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The map label for this gene is kdgR [H]

Identifier: 134298292

GI number: 134298292

Start: 457301

End: 458041

Strand: Reverse

Name: kdgR [H]

Synonym: Dred_0416

Alternate gene names: 134298292

Gene position: 458041-457301 (Counterclockwise)

Preceding gene: 134298293

Following gene: 134298264

Centisome position: 12.69

GC content: 35.22

Gene sequence:

>741_bases
ATGAATAGCATAGAAAAAGTTCTTTGGATTTTAAATAGATTAGGTGAGGAACCCTATGAAATGAATCTGACTGCACTTGC
CAATGAAATGAATACTGTAAAAAGTGGTGTACACAAAACATTAGGTATTATGATGAAACAAGGTTTCATTCTTCAAAACC
CAGAAACCAAAAAGTACTCAATTGGCCCCACTATGTATAGACTTGGAAATGTTTATAATAACCGAGTAGGTATTTGGGAA
ATTGCAAAACCCATTATCATGCAAGTAGCAGAAGTTACACATGAAACGGTTTCAATAGGCATTAGAGAAGGGGATAATGC
TTTTCTCGCCTATAAAATTGATTCTCCACTGCCTGTTCGCTATTTTGAGGATATTGGTACTCAATTTCCCATGAATGCTA
GTGCTGTAGGAAAAGTATTAGCAGCGTACCACGATACTGAAAGGGTAAAAGAACTATTAAAATCAAATACATTTAAAAAG
CATACGCCTAACACAATAGTTAAACCTGATGCAATTTTACAAGAATACCAAAAGATTCGCGAGCAAGGTTATGCCATTAG
CGATGAAGAGAGATTTTTGGAATCCTTTGGAATTGCAGTACCCATAATAAATAGCAGTAAAGATGTATGGTCGTGTTTAT
GTATTACAGGACCAAAAGCACGCTTCACTCCAGATAAGGTTAATAATTGGGTTGAACTATTGAAAAGCAAAGCCAATGAA
ATCTCAAGTGTATTAGCATAA

Upstream 100 bases:

>100_bases
TAACATTATGTTAACATTTAGCTTACATTAGTTATAATAATAACGGGTCGAATATTAAAATATCTGTTAAAGTAATCTAT
CTTGGAGGCTTCCTATTATA

Downstream 100 bases:

>100_bases
CACAACAGCTTGGGACCTAAAAAACCCCTATACACAGTTTTATTCTTAACTCTGTGTATAGGGGTTTAGGATAAATTTTG
TCTACCAAAAAATACCCTGT

Product: regulatory protein IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MNSIEKVLWILNRLGEEPYEMNLTALANEMNTVKSGVHKTLGIMMKQGFILQNPETKKYSIGPTMYRLGNVYNNRVGIWE
IAKPIIMQVAEVTHETVSIGIREGDNAFLAYKIDSPLPVRYFEDIGTQFPMNASAVGKVLAAYHDTERVKELLKSNTFKK
HTPNTIVKPDAILQEYQKIREQGYAISDEERFLESFGIAVPIINSSKDVWSCLCITGPKARFTPDKVNNWVELLKSKANE
ISSVLA

Sequences:

>Translated_246_residues
MNSIEKVLWILNRLGEEPYEMNLTALANEMNTVKSGVHKTLGIMMKQGFILQNPETKKYSIGPTMYRLGNVYNNRVGIWE
IAKPIIMQVAEVTHETVSIGIREGDNAFLAYKIDSPLPVRYFEDIGTQFPMNASAVGKVLAAYHDTERVKELLKSNTFKK
HTPNTIVKPDAILQEYQKIREQGYAISDEERFLESFGIAVPIINSSKDVWSCLCITGPKARFTPDKVNNWVELLKSKANE
ISSVLA
>Mature_246_residues
MNSIEKVLWILNRLGEEPYEMNLTALANEMNTVKSGVHKTLGIMMKQGFILQNPETKKYSIGPTMYRLGNVYNNRVGIWE
IAKPIIMQVAEVTHETVSIGIREGDNAFLAYKIDSPLPVRYFEDIGTQFPMNASAVGKVLAAYHDTERVKELLKSNTFKK
HTPNTIVKPDAILQEYQKIREQGYAISDEERFLESFGIAVPIINSSKDVWSCLCITGPKARFTPDKVNNWVELLKSKANE
ISSVLA

Specific function: Transcriptional repressor of genes involved in pectinolysis and in pectinase secretion. Controls all the genes involved in pectin catabolism, including the pel genes encoding pectate lyases, kdgT which encodes the 2-keto-3-deoxygluconate transport system

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=243, Percent_Identity=32.0987654320988, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1786468, Length=246, Percent_Identity=28.4552845528455, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI87082359, Length=244, Percent_Identity=26.2295081967213, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1786715, Length=245, Percent_Identity=24.0816326530612, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790752, Length=218, Percent_Identity=28.4403669724771, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1789999, Length=248, Percent_Identity=27.4193548387097, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788581, Length=186, Percent_Identity=20.4301075268817, Blast_Score=67, Evalue=8e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 27769; Mature: 27769

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIEKVLWILNRLGEEPYEMNLTALANEMNTVKSGVHKTLGIMMKQGFILQNPETKKYS
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEE
IGPTMYRLGNVYNNRVGIWEIAKPIIMQVAEVTHETVSIGIREGDNAFLAYKIDSPLPVR
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCHH
YFEDIGTQFPMNASAVGKVLAAYHDTERVKELLKSNTFKKHTPNTIVKPDAILQEYQKIR
HHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
EQGYAISDEERFLESFGIAVPIINSSKDVWSCLCITGPKARFTPDKVNNWVELLKSKANE
HCCCCCCHHHHHHHHCCCEEEEECCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
ISSVLA
HHHHCC
>Mature Secondary Structure
MNSIEKVLWILNRLGEEPYEMNLTALANEMNTVKSGVHKTLGIMMKQGFILQNPETKKYS
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEE
IGPTMYRLGNVYNNRVGIWEIAKPIIMQVAEVTHETVSIGIREGDNAFLAYKIDSPLPVR
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCHH
YFEDIGTQFPMNASAVGKVLAAYHDTERVKELLKSNTFKKHTPNTIVKPDAILQEYQKIR
HHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
EQGYAISDEERFLESFGIAVPIINSSKDVWSCLCITGPKARFTPDKVNNWVELLKSKANE
HCCCCCCHHHHHHHHCCCEEEEECCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHH
ISSVLA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1840643; 1545709 [H]