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The map label for this gene is bioF [C]

Identifier: 126696996

GI number: 126696996

Start: 1389203

End: 1390342

Strand: Direct

Name: bioF [C]

Synonym: P9301_16581

Alternate gene names: 126696996

Gene position: 1389203-1390342 (Clockwise)

Preceding gene: 126696994

Following gene: 126696997

Centisome position: 84.61

GC content: 32.81

Gene sequence:

>1140_bases
ATGAAAAAAATAAAAATTCCAAAAAATAGAATCCGGAAATTAAAAACATTTTCTTTAGGTAACAAATCATTCGAACTTCA
AAGTTTAAATTCGCAAAATAAAAAACTTATAGACTTATGCAGTAATGATTATTTTGGATTAAGTAGGGACAAGGATTTAA
TAAAAGCTGCTTACGAAATAAGCAATTTAGAAGGTATTGGTTCAGGGAGCTCAAGGTTTATTACAGGATCAAGACCAATA
CATAAATTATTAGAAACAGAACTTGCCAAGTGGATTGATCAAGAGAAAGTATTACTTTTTCCAAGCGGATTTCAAGCAAA
TATAGCCGCTATCCAAGCTTTAGCGAACAGAAATAGTATCGTAATAGCAGATAAATTGATCCATAACTCTTTATTGGTGG
GAGTTAAGGCTTCTCAAGCAAAACTAGTTCGATTTTCACACAATAATTTAAAAGATTTAGAAGATAAAATTATAAAATCT
AACCCCACAAAAAATTCCATTTTAGTTGTTGTCGAATCTCTTTATAGCATGGAGGGATCAATTGCTCCACTCAGAGAAAT
AACGGAAATTTGCAAAAAAAATAGTGTTCAATTATTAGTTGATGAAGCCCATGCAATTGGGATCTTGGGCTCTGAAGGCA
GGGGGCTAAGTTTTAATTGCCGTTCAGATATAACTATGATTACTGGAACTTTTGGAAAAGCATTTGGCAGCGGTGGAGCT
TTCTTAGCTTCCAATTCAGAAATTGGTGAATATATTATCCAAACAAGTGGTGCATTTAGGTATACAACCGCCCTTGCGCC
ACCTTTAGCTGCTGGAGCGCTAGAAGGTTTAAAAAAAATTTTAGCAAATAAAGAATGGGGTAATGATTTGTTATCTTCTG
CGAAGATATGGAAAGATGAAATTATTAAAAATTTTAGTTTTCCAGTTCAGGGAGATTCTCACATTCTATCAATTATTGTT
GGCCAAGAAGAGAAGGCGATTTATCTACAAAAATATCTTGAGGAAAATGGGTTTTTAGCAATTGCAATAAGACCTCCTAC
TGTACCAGTTGGGCAATCAAGAATTAGAATAACAATACGAAGAAACTTAGATTTTAATCTGCTACAAAATTTCATTGCAG
TATTAAAAAAGTTTAAATGA

Upstream 100 bases:

>100_bases
TATGATCTATATAGATATTAATAAACAAAAAATACCTTGCAAACTTTAATAGTAAATCTAAATCTTTTTAATTAAAGCCA
CTATATTTAATTTTGCTAAA

Downstream 100 bases:

>100_bases
AACAAATTATTACTCAACATGGGTGGGGACTAAATAAATATTTCTGGGATGATTATAAAGTTGATTTTTTAAATAATAAT
TGGCATTGGCAAGATAATGA

Product: putative 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKKIKIPKNRIRKLKTFSLGNKSFELQSLNSQNKKLIDLCSNDYFGLSRDKDLIKAAYEISNLEGIGSGSSRFITGSRPI
HKLLETELAKWIDQEKVLLFPSGFQANIAAIQALANRNSIVIADKLIHNSLLVGVKASQAKLVRFSHNNLKDLEDKIIKS
NPTKNSILVVVESLYSMEGSIAPLREITEICKKNSVQLLVDEAHAIGILGSEGRGLSFNCRSDITMITGTFGKAFGSGGA
FLASNSEIGEYIIQTSGAFRYTTALAPPLAAGALEGLKKILANKEWGNDLLSSAKIWKDEIIKNFSFPVQGDSHILSIIV
GQEEKAIYLQKYLEENGFLAIAIRPPTVPVGQSRIRITIRRNLDFNLLQNFIAVLKKFK

Sequences:

>Translated_379_residues
MKKIKIPKNRIRKLKTFSLGNKSFELQSLNSQNKKLIDLCSNDYFGLSRDKDLIKAAYEISNLEGIGSGSSRFITGSRPI
HKLLETELAKWIDQEKVLLFPSGFQANIAAIQALANRNSIVIADKLIHNSLLVGVKASQAKLVRFSHNNLKDLEDKIIKS
NPTKNSILVVVESLYSMEGSIAPLREITEICKKNSVQLLVDEAHAIGILGSEGRGLSFNCRSDITMITGTFGKAFGSGGA
FLASNSEIGEYIIQTSGAFRYTTALAPPLAAGALEGLKKILANKEWGNDLLSSAKIWKDEIIKNFSFPVQGDSHILSIIV
GQEEKAIYLQKYLEENGFLAIAIRPPTVPVGQSRIRITIRRNLDFNLLQNFIAVLKKFK
>Mature_379_residues
MKKIKIPKNRIRKLKTFSLGNKSFELQSLNSQNKKLIDLCSNDYFGLSRDKDLIKAAYEISNLEGIGSGSSRFITGSRPI
HKLLETELAKWIDQEKVLLFPSGFQANIAAIQALANRNSIVIADKLIHNSLLVGVKASQAKLVRFSHNNLKDLEDKIIKS
NPTKNSILVVVESLYSMEGSIAPLREITEICKKNSVQLLVDEAHAIGILGSEGRGLSFNCRSDITMITGTFGKAFGSGGA
FLASNSEIGEYIIQTSGAFRYTTALAPPLAAGALEGLKKILANKEWGNDLLSSAKIWKDEIIKNFSFPVQGDSHILSIIV
GQEEKAIYLQKYLEENGFLAIAIRPPTVPVGQSRIRITIRRNLDFNLLQNFIAVLKKFK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=345, Percent_Identity=31.8840579710145, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI83977440, Length=345, Percent_Identity=31.8840579710145, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI83977444, Length=345, Percent_Identity=31.8840579710145, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI284448556, Length=335, Percent_Identity=28.3582089552239, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI7657118, Length=328, Percent_Identity=28.3536585365854, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI119220554, Length=345, Percent_Identity=27.8260869565217, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4502025, Length=346, Percent_Identity=29.4797687861272, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI40316939, Length=346, Percent_Identity=29.4797687861272, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI4758668, Length=346, Percent_Identity=29.1907514450867, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI5454084, Length=247, Percent_Identity=27.5303643724696, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786993, Length=357, Percent_Identity=33.3333333333333, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1790046, Length=336, Percent_Identity=30.952380952381, Blast_Score=181, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=362, Percent_Identity=28.7292817679558, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32566772, Length=368, Percent_Identity=29.0760869565217, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17560912, Length=263, Percent_Identity=30.0380228136882, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560914, Length=263, Percent_Identity=30.0380228136882, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71982617, Length=225, Percent_Identity=28.8888888888889, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=225, Percent_Identity=28.8888888888889, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=368, Percent_Identity=29.3478260869565, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320267, Length=346, Percent_Identity=26.878612716763, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=281, Percent_Identity=25.2669039145907, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24662918, Length=336, Percent_Identity=29.1666666666667, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17137420, Length=353, Percent_Identity=30.8781869688385, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=28.9256198347107, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653280, Length=288, Percent_Identity=25, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24653276, Length=288, Percent_Identity=25, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24653278, Length=288, Percent_Identity=25, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 41849; Mature: 41849

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIKIPKNRIRKLKTFSLGNKSFELQSLNSQNKKLIDLCSNDYFGLSRDKDLIKAAYEI
CCCCCCCHHHHHHHHHEECCCCCEEEECCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHH
SNLEGIGSGSSRFITGSRPIHKLLETELAKWIDQEKVLLFPSGFQANIAAIQALANRNSI
HCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCE
VIADKLIHNSLLVGVKASQAKLVRFSHNNLKDLEDKIIKSNPTKNSILVVVESLYSMEGS
EEEHHHHHCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCCCHHEEEEHHHHHCCCC
IAPLREITEICKKNSVQLLVDEAHAIGILGSEGRGLSFNCRSDITMITGTFGKAFGSGGA
CCCHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCCEEECCCCCEEEEECCHHHHCCCCE
FLASNSEIGEYIIQTSGAFRYTTALAPPLAAGALEGLKKILANKEWGNDLLSSAKIWKDE
EEECCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IIKNFSFPVQGDSHILSIIVGQEEKAIYLQKYLEENGFLAIAIRPPTVPVGQSRIRITIR
HHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEE
RNLDFNLLQNFIAVLKKFK
ECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIKIPKNRIRKLKTFSLGNKSFELQSLNSQNKKLIDLCSNDYFGLSRDKDLIKAAYEI
CCCCCCCHHHHHHHHHEECCCCCEEEECCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHH
SNLEGIGSGSSRFITGSRPIHKLLETELAKWIDQEKVLLFPSGFQANIAAIQALANRNSI
HCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCE
VIADKLIHNSLLVGVKASQAKLVRFSHNNLKDLEDKIIKSNPTKNSILVVVESLYSMEGS
EEEHHHHHCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCCCCCCHHEEEEHHHHHCCCC
IAPLREITEICKKNSVQLLVDEAHAIGILGSEGRGLSFNCRSDITMITGTFGKAFGSGGA
CCCHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCCEEECCCCCEEEEECCHHHHCCCCE
FLASNSEIGEYIIQTSGAFRYTTALAPPLAAGALEGLKKILANKEWGNDLLSSAKIWKDE
EEECCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IIKNFSFPVQGDSHILSIIVGQEEKAIYLQKYLEENGFLAIAIRPPTVPVGQSRIRITIR
HHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEE
RNLDFNLLQNFIAVLKKFK
ECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA