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The map label for this gene is gadB [H]

Identifier: 126696280

GI number: 126696280

Start: 810266

End: 811651

Strand: Direct

Name: gadB [H]

Synonym: P9301_09421

Alternate gene names: 126696280

Gene position: 810266-811651 (Clockwise)

Preceding gene: 126696278

Following gene: 126696281

Centisome position: 49.35

GC content: 31.02

Gene sequence:

>1386_bases
ATGACTGAAGATTTAATTAATAAAAAAGATATATACTTCCCTTCGTATTCAGGGACTAACGATAACTTAATTACTCTCCT
AAACAAAACAACTCAAATTCTTTGTGACTGGTACTCTAAAGCAGATAAAAATGGTCCTTTACCTTTTGATGAGAGTTTCA
ATTGTATTATGCCTTCGGAAGATGGTAACTCTGAGGAAGATTTGTTTTCTGAGATTGAATCTCTTTTGAATAATTCATTT
AATCCCGTTCATCCTGGCTCACTAGCTCACCTTGATCCCCCACCATTAATTTTCTCTATTTTGGGAGATTTGATTGCTGC
TGGTTTAAATAATAATCTTCTTGCATACGAATTATCACCAAGTGTAACCTTGCTTGAGGAATCATTATGCAAATGGATTG
CCAAGAAAATAGGGTTTAATGATTCCTCAGGAGGTATAGCTGCTAGCGGAGGTACATTAAGTAATCTGAATGCACTTATT
GCAGCTAGAAATAATGCTGGATTAGCTACAAATCCTAATTCTGTATTACTTGTTAGTGAAGATGCTCATTCTTCTTTCGT
TAAATGTATAAAAGTAATGGGTCTTGATACTAGGAATCTTGTCAGGATTAAAACTGATAATCATGGTCGAATGGATATAA
ACGATCTGAGAAACTCTTTAGATAAATGTTCAACAGAAAATAAAAAAATATTTGCTATTGTTGCCACTCTTGGGACAACT
GTAAGAGGAGCCATTGATCCTATTAAAGAAATAAGTGAAATCTGTAAACAAAGAAACATATGGTTACATATTGATGGTTC
AATTGGAGGGATTTTTGCTATAACTTCTATTCCAGTAGAAGGTCTAAATAATATTAATCAGGCTAATTCGATAACGATAA
ATCCACAAAAAATTATTGGTATTACAAAGACTTCATCTTTGTTATTGGTTTCAAATATGAGTACTTTAGAAAATACTTTT
AATACTGGACTACCTTATATGTCATCTAAAGAAAATATTATAAATAGAGGAGAAATAGGCATACAAGGTTCTAGACCTGC
AGAGGTTATCAAACTATGGCTTGGGTTACGTTTTTTAGGTCTCAAAGGAATAGAAAATATATTAAAAACATCAATTAAAA
GAAAAGAATTTTTTGTAAAAAATATTAGTAAAAATAAATTTGATATATATTCAGGTCCTCTTCATATTGTTTCATTCTTA
CCAAATAAACTTGAGCAAAAAGACTCTGATGCATGGACTCAAACTAAAGTAAATGAACTAAGTAATAATAATTTTATGCT
TTCCAGACCAAAATTTAAAGGTAGATATTTTTTAAGGGTTGTCATGGGAAATTACAATACAAAGGATTCTCATATTGAAG
AACTTTTGAGACTTCTTGATGCTTAA

Upstream 100 bases:

>100_bases
ATTTGTTCCTTTCTGTTCATCATAATTACTATTTACATTTTCAAAAATATACCTCATTTACAAATATTAAGAATAAACTT
ATTAATAGATATCTTATCTG

Downstream 100 bases:

>100_bases
CTAATGAATATGGGAAGACCAAAAATTATTGCAAAAGTAACAGGGTTTATCTCTATAGCTATTTGCATTGCTTATTTACT
ATTAATAACCATCTTTGATT

Product: pyridoxal-dependent decarboxylase family protein

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTEDLINKKDIYFPSYSGTNDNLITLLNKTTQILCDWYSKADKNGPLPFDESFNCIMPSEDGNSEEDLFSEIESLLNNSF
NPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSPSVTLLEESLCKWIAKKIGFNDSSGGIAASGGTLSNLNALI
AARNNAGLATNPNSVLLVSEDAHSSFVKCIKVMGLDTRNLVRIKTDNHGRMDINDLRNSLDKCSTENKKIFAIVATLGTT
VRGAIDPIKEISEICKQRNIWLHIDGSIGGIFAITSIPVEGLNNINQANSITINPQKIIGITKTSSLLLVSNMSTLENTF
NTGLPYMSSKENIINRGEIGIQGSRPAEVIKLWLGLRFLGLKGIENILKTSIKRKEFFVKNISKNKFDIYSGPLHIVSFL
PNKLEQKDSDAWTQTKVNELSNNNFMLSRPKFKGRYFLRVVMGNYNTKDSHIEELLRLLDA

Sequences:

>Translated_461_residues
MTEDLINKKDIYFPSYSGTNDNLITLLNKTTQILCDWYSKADKNGPLPFDESFNCIMPSEDGNSEEDLFSEIESLLNNSF
NPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSPSVTLLEESLCKWIAKKIGFNDSSGGIAASGGTLSNLNALI
AARNNAGLATNPNSVLLVSEDAHSSFVKCIKVMGLDTRNLVRIKTDNHGRMDINDLRNSLDKCSTENKKIFAIVATLGTT
VRGAIDPIKEISEICKQRNIWLHIDGSIGGIFAITSIPVEGLNNINQANSITINPQKIIGITKTSSLLLVSNMSTLENTF
NTGLPYMSSKENIINRGEIGIQGSRPAEVIKLWLGLRFLGLKGIENILKTSIKRKEFFVKNISKNKFDIYSGPLHIVSFL
PNKLEQKDSDAWTQTKVNELSNNNFMLSRPKFKGRYFLRVVMGNYNTKDSHIEELLRLLDA
>Mature_460_residues
TEDLINKKDIYFPSYSGTNDNLITLLNKTTQILCDWYSKADKNGPLPFDESFNCIMPSEDGNSEEDLFSEIESLLNNSFN
PVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSPSVTLLEESLCKWIAKKIGFNDSSGGIAASGGTLSNLNALIA
ARNNAGLATNPNSVLLVSEDAHSSFVKCIKVMGLDTRNLVRIKTDNHGRMDINDLRNSLDKCSTENKKIFAIVATLGTTV
RGAIDPIKEISEICKQRNIWLHIDGSIGGIFAITSIPVEGLNNINQANSITINPQKIIGITKTSSLLLVSNMSTLENTFN
TGLPYMSSKENIINRGEIGIQGSRPAEVIKLWLGLRFLGLKGIENILKTSIKRKEFFVKNISKNKFDIYSGPLHIVSFLP
NKLEQKDSDAWTQTKVNELSNNNFMLSRPKFKGRYFLRVVMGNYNTKDSHIEELLRLLDA

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI58331246, Length=440, Percent_Identity=27.9545454545455, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI197276620, Length=333, Percent_Identity=29.1291291291291, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4503875, Length=333, Percent_Identity=29.1291291291291, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI197383062, Length=410, Percent_Identity=25.8536585365854, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI194294551, Length=408, Percent_Identity=25.7352941176471, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI92110055, Length=348, Percent_Identity=26.7241379310345, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI4503281, Length=356, Percent_Identity=23.0337078651685, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI132814448, Length=356, Percent_Identity=23.0337078651685, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71993058, Length=335, Percent_Identity=27.1641791044776, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17555682, Length=335, Percent_Identity=27.1641791044776, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71993062, Length=335, Percent_Identity=27.1641791044776, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534817, Length=470, Percent_Identity=24.468085106383, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17534819, Length=470, Percent_Identity=24.468085106383, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17543922, Length=216, Percent_Identity=26.3888888888889, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17136594, Length=339, Percent_Identity=28.3185840707965, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24657193, Length=409, Percent_Identity=27.8728606356968, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24657185, Length=409, Percent_Identity=27.8728606356968, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24657188, Length=409, Percent_Identity=27.8728606356968, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356415, Length=362, Percent_Identity=27.0718232044199, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28573972, Length=397, Percent_Identity=26.7002518891688, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24652373, Length=362, Percent_Identity=24.8618784530387, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136190, Length=379, Percent_Identity=24.0105540897098, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24585135, Length=375, Percent_Identity=23.7333333333333, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24586044, Length=364, Percent_Identity=24.1758241758242, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221476190, Length=424, Percent_Identity=22.4056603773585, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24585143, Length=424, Percent_Identity=22.4056603773585, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24585139, Length=424, Percent_Identity=22.4056603773585, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 50952; Mature: 50821

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDLINKKDIYFPSYSGTNDNLITLLNKTTQILCDWYSKADKNGPLPFDESFNCIMPSE
CCCHHCCCCCEECCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
DGNSEEDLFSEIESLLNNSFNPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSP
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
SVTLLEESLCKWIAKKIGFNDSSGGIAASGGTLSNLNALIAARNNAGLATNPNSVLLVSE
CHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHCCEEEEEECCCCCCEECCCEEEEEEC
DAHSSFVKCIKVMGLDTRNLVRIKTDNHGRMDINDLRNSLDKCSTENKKIFAIVATLGTT
CHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHCCH
VRGAIDPIKEISEICKQRNIWLHIDGSIGGIFAITSIPVEGLNNINQANSITINPQKIIG
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCCHHHHCCCCCCCEEEECHHHEEE
ITKTSSLLLVSNMSTLENTFNTGLPYMSSKENIINRGEIGIQGSRPAEVIKLWLGLRFLG
EECCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LKGIENILKTSIKRKEFFVKNISKNKFDIYSGPLHIVSFLPNKLEQKDSDAWTQTKVNEL
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHCCHHHHCCCCCHHHHHHHHHC
SNNNFMLSRPKFKGRYFLRVVMGNYNTKDSHIEELLRLLDA
CCCCEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TEDLINKKDIYFPSYSGTNDNLITLLNKTTQILCDWYSKADKNGPLPFDESFNCIMPSE
CCHHCCCCCEECCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
DGNSEEDLFSEIESLLNNSFNPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSP
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
SVTLLEESLCKWIAKKIGFNDSSGGIAASGGTLSNLNALIAARNNAGLATNPNSVLLVSE
CHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHCCEEEEEECCCCCCEECCCEEEEEEC
DAHSSFVKCIKVMGLDTRNLVRIKTDNHGRMDINDLRNSLDKCSTENKKIFAIVATLGTT
CHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHCCH
VRGAIDPIKEISEICKQRNIWLHIDGSIGGIFAITSIPVEGLNNINQANSITINPQKIIG
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCCHHHHCCCCCCCEEEECHHHEEE
ITKTSSLLLVSNMSTLENTFNTGLPYMSSKENIINRGEIGIQGSRPAEVIKLWLGLRFLG
EECCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LKGIENILKTSIKRKEFFVKNISKNKFDIYSGPLHIVSFLPNKLEQKDSDAWTQTKVNEL
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHCCHHHHCCCCCHHHHHHHHHC
SNNNFMLSRPKFKGRYFLRVVMGNYNTKDSHIEELLRLLDA
CCCCEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]