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The map label for this gene is cmk

Identifier: 126697120

GI number: 126697120

Start: 1503722

End: 1505254

Strand: Direct

Name: cmk

Synonym: P9301_17821

Alternate gene names: 126697120

Gene position: 1503722-1505254 (Clockwise)

Preceding gene: 126697114

Following gene: 126697126

Centisome position: 91.59

GC content: 28.9

Gene sequence:

>1533_bases
GTGAAGAAAGTAATCATAAGGAAAACTGAAGAAATAGAAAATTGGAGGAGAAATATAAATAGTGAAATTAACTTCATTCC
AACAATGGGTAATCTTCATGATGGTCATATTAAACTAATATCAACAGCAAAAAATGACAATTCCAATGTTAATTTAGTAA
GTATTTTTATTAATCCACTTCAATTTGATAACAAGTTAGATTTAGAGAATTACCCTCAAACAATTGATAATGATATAAAA
ATCTCCTTTTCAAATGGCGCAGATGCTATCTTCATACCAAGTTATGAAGATATATATCCACCGAATAATAAAAATATTAA
ATTCCTAAAAGCTCCAAAAGAACTATCTTCTGCATTATGTGGATTAAATCGAATTGGACATTTTGATGGCGTTTGTACAG
TAGTTTATAGATTACTTAATCTCATAAAGCCAAAAAATCTTTACTTAGGAGAAAAAGATTGGCAACAACTTTTAATTTTA
AAAAATCTAGTCCTTAGAAAAAATTTAAATGTTGCTATTAGATCCATACCTACACAAAGAGATTTTGATGGAATTCCTCT
AAGTTCACGTAATGTACATTTATCAAAAAACGAAAGAAAATTGATTAGTTTTTTTTCAAGTGAGTTATTAGAAGCAAAAA
AAATTTTTCAACAAGATAAAAAGATCAATTTAAACCAAATAATTAAGAAGTTATCAGCAAAAAAAATTTCAGTTGAATAT
TTAGAACATTTACACCCTCATACACTCCAAAAAGCAAGACCTGAGGATAATATTTCGTTATTGGCTGGTGCGATAAGATG
TGGGGAGACAAGATTAATTGATCACGTTTTTTTAATGAAAAGAAGGCCTATTATTGCAATTGATGGTCCTGCAGGTTCAG
GTAAAAGTACTGTAACAAAGTTAATAGCGAAGAAACTTAATCTCTTATATTTAGATACTGGCGCAATGTATAGGGCATTG
AGTTGGCTTATAATAAAAGAAAGTGTTGATTATAAAATAGAAAAAAAATTGCAGAATATTCTTAAAGATATATCTATATT
TTTCAAGTCGAATACAAATTCACATCAGGATGTTTATGTTAATAACTACTGTGTTACTAAAGAAATTAGGTCGCAAAAGA
TAAGTTCCATCGTTTCTAAAATTTCCTCAATAAAAGAAGTAAGAAAATTTTTAGTAGCCGAACAAAGAAAAATTGGAGAA
TCAGGCGGACTTGTAGCTGAGGGAAGAGATATAGGAACTACTGTTTTTCCTCATGCAGAACTTAAAATATTTTTAACTGC
TAGCATCGATGAAAGAGCAAAAAGAAGAAAATATGATAAAAATAGTAAAGACTCACAAGAAATAGACCTTTATACGTTAA
AAGAACTTATAAAGAAAAGAGATTTTGAAGATTCCAATAGGGAAATTTCTCCTCTAATAAAGGCGAATGACGCAATAGAA
ATTATTACGGACGGATATACAATTGATGAGGTAGTGGATAAAATTATTGACCTTTATAATGATAGGATTCCTAAAGAGAC
TGAGATCAAATAA

Upstream 100 bases:

>100_bases
ATGAAATAAAAATGATAGACTTTACCTATATAGATATTCCTCCTAAGATTACTTTTGTCCAGTAATTATTTATCAAATAG
ATTTATTTTTTAAAAACAAA

Downstream 100 bases:

>100_bases
ATTCAAGAAATACTTCCCAAAAAACCGGTTACAGAGTCTTCTAAAATATCAAGAACATAATCGAAGCCCTCATCACCTCC
AAAATATGGGTCAGGAACTT

Product: bifunctional pantoate ligase/cytidylate kinase

Products: NA

Alternate protein names: Pantothenate synthetase; PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme; Cytidylate kinase; CK; Cytidine monophosphate kinase; CMP kinase

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKKVIIRKTEEIENWRRNINSEINFIPTMGNLHDGHIKLISTAKNDNSNVNLVSIFINPLQFDNKLDLENYPQTIDNDIK
ISFSNGADAIFIPSYEDIYPPNNKNIKFLKAPKELSSALCGLNRIGHFDGVCTVVYRLLNLIKPKNLYLGEKDWQQLLIL
KNLVLRKNLNVAIRSIPTQRDFDGIPLSSRNVHLSKNERKLISFFSSELLEAKKIFQQDKKINLNQIIKKLSAKKISVEY
LEHLHPHTLQKARPEDNISLLAGAIRCGETRLIDHVFLMKRRPIIAIDGPAGSGKSTVTKLIAKKLNLLYLDTGAMYRAL
SWLIIKESVDYKIEKKLQNILKDISIFFKSNTNSHQDVYVNNYCVTKEIRSQKISSIVSKISSIKEVRKFLVAEQRKIGE
SGGLVAEGRDIGTTVFPHAELKIFLTASIDERAKRRKYDKNSKDSQEIDLYTLKELIKKRDFEDSNREISPLIKANDAIE
IITDGYTIDEVVDKIIDLYNDRIPKETEIK

Sequences:

>Translated_510_residues
MKKVIIRKTEEIENWRRNINSEINFIPTMGNLHDGHIKLISTAKNDNSNVNLVSIFINPLQFDNKLDLENYPQTIDNDIK
ISFSNGADAIFIPSYEDIYPPNNKNIKFLKAPKELSSALCGLNRIGHFDGVCTVVYRLLNLIKPKNLYLGEKDWQQLLIL
KNLVLRKNLNVAIRSIPTQRDFDGIPLSSRNVHLSKNERKLISFFSSELLEAKKIFQQDKKINLNQIIKKLSAKKISVEY
LEHLHPHTLQKARPEDNISLLAGAIRCGETRLIDHVFLMKRRPIIAIDGPAGSGKSTVTKLIAKKLNLLYLDTGAMYRAL
SWLIIKESVDYKIEKKLQNILKDISIFFKSNTNSHQDVYVNNYCVTKEIRSQKISSIVSKISSIKEVRKFLVAEQRKIGE
SGGLVAEGRDIGTTVFPHAELKIFLTASIDERAKRRKYDKNSKDSQEIDLYTLKELIKKRDFEDSNREISPLIKANDAIE
IITDGYTIDEVVDKIIDLYNDRIPKETEIK
>Mature_510_residues
MKKVIIRKTEEIENWRRNINSEINFIPTMGNLHDGHIKLISTAKNDNSNVNLVSIFINPLQFDNKLDLENYPQTIDNDIK
ISFSNGADAIFIPSYEDIYPPNNKNIKFLKAPKELSSALCGLNRIGHFDGVCTVVYRLLNLIKPKNLYLGEKDWQQLLIL
KNLVLRKNLNVAIRSIPTQRDFDGIPLSSRNVHLSKNERKLISFFSSELLEAKKIFQQDKKINLNQIIKKLSAKKISVEY
LEHLHPHTLQKARPEDNISLLAGAIRCGETRLIDHVFLMKRRPIIAIDGPAGSGKSTVTKLIAKKLNLLYLDTGAMYRAL
SWLIIKESVDYKIEKKLQNILKDISIFFKSNTNSHQDVYVNNYCVTKEIRSQKISSIVSKISSIKEVRKFLVAEQRKIGE
SGGLVAEGRDIGTTVFPHAELKIFLTASIDERAKRRKYDKNSKDSQEIDLYTLKELIKKRDFEDSNREISPLIKANDAIE
IITDGYTIDEVVDKIIDLYNDRIPKETEIK

Specific function: Displays a CMP kinase activity

COG id: COG0283

COG function: function code F; Cytidylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1786325, Length=257, Percent_Identity=35.0194552529183, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI1787139, Length=214, Percent_Identity=37.8504672897196, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6322046, Length=208, Percent_Identity=37.0192307692308, Blast_Score=126, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANCY_PROM0 (A3PF80)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001092006.1
- ProteinModelPortal:   A3PF80
- SMR:   A3PF80
- STRING:   A3PF80
- GeneID:   4911848
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_17821
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   LGEKDWQ
- ProtClustDB:   PRK13477
- BioCyc:   PMAR167546:P9301ORF_1818-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01349
- InterPro:   IPR003136
- InterPro:   IPR011994
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00017

Pfam domain/function: PF02224 Cytidylate_kin; PF02569 Pantoate_ligase

EC number: =6.3.2.1; =2.7.4.14

Molecular weight: Translated: 58445; Mature: 58445

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: ACT_SITE 36-36 BINDING 61-61 BINDING 61-61 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVIIRKTEEIENWRRNINSEINFIPTMGNLHDGHIKLISTAKNDNSNVNLVSIFINPL
CCCEEEECHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCEEEEEEEEECC
QFDNKLDLENYPQTIDNDIKISFSNGADAIFIPSYEDIYPPNNKNIKFLKAPKELSSALC
CCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCHHCCCCCCCCEEEEECHHHHHHHHH
GLNRIGHFDGVCTVVYRLLNLIKPKNLYLGEKDWQQLLILKNLVLRKNLNVAIRSIPTQR
HHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCC
DFDGIPLSSRNVHLSKNERKLISFFSSELLEAKKIFQQDKKINLNQIIKKLSAKKISVEY
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LEHLHPHTLQKARPEDNISLLAGAIRCGETRLIDHVFLMKRRPIIAIDGPAGSGKSTVTK
HHHCCHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
LIAKKLNLLYLDTGAMYRALSWLIIKESVDYKIEKKLQNILKDISIFFKSNTNSHQDVYV
HHHHHCCEEEEECCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHEECCCCCCCEEEE
NNYCVTKEIRSQKISSIVSKISSIKEVRKFLVAEQRKIGESGGLVAEGRDIGTTVFPHAE
ECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCE
LKIFLTASIDERAKRRKYDKNSKDSQEIDLYTLKELIKKRDFEDSNREISPLIKANDAIE
EEEEEEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCEE
IITDGYTIDEVVDKIIDLYNDRIPKETEIK
EEECCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKKVIIRKTEEIENWRRNINSEINFIPTMGNLHDGHIKLISTAKNDNSNVNLVSIFINPL
CCCEEEECHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCEEEEEEEEECC
QFDNKLDLENYPQTIDNDIKISFSNGADAIFIPSYEDIYPPNNKNIKFLKAPKELSSALC
CCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCHHCCCCCCCCEEEEECHHHHHHHHH
GLNRIGHFDGVCTVVYRLLNLIKPKNLYLGEKDWQQLLILKNLVLRKNLNVAIRSIPTQR
HHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCC
DFDGIPLSSRNVHLSKNERKLISFFSSELLEAKKIFQQDKKINLNQIIKKLSAKKISVEY
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LEHLHPHTLQKARPEDNISLLAGAIRCGETRLIDHVFLMKRRPIIAIDGPAGSGKSTVTK
HHHCCHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
LIAKKLNLLYLDTGAMYRALSWLIIKESVDYKIEKKLQNILKDISIFFKSNTNSHQDVYV
HHHHHCCEEEEECCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHEECCCCCCCEEEE
NNYCVTKEIRSQKISSIVSKISSIKEVRKFLVAEQRKIGESGGLVAEGRDIGTTVFPHAE
ECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCEECCCCE
LKIFLTASIDERAKRRKYDKNSKDSQEIDLYTLKELIKKRDFEDSNREISPLIKANDAIE
EEEEEEECHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCEE
IITDGYTIDEVVDKIIDLYNDRIPKETEIK
EEECCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA