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The map label for this gene is fumC [H]

Identifier: 126696994

GI number: 126696994

Start: 1384941

End: 1386326

Strand: Direct

Name: fumC [H]

Synonym: P9301_16561

Alternate gene names: 126696994

Gene position: 1384941-1386326 (Clockwise)

Preceding gene: 126696993

Following gene: 126696996

Centisome position: 84.35

GC content: 32.03

Gene sequence:

>1386_bases
ATGACAAAAAACTTTAGGATTGAAAAAGATAGTATGGGAACAATAAAGGTTCCCATTGAAGCTTTGTGGGGCGCTCAAAC
ACAAAGATCGATAATAAATTTTTCTATTGGAGAAGAATTAATTCCAATTGAATTAATTTATTCACTCACCCTCATAAAAA
AAGCTGCTTCAATTGCAAATTTCAATTTAGGATTAATAGATAAAAGAAAAAAAGATTTGATTGTAGAGGCATGTACAGAA
ATACTTGATGGGCTTCATGATTCACAGTTTCCCTTAAAGGTTTGGCAAACAGGTAGTGGCACGCAAACAAATATGAATGT
TAATGAGGTAATTTCAAATATTGCAGCTTTAAAAACAAATTCAGAGCTTGGTAGTCATCAACCACTTCATCCGAATGATG
ATGTAAATAAATCTCAGTCAACAAATGATACTTTTCCTGCTGCTATTCAAATATCAGTTGTTAATGAAATAATCAAAAAT
TTAGTTCCAACGATAAGAGAACTTACTAAGATCCTTGATAATAAAAGTGAGCAATGGAAAGACCTTATAAAAATAGGAAG
AACCCATTTTCAAGATGCAGTGCCCCTTACTTTTGGCCAAGAAATATCTGGATGGTCAGAGCAACTTAAAGATGCTGAGA
ATGCAATTATTATAAGTCTGAATGAATTGTATTTTTTACCTCTGGGAGGCACTGCAGTTGGAACAGGGATTAATTGTCCA
AAAGGATTTTGTGAGGAGTCTATAAAATCAATTTCCGATGATACTAATCTGATGTTCTATAAATCAAAAAATAATTTTTC
TATCATGGCCTCGCATGATCGTTTAGCTCAAGTAATGAGTCAGATAAAAATATTAGCAGGTGCTTTATTTAAAATTTCAA
ATGATATAAAAATTCTATCTTCAGGACCAAGGTCAGGAATATATGAATTAATCATCCCTCAAAATGAACCTGGAAGTTCT
ATCATGCCGGGCAAAGTGAATCCGACTCAGTGCGAAGCCTTATCAATGGTTTGCACTCAGATAATGGGCCTTGAATATGC
AGTTTCAATGGCAAATTCTAGCGGAACTTTGCAGATGAATGAATATAAGCCTCTGATAGGATTTAATATTCTTACAAGTT
TAAAATTACTTAAAAATGCAATAGAAAACTTCAGAACAAAATTAGTTTATGGAATGGAACCTAATCAAAAAAAAATGAAG
TTTAATTTAGATAATTCACTAATGTTGATTACAGCCATAGTGCCAAAAGTTGGTTATGAAAAAGCAGCTGAAATTGCAAA
CCTTGCCTTCAAAGAATCATTAAATTTAAAAGAGGCAACACTTAAATTAGGTTATTTAAACGAAGATGAATTTGATGATG
CGATGAATATTAATTCAATGATTTAA

Upstream 100 bases:

>100_bases
TTCAATTCATCTCAATAATTTAAGTGTAATATGGGAGAAGTTAGGTATCTAGGATTACTGAAAACCTTATCTAAGTTAAA
CCGGTGTTTTCAGAGGAATA

Downstream 100 bases:

>100_bases
TTAAAAAAATTTAAGAATTATTTTCAATTCTTTTTGTCGCAGGATTAATATCTTCAGAGACTTTTATAAGATCGTTAGAT
TCAGAAACAGGAAAACGATT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTKNFRIEKDSMGTIKVPIEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIANFNLGLIDKRKKDLIVEACTE
ILDGLHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALKTNSELGSHQPLHPNDDVNKSQSTNDTFPAAIQISVVNEIIKN
LVPTIRELTKILDNKSEQWKDLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIISLNELYFLPLGGTAVGTGINCP
KGFCEESIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILAGALFKISNDIKILSSGPRSGIYELIIPQNEPGSS
IMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMNEYKPLIGFNILTSLKLLKNAIENFRTKLVYGMEPNQKKMK
FNLDNSLMLITAIVPKVGYEKAAEIANLAFKESLNLKEATLKLGYLNEDEFDDAMNINSMI

Sequences:

>Translated_461_residues
MTKNFRIEKDSMGTIKVPIEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIANFNLGLIDKRKKDLIVEACTE
ILDGLHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALKTNSELGSHQPLHPNDDVNKSQSTNDTFPAAIQISVVNEIIKN
LVPTIRELTKILDNKSEQWKDLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIISLNELYFLPLGGTAVGTGINCP
KGFCEESIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILAGALFKISNDIKILSSGPRSGIYELIIPQNEPGSS
IMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMNEYKPLIGFNILTSLKLLKNAIENFRTKLVYGMEPNQKKMK
FNLDNSLMLITAIVPKVGYEKAAEIANLAFKESLNLKEATLKLGYLNEDEFDDAMNINSMI
>Mature_460_residues
TKNFRIEKDSMGTIKVPIEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIANFNLGLIDKRKKDLIVEACTEI
LDGLHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALKTNSELGSHQPLHPNDDVNKSQSTNDTFPAAIQISVVNEIIKNL
VPTIRELTKILDNKSEQWKDLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIISLNELYFLPLGGTAVGTGINCPK
GFCEESIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILAGALFKISNDIKILSSGPRSGIYELIIPQNEPGSSI
MPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMNEYKPLIGFNILTSLKLLKNAIENFRTKLVYGMEPNQKKMKF
NLDNSLMLITAIVPKVGYEKAAEIANLAFKESLNLKEATLKLGYLNEDEFDDAMNINSMI

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=47.3913043478261, Blast_Score=424, Evalue=1e-119,
Organism=Escherichia coli, GI1787896, Length=456, Percent_Identity=48.4649122807018, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI87082375, Length=466, Percent_Identity=37.1244635193133, Blast_Score=294, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17553882, Length=448, Percent_Identity=48.8839285714286, Blast_Score=437, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI32565146, Length=314, Percent_Identity=47.4522292993631, Blast_Score=301, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6324993, Length=455, Percent_Identity=45.9340659340659, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=48.3801295896328, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=48.3801295896328, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=48.1561822125813, Blast_Score=440, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24662684, Length=460, Percent_Identity=46.5217391304348, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24583245, Length=448, Percent_Identity=43.75, Blast_Score=397, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 51048; Mature: 50916

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNFRIEKDSMGTIKVPIEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIAN
CCCCCEEECCCCCEEEECHHHHHCCHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHC
FNLGLIDKRKKDLIVEACTEILDGLHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALKTN
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
SELGSHQPLHPNDDVNKSQSTNDTFPAAIQISVVNEIIKNLVPTIRELTKILDNKSEQWK
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
DLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIISLNELYFLPLGGTAVGTGINCP
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEEEEEEEECCCCEECCCCCCC
KGFCEESIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILAGALFKISNDIKILS
HHHHHHHHHHCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
SGPRSGIYELIIPQNEPGSSIMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMN
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEC
EYKPLIGFNILTSLKLLKNAIENFRTKLVYGMEPNQKKMKFNLDNSLMLITAIVPKVGYE
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCEEEEEHHHCCCCHH
KAAEIANLAFKESLNLKEATLKLGYLNEDEFDDAMNINSMI
HHHHHHHHHHHHCCCCCHHEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKNFRIEKDSMGTIKVPIEALWGAQTQRSIINFSIGEELIPIELIYSLTLIKKAASIAN
CCCCEEECCCCCEEEECHHHHHCCHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHC
FNLGLIDKRKKDLIVEACTEILDGLHDSQFPLKVWQTGSGTQTNMNVNEVISNIAALKTN
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCC
SELGSHQPLHPNDDVNKSQSTNDTFPAAIQISVVNEIIKNLVPTIRELTKILDNKSEQWK
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
DLIKIGRTHFQDAVPLTFGQEISGWSEQLKDAENAIIISLNELYFLPLGGTAVGTGINCP
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEEEEEEEECCCCEECCCCCCC
KGFCEESIKSISDDTNLMFYKSKNNFSIMASHDRLAQVMSQIKILAGALFKISNDIKILS
HHHHHHHHHHCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
SGPRSGIYELIIPQNEPGSSIMPGKVNPTQCEALSMVCTQIMGLEYAVSMANSSGTLQMN
CCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEC
EYKPLIGFNILTSLKLLKNAIENFRTKLVYGMEPNQKKMKFNLDNSLMLITAIVPKVGYE
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCEEEEEHHHCCCCHH
KAAEIANLAFKESLNLKEATLKLGYLNEDEFDDAMNINSMI
HHHHHHHHHHHHCCCCCHHEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]