content: 40.97

Gene sequence:

>1728_bases
TTGCAACACCTCTTGAGTATTTTTCTAAAGTTTGTTTTATCTGATTATACGCTTATTGCTTTTATTTTTGCAATATATCG
TGTTTTTTCGTTTTTGTATCTTTTCCTACACCTACTTGTAGTATATAATTCACATAAAGAAAAATATCCAAAAGGGAGGT
CGATTTTACTGAATAATAAAAATATTTTTCCTTTCTTTAAACAAAATAGTCTAACTAATCAGATAGTAACTATTATTGCA
GTGATTATGCTTGTACCTATTGTAGCATTGATGTATGACGTATTCTTCGCCTCCCAAACAGATAAGGTAATATTTCTAGA
GAAAGAGCAGCGATTAAAAGCTCTGGTTAAGAGTACTAACCAAAGTTTTATGAAAAACCTTGAGTCTCTAAGAATAACTC
CCGAGAATATCTCCTCAACCACACTGCATAATGAATTTACACGGGTGGTAGAGCCGCACCTGCCTGCTAATTCTGGCATC
CGCTTCGGTCTCTATGTACCTCAAACAGAAAAAATCAAAGTACTGGGTTTCCTGCATAACTATCGTAATCTCTCCCCTGA
AGAGGAAGCCCAGCGGGAAAAAATTATTTTCGCCAATACTAAGCCTCGCTTGGTGGCAACTGAAATGAGCAAGGAGCCCA
ATTTTTACATTTCCGGTTCCTGGGATGACCAAGTTGTTGAGTACATTTCCCCTGTGATATTGCAAGGAAAAGTGGTAGCA
GTTATGTGGGCAGGCGAACGTTTAAACCCCTTCTTCTACCAAAGCAATTATGCTCGGAAATTCCTTCGTTACTTTACTTT
AGCAGTGTTGGCCATGGTCATGTTTGCAACCCTTTTAACAATCCGCAATATTACAACCGGTGTTGATCGTTTAAAAAAGG
GGTTACATCGCATGGAACACGATATTCACCACCTACTGCCCGAGATGTCCGGCGAACTGGGCCAGGTAGCCCAGGCAGTT
AACCGTATGGCCCTTGGCTTGTTGGAAAAGGAACGACTGGAAGACCAACTGCGTCAGTCGGAGCACCTTATTGCACTTGG
CCGTCTGGCAACGGGCGTAGCTCACGAGTTGCGAAACCCCATCGGTATTATTAAAACCCTGGTGGAACTAATGAAAGATG
AGTACTCTCAGGTTAGTGGTATCGATGAATTTACCAAAGCAGTTGACGAACAAGTGGATCGCCAAAACATGGTGATTCAA
GAACTTCTAGATTTTGGCCGTCCAACAAAGGTATCTATTAAGGAATGTTCTGTTAATGACCTTCTAAAGGGTGTACTATC
CTTCTCTGCTGCGATGTTGCGAAAAGAAAATGTAACGGTTCACTTGCATTTGGATGAAAGTCTGCCTAAAATCATGGCGG
ATACTGAAAAACTTAAACAGGTATTTGTTAATCTTATTGTTAATGCTGCGGAGGCCATGCCATCCGGTGGAACATTGGAT
ATTAAAACAGAGCAAAGTGAAAACTTGGTGACAGTCACCTTCTCGGACACGGGTGAAGGTATTGACTTAGAAGAAAAGTC
TAAGATTTTTGATCCCTTTTACACGACCAAAAAGGCTGGCACTGGGCTTGGGCTTTCTATTTCTTACCAAAACATTAAGC
TACATGAAGGAACCATTGAAGTGTCTAGTACCCGGAACAAAGGAACCACATTTACCATTCGGTTGCCAAGGAAAAAACAT
ATCTCCGAGAGGAGGGATTGTCTTGATACCACGAATTCTGGTCATTGA

Upstream 100 bases:

>100_bases
TTATTTGTGATTTAATTCTTTATATAGCAAAGTCTGTGCCAACATCATAATTCCTTTGTTTCCAAGCTTTCTTTAGAAAA
ATACTCAAGAGGTGTAGCAA

Downstream 100 bases:

