Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 126697140

GI number: 126697140

Start: 1522860

End: 1524104

Strand: Direct

Name: fabF [H]

Synonym: P9301_18021

Alternate gene names: 126697140

Gene position: 1522860-1524104 (Clockwise)

Preceding gene: 126697139

Following gene: 126697141

Centisome position: 92.75

GC content: 39.44

Gene sequence:

>1245_bases
ATGCCAAATTTCCATCGAGTAGTTATTACTGGTATCGGAGCGGTAACTCCAATTGGCAATAACATTGATGAATATTTAGT
CGGTCTTCAAAAAGGTACCAATGGGGTTTCAGATATTACTCTCTTTGATCCTGAACAACATCCCTGCAAATTTGCTGCAG
AAGTAAAAAATCTTCAATCTGAAAATTTTATTGAAGCTAAAGAATCGAAAAGATGGGATCGTTTTTCCCAGTTTGGAGTT
ATTGCTGCAAAGCAAGCCTTTAACGATTCTGGACTTGAAATCACTGAAGCTAATGCATCAAGAATTGGAGTGATTATTGG
TTCTGGTGTTGGAGGCTTACTAACTATGGAAAGTCAAGCTCAAATATTGAGTCACAAAGGTCCTAAAAGAGTAAGTCCAT
TTACAGTCCCAATGATGATTCCAAACATGGCCACTGGATTGGCTGCAATCGCTTTGGGTGCGAAAGGACCTAGTTCCTCT
GTTTCCACCGCTTGCGCTGCCGGTTCAAATGCAATTGGTGATTCTTTTAGATTACTCCAACTTGGAAAAGCAGATGCAAT
GATCTGTGGGGGAGCAGAAGCAAGTATTACGCCTCTCGGAGTAGCTGGTTTTGCAAGTGCCAAAGCTCTTTCCTCCAGAA
ATGAAAGCCCTCAAACTGCTAGCAGACCTTTTGATGCAGAAAGAGATGGATTTGTTATTGGAGAAGGATCTGGAATTCTT
GTTTTAGAAACTTTAGAAAATGCACAAAAGAGGAATGCTAGAATTTATGCAGAAATAGTTGGATATGGAACAACATGTGA
TGCTCATCATATTACTGCTCCATCTCCAGGCGGGGTTGGAGGCGCCGAAGCTATCAAATTAGCAATTGAAGACGCTTCTC
TTAGCCTTGAAAATGTTGATTACATAAATGCTCATGGAACAAGTACATCAGCTAATGATAAAAATGAAACTTCTGCAATT
AAATCTATTTTTAGAGACAGATCTTACCTCATTCCTGTAAGCTCTACTAAGTCGATGACTGGTCATCTCCTAGGAGGCTC
AGGAGGTATAGAAGCTGTAGCTTGTATACTTTCTTTGACACATAATTTTATCCCTCCTACAATTAACTACGTCAATCCAG
ATCCTGAATGTGATCTTGATTATGTACCAAATAATGCAAGAGAAGCTCAAGTAAGAGTTACTCTTTCTAATTCTTTCGGC
TTTGGTGGTCACAATGTTTGCCTTGCTTTTAGCAAAATGAATTGA

Upstream 100 bases:

>100_bases
AGAAGCCTTTGATATTGAAATTCCAGATGAAGCAGCTGAAGGAATCGCAACTGTCGGCGATGCAGTAAAATTCATCGAAG
AAAAAAAAGGTTAATAAAGA

Downstream 100 bases:

>100_bases
AGACAACCAATTCTGTATTTCCAACTTAACTTTTTTTTAAAACAATGGTCGCTGCATCTGTTTCATTAGAATCACTTTGT
GTAAATAGTATAAGAATGCT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MPNFHRVVITGIGAVTPIGNNIDEYLVGLQKGTNGVSDITLFDPEQHPCKFAAEVKNLQSENFIEAKESKRWDRFSQFGV
IAAKQAFNDSGLEITEANASRIGVIIGSGVGGLLTMESQAQILSHKGPKRVSPFTVPMMIPNMATGLAAIALGAKGPSSS
VSTACAAGSNAIGDSFRLLQLGKADAMICGGAEASITPLGVAGFASAKALSSRNESPQTASRPFDAERDGFVIGEGSGIL
VLETLENAQKRNARIYAEIVGYGTTCDAHHITAPSPGGVGGAEAIKLAIEDASLSLENVDYINAHGTSTSANDKNETSAI
KSIFRDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLTHNFIPPTINYVNPDPECDLDYVPNNAREAQVRVTLSNSFG
FGGHNVCLAFSKMN

Sequences:

>Translated_414_residues
MPNFHRVVITGIGAVTPIGNNIDEYLVGLQKGTNGVSDITLFDPEQHPCKFAAEVKNLQSENFIEAKESKRWDRFSQFGV
IAAKQAFNDSGLEITEANASRIGVIIGSGVGGLLTMESQAQILSHKGPKRVSPFTVPMMIPNMATGLAAIALGAKGPSSS
VSTACAAGSNAIGDSFRLLQLGKADAMICGGAEASITPLGVAGFASAKALSSRNESPQTASRPFDAERDGFVIGEGSGIL
VLETLENAQKRNARIYAEIVGYGTTCDAHHITAPSPGGVGGAEAIKLAIEDASLSLENVDYINAHGTSTSANDKNETSAI
KSIFRDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLTHNFIPPTINYVNPDPECDLDYVPNNAREAQVRVTLSNSFG
FGGHNVCLAFSKMN
>Mature_413_residues
PNFHRVVITGIGAVTPIGNNIDEYLVGLQKGTNGVSDITLFDPEQHPCKFAAEVKNLQSENFIEAKESKRWDRFSQFGVI
AAKQAFNDSGLEITEANASRIGVIIGSGVGGLLTMESQAQILSHKGPKRVSPFTVPMMIPNMATGLAAIALGAKGPSSSV
STACAAGSNAIGDSFRLLQLGKADAMICGGAEASITPLGVAGFASAKALSSRNESPQTASRPFDAERDGFVIGEGSGILV
LETLENAQKRNARIYAEIVGYGTTCDAHHITAPSPGGVGGAEAIKLAIEDASLSLENVDYINAHGTSTSANDKNETSAIK
SIFRDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLTHNFIPPTINYVNPDPECDLDYVPNNAREAQVRVTLSNSFGF
GGHNVCLAFSKMN

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=43.0622009569378, Blast_Score=321, Evalue=9e-88,
Organism=Homo sapiens, GI223972627, Length=150, Percent_Identity=45.3333333333333, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI41872631, Length=419, Percent_Identity=25.5369928400955, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=50.2439024390244, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1788663, Length=418, Percent_Identity=36.3636363636364, Blast_Score=228, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=33.8942307692308, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=38.2575757575758, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI212642053, Length=426, Percent_Identity=26.2910798122066, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=277, Percent_Identity=26.3537906137184, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=37.6975169300226, Blast_Score=270, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=41.866028708134, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI221330659, Length=424, Percent_Identity=26.4150943396226, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19920632, Length=424, Percent_Identity=26.4150943396226, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24581345, Length=420, Percent_Identity=23.8095238095238, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43332; Mature: 43201

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNFHRVVITGIGAVTPIGNNIDEYLVGLQKGTNGVSDITLFDPEQHPCKFAAEVKNLQS
CCCCEEEEEEECCEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCC
ENFIEAKESKRWDRFSQFGVIAAKQAFNDSGLEITEANASRIGVIIGSGVGGLLTMESQA
CCCEECHHHHHHHHHHHCCEEEEHHHCCCCCCEEEECCCCEEEEEEECCCCCEEEECHHH
QILSHKGPKRVSPFTVPMMIPNMATGLAAIALGAKGPSSSVSTACAAGSNAIGDSFRLLQ
HHHHCCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCCCCHHHHHHCCCCCCCCCEEEEE
LGKADAMICGGAEASITPLGVAGFASAKALSSRNESPQTASRPFDAERDGFVIGEGSGIL
ECCCCEEEECCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLETLENAQKRNARIYAEIVGYGTTCDAHHITAPSPGGVGGAEAIKLAIEDASLSLENVD
EEEEHHHHHHCCCEEEEEEEECCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCEECCCE
YINAHGTSTSANDKNETSAIKSIFRDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLT
EEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHH
HNFIPPTINYVNPDPECDLDYVPNNAREAQVRVTLSNSFGFGGHNVCLAFSKMN
HCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
PNFHRVVITGIGAVTPIGNNIDEYLVGLQKGTNGVSDITLFDPEQHPCKFAAEVKNLQS
CCCEEEEEEECCEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHCCC
ENFIEAKESKRWDRFSQFGVIAAKQAFNDSGLEITEANASRIGVIIGSGVGGLLTMESQA
CCCEECHHHHHHHHHHHCCEEEEHHHCCCCCCEEEECCCCEEEEEEECCCCCEEEECHHH
QILSHKGPKRVSPFTVPMMIPNMATGLAAIALGAKGPSSSVSTACAAGSNAIGDSFRLLQ
HHHHCCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCCCCHHHHHHCCCCCCCCCEEEEE
LGKADAMICGGAEASITPLGVAGFASAKALSSRNESPQTASRPFDAERDGFVIGEGSGIL
ECCCCEEEECCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLETLENAQKRNARIYAEIVGYGTTCDAHHITAPSPGGVGGAEAIKLAIEDASLSLENVD
EEEEHHHHHHCCCEEEEEEEECCCCCCCCEECCCCCCCCCCCCEEEEEEECCCCEECCCE
YINAHGTSTSANDKNETSAIKSIFRDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLT
EEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHH
HNFIPPTINYVNPDPECDLDYVPNNAREAQVRVTLSNSFGFGGHNVCLAFSKMN
HCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]