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The map label for this gene is lldD [H]

Identifier: 134299120

GI number: 134299120

Start: 1328829

End: 1329851

Strand: Reverse

Name: lldD [H]

Synonym: Dred_1257

Alternate gene names: 134299120

Gene position: 1329851-1328829 (Counterclockwise)

Preceding gene: 134299121

Following gene: 134299114

Centisome position: 36.86

GC content: 43.7

Gene sequence:

>1023_bases
ATGGATTTAAAAACAATTAAAACAGAAGCAAAGGACAAATTAAAAGGCTATTGTCGCGTTTGTCCAGTGTGTGATGGTCG
TGCCTGTAGCGGGGAAGTTCCTGGTATGGGTGGTACTGGTACCGGTGTTAGTTTTCGCAACAATTTAAATGCTTTAGCTT
CCTATAACTTAAACATGCGTACCTTACACAATGCTAAGAACCCCAGCACCGAAACTGAATTATTTGGTGTTGCACTTACT
TCCCCCATTATGGCTGCGCCCATGACTGGTACTCCATACAATATGGGAGGATCATTATCAGAGAAAGAATTCATTAGCAT
GATTGTTTCCGGGAGCAAACAGGCAGGAACACTGGGTTGGACCGGTGACGGCGCTGACCCAGAAATGTATAACTCAGGTC
TAGAAGCCATCACAAATGAACAAGGATACGGTATTCCTATTATTAAGCCACGGGAACAAAATGTTATTATTGAATGTATT
GGTCGTGCCGAACGAGCTGGGGCCAAAGCAGTTGGGGTTGATATTGACGGTGCTGGTCTTGTAACGATGGCCCTAAAAGG
TCAACCTGTAGGTCCTAAATCAAAAAGAGAAATTAAGGAACTTGTTAATGCCACTAAGTTGCCTTTCATTCTTAAGGGAA
TTATGACGGTTGATGAAGCCGAAATGGCAGTAGAAGCTGGAGTCAGTGCTATTGTAGTATCGAACCACGGTGGTCGTATA
TTGGATTTTACTCCAGGAGCAGCTGATGTATTGCCTGCCATTGCTGCAGCTGTAAAAGGGAAGGTTACAATCCTTGCCGA
TGGCGGTGTACGTACCGGTGTGGATGTTCTGAAACTTCTTGCCCTGGGGGCGGATGGGGTACTGGTTGGACGTCCATTGG
TTGTTGGGGCCTTCGGTGGGCATACTGAAGGGGTTAAGTTCTTGATTGAAAAAATGACATCTGAACTAAAACAAGCTATG
ATTTTAACTGGCTGCAATACTATTAAAGAAATAAATGACAGTGTAATTTATAATGCGCAATAA

Upstream 100 bases:

>100_bases
AGTCGATAACAAGTTAGAAAAATAAAATAGCAGGATTATTTAGCATCCAAATAGAAATTGAATATAGAAATATTCAATAC
TAGTGTCAGGAGTGAAAAGC

Downstream 100 bases:

>100_bases
AAAATGCCCCTCGGGGCATTTTTTATTAGCTAATTGAAAGTACTGGAATTCCTCTGGCTTCCAGCTCTTTTACCAGTGGT
TCAGGCTCTATGGTATTCAC

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MDLKTIKTEAKDKLKGYCRVCPVCDGRACSGEVPGMGGTGTGVSFRNNLNALASYNLNMRTLHNAKNPSTETELFGVALT
SPIMAAPMTGTPYNMGGSLSEKEFISMIVSGSKQAGTLGWTGDGADPEMYNSGLEAITNEQGYGIPIIKPREQNVIIECI
GRAERAGAKAVGVDIDGAGLVTMALKGQPVGPKSKREIKELVNATKLPFILKGIMTVDEAEMAVEAGVSAIVVSNHGGRI
LDFTPGAADVLPAIAAAVKGKVTILADGGVRTGVDVLKLLALGADGVLVGRPLVVGAFGGHTEGVKFLIEKMTSELKQAM
ILTGCNTIKEINDSVIYNAQ

Sequences:

>Translated_340_residues
MDLKTIKTEAKDKLKGYCRVCPVCDGRACSGEVPGMGGTGTGVSFRNNLNALASYNLNMRTLHNAKNPSTETELFGVALT
SPIMAAPMTGTPYNMGGSLSEKEFISMIVSGSKQAGTLGWTGDGADPEMYNSGLEAITNEQGYGIPIIKPREQNVIIECI
GRAERAGAKAVGVDIDGAGLVTMALKGQPVGPKSKREIKELVNATKLPFILKGIMTVDEAEMAVEAGVSAIVVSNHGGRI
LDFTPGAADVLPAIAAAVKGKVTILADGGVRTGVDVLKLLALGADGVLVGRPLVVGAFGGHTEGVKFLIEKMTSELKQAM
ILTGCNTIKEINDSVIYNAQ
>Mature_340_residues
MDLKTIKTEAKDKLKGYCRVCPVCDGRACSGEVPGMGGTGTGVSFRNNLNALASYNLNMRTLHNAKNPSTETELFGVALT
SPIMAAPMTGTPYNMGGSLSEKEFISMIVSGSKQAGTLGWTGDGADPEMYNSGLEAITNEQGYGIPIIKPREQNVIIECI
GRAERAGAKAVGVDIDGAGLVTMALKGQPVGPKSKREIKELVNATKLPFILKGIMTVDEAEMAVEAGVSAIVVSNHGGRI
LDFTPGAADVLPAIAAAVKGKVTILADGGVRTGVDVLKLLALGADGVLVGRPLVVGAFGGHTEGVKFLIEKMTSELKQAM
ILTGCNTIKEINDSVIYNAQ

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=335, Percent_Identity=33.134328358209, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI54234014, Length=132, Percent_Identity=49.2424242424242, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI7705393, Length=132, Percent_Identity=49.2424242424242, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1790033, Length=144, Percent_Identity=43.75, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI193208036, Length=136, Percent_Identity=43.3823529411765, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6323587, Length=337, Percent_Identity=26.4094955489614, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI281363140, Length=147, Percent_Identity=36.734693877551, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI78707190, Length=147, Percent_Identity=36.734693877551, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI78707188, Length=147, Percent_Identity=36.734693877551, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 35394; Mature: 35394

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKTIKTEAKDKLKGYCRVCPVCDGRACSGEVPGMGGTGTGVSFRNNLNALASYNLNMR
CCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHCCCCCCE
TLHNAKNPSTETELFGVALTSPIMAAPMTGTPYNMGGSLSEKEFISMIVSGSKQAGTLGW
EECCCCCCCCCHHEEEEEHHCCHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
TGDGADPEMYNSGLEAITNEQGYGIPIIKPREQNVIIECIGRAERAGAKAVGVDIDGAGL
CCCCCCHHHHHCCHHHHCCCCCCCCCEECCCCCCCCEEECCCHHHCCCEEEEEEECCCCE
VTMALKGQPVGPKSKREIKELVNATKLPFILKGIMTVDEAEMAVEAGVSAIVVSNHGGRI
EEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEE
LDFTPGAADVLPAIAAAVKGKVTILADGGVRTGVDVLKLLALGADGVLVGRPLVVGAFGG
EEECCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCEEECCCEEEEECCC
HTEGVKFLIEKMTSELKQAMILTGCNTIKEINDSVIYNAQ
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECC
>Mature Secondary Structure
MDLKTIKTEAKDKLKGYCRVCPVCDGRACSGEVPGMGGTGTGVSFRNNLNALASYNLNMR
CCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHCCCCCCE
TLHNAKNPSTETELFGVALTSPIMAAPMTGTPYNMGGSLSEKEFISMIVSGSKQAGTLGW
EECCCCCCCCCHHEEEEEHHCCHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
TGDGADPEMYNSGLEAITNEQGYGIPIIKPREQNVIIECIGRAERAGAKAVGVDIDGAGL
CCCCCCHHHHHCCHHHHCCCCCCCCCEECCCCCCCCEEECCCHHHCCCEEEEEEECCCCE
VTMALKGQPVGPKSKREIKELVNATKLPFILKGIMTVDEAEMAVEAGVSAIVVSNHGGRI
EEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEE
LDFTPGAADVLPAIAAAVKGKVTILADGGVRTGVDVLKLLALGADGVLVGRPLVVGAFGG
EEECCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCEEECCCEEEEECCC
HTEGVKFLIEKMTSELKQAMILTGCNTIKEINDSVIYNAQ
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA