Click here to switch to the map view.

The map label for this gene is wzb [C]

Identifier: 126697121

GI number: 126697121

Start: 1505257

End: 1505730

Strand: Reverse

Name: wzb [C]

Synonym: P9301_17831

Alternate gene names: 126697121

Gene position: 1505730-1505257 (Counterclockwise)

Preceding gene: 126697122

Following gene: 126697119

Centisome position: 91.71

GC content: 33.76

Gene sequence:

>474_bases
ATGAATAAAATTTCCGTTCTTTTTGTATGTTTGGGAAATATTTGTAGGTCTCCAGCAGCAGAAGCTATTTTTATAAGTCT
ACTCGAAAAGAAGGAATTAACAGATGGCTTTATTGTAGATTCTGCTGGAACTGGGAGTTGGCATATTGGAAAAAAAGCTG
ACTCTAGGATGAGAATTGCGGCTGAAAGAAGAGATATAAATATCCTAAGCAGGGCTCGTCAAATTACTATCGAAGATTTT
GACAAATTTAACTATATTCTTGCGATGGACGATTCAAATTTTAGAAATATTCAAAATCTTAAAAATAGCACAGCTTCAAC
TGGCTTTGCATCAATCAAAAAAATACAAGATTTTAGATCTGTTTTTAATGAACAAGAAGTTCCTGACCCATATTTTGGAG
GTGATGAGGGCTTCGATTATGTTCTTGATATTTTAGAAGACTCTGTAACCGGTTTTTTGGGAAGTATTTCTTGA

Upstream 100 bases:

>100_bases
TGTTGTCGAGTTTGTTTGGTAAAGAATTTACTGAATCTTTAATTGAAGAAGTTTTATTTACTACTTAAAAGTCTTATAAT
TTACTGGAATTTGAAATCAT

Downstream 100 bases:

>100_bases
ATTTATTTGATCTCAGTCTCTTTAGGAATCCTATCATTATAAAGGTCAATAATTTTATCCACTACCTCATCAATTGTATA
TCCGTCCGTAATAATTTCTA

Product: low molecular weight phosphotyrosine protein phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MNKISVLFVCLGNICRSPAAEAIFISLLEKKELTDGFIVDSAGTGSWHIGKKADSRMRIAAERRDINILSRARQITIEDF
DKFNYILAMDDSNFRNIQNLKNSTASTGFASIKKIQDFRSVFNEQEVPDPYFGGDEGFDYVLDILEDSVTGFLGSIS

Sequences:

>Translated_157_residues
MNKISVLFVCLGNICRSPAAEAIFISLLEKKELTDGFIVDSAGTGSWHIGKKADSRMRIAAERRDINILSRARQITIEDF
DKFNYILAMDDSNFRNIQNLKNSTASTGFASIKKIQDFRSVFNEQEVPDPYFGGDEGFDYVLDILEDSVTGFLGSIS
>Mature_157_residues
MNKISVLFVCLGNICRSPAAEAIFISLLEKKELTDGFIVDSAGTGSWHIGKKADSRMRIAAERRDINILSRARQITIEDF
DKFNYILAMDDSNFRNIQNLKNSTASTGFASIKKIQDFRSVFNEQEVPDPYFGGDEGFDYVLDILEDSVTGFLGSIS

Specific function: Dephosphorylates Wzc. Required For The Extracellular Polysaccharide Colanic Acid Synthesis. Probably Involved In The Export Of Colanic Acid From The Cell To Medium. [C]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI6005988, Length=149, Percent_Identity=38.255033557047, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4757714, Length=149, Percent_Identity=40.9395973154362, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI96304457, Length=76, Percent_Identity=44.7368421052632, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325330, Length=141, Percent_Identity=36.8794326241135, Blast_Score=94, Evalue=8e-21,
Organism=Drosophila melanogaster, GI78706766, Length=136, Percent_Identity=36.7647058823529, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI78706768, Length=136, Percent_Identity=36.7647058823529, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI78711846, Length=145, Percent_Identity=36.551724137931, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI78706764, Length=128, Percent_Identity=35.9375, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI78706770, Length=153, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI78706772, Length=153, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24648069, Length=92, Percent_Identity=36.9565217391304, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17545; Mature: 17545

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKISVLFVCLGNICRSPAAEAIFISLLEKKELTDGFIVDSAGTGSWHIGKKADSRMRIA
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCEECCCCCCCHHHHH
AERRDINILSRARQITIEDFDKFNYILAMDDSNFRNIQNLKNSTASTGFASIKKIQDFRS
HHHHHHHHHHHHHHCCHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
VFNEQEVPDPYFGGDEGFDYVLDILEDSVTGFLGSIS
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKISVLFVCLGNICRSPAAEAIFISLLEKKELTDGFIVDSAGTGSWHIGKKADSRMRIA
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCEECCCCCCCHHHHH
AERRDINILSRARQITIEDFDKFNYILAMDDSNFRNIQNLKNSTASTGFASIKKIQDFRS
HHHHHHHHHHHHHHCCHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
VFNEQEVPDPYFGGDEGFDYVLDILEDSVTGFLGSIS
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]