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The map label for this gene is norM [H]

Identifier: 134298264

GI number: 134298264

Start: 418539

End: 419912

Strand: Reverse

Name: norM [H]

Synonym: Dred_0387

Alternate gene names: 134298264

Gene position: 419912-418539 (Counterclockwise)

Preceding gene: 134298292

Following gene: 134298263

Centisome position: 11.64

GC content: 45.63

Gene sequence:

>1374_bases
ATGAAAAAAACATTCTCCACAAAGGAAAAAATACTCCAATTTATGACAATATTATGGCCCATACTTATTACTCAAATTTC
ACTTTCTGCCATGGTCATGCTGGATACAGTCATGTCCGGCAATGCAGGGGCCAGGGATCTAGCCGGGGTTGCCATCGGTT
CCAGCCTCTGGGTACCCATTTCCACTGGCATTACGGGCATTTTACTGGCTGTAACCCCCATCATTGCCCAGTCTGTAGGA
GCGGGAAGGAGGGACCATGTCCCCTTTACGGTAATCCAAGGGAGCTATCTGGCCATTGCCATTTCCATTATTGTTCTTAT
TTGTGGTGCCATCGCATTAAAACCAGTTTTAAATACCATGCACTTGGAGTCACCCGTGCGGGACATTGCCAGACGTTACT
TAGTGGGGCTTTCCTTCGGCATTACCCCCCTGTTCATCTATACCATATTTCGCTGCTTTATTGATGCCCTGGGCCAAACA
CGGGTGTCTATGTTTATTACGTTGCTGTCCTTGCCCATCAACATATTATTAAATTACGTACTGATTTTTGGCAAGCTGGG
TTTTCCCCGTTTGGGTGGCGTGGGTGCAGGTTATGCAACAGCCATAACTTATTGGTGTGTTTTTTTCATTGCTCTTTATG
TATTGCACAGGGTAGAGCCCTTTTCCTGTTACAATTTTTTTAAAAAATGGCTTGGTATCTCTTTCTCCGCTTGGCGAACC
CAGCTTAAGCTGGGTATACCCATTGGCTTCTCTATCTTTTTTGAGACCAGTGTTTTCTCTGGGGTAACACTATTGATGAG
TCAGTATAACACCGTTACCATCGCTGCACACCAAGCCGCCTTAAACTTTGCCTCATTTTTATATATGGTGCCCTTAAGTA
TCTCCATGGCCCTAACTATTACCATTGGTTTTGAAGTAGGTGCCCAGCGATACTCCGATGCTAAACAATACAGTTTATTG
GGGTTAGGTATTGCGGTGGGAATGGCTGTCTGCTGTGGCATTGGTCTACTGCTCTTTGGCGATCAAGTGGCTGGGTTGTA
CACCAAAGATCAGACGGTTTTTAAATTGACCCAGCAGTTCCTAGTATATGCCCTTTTCTTTCAACTTTCTGATGCCATCG
CCACACCGGTGCAGGGAATACTCCGGGGCTATAAGGATGTAAATGTTTCATTTATTGTTGCACTGGCCTCATACTGGGTT
ATTGGCCTGCCCCTGGGACATATCCTTTCCCTCTATACGCCCCTGGCAGCCTTTGGCTACTGGGTAGGACTTATTGTGGG
TCTAGCCATAGGTGCAACAAGCTTACTGATTCGTATGGTTATCGTTCAACGAAATGCGGCAATGGGAGGAAAAAAGATTG
GTCTGTGCAAATAA

Upstream 100 bases:

>100_bases
CTCAGAGAAATTGGAAAATCGATTTTTTAGCACCTAAAGTCTTTTTAAGCAATAAAGATGATATAATGTTATTTTAAAAA
TACTCTATTAGGTAGGAACC

Downstream 100 bases:

>100_bases
CCAGGTTGTCCTTTGTGTGGAAGCCAGCCAGAACGGTAAATTCCTTAGAGATTTTCTTAAACACAAGGATATTTCGGATA
GAGCATTGAAAAAACTCCGA

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKKTFSTKEKILQFMTILWPILITQISLSAMVMLDTVMSGNAGARDLAGVAIGSSLWVPISTGITGILLAVTPIIAQSVG
AGRRDHVPFTVIQGSYLAIAISIIVLICGAIALKPVLNTMHLESPVRDIARRYLVGLSFGITPLFIYTIFRCFIDALGQT
RVSMFITLLSLPINILLNYVLIFGKLGFPRLGGVGAGYATAITYWCVFFIALYVLHRVEPFSCYNFFKKWLGISFSAWRT
QLKLGIPIGFSIFFETSVFSGVTLLMSQYNTVTIAAHQAALNFASFLYMVPLSISMALTITIGFEVGAQRYSDAKQYSLL
GLGIAVGMAVCCGIGLLLFGDQVAGLYTKDQTVFKLTQQFLVYALFFQLSDAIATPVQGILRGYKDVNVSFIVALASYWV
IGLPLGHILSLYTPLAAFGYWVGLIVGLAIGATSLLIRMVIVQRNAAMGGKKIGLCK

Sequences:

>Translated_457_residues
MKKTFSTKEKILQFMTILWPILITQISLSAMVMLDTVMSGNAGARDLAGVAIGSSLWVPISTGITGILLAVTPIIAQSVG
AGRRDHVPFTVIQGSYLAIAISIIVLICGAIALKPVLNTMHLESPVRDIARRYLVGLSFGITPLFIYTIFRCFIDALGQT
RVSMFITLLSLPINILLNYVLIFGKLGFPRLGGVGAGYATAITYWCVFFIALYVLHRVEPFSCYNFFKKWLGISFSAWRT
QLKLGIPIGFSIFFETSVFSGVTLLMSQYNTVTIAAHQAALNFASFLYMVPLSISMALTITIGFEVGAQRYSDAKQYSLL
GLGIAVGMAVCCGIGLLLFGDQVAGLYTKDQTVFKLTQQFLVYALFFQLSDAIATPVQGILRGYKDVNVSFIVALASYWV
IGLPLGHILSLYTPLAAFGYWVGLIVGLAIGATSLLIRMVIVQRNAAMGGKKIGLCK
>Mature_457_residues
MKKTFSTKEKILQFMTILWPILITQISLSAMVMLDTVMSGNAGARDLAGVAIGSSLWVPISTGITGILLAVTPIIAQSVG
AGRRDHVPFTVIQGSYLAIAISIIVLICGAIALKPVLNTMHLESPVRDIARRYLVGLSFGITPLFIYTIFRCFIDALGQT
RVSMFITLLSLPINILLNYVLIFGKLGFPRLGGVGAGYATAITYWCVFFIALYVLHRVEPFSCYNFFKKWLGISFSAWRT
QLKLGIPIGFSIFFETSVFSGVTLLMSQYNTVTIAAHQAALNFASFLYMVPLSISMALTITIGFEVGAQRYSDAKQYSLL
GLGIAVGMAVCCGIGLLLFGDQVAGLYTKDQTVFKLTQQFLVYALFFQLSDAIATPVQGILRGYKDVNVSFIVALASYWV
IGLPLGHILSLYTPLAAFGYWVGLIVGLAIGATSLLIRMVIVQRNAAMGGKKIGLCK

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=416, Percent_Identity=22.5961538461538, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI22907060, Length=433, Percent_Identity=23.094688221709, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38261960, Length=448, Percent_Identity=21.875, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI48994890, Length=446, Percent_Identity=34.304932735426, Blast_Score=262, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6320545, Length=448, Percent_Identity=25.6696428571429, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321821, Length=395, Percent_Identity=23.7974683544304, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49641; Mature: 49641

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]