>100_bases
TGATGAAGAAAGAATGTGCTGGGCCCTTGAGAGGGCATTAGGCCATGAAGGATACCAAGTGATAACAGCTACCCGGGGTC
TTCGGGGTATTGAGTTAGCC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MQHLLSIFLKFVLSDYTLIAFIFAIYRVFSFLYLFLHLLVVYNSHKEKYPKGRSILLNNKNIFPFFKQNSLTNQIVTIIA
VIMLVPIVALMYDVFFASQTDKVIFLEKEQRLKALVKSTNQSFMKNLESLRITPENISSTTLHNEFTRVVEPHLPANSGI
RFGLYVPQTEKIKVLGFLHNYRNLSPEEEAQREKIIFANTKPRLVATEMSKEPNFYISGSWDDQVVEYISPVILQGKVVA
VMWAGERLNPFFYQSNYARKFLRYFTLAVLAMVMFATLLTIRNITTGVDRLKKGLHRMEHDIHHLLPEMSGELGQVAQAV
NRMALGLLEKERLEDQLRQSEHLIALGRLATGVAHELRNPIGIIKTLVELMKDEYSQVSGIDEFTKAVDEQVDRQNMVIQ
ELLDFGRPTKVSIKECSVNDLLKGVLSFSAAMLRKENVTVHLHLDESLPKIMADTEKLKQVFVNLIVNAAEAMPSGGTLD
IKTEQSENLVTVTFSDTGEGIDLEEKSKIFDPFYTTKKAGTGLGLSISYQNIKLHEGTIEVSSTRNKGTTFTIRLPRKKH
ISERRDCLDTTNSGH

Sequences:

>Translated_575_residues
MQHLLSIFLKFVLSDYTLIAFIFAIYRVFSFLYLFLHLLVVYNSHKEKYPKGRSILLNNKNIFPFFKQNSLTNQIVTIIA
VIMLVPIVALMYDVFFASQTDKVIFLEKEQRLKALVKSTNQSFMKNLESLRITPENISSTTLHNEFTRVVEPHLPANSGI
RFGLYVPQTEKIKVLGFLHNYRNLSPEEEAQREKIIFANTKPRLVATEMSKEPNFYISGSWDDQVVEYISPVILQGKVVA
VMWAGERLNPFFYQSNYARKFLRYFTLAVLAMVMFATLLTIRNITTGVDRLKKGLHRMEHDIHHLLPEMSGELGQVAQAV
NRMALGLLEKERLEDQLRQSEHLIALGRLATGVAHELRNPIGIIKTLVELMKDEYSQVSGIDEFTKAVDEQVDRQNMVIQ
ELLDFGRPTKVSIKECSVNDLLKGVLSFSAAMLRKENVTVHLHLDESLPKIMADTEKLKQVFVNLIVNAAEAMPSGGTLD
IKTEQSENLVTVTFSDTGEGIDLEEKSKIFDPFYTTKKAGTGLGLSISYQNIKLHEGTIEVSSTRNKGTTFTIRLPRKKH
ISERRDCLDTTNSGH
>Mature_575_residues
MQHLLSIFLKFVLSDYTLIAFIFAIYRVFSFLYLFLHLLVVYNSHKEKYPKGRSILLNNKNIFPFFKQNSLTNQIVTIIA
VIMLVPIVALMYDVFFASQTDKVIFLEKEQRLKALVKSTNQSFMKNLESLRITPENISSTTLHNEFTRVVEPHLPANSGI
RFGLYVPQTEKIKVLGFLHNYRNLSPEEEAQREKIIFANTKPRLVATEMSKEPNFYISGSWDDQVVEYISPVILQGKVVA
VMWAGERLNPFFYQSNYARKFLRYFTLAVLAMVMFATLLTIRNITTGVDRLKKGLHRMEHDIHHLLPEMSGELGQVAQAV
NRMALGLLEKERLEDQLRQSEHLIALGRLATGVAHELRNPIGIIKTLVELMKDEYSQVSGIDEFTKAVDEQVDRQNMVIQ
ELLDFGRPTKVSIKECSVNDLLKGVLSFSAAMLRKENVTVHLHLDESLPKIMADTEKLKQVFVNLIVNAAEAMPSGGTLD
IKTEQSENLVTVTFSDTGEGIDLEEKSKIFDPFYTTKKAGTGLGLSISYQNIKLHEGTIEVSSTRNKGTTFTIRLPRKKH
ISERRDCLDTTNSGH

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=33.9130434782609, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1788549, Length=231, Percent_Identity=38.5281385281385, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1790300, Length=242, Percent_Identity=29.7520661157025, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1788393, Length=304, Percent_Identity=25.6578947368421, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=27.5303643724696, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=25.462962962963, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87081816, Length=341, Percent_Identity=25.2199413489736, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1790861, Length=344, Percent_Identity=24.1279069767442, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=256, Percent_Identity=25.78125, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789808, Length=336, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=334, Percent_Identity=24.8502994011976, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790346, Length=218, Percent_Identity=23.8532110091743, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=24.5762711864407, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1789149, Length=321, Percent_Identity=22.7414330218069, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65467; Mature: 65467

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHLLSIFLKFVLSDYTLIAFIFAIYRVFSFLYLFLHLLVVYNSHKEKYPKGRSILLNNK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEECC
NIFPFFKQNSLTNQIVTIIAVIMLVPIVALMYDVFFASQTDKVIFLEKEQRLKALVKSTN
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCC
QSFMKNLESLRITPENISSTTLHNEFTRVVEPHLPANSGIRFGLYVPQTEKIKVLGFLHN
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHH
YRNLSPEEEAQREKIIFANTKPRLVATEMSKEPNFYISGSWDDQVVEYISPVILQGKVVA
HCCCCCHHHHHHCEEEEECCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHCCCEEE
VMWAGERLNPFFYQSNYARKFLRYFTLAVLAMVMFATLLTIRNITTGVDRLKKGLHRMEH
EEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIHHLLPEMSGELGQVAQAVNRMALGLLEKERLEDQLRQSEHLIALGRLATGVAHELRNP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
IGIIKTLVELMKDEYSQVSGIDEFTKAVDEQVDRQNMVIQELLDFGRPTKVSIKECSVND
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCHHH
LLKGVLSFSAAMLRKENVTVHLHLDESLPKIMADTEKLKQVFVNLIVNAAEAMPSGGTLD
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IKTEQSENLVTVTFSDTGEGIDLEEKSKIFDPFYTTKKAGTGLGLSISYQNIKLHEGTIE
EEECCCCCEEEEEECCCCCCCCCHHHHHHCCCHHHHHCCCCCCEEEEEECEEEEECCEEE
VSSTRNKGTTFTIRLPRKKHISERRDCLDTTNSGH
EECCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQHLLSIFLKFVLSDYTLIAFIFAIYRVFSFLYLFLHLLVVYNSHKEKYPKGRSILLNNK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEECC
NIFPFFKQNSLTNQIVTIIAVIMLVPIVALMYDVFFASQTDKVIFLEKEQRLKALVKSTN
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCC
QSFMKNLESLRITPENISSTTLHNEFTRVVEPHLPANSGIRFGLYVPQTEKIKVLGFLHN
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHHH
YRNLSPEEEAQREKIIFANTKPRLVATEMSKEPNFYISGSWDDQVVEYISPVILQGKVVA
HCCCCCHHHHHHCEEEEECCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHCCCEEE
VMWAGERLNPFFYQSNYARKFLRYFTLAVLAMVMFATLLTIRNITTGVDRLKKGLHRMEH
EEECCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIHHLLPEMSGELGQVAQAVNRMALGLLEKERLEDQLRQSEHLIALGRLATGVAHELRNP
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
IGIIKTLVELMKDEYSQVSGIDEFTKAVDEQVDRQNMVIQELLDFGRPTKVSIKECSVND
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCHHH
LLKGVLSFSAAMLRKENVTVHLHLDESLPKIMADTEKLKQVFVNLIVNAAEAMPSGGTLD
HHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
IKTEQSENLVTVTFSDTGEGIDLEEKSKIFDPFYTTKKAGTGLGLSISYQNIKLHEGTIE
EEECCCCCEEEEEECCCCCCCCCHHHHHHCCCHHHHHCCCCCCEEEEEECEEEEECCEEE
VSSTRNKGTTFTIRLPRKKHISERRDCLDTTNSGH
EECCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]