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The map label for this gene is icd [H]

Identifier: 126697126

GI number: 126697126

Start: 1508651

End: 1510075

Strand: Direct

Name: icd [H]

Synonym: P9301_17881

Alternate gene names: 126697126

Gene position: 1508651-1510075 (Clockwise)

Preceding gene: 126697120

Following gene: 126697131

Centisome position: 91.89

GC content: 34.11

Gene sequence:

>1425_bases
ATGCCAAAATTTGAAAAATTAACTTTACCTAATGAAGGCGAAATAATAACTTTTAATCAAGGCAAACCTAATGTTCCTAA
TAATCCAATTGTCCCATTTATTCGGGGTGATGGTACTGGAGTTGATATTTGGCCTGCAACTCAAATCGTTCTTGATTCAG
CTATTAAAAAAAGCTACAAAGATGAAAGAAAAATTAATTGGTTTAAAGTCTATGCAGGCGATGAAGCTTGTGAACTTTAT
GGAACATATAACTATCTCCCTCAAGATACTATTGAAGCAATCAAACACTTTGGTGTAGCCATCAAAGGGCCTTTAACGAC
TCCCATCGGAGGAGGTATTAGATCTCTTAATGTTGCATTAAGGCAAATATTTGATTTATATAGCTGTGTTAGGCCATGTA
AATATTATTCAGGAACTCCAAGCCCTCACAAAAATCCTCAAAATTTAGACGTTATTGTTTATAGAGAAAATACTGAGGAT
ATCTACATGGGAATTGAATGGGAAGCGGAGGATAATAATTGTCTTGAATTAATTAATCACTTAAATAACGTTGTAATACC
AAAAAGTAAAAATTTAAAAAATAGATCTATACCCGACGGATCAGGTATTGGAATAAAACCAGTGAGTAAATCTGGTAGCC
AAAGGCATATTAGAAAAGCTATTGAACATGCCAAAAGATTATCAGGAGATAAAAGGCATGTGACTCTTGTACATAAAGGG
AATATTATGAAATATACAGAAGGTGCATTTAGAGATTGGGGATATGAATTAGCAGTAAATGAATTTAGAGAAGATTGCAT
TACAGAAAGAGAAAGCTGGATTTTAGATAATATTCAGAAAAATCCAGAAATTACAATTGAAAATAATGCTCGAAAAATTG
AACCGGGTTTTGACAAGCTTACAAATAATAAAAAAGCATTCATTTGCGAAGAAATTAAAGAAGTTATTGCATCAATATCA
AATTCTCACGGAGATGGAAAATGGAAAGAACTTATTCTTGTTGATGATCGGATAGCTGATAGTATATTTCAACAAATTCA
AACTAGACCTCAAGAATATTCAATTCTTGCAACCTTAAATCTCAATGGAGACTATGTTTCTGATGCAGCTGCAGCAATTG
TTGGTGGCCTAGGTATGGCTCCTGGTGCAAATATTGGAGATAATGCAGCAATTTTCGAAGCTACGCACGGTACTGCGCCA
AAACATGCAGGTTTAAATAAGATTAATCCAGGCTCAGTGATTCTTAGTGGTGTAATGATGCTTGAATATTTTGGTTGGGA
TGAGGCAGCTAACTTAATTACTAATGGTTTAAGTAAGGCAATAGAGCAAAAAAAAGTCACCTATGATCTAGCACGCTTAA
TGGAACCAAAAGTAGAGCCCTTATCCTGCAGCAGTTTTGCTGAAGAAATTATCTCAAATTTCTAA

Upstream 100 bases:

>100_bases
TCACATTTGAATAATAAATTTCTAGGTTTTAATGAAAATAACTCATCGCAAATTACAATACGAGGAACTTCAATGAGTTA
TCTTTTATTAATTCAATGCT

Downstream 100 bases:

>100_bases
TTTTAAAAATTATTTTTATTTTCAAAAACTTTCCAAATATTAACCAGTGAATCTTTAGTGCCAATGTTTCCAGGATGAGT
AACAATTGGAAGTTTTTCGC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MPKFEKLTLPNEGEIITFNQGKPNVPNNPIVPFIRGDGTGVDIWPATQIVLDSAIKKSYKDERKINWFKVYAGDEACELY
GTYNYLPQDTIEAIKHFGVAIKGPLTTPIGGGIRSLNVALRQIFDLYSCVRPCKYYSGTPSPHKNPQNLDVIVYRENTED
IYMGIEWEAEDNNCLELINHLNNVVIPKSKNLKNRSIPDGSGIGIKPVSKSGSQRHIRKAIEHAKRLSGDKRHVTLVHKG
NIMKYTEGAFRDWGYELAVNEFREDCITERESWILDNIQKNPEITIENNARKIEPGFDKLTNNKKAFICEEIKEVIASIS
NSHGDGKWKELILVDDRIADSIFQQIQTRPQEYSILATLNLNGDYVSDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAP
KHAGLNKINPGSVILSGVMMLEYFGWDEAANLITNGLSKAIEQKKVTYDLARLMEPKVEPLSCSSFAEEIISNF

Sequences:

>Translated_474_residues
MPKFEKLTLPNEGEIITFNQGKPNVPNNPIVPFIRGDGTGVDIWPATQIVLDSAIKKSYKDERKINWFKVYAGDEACELY
GTYNYLPQDTIEAIKHFGVAIKGPLTTPIGGGIRSLNVALRQIFDLYSCVRPCKYYSGTPSPHKNPQNLDVIVYRENTED
IYMGIEWEAEDNNCLELINHLNNVVIPKSKNLKNRSIPDGSGIGIKPVSKSGSQRHIRKAIEHAKRLSGDKRHVTLVHKG
NIMKYTEGAFRDWGYELAVNEFREDCITERESWILDNIQKNPEITIENNARKIEPGFDKLTNNKKAFICEEIKEVIASIS
NSHGDGKWKELILVDDRIADSIFQQIQTRPQEYSILATLNLNGDYVSDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAP
KHAGLNKINPGSVILSGVMMLEYFGWDEAANLITNGLSKAIEQKKVTYDLARLMEPKVEPLSCSSFAEEIISNF
>Mature_473_residues
PKFEKLTLPNEGEIITFNQGKPNVPNNPIVPFIRGDGTGVDIWPATQIVLDSAIKKSYKDERKINWFKVYAGDEACELYG
TYNYLPQDTIEAIKHFGVAIKGPLTTPIGGGIRSLNVALRQIFDLYSCVRPCKYYSGTPSPHKNPQNLDVIVYRENTEDI
YMGIEWEAEDNNCLELINHLNNVVIPKSKNLKNRSIPDGSGIGIKPVSKSGSQRHIRKAIEHAKRLSGDKRHVTLVHKGN
IMKYTEGAFRDWGYELAVNEFREDCITERESWILDNIQKNPEITIENNARKIEPGFDKLTNNKKAFICEEIKEVIASISN
SHGDGKWKELILVDDRIADSIFQQIQTRPQEYSILATLNLNGDYVSDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPK
HAGLNKINPGSVILSGVMMLEYFGWDEAANLITNGLSKAIEQKKVTYDLARLMEPKVEPLSCSSFAEEIISNF

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=209, Percent_Identity=32.0574162679426, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI28178838, Length=133, Percent_Identity=30.8270676691729, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4758582, Length=116, Percent_Identity=31.0344827586207, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787381, Length=469, Percent_Identity=48.4008528784648, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI87081683, Length=159, Percent_Identity=30.8176100628931, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788101, Length=134, Percent_Identity=30.5970149253731, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71986051, Length=191, Percent_Identity=34.5549738219895, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17505779, Length=139, Percent_Identity=33.8129496402878, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25144293, Length=110, Percent_Identity=33.6363636363636, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324709, Length=461, Percent_Identity=28.1995661605206, Blast_Score=146, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6322097, Length=411, Percent_Identity=27.9805352798054, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324291, Length=168, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643268, Length=451, Percent_Identity=29.0465631929047, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24643270, Length=451, Percent_Identity=29.490022172949, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24661184, Length=126, Percent_Identity=40.4761904761905, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI161078639, Length=169, Percent_Identity=28.4023668639053, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI161078633, Length=169, Percent_Identity=28.4023668639053, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24650122, Length=169, Percent_Identity=28.4023668639053, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI161078637, Length=169, Percent_Identity=28.4023668639053, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI161078635, Length=169, Percent_Identity=28.4023668639053, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 52766; Mature: 52634

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKFEKLTLPNEGEIITFNQGKPNVPNNPIVPFIRGDGTGVDIWPATQIVLDSAIKKSYK
CCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHH
DERKINWFKVYAGDEACELYGTYNYLPQDTIEAIKHFGVAIKGPLTTPIGGGIRSLNVAL
HCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHH
RQIFDLYSCVRPCKYYSGTPSPHKNPQNLDVIVYRENTEDIYMGIEWEAEDNNCLELINH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCHHHHHHHH
LNNVVIPKSKNLKNRSIPDGSGIGIKPVSKSGSQRHIRKAIEHAKRLSGDKRHVTLVHKG
HCCEECCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECC
NIMKYTEGAFRDWGYELAVNEFREDCITERESWILDNIQKNPEITIENNARKIEPGFDKL
CEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCCHHHH
TNNKKAFICEEIKEVIASISNSHGDGKWKELILVDDRIADSIFQQIQTRPQEYSILATLN
CCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYVSDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKHAGLNKINPGSVILSGVMM
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LEYFGWDEAANLITNGLSKAIEQKKVTYDLARLMEPKVEPLSCSSFAEEIISNF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PKFEKLTLPNEGEIITFNQGKPNVPNNPIVPFIRGDGTGVDIWPATQIVLDSAIKKSYK
CCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHH
DERKINWFKVYAGDEACELYGTYNYLPQDTIEAIKHFGVAIKGPLTTPIGGGIRSLNVAL
HCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHH
RQIFDLYSCVRPCKYYSGTPSPHKNPQNLDVIVYRENTEDIYMGIEWEAEDNNCLELINH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCHHHHHHHH
LNNVVIPKSKNLKNRSIPDGSGIGIKPVSKSGSQRHIRKAIEHAKRLSGDKRHVTLVHKG
HCCEECCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECC
NIMKYTEGAFRDWGYELAVNEFREDCITERESWILDNIQKNPEITIENNARKIEPGFDKL
CEEEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEECCCCHHHH
TNNKKAFICEEIKEVIASISNSHGDGKWKELILVDDRIADSIFQQIQTRPQEYSILATLN
CCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCCEEEEEEEE
LNGDYVSDAAAAIVGGLGMAPGANIGDNAAIFEATHGTAPKHAGLNKINPGSVILSGVMM
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LEYFGWDEAANLITNGLSKAIEQKKVTYDLARLMEPKVEPLSCSSFAEEIISNF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8169222; 11759840 [H]