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The map label for this gene is pyrC [H]

Identifier: 126695933

GI number: 126695933

Start: 521448

End: 522497

Strand: Direct

Name: pyrC [H]

Synonym: P9301_05951

Alternate gene names: 126695933

Gene position: 521448-522497 (Clockwise)

Preceding gene: 126695931

Following gene: 126695934

Centisome position: 31.76

GC content: 30.95

Gene sequence:

>1050_bases
TTGAAGACTTTAACCATAATAAAACCTGATGATTGGCATTTACATCTAAGAGAAGGTCTTGTATTAAAAAATATCATTCA
TTTTACTTCAGAATATTTTGGGAGAGCCATTGTCATGCCAAATACTAAAGTTCCCATAACATCAATTAAAAGCGCTATTT
CTTATAAGAAATCTATTATTGAAGCGTTGCCAGAAAGTTCTAAGTTTAAACCCCTAATGACAATGTATCTTACAGATGAA
ACTGATAAAGGAGAATTAATAAATGGTTTTAAAAATAATGTCTTTTTTGCTGCAAAATTATATCCTGCTAACGCTACAAC
AAATTCCAGTCATGGAGTAAGGAAAATAGAAAATTTATATAAGATCTTTGAATCAATGCAAGATTCTGGAATGCCTCTTT
TAATTCATGGGGAAGTGACTGATTCTGAAGTAGATGTATTCGATAGAGAAGAAGTTTTTATAGACAAAGAACTCTCTCAA
ATCACTAAAAGATTTCCAAAATTAAAAATCGTTTTAGAACATATAACTACCTCTTATGCAGTGAATTTTGTTAAGGAAAA
TAATATTGGAGCAACTATCACTCCGCATCATTTACATATCAATAGAAATGCAATGTTTTTTGGAGGTTTAAATAGTGATT
TTTACTGCTTACCAGTTGCTAAGAGGGAAAATAATAGACTTGCTTTAAGAAAAGCTGCAACAAGTGGGGAAAAATGTTTT
TTCTTGGGAACTGACTCCGCTCCACATCTTAGGAAGTGGAAAGCTTTTTGTGGATGCGCAGGTATTTTTAATTCACCAGT
TGCAATAGAAAGCTATTTAACGGTATTTGAAGAGGAGGATGCTCTAGATAATTTTGAAAAGTTTGCAAGTTTGAATGGCC
CTAATTTTTATAATGTGCCCCCAAATAAAGAAAAATTAAAATTAGTGTCTAGACCTAATAAAATTAAAGAATTTATTGAT
GTTATTCAAGAAAAAAATACTGTAGGACAAATAAAACCATTTCATGCAGGTGAAACTTTACAATGGCAAGTGGAAGGGAA
ATTAATTTAA

Upstream 100 bases:

>100_bases
CTCATAATTGATTAGTAAATTGATTAATAACTATCCTCGAATATCTATAATTTATTGTCAATTTTAATTTGCTGTTAAAA
TTGATTAAATAGAAAAAATT

Downstream 100 bases:

>100_bases
AAAATTAGATTTAATCTAAGAATCAAAAGTGTAAATTTTCCAATTTTTCTTGGATAAATGGGTