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The map label for this gene is ribH

Identifier: 126697171

GI number: 126697171

Start: 1554812

End: 1555288

Strand: Reverse

Name: ribH

Synonym: P9301_18331

Alternate gene names: 126697171

Gene position: 1555288-1554812 (Counterclockwise)

Preceding gene: 126697172

Following gene: 126697170

Centisome position: 94.73

GC content: 32.29

Gene sequence:

>477_bases
ATGGCTATTTTTGAGGGTTCTTTTACTAATGCCTCTACTTTAAAAGTTGGGATTGTAATAGCAAGATTTAATGATTTAAT
TACAAATAAAATTCTATCTGGTTGTCTTGATTGTTTAAAAAGACATGGTTTAGATACTTCTGAATTAAGCAATCAAGTAG
ATATTGTTTGGGTTCCTGGTTCATTCGAATTACCAATTGCAGCTAAAACCCTCATGAAAAAAAAGAGTTATGACGTTGTA
ATTGCTCTTGGGGCAGTGATCCGTGGCGAAACTTCCCACTATGATGTAGTTATATCTGAGGCGAGCAAAGGTATTTCACA
AGTTTCAAATGAAAATAACATTCCAATTATTTTTGGTGTTTTAACTACTGATACTATGCAGCAGGCTTTAGAAAGAGCAG
GGATTAAAAATAATCTTGGTTGGAATTATGCTTTACAAGCAATTGAGATGGGATCCTTAATTAAAAATTTAAATTAA

Upstream 100 bases:

>100_bases
GTTTGGGTTGTTTTGGTTTTTGTTACAGGGATTGTTTCTTCATTAGTTTGAACTTGATACCTTTTCGTGAGAGTCTATTA
ATATATCTAAGTAAAATTTA

Downstream 100 bases:

>100_bases
TTGAAAAAATTTAATTATTTTTATCATTAATCCCTTCTTTGAGATAAAATAAAAAAGCTATGCGGATGTAGCTCAGTGGT
AGAGCATCTCCTTGCCAAGG

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MAIFEGSFTNASTLKVGIVIARFNDLITNKILSGCLDCLKRHGLDTSELSNQVDIVWVPGSFELPIAAKTLMKKKSYDVV
IALGAVIRGETSHYDVVISEASKGISQVSNENNIPIIFGVLTTDTMQQALERAGIKNNLGWNYALQAIEMGSLIKNLN

Sequences:

>Translated_158_residues
MAIFEGSFTNASTLKVGIVIARFNDLITNKILSGCLDCLKRHGLDTSELSNQVDIVWVPGSFELPIAAKTLMKKKSYDVV
IALGAVIRGETSHYDVVISEASKGISQVSNENNIPIIFGVLTTDTMQQALERAGIKNNLGWNYALQAIEMGSLIKNLN
>Mature_157_residues
AIFEGSFTNASTLKVGIVIARFNDLITNKILSGCLDCLKRHGLDTSELSNQVDIVWVPGSFELPIAAKTLMKKKSYDVVI
ALGAVIRGETSHYDVVISEASKGISQVSNENNIPIIFGVLTTDTMQQALERAGIKNNLGWNYALQAIEMGSLIKNLN

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=142, Percent_Identity=48.5915492957746, Blast_Score=139, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6324429, Length=151, Percent_Identity=32.4503311258278, Blast_Score=88, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_PROM0 (A3PFD1)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001092057.1
- ProteinModelPortal:   A3PFD1
- SMR:   A3PFD1
- STRING:   A3PFD1
- GeneID:   4911216
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_18331
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- ProtClustDB:   PRK00061
- BioCyc:   PMAR167546:P9301ORF_1873-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 17171; Mature: 17040

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIFEGSFTNASTLKVGIVIARFNDLITNKILSGCLDCLKRHGLDTSELSNQVDIVWVPG
CEEECCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECC
SFELPIAAKTLMKKKSYDVVIALGAVIRGETSHYDVVISEASKGISQVSNENNIPIIFGV
CCCCCHHHHHHHHCCCCCEEEEECHHHCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEE
LTTDTMQQALERAGIKNNLGWNYALQAIEMGSLIKNLN
ECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIFEGSFTNASTLKVGIVIARFNDLITNKILSGCLDCLKRHGLDTSELSNQVDIVWVPG
EEECCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEECC
SFELPIAAKTLMKKKSYDVVIALGAVIRGETSHYDVVISEASKGISQVSNENNIPIIFGV
CCCCCHHHHHHHHCCCCCEEEEECHHHCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEE
LTTDTMQQALERAGIKNNLGWNYALQAIEMGSLIKNLN
ECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA