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The map label for this gene is serA [H]

Identifier: 126696878

GI number: 126696878

Start: 1305753

End: 1307339

Strand: Reverse

Name: serA [H]

Synonym: P9301_15401

Alternate gene names: 126696878

Gene position: 1307339-1305753 (Counterclockwise)

Preceding gene: 126696884

Following gene: 126696877

Centisome position: 79.62

GC content: 38.12

Gene sequence:

>1587_bases
ATGACAAAAGTTCTCATTACAGATCCAATTGATCAAAAAGGAATCGATATTCTTTCACAAGTTGCTCAGGTTGATCACAA
GATAGGGATCTCAGACTCTGAGTTAGCTTCCATTATTGGAGATTATGATGCCTTAATGATTCGCTCTGGTACTCAAGTGA
CCGAAGAAATTATTAACTCTTCAAGTAAACTGAGAATCATTGGGAGAGCAGGAGTTGGAGTCGATAATGTAGATGTTAAG
GCTGCTACGCAAAAAGGAGTCCTTGTTGTTAATTCTCCAGGGGGTAACACAATAGCAGCGGCTGAACATACTATAGCTAT
GATGTTGGCCTTATCTAGGCATATTCCAATTGCTAATAGTAGTACTTTGTTAGGTAAATGGGAGAGAAAGAAATTCGTTG
GGAATGAGCTTTATAAGAAAAAATTAGGTGTAGTAGGTTTAGGGAAAATTGGTGCTCATGTAGCAAAAGTTGCTAATGCA
TTAGGGATGGAAGTTTGCGGATATGATCCATTTGTTTCAACTGAAAGAGCTCAACAAATCCAAGTTAAACTATCTGATCT
AGAAGATTTATTCCAACAATCCGATTATGTAACTTTGCATTTACCTCGCACACCAGAGACAGAGAATTTAGTCAATATGG
ATGTGCTTAAAAATATGAAAAGTAGCGCAAAATTAATTAATTGTGCTCGAGGAGGCTTGATTGATGAAGAGGCATTAGCA
CAAGCTTTAAATCAATCATTGATTGCAGGTGCTGCAATAGATGTTTTTTCTAAAGAACCTTTGGAATCTAATTCACCACT
TTTGAAGGTTGAAAAGAATCTTATTCTTACCCCCCACTTAGGAGCATCTACTCGGGAAGCACAAGAAAATGTAGCTGTTG
ATGTTGCGGAACAAATAAGGGATGTCTTGCTTGGTTTATCTGCTAGAACTGCAGTAAATATTCCAGGTTTGAGCCCTGAT
ATTATGGATAGTCTGAAACCTCATTTGCAGTTAGCTGAAACCATGGGTCTGCTTATAAGCCAGCTTTCAGGTGGACAGAT
ACAGAAACTAGAAGTAAAGCTTCAAGGTGAATTTGTTCAACATCCTTCTCAGCCATTAATAATAGCTAGTCTAAAAGGCC
TTCTAAGTAAAGCTTTGGGAGATAGGATTAATTATGTAAATGCTTCGCTAGAAGCAGATTCAAGAGGTATTTCAGTAGTC
GAGAATAAAGATGAGGCAAGACCTGAATTTGCTAGTGGTTCGCTTCAGTTAACCACTTATGGAGATAACGGCGACCATAG
CGTAGCGGGAAGCATTTTTGCTGATGGGGAATTAAGAATTATTAGTATTGATCAATACCCAGTTAATGTATCACCAAGCA
GATATATGTTGGTTACTAGGCACAGGGATATGCCTGGTATTATTGGCAAGCTGGGGTCTTTATTAGGTAGCAATAATGTA
AATATTGCCTCAATGCAAGTTGGGCGCAAAATTGTAAGAGGGGAAGCTGTTATGGTTCTAAGTATTGATGATCCAATACC
TAATAAGTTACTTGATACCATTATTGAAGTGGATGGGATTACCAACGCTAATCCAGTTACTCTATGA

Upstream 100 bases:

>100_bases
AATTTCAATCCTCAAATGTTTGTGTGTTATTCAAATTAATAAAATAAGATACATACACTATAGATTAAGTTAAAGTAAAA
GATTAAAGAACCAATCTTAA

Downstream 100 bases:

>100_bases
AGTGGCTTTAACTAGTTAATGGAAACTAAAGATTGGTATAAACTAACTTTTCTGATAGAAAGTGATTCTGAAGAAATTAT
TATTTGGAAATTAAATGAGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTKVLITDPIDQKGIDILSQVAQVDHKIGISDSELASIIGDYDALMIRSGTQVTEEIINSSSKLRIIGRAGVGVDNVDVK
AATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRHIPIANSSTLLGKWERKKFVGNELYKKKLGVVGLGKIGAHVAKVANA
LGMEVCGYDPFVSTERAQQIQVKLSDLEDLFQQSDYVTLHLPRTPETENLVNMDVLKNMKSSAKLINCARGGLIDEEALA
QALNQSLIAGAAIDVFSKEPLESNSPLLKVEKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPD
IMDSLKPHLQLAETMGLLISQLSGGQIQKLEVKLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVV
ENKDEARPEFASGSLQLTTYGDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVDGITNANPVTL

Sequences:

>Translated_528_residues
MTKVLITDPIDQKGIDILSQVAQVDHKIGISDSELASIIGDYDALMIRSGTQVTEEIINSSSKLRIIGRAGVGVDNVDVK
AATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRHIPIANSSTLLGKWERKKFVGNELYKKKLGVVGLGKIGAHVAKVANA
LGMEVCGYDPFVSTERAQQIQVKLSDLEDLFQQSDYVTLHLPRTPETENLVNMDVLKNMKSSAKLINCARGGLIDEEALA
QALNQSLIAGAAIDVFSKEPLESNSPLLKVEKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPD
IMDSLKPHLQLAETMGLLISQLSGGQIQKLEVKLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVV
ENKDEARPEFASGSLQLTTYGDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVDGITNANPVTL
>Mature_527_residues
TKVLITDPIDQKGIDILSQVAQVDHKIGISDSELASIIGDYDALMIRSGTQVTEEIINSSSKLRIIGRAGVGVDNVDVKA
ATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRHIPIANSSTLLGKWERKKFVGNELYKKKLGVVGLGKIGAHVAKVANAL
GMEVCGYDPFVSTERAQQIQVKLSDLEDLFQQSDYVTLHLPRTPETENLVNMDVLKNMKSSAKLINCARGGLIDEEALAQ
ALNQSLIAGAAIDVFSKEPLESNSPLLKVEKNLILTPHLGASTREAQENVAVDVAEQIRDVLLGLSARTAVNIPGLSPDI
MDSLKPHLQLAETMGLLISQLSGGQIQKLEVKLQGEFVQHPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVVE
NKDEARPEFASGSLQLTTYGDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNVN
IASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVDGITNANPVTL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=410, Percent_Identity=40.4878048780488, Blast_Score=298, Evalue=6e-81,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=37.2693726937269, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=37.2693726937269, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI145580578, Length=393, Percent_Identity=31.8066157760814, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4557499, Length=393, Percent_Identity=31.8066157760814, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI145580575, Length=396, Percent_Identity=32.0707070707071, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI6912396, Length=311, Percent_Identity=28.9389067524116, Blast_Score=134, Evalue=3e-31,
Organism=Escherichia coli, GI1789279, Length=323, Percent_Identity=37.1517027863777, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI87082289, Length=282, Percent_Identity=32.2695035460993, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=35.2040816326531, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=30.4182509505703, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87081824, Length=158, Percent_Identity=30.379746835443, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=42.7244582043344, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI25147481, Length=302, Percent_Identity=28.8079470198675, Blast_Score=126, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=333, Percent_Identity=34.5345345345345, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320925, Length=326, Percent_Identity=34.3558282208589, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324964, Length=261, Percent_Identity=28.3524904214559, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=243, Percent_Identity=27.5720164609054, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321253, Length=175, Percent_Identity=31.4285714285714, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=176, Percent_Identity=26.1363636363636, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324980, Length=191, Percent_Identity=27.2251308900524, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=41.6666666666667, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24646446, Length=301, Percent_Identity=35.8803986710963, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646448, Length=301, Percent_Identity=35.8803986710963, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646452, Length=301, Percent_Identity=35.8803986710963, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24646450, Length=301, Percent_Identity=35.8803986710963, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI62472511, Length=303, Percent_Identity=35.6435643564356, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=29.4871794871795, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI28574286, Length=329, Percent_Identity=29.7872340425532, Blast_Score=122, Evalue=9e-28,
Organism=Drosophila melanogaster, GI28574284, Length=327, Percent_Identity=27.217125382263, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45551003, Length=327, Percent_Identity=27.217125382263, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585514, Length=327, Percent_Identity=27.217125382263, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574282, Length=327, Percent_Identity=27.217125382263, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45552429, Length=327, Percent_Identity=27.217125382263, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585516, Length=311, Percent_Identity=27.0096463022508, Blast_Score=115, Evalue=1e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56550; Mature: 56419

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVLITDPIDQKGIDILSQVAQVDHKIGISDSELASIIGDYDALMIRSGTQVTEEIINS
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCC
SSKLRIIGRAGVGVDNVDVKAATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRHIPIANS
CCEEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCC
STLLGKWERKKFVGNELYKKKLGVVGLGKIGAHVAKVANALGMEVCGYDPFVSTERAQQI
CCHHCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHH
QVKLSDLEDLFQQSDYVTLHLPRTPETENLVNMDVLKNMKSSAKLINCARGGLIDEEALA
EEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QALNQSLIAGAAIDVFSKEPLESNSPLLKVEKNLILTPHLGASTREAQENVAVDVAEQIR
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHH
DVLLGLSARTAVNIPGLSPDIMDSLKPHLQLAETMGLLISQLSGGQIQKLEVKLQGEFVQ
HHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHC
HPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVVENKDEARPEFASGSLQLTTY
CCCCCCHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEC
GDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
CCCCCCCEECEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCC
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVDGITNANPVTL
EEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TKVLITDPIDQKGIDILSQVAQVDHKIGISDSELASIIGDYDALMIRSGTQVTEEIINS
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCC
SSKLRIIGRAGVGVDNVDVKAATQKGVLVVNSPGGNTIAAAEHTIAMMLALSRHIPIANS
CCEEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCCCC
STLLGKWERKKFVGNELYKKKLGVVGLGKIGAHVAKVANALGMEVCGYDPFVSTERAQQI
CCHHCCHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHH
QVKLSDLEDLFQQSDYVTLHLPRTPETENLVNMDVLKNMKSSAKLINCARGGLIDEEALA
EEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QALNQSLIAGAAIDVFSKEPLESNSPLLKVEKNLILTPHLGASTREAQENVAVDVAEQIR
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHHHHH
DVLLGLSARTAVNIPGLSPDIMDSLKPHLQLAETMGLLISQLSGGQIQKLEVKLQGEFVQ
HHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHC
HPSQPLIIASLKGLLSKALGDRINYVNASLEADSRGISVVENKDEARPEFASGSLQLTTY
CCCCCCHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEC
GDNGDHSVAGSIFADGELRIISIDQYPVNVSPSRYMLVTRHRDMPGIIGKLGSLLGSNNV
CCCCCCCEECEEEECCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCC
NIASMQVGRKIVRGEAVMVLSIDDPIPNKLLDTIIEVDGITNANPVTL
EEEHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]