Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 126696535

GI number: 126696535

Start: 1011653

End: 1013026

Strand: Direct

Name: lysA [H]

Synonym: P9301_11971

Alternate gene names: 126696535

Gene position: 1011653-1013026 (Clockwise)

Preceding gene: 126696530

Following gene: 126696536

Centisome position: 61.62

GC content: 32.31

Gene sequence:

>1374_bases
ATGGAAGAAAAACAATCTTTTTTAAAACAAAAAATTGACTTGGAAAGTCCTAACAGAAATATTATTCCTATTACCACATC
CATTGATAGTGATGGGAAATTATCAGTTGGTGGGTGTTCTATTGAAGAACTAGTTAAAAAATATGATTCTCCTCTTTACA
TTTTAGATGAAATCACATTAAGAAATTCTTGTAAGGCGTACAAAAAAGCATTAGAAAAATACTACCCAGGAAAATCCTTG
CCCATATATGCTTCAAAAGCAAATAGTTCCATTTTTATGAGTAGTCTTGTTTCTTCGGAAGGTTTAGGACTTGATGCTGT
TTCAGAAGGAGAACTATTAACTGCTATTAAAGGTGGGGTTCCAAATGAGAAAATTGTTTTTCACGGTAATAACAAATCGG
ACAAAGAATTAGAATTCGCAGTTAGAAATAATATTAAGGTTATTGTTGATAATGATTACGACTTAGAAAGATTAGATGAG
ATCTCAAATGCATTTAATCATGATCTTGAAATAATGATTCGCTTTACTCCTGGGATAGAATGCCATACACATGAATATAT
TAGAACTGGATCATTTGATAGCAAATTTGGTTTCGGAATAGAATATTTAAATATTTTATTTAACAGAATCAGCAATACAA
AGCATCTAAAATTAAAAGGTTTACATGCTCATATTGGTTCCCAGATTTTTGAACTGGACCCTCATAAGGATCTGGGAGAA
ATAATGGTAAAGGTTATCTTAGAAGCTAAAAAATTTGGTCATAATGTTGAGGAACTTAATGTTGGCGGGGGTTTAGGTAT
CAGGTATACAGAAAGTGACGATCCCCCTTCAATTGATGAATGGGTAAAAACAATTTCTTCTTCCGTTGTTGAAGCTTGTA
AAAAAAACAACTTAGATTTTCCCACTTTAATGTGCGAACCTGGTAGATCTATTGTTTCTACAGCAGGTATAACCATTTAC
AAAATTGGGGCTTTTAAAGAAATTCCTGGTATCAGAACATATTTATCTGTGGATGGTGGTATGAGTGATAATCCAAGACC
AATTACATATCAATCAAATTATTCTGCATGTTTAGTGAGTAATCCATTTAATATTAATTCCAAAAATAAATATACTATTG
CTGGTAAGCACTGCGAATCGGGAGATGTATTGTTTAAAGAAATTGAACTAGCAGAGTGTAAGACGGGAGATCTTATATGT
GTTTTTGGTACTGGTGCATATAATAATTCAATGAGTTCTAACTACAACAGAATTCCAAGACCAGCTACTCTCTTAGTTAA
AGATGGAGAGGCAGAAATTATTCAAAAAAGAGAAAGCCCATTGGATCTTTTAAAATACGACGTATTACCTGATCGCTTTA
TCAAACAAAATTAG

Upstream 100 bases:

>100_bases
TAATAGATATCATTTATTATGTATTTATAAATAGAAAGTTCAAATCTAAAGTCATTATAAAATATGACAGTTTTAGCAAA
GCTTTACTTAACGTTCTCCC

Downstream 100 bases:

>100_bases
GTACATTTAAATTAATTTTGTTTTTAGTGTGAATTTCTGGGGGATTATAAATTTAAAGCTTTTATTAGATGTCTTATTTG
CTGTTGGTTTCGGACTATTA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MEEKQSFLKQKIDLESPNRNIIPITTSIDSDGKLSVGGCSIEELVKKYDSPLYILDEITLRNSCKAYKKALEKYYPGKSL
PIYASKANSSIFMSSLVSSEGLGLDAVSEGELLTAIKGGVPNEKIVFHGNNKSDKELEFAVRNNIKVIVDNDYDLERLDE
ISNAFNHDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIEYLNILFNRISNTKHLKLKGLHAHIGSQIFELDPHKDLGE
IMVKVILEAKKFGHNVEELNVGGGLGIRYTESDDPPSIDEWVKTISSSVVEACKKNNLDFPTLMCEPGRSIVSTAGITIY
KIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVSNPFNINSKNKYTIAGKHCESGDVLFKEIELAECKTGDLIC
VFGTGAYNNSMSSNYNRIPRPATLLVKDGEAEIIQKRESPLDLLKYDVLPDRFIKQN

Sequences:

>Translated_457_residues
MEEKQSFLKQKIDLESPNRNIIPITTSIDSDGKLSVGGCSIEELVKKYDSPLYILDEITLRNSCKAYKKALEKYYPGKSL
PIYASKANSSIFMSSLVSSEGLGLDAVSEGELLTAIKGGVPNEKIVFHGNNKSDKELEFAVRNNIKVIVDNDYDLERLDE
ISNAFNHDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIEYLNILFNRISNTKHLKLKGLHAHIGSQIFELDPHKDLGE
IMVKVILEAKKFGHNVEELNVGGGLGIRYTESDDPPSIDEWVKTISSSVVEACKKNNLDFPTLMCEPGRSIVSTAGITIY
KIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVSNPFNINSKNKYTIAGKHCESGDVLFKEIELAECKTGDLIC
VFGTGAYNNSMSSNYNRIPRPATLLVKDGEAEIIQKRESPLDLLKYDVLPDRFIKQN
>Mature_457_residues
MEEKQSFLKQKIDLESPNRNIIPITTSIDSDGKLSVGGCSIEELVKKYDSPLYILDEITLRNSCKAYKKALEKYYPGKSL
PIYASKANSSIFMSSLVSSEGLGLDAVSEGELLTAIKGGVPNEKIVFHGNNKSDKELEFAVRNNIKVIVDNDYDLERLDE
ISNAFNHDLEIMIRFTPGIECHTHEYIRTGSFDSKFGFGIEYLNILFNRISNTKHLKLKGLHAHIGSQIFELDPHKDLGE
IMVKVILEAKKFGHNVEELNVGGGLGIRYTESDDPPSIDEWVKTISSSVVEACKKNNLDFPTLMCEPGRSIVSTAGITIY
KIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVSNPFNINSKNKYTIAGKHCESGDVLFKEIELAECKTGDLIC
VFGTGAYNNSMSSNYNRIPRPATLLVKDGEAEIIQKRESPLDLLKYDVLPDRFIKQN

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=412, Percent_Identity=26.9417475728155, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789307, Length=284, Percent_Identity=25, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586472, Length=401, Percent_Identity=22.6932668329177, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24586474, Length=390, Percent_Identity=23.8461538461538, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 50921; Mature: 50921

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKQSFLKQKIDLESPNRNIIPITTSIDSDGKLSVGGCSIEELVKKYDSPLYILDEITL
CCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEECCCCHHHHHHHCCCCEEEEEEHHH
RNSCKAYKKALEKYYPGKSLPIYASKANSSIFMSSLVSSEGLGLDAVSEGELLTAIKGGV
HHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCC
PNEKIVFHGNNKSDKELEFAVRNNIKVIVDNDYDLERLDEISNAFNHDLEIMIRFTPGIE
CCCEEEEECCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCE
CHTHEYIRTGSFDSKFGFGIEYLNILFNRISNTKHLKLKGLHAHIGSQIFELDPHKDLGE
ECCCHHEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHCCEEEECCCCCCHHH
IMVKVILEAKKFGHNVEELNVGGGLGIRYTESDDPPSIDEWVKTISSSVVEACKKNNLDF
HHHHHHHHHHHHCCCHHEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PTLMCEPGRSIVSTAGITIYKIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVS
CEEEECCCCHHHHHCCEEEEEECCHHHCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEE
NPFNINSKNKYTIAGKHCESGDVLFKEIELAECKTGDLICVFGTGAYNNSMSSNYNRIPR
CCCCCCCCCEEEEECCCCCCCCEEEEEEEHHCCCCCCEEEEEECCCCCCCCCCCCCCCCC
PATLLVKDGEAEIIQKRESPLDLLKYDVLPDRFIKQN
CEEEEEECCCHHHHHHCCCCHHHHHHHCCCHHHHCCC
>Mature Secondary Structure
MEEKQSFLKQKIDLESPNRNIIPITTSIDSDGKLSVGGCSIEELVKKYDSPLYILDEITL
CCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEECCCCHHHHHHHCCCCEEEEEEHHH
RNSCKAYKKALEKYYPGKSLPIYASKANSSIFMSSLVSSEGLGLDAVSEGELLTAIKGGV
HHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCC
PNEKIVFHGNNKSDKELEFAVRNNIKVIVDNDYDLERLDEISNAFNHDLEIMIRFTPGIE
CCCEEEEECCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCE
CHTHEYIRTGSFDSKFGFGIEYLNILFNRISNTKHLKLKGLHAHIGSQIFELDPHKDLGE
ECCCHHEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHCCEEEECCCCCCHHH
IMVKVILEAKKFGHNVEELNVGGGLGIRYTESDDPPSIDEWVKTISSSVVEACKKNNLDF
HHHHHHHHHHHHCCCHHEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
PTLMCEPGRSIVSTAGITIYKIGAFKEIPGIRTYLSVDGGMSDNPRPITYQSNYSACLVS
CEEEECCCCHHHHHCCEEEEEECCHHHCCCCEEEEEECCCCCCCCCEEEECCCCCEEEEE
NPFNINSKNKYTIAGKHCESGDVLFKEIELAECKTGDLICVFGTGAYNNSMSSNYNRIPR
CCCCCCCCCEEEEECCCCCCCCEEEEEEEHHCCCCCCEEEEEECCCCCCCCCCCCCCCCC
PATLLVKDGEAEIIQKRESPLDLLKYDVLPDRFIKQN
CEEEEEECCCHHHHHHCCCCHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]