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The map label for this gene is iscS [H]

Identifier: 126696310

GI number: 126696310

Start: 841357

End: 842529

Strand: Direct

Name: iscS [H]

Synonym: P9301_09721

Alternate gene names: 126696310

Gene position: 841357-842529 (Clockwise)

Preceding gene: 126696309

Following gene: 126696311

Centisome position: 51.24

GC content: 26.34

Gene sequence:

>1173_bases
ATGGAAAATAATTTTATCTATTTAGATAATGCATCCACAACTCCATTATCTGAGAATGTTTTAAATATAATAAATTCAAC
TTATAGGGATTATTGGCATAACCCTTCATCTACATATGAGTTAGGGATAAAATGCTCTACATATCTTGAAAAAATTAGAT
CTAAAATTGCTTGTATATTTGAAGCAGATCCAGAGGATATAATTTTTACATCTGGTTCTTCGGAATCGACATATATTGTA
TTTGATAATATTTATGAGAAATTTAAAAATGGTAGAGTTGTAATTTCAAATGTTGAACATCAAGCAACAACTATTTGTGC
TAATAAACTAAGAAAACAAAATTGGGATATTTACGAATGGACGGTAAATAATGATGGAATTTTAAATATTTCTAATATCG
AAAAATTTTTAAACAATAATACTAAGCTTGTATCAATTATTTGGGGACAAAGTGAAATTGGGACAATACAACCTGTCCAA
TTTATTGGTTCCAAATGTGAAGAATTAAATATAATGTTTCATTTAGATGGAACTCAAATATTAAGTAATGGAATATTCAG
TTGGAAAGATCTTAAATGTGATTTTTTAAGTCTATCCGCTCATAAATTTGGAGGTCCAAAAGGGATCGGTATTCTTTTAA
CAAAAGAAAAGTCTAGACAAATTTTAAAAAATAATGACATATCACTTACTCAGGAATTTTCAATTAGACAAGGTACACAA
GCTTTGCCATTAATCGCTGGAATGTATGAATCACTAAAGAATATTGAAGGAAAAATAAAACTATATGATTACATAACTGA
ATTTCCTTCTAATAATATTAATAAACTTAAAAATTATTTTTTTCAAAAAATTAAAGATAATAATCATATAAAGATTACCG
GTAGTATTAACCATAGACTGCCCAGTCATATTTCTTTTCTACTATTAAATAAAATATTTGAGCCTATTAGGGCCTATAAG
ATTGTTAATTTTATGTCAGAAAATAAAATAGCCATAAGTAGTGGAAGTGCTTGTTCAAGCTCATCTGGGAAACCTAGCTC
AACACTTAAAAATATTGGTTTAAAAGATGATGAACTATATTCAAATATTCGTGTTACTTTAGGTTCAATAAACAATAAGT
CAGAAATAGATAAATTTTTAGAACTTATTCAAATATGTATTGACAAATTTTAA

Upstream 100 bases:

>100_bases
CAGGAGGTAATCTTAAAATTGATTGGTCAAAAGACGATTGTGAAGTCATGATGACCGGTAATGCTAAAAAGGTTTTCTCA
GGATCAATGCTAGTAAATTA

Downstream 100 bases:

>100_bases
TGGAAACCAATTACAGACTACCTAAAGATTTAAATGAATCTCTTAAGAATATGGAGGATGCAATTATTCCAAGTTTATTA
GATTCAAATAAAAGATTTAC

Product: class-V aminotransferase family cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MENNFIYLDNASTTPLSENVLNIINSTYRDYWHNPSSTYELGIKCSTYLEKIRSKIACIFEADPEDIIFTSGSSESTYIV
FDNIYEKFKNGRVVISNVEHQATTICANKLRKQNWDIYEWTVNNDGILNISNIEKFLNNNTKLVSIIWGQSEIGTIQPVQ
FIGSKCEELNIMFHLDGTQILSNGIFSWKDLKCDFLSLSAHKFGGPKGIGILLTKEKSRQILKNNDISLTQEFSIRQGTQ
ALPLIAGMYESLKNIEGKIKLYDYITEFPSNNINKLKNYFFQKIKDNNHIKITGSINHRLPSHISFLLLNKIFEPIRAYK
IVNFMSENKIAISSGSACSSSSGKPSSTLKNIGLKDDELYSNIRVTLGSINNKSEIDKFLELIQICIDKF

Sequences:

>Translated_390_residues
MENNFIYLDNASTTPLSENVLNIINSTYRDYWHNPSSTYELGIKCSTYLEKIRSKIACIFEADPEDIIFTSGSSESTYIV
FDNIYEKFKNGRVVISNVEHQATTICANKLRKQNWDIYEWTVNNDGILNISNIEKFLNNNTKLVSIIWGQSEIGTIQPVQ
FIGSKCEELNIMFHLDGTQILSNGIFSWKDLKCDFLSLSAHKFGGPKGIGILLTKEKSRQILKNNDISLTQEFSIRQGTQ
ALPLIAGMYESLKNIEGKIKLYDYITEFPSNNINKLKNYFFQKIKDNNHIKITGSINHRLPSHISFLLLNKIFEPIRAYK
IVNFMSENKIAISSGSACSSSSGKPSSTLKNIGLKDDELYSNIRVTLGSINNKSEIDKFLELIQICIDKF
>Mature_390_residues
MENNFIYLDNASTTPLSENVLNIINSTYRDYWHNPSSTYELGIKCSTYLEKIRSKIACIFEADPEDIIFTSGSSESTYIV
FDNIYEKFKNGRVVISNVEHQATTICANKLRKQNWDIYEWTVNNDGILNISNIEKFLNNNTKLVSIIWGQSEIGTIQPVQ
FIGSKCEELNIMFHLDGTQILSNGIFSWKDLKCDFLSLSAHKFGGPKGIGILLTKEKSRQILKNNDISLTQEFSIRQGTQ
ALPLIAGMYESLKNIEGKIKLYDYITEFPSNNINKLKNYFFQKIKDNNHIKITGSINHRLPSHISFLLLNKIFEPIRAYK
IVNFMSENKIAISSGSACSSSSGKPSSTLKNIGLKDDELYSNIRVTLGSINNKSEIDKFLELIQICIDKF

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=380, Percent_Identity=28.9473684210526, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI156713448, Length=428, Percent_Identity=25.2336448598131, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI48994898, Length=391, Percent_Identity=30.690537084399, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1787970, Length=394, Percent_Identity=22.8426395939086, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25143064, Length=387, Percent_Identity=29.1989664082687, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17533177, Length=347, Percent_Identity=24.7838616714697, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319831, Length=385, Percent_Identity=31.4285714285714, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI20129463, Length=385, Percent_Identity=29.3506493506493, Blast_Score=170, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44343; Mature: 44343

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNFIYLDNASTTPLSENVLNIINSTYRDYWHNPSSTYELGIKCSTYLEKIRSKIACIF
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHEEEEE
EADPEDIIFTSGSSESTYIVFDNIYEKFKNGRVVISNVEHQATTICANKLRKQNWDIYEW
ECCCCCEEEECCCCCCEEEEEHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEE
TVNNDGILNISNIEKFLNNNTKLVSIIWGQSEIGTIQPVQFIGSKCEELNIMFHLDGTQI
EECCCCEEEHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCCCEEEEEEEECCHHH
LSNGIFSWKDLKCDFLSLSAHKFGGPKGIGILLTKEKSRQILKNNDISLTQEFSIRQGTQ
HHCCCCCCCCCCEEEEEECHHHCCCCCCEEEEEECHHHHHHHCCCCCCEEEECCCCCCCC
ALPLIAGMYESLKNIEGKIKLYDYITEFPSNNINKLKNYFFQKIKDNNHIKITGSINHRL
HHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
PSHISFLLLNKIFEPIRAYKIVNFMSENKIAISSGSACSSSSGKPSSTLKNIGLKDDELY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCHHHH
SNIRVTLGSINNKSEIDKFLELIQICIDKF
CCEEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MENNFIYLDNASTTPLSENVLNIINSTYRDYWHNPSSTYELGIKCSTYLEKIRSKIACIF
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHEEEEE
EADPEDIIFTSGSSESTYIVFDNIYEKFKNGRVVISNVEHQATTICANKLRKQNWDIYEW
ECCCCCEEEECCCCCCEEEEEHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCEEEE
TVNNDGILNISNIEKFLNNNTKLVSIIWGQSEIGTIQPVQFIGSKCEELNIMFHLDGTQI
EECCCCEEEHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHCCCCCEEEEEEEECCHHH
LSNGIFSWKDLKCDFLSLSAHKFGGPKGIGILLTKEKSRQILKNNDISLTQEFSIRQGTQ
HHCCCCCCCCCCEEEEEECHHHCCCCCCEEEEEECHHHHHHHCCCCCCEEEECCCCCCCC
ALPLIAGMYESLKNIEGKIKLYDYITEFPSNNINKLKNYFFQKIKDNNHIKITGSINHRL
HHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
PSHISFLLLNKIFEPIRAYKIVNFMSENKIAISSGSACSSSSGKPSSTLKNIGLKDDELY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHCCCCCHHHH
SNIRVTLGSINNKSEIDKFLELIQICIDKF
CCEEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA