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The map label for this gene is tktA [H]

Identifier: 126697141

GI number: 126697141

Start: 1524149

End: 1526155

Strand: Direct

Name: tktA [H]

Synonym: P9301_18031

Alternate gene names: 126697141

Gene position: 1524149-1526155 (Clockwise)

Preceding gene: 126697140

Following gene: 126697146

Centisome position: 92.83

GC content: 38.61

Gene sequence:

>2007_bases
ATGGTCGCTGCATCTGTTTCATTAGAATCACTTTGTGTAAATAGTATAAGAATGCTTGCTGTAGATGCAGTAAATAAATC
TAATAGTGGTCATCCTGGTTTGCCAATGGGATGTGCTCCTATGGGTTATGCATTATGGCAAAACATACTTAATCACAACC
CTAATAACCCAAAATGGTTCAACAGAGACCGTTTTGTATTATCAGCTGGTCATGGCTGTATGCTGTTATATTCCTTACTT
CATTTGACAGGATATAAATCAGTCTCAATAGACGATATTAAAGAATTTAGGCAATGGGGATCAAAGACTCCTGGGCATCC
AGAAACATTCGAAACTGAAGGTGTTGAAGTTACAGCAGGGCCTCTTGGAGCCGGAATTTCAAATGCAGTTGGTTTAGCAA
TAGCTGAAACTCACTTGGCAGCTAAATTTAATAAGCCTGATTGTAAGATCGTTGATCACTATACTTACGTCATAATGGGT
GACGGCTGTAATCAAGAAGGCATCGCATCTGAGGCCTGCTCACTAGCTGGTCACCTTAAGCTTGGAAAATTAATTGCACT
CTATGACGATAATCAAATTACAATTGATGGGCGAACCGATGTTTCTTTTACTGAAGATGTATTAAAAAGATACGAAGCTT
ATGGATGGCATGTACAACATGTGGAAGATGGGAATCATGATGTTAAAGGAATAACTGAAGCTATCGAAAAAGCAAAATTA
ATCACAGACAAACCTTCAATTATAAAAATTTCTACAACAATAGGTTATGGTTCGCCTAATAAATCAGATACTGCTGGAAT
TCATGGAGCAGCTGTTGGAGAAGAAGAAGCTGCTTTAACTAGAGAGTTTCTAAATTGGGAATATCCTCCATTTGAAATAC
CAGATGAAGTATATGCCCATTTTAGAAAATCAATAGACAAAGGAGGAAGCCTAGAGAAAGAATGGGATTCTAAATTTGAA
GAATATCAAAGCAAATATCCTTCTGAAGGAGCCGAGTTAAACAGAATGTTGAAAGGACAATTACCTGAGAATTGGGACTC
AGATCTCCCTTCTTATACACCAGAAGATAAGGGTTTAGCAACCAGAAAGCATTCGCAAATATGTCTGGGTGCTCTAGGTC
CTAACCTACCCGAATTAATTGGTGGTTCAGCAGATTTAACTCACTCCAACTACACAGATATCAAGGGAGAATCCGGGTCA
TTCCAGCCTCATAGTCCTGAAAAAAGATATTTGCACTTTGGTGTGCGAGAGCATGCAATGGCAGCTGTACTTAATGGAAT
TGCCTATCACAATAGTGGTCTTATTCCTTATGGTGGAACCTTCCTTGTTTTCGCTGATTATATGAGAGGTTCAATGAGAC
TTTCGGCACTAAGCGAACTAGGAGTGATCTATGTATTAACCCATGATTCAATTGGTGTAGGAGAAGACGGCCCAACACAT
CAACCTATTGAAACTATCCCTTCTCTTCGTGCTATGCCTAACATGCTAGTTTTCAGACCAGGAGATGGAAATGAGACAAG
TGGTGCTTATAAGCTTGCTATTCAAAATCGAAAAAGACCTTCTGCCCTTTGTTTAAGTAGACAAGGAATGCCAAATCAAG
AAAACACTTCGATCGACAAAGTTGCTCTTGGAGGATACGTAGTTTCCGATTGCGAAGGAACACCAGATCTAATATTTATT
GGTACTGGAAGCGAACTGAATCTTTGCATTGAAGCAAGTAAGGAAATTTCAAGCTTAGGGAAAAAGGTTAGAGTTGTTTC
TATGCCATGTGTAGAACTTTTCGAAGAGCAAGAAGATTCTTACAAAGAAAGTGTTTTACCAAGTAGTGTGAAAAAGAGAG
TTGTGGTAGAAGCTGCCCATTCATTTGGTTGGCATAAATATACAGGTTTTGATGGAATTTGTATTACTATGGATAGGTTT
GGTGCATCAGCACCAGGTGGAGAATGTATGAAAAATTTTGGATTTACAGTCGAAAACGTAGTTAATAAGACGAAGGAAAT
TCTATAA

Upstream 100 bases:

>100_bases
ATTCTTTCGGCTTTGGTGGTCACAATGTTTGCCTTGCTTTTAGCAAAATGAATTGAAGACAACCAATTCTGTATTTCCAA
CTTAACTTTTTTTTAAAACA

Downstream 100 bases:

>100_bases
CTATTAATAATTGATAACTAAGCTGAAGTACTACATTCTTCAAGTTTATCTTTTAACTGATCAAGAGATTCATCTGAAAT
CTTTGAATTCATTGGACAAT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIDDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCKIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKL
ITDKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEAALTREFLNWEYPPFEIPDEVYAHFRKSIDKGGSLEKEWDSKFE
EYQSKYPSEGAELNRMLKGQLPENWDSDLPSYTPEDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGESGS
FQPHSPEKRYLHFGVREHAMAAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIQNRKRPSALCLSRQGMPNQENTSIDKVALGGYVVSDCEGTPDLIFI
GTGSELNLCIEASKEISSLGKKVRVVSMPCVELFEEQEDSYKESVLPSSVKKRVVVEAAHSFGWHKYTGFDGICITMDRF
GASAPGGECMKNFGFTVENVVNKTKEIL

Sequences:

>Translated_668_residues
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIDDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCKIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKL
ITDKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEAALTREFLNWEYPPFEIPDEVYAHFRKSIDKGGSLEKEWDSKFE
EYQSKYPSEGAELNRMLKGQLPENWDSDLPSYTPEDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGESGS
FQPHSPEKRYLHFGVREHAMAAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIQNRKRPSALCLSRQGMPNQENTSIDKVALGGYVVSDCEGTPDLIFI
GTGSELNLCIEASKEISSLGKKVRVVSMPCVELFEEQEDSYKESVLPSSVKKRVVVEAAHSFGWHKYTGFDGICITMDRF
GASAPGGECMKNFGFTVENVVNKTKEIL
>Mature_668_residues
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWFNRDRFVLSAGHGCMLLYSLL
HLTGYKSVSIDDIKEFRQWGSKTPGHPETFETEGVEVTAGPLGAGISNAVGLAIAETHLAAKFNKPDCKIVDHYTYVIMG
DGCNQEGIASEACSLAGHLKLGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKL
ITDKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEAALTREFLNWEYPPFEIPDEVYAHFRKSIDKGGSLEKEWDSKFE
EYQSKYPSEGAELNRMLKGQLPENWDSDLPSYTPEDKGLATRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGESGS
FQPHSPEKRYLHFGVREHAMAAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIQNRKRPSALCLSRQGMPNQENTSIDKVALGGYVVSDCEGTPDLIFI
GTGSELNLCIEASKEISSLGKKVRVVSMPCVELFEEQEDSYKESVLPSSVKKRVVVEAAHSFGWHKYTGFDGICITMDRF
GASAPGGECMKNFGFTVENVVNKTKEIL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=679, Percent_Identity=24.1531664212077, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI4507521, Length=679, Percent_Identity=24.1531664212077, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI133778974, Length=581, Percent_Identity=25.9896729776248, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI225637459, Length=583, Percent_Identity=21.9554030874786, Blast_Score=116, Evalue=8e-26,
Organism=Homo sapiens, GI225637463, Length=482, Percent_Identity=23.2365145228216, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI225637461, Length=482, Percent_Identity=23.2365145228216, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=51.2084592145015, Blast_Score=686, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=50.6787330316742, Blast_Score=671, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=583, Percent_Identity=24.3567753001715, Blast_Score=133, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6325331, Length=668, Percent_Identity=52.9940119760479, Blast_Score=683, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=672, Percent_Identity=50.1488095238095, Blast_Score=654, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=681, Percent_Identity=25.8443465491924, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI45550715, Length=681, Percent_Identity=25.8443465491924, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24645119, Length=652, Percent_Identity=25.7668711656442, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24666278, Length=584, Percent_Identity=24.3150684931507, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72922; Mature: 72922

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWF
CEECCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLLYSLLHLTGYKSVSIDDIKEFRQWGSKTPGHPETFETEGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECC
PLGAGISNAVGLAIAETHLAAKFNKPDCKIVDHYTYVIMGDGCNQEGIASEACSLAGHLK
CCCCCHHHHHHHHEEHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHCCCC
LGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKL
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
ITDKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEAALTREFLNWEYPPFEIPDEVYAH
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
FRKSIDKGGSLEKEWDSKFEEYQSKYPSEGAELNRMLKGQLPENWDSDLPSYTPEDKGLA
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
TRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGESGSFQPHSPEKRYLHFGVREHAM
CCCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCHHHHHH
AAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHCCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIQNRKRPSALCLSRQGMPNQENTSIDK
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCCCCE
VALGGYVVSDCEGTPDLIFIGTGSELNLCIEASKEISSLGKKVRVVSMPCVELFEEQEDS
EEECCEEEECCCCCCCEEEEECCCCEEEEEECHHHHHHHCCEEEEEECCHHHHHHHHHHH
YKESVLPSSVKKRVVVEAAHSFGWHKYTGFDGICITMDRFGASAPGGECMKNFGFTVENV
HHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHH
VNKTKEIL
HHHHHHCC
>Mature Secondary Structure
MVAASVSLESLCVNSIRMLAVDAVNKSNSGHPGLPMGCAPMGYALWQNILNHNPNNPKWF
CEECCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
NRDRFVLSAGHGCMLLYSLLHLTGYKSVSIDDIKEFRQWGSKTPGHPETFETEGVEVTAG
CCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECC
PLGAGISNAVGLAIAETHLAAKFNKPDCKIVDHYTYVIMGDGCNQEGIASEACSLAGHLK
CCCCCHHHHHHHHEEHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHCCCC
LGKLIALYDDNQITIDGRTDVSFTEDVLKRYEAYGWHVQHVEDGNHDVKGITEAIEKAKL
CCCEEEEEECCEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHH
ITDKPSIIKISTTIGYGSPNKSDTAGIHGAAVGEEEAALTREFLNWEYPPFEIPDEVYAH
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHH
FRKSIDKGGSLEKEWDSKFEEYQSKYPSEGAELNRMLKGQLPENWDSDLPSYTPEDKGLA
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
TRKHSQICLGALGPNLPELIGGSADLTHSNYTDIKGESGSFQPHSPEKRYLHFGVREHAM
CCCCCCEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEECCHHHHHH
AAVLNGIAYHNSGLIPYGGTFLVFADYMRGSMRLSALSELGVIYVLTHDSIGVGEDGPTH
HHHHHHHHCCCCCCCCCCCHHEEEEHHHCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCC
QPIETIPSLRAMPNMLVFRPGDGNETSGAYKLAIQNRKRPSALCLSRQGMPNQENTSIDK
CCHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCCCCCCCCCCCE
VALGGYVVSDCEGTPDLIFIGTGSELNLCIEASKEISSLGKKVRVVSMPCVELFEEQEDS
EEECCEEEECCCCCCCEEEEECCCCEEEEEECHHHHHHHCCEEEEEECCHHHHHHHHHHH
YKESVLPSSVKKRVVVEAAHSFGWHKYTGFDGICITMDRFGASAPGGECMKNFGFTVENV
HHHHCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCHHHHHHCCCCHHHH
VNKTKEIL
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]