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The map label for this gene is fmt [H]

Identifier: 126696365

GI number: 126696365

Start: 886946

End: 887986

Strand: Direct

Name: fmt [H]

Synonym: P9301_10271

Alternate gene names: 126696365

Gene position: 886946-887986 (Clockwise)

Preceding gene: 126696364

Following gene: 126696367

Centisome position: 54.02

GC content: 30.26

Gene sequence:

>1041_bases
GTGAGAATTATATTCTGGGGAACACCTGAATATTCAATTGCGAGCCTTGATATTTTTATTAAATCTAAGCACGAGGTAAT
TGGAGTAGTTAGCCAACCCGATAAGAAAAGATCTAGGGGAAATAAATTAATATCCTCACCTGTTAAAAGCTTTGCCGAGC
AAGAATCTATAAAAATTTATACTCCAACAAAAATCAGAGACAATATACATTTTATAAATGAACTTAAGTCACTATCTTGT
GATTTATTTATTGTTATAGCTTACGGGAAAATATTACCTAAAGAGATATTGGAAATCCCAAAATTTGGGTGTTGGAACGC
ACATGCTTCACTACTTCCAAGATGGCGTGGTGCAGCCCCAATCCAATGGTCCCTAATAAAAGGCGATGAATTTACTGGTG
TAGGAATTATGAAAATGAATGAGGGACTAGATACTGGCGACTTATTATTGGAAGAAAAAATTAAAATTGATAATGACGAT
AATTTAAATACACTATCGGAAAAACTTAGTATTTTATCTGCAAAATTATTTTTAAATGCCACATCACTACTCGAAGAAAA
TATTTATAAAAATACTAATTGGCAACTAACAAAACAAAATACCCTTGCAAGAGAAATTACTTACGCAAGAATGATTGAAA
AATCAGACTTTAGAGTTGATTGGACTAATGATGCAATTAAAATTTCTCAAAAAATAAAAGGATTATACCCACGAGCAAAT
ACAACTTTTAGAGGTAAGAACCTACAAATACTTAAAATCAAAGTTTTGACTAGTGATGAAATTAAAAATAAAAACCTTAT
CACGAGCAATTATTCAAGACCAGGTATTATTCTTTCTGTAATAGAAAATGAAGGAATAATAATTTCAACTAAAACTGATC
CAATTATTTTATTAGAAGCAAAACTTGAAGGAAAAAACATTTCTAGCAAAAAGCAATTGATACAACAGTTAAAGCCAACA
ATAGGTGAATATATCTCAGATCATGTTTTAGATTCTTTTTTAGAGAATCCCCAAGTGAAGGCAAAAAGAATCAAAAAATA
A

Upstream 100 bases:

>100_bases
TTTTGAAAAATATAGTAAATATTGAATCAAACCAGGAAGTAACAACAAGTGGAATTTCTCCACATATATGGGTGGATGAA
TTATCAATAACTGGTGACGC

Downstream 100 bases:

>100_bases
AAATAATAGTCTGGAAGAATAGATTCTTTAATTAATGTATTCAGTAAAAGTTTAATCCCAACAATTAAAATAGCAACATA
ACCAGCTGTTTCTAATCTAG

Product: putative methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MRIIFWGTPEYSIASLDIFIKSKHEVIGVVSQPDKKRSRGNKLISSPVKSFAEQESIKIYTPTKIRDNIHFINELKSLSC
DLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAPIQWSLIKGDEFTGVGIMKMNEGLDTGDLLLEEKIKIDNDD
NLNTLSEKLSILSAKLFLNATSLLEENIYKNTNWQLTKQNTLAREITYARMIEKSDFRVDWTNDAIKISQKIKGLYPRAN
TTFRGKNLQILKIKVLTSDEIKNKNLITSNYSRPGIILSVIENEGIIISTKTDPIILLEAKLEGKNISSKKQLIQQLKPT
IGEYISDHVLDSFLENPQVKAKRIKK

Sequences:

>Translated_346_residues
MRIIFWGTPEYSIASLDIFIKSKHEVIGVVSQPDKKRSRGNKLISSPVKSFAEQESIKIYTPTKIRDNIHFINELKSLSC
DLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAPIQWSLIKGDEFTGVGIMKMNEGLDTGDLLLEEKIKIDNDD
NLNTLSEKLSILSAKLFLNATSLLEENIYKNTNWQLTKQNTLAREITYARMIEKSDFRVDWTNDAIKISQKIKGLYPRAN
TTFRGKNLQILKIKVLTSDEIKNKNLITSNYSRPGIILSVIENEGIIISTKTDPIILLEAKLEGKNISSKKQLIQQLKPT
IGEYISDHVLDSFLENPQVKAKRIKK
>Mature_346_residues
MRIIFWGTPEYSIASLDIFIKSKHEVIGVVSQPDKKRSRGNKLISSPVKSFAEQESIKIYTPTKIRDNIHFINELKSLSC
DLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAPIQWSLIKGDEFTGVGIMKMNEGLDTGDLLLEEKIKIDNDD
NLNTLSEKLSILSAKLFLNATSLLEENIYKNTNWQLTKQNTLAREITYARMIEKSDFRVDWTNDAIKISQKIKGLYPRAN
TTFRGKNLQILKIKVLTSDEIKNKNLITSNYSRPGIILSVIENEGIIISTKTDPIILLEAKLEGKNISSKKQLIQQLKPT
IGEYISDHVLDSFLENPQVKAKRIKK

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI21614513, Length=287, Percent_Identity=26.8292682926829, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI238814322, Length=281, Percent_Identity=24.1992882562278, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI164663775, Length=215, Percent_Identity=26.5116279069767, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789683, Length=318, Percent_Identity=36.4779874213836, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1788589, Length=177, Percent_Identity=25.9887005649718, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI133930964, Length=179, Percent_Identity=30.7262569832402, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319458, Length=176, Percent_Identity=28.9772727272727, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550868, Length=259, Percent_Identity=30.1158301158301, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571984, Length=179, Percent_Identity=33.5195530726257, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585660, Length=176, Percent_Identity=30.1136363636364, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 39355; Mature: 39355

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIFWGTPEYSIASLDIFIKSKHEVIGVVSQPDKKRSRGNKLISSPVKSFAEQESIKIY
CEEEEECCCCCEEEEEEEEEECCCEEEEEECCCHHHHHHCCHHHHHHHHHHHCCCCEEEE
TPTKIRDNIHFINELKSLSCDLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAP
CCCCCCCCHHHHHHHHHCCCCEEEEEEHHHCCHHHHHHCCCCCCCCCHHHHCCCCCCCCC
IQWSLIKGDEFTGVGIMKMNEGLDTGDLLLEEKIKIDNDDNLNTLSEKLSILSAKLFLNA
EEEEEEECCCCCCEEEEEECCCCCHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TSLLEENIYKNTNWQLTKQNTLAREITYARMIEKSDFRVDWTNDAIKISQKIKGLYPRAN
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCC
TTFRGKNLQILKIKVLTSDEIKNKNLITSNYSRPGIILSVIENEGIIISTKTDPIILLEA
CEECCCCEEEEEEEEEECCCCCCCCEEECCCCCCCEEEEEECCCCEEEEECCCCEEEEEE
KLEGKNISSKKQLIQQLKPTIGEYISDHVLDSFLENPQVKAKRIKK
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
>Mature Secondary Structure
MRIIFWGTPEYSIASLDIFIKSKHEVIGVVSQPDKKRSRGNKLISSPVKSFAEQESIKIY
CEEEEECCCCCEEEEEEEEEECCCEEEEEECCCHHHHHHCCHHHHHHHHHHHCCCCEEEE
TPTKIRDNIHFINELKSLSCDLFIVIAYGKILPKEILEIPKFGCWNAHASLLPRWRGAAP
CCCCCCCCHHHHHHHHHCCCCEEEEEEHHHCCHHHHHHCCCCCCCCCHHHHCCCCCCCCC
IQWSLIKGDEFTGVGIMKMNEGLDTGDLLLEEKIKIDNDDNLNTLSEKLSILSAKLFLNA
EEEEEEECCCCCCEEEEEECCCCCHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TSLLEENIYKNTNWQLTKQNTLAREITYARMIEKSDFRVDWTNDAIKISQKIKGLYPRAN
HHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCC
TTFRGKNLQILKIKVLTSDEIKNKNLITSNYSRPGIILSVIENEGIIISTKTDPIILLEA
CEECCCCEEEEEEEEEECCCCCCCCEEECCCCCCCEEEEEECCCCEEEEECCCCEEEEEE
KLEGKNISSKKQLIQQLKPTIGEYISDHVLDSFLENPQVKAKRIKK
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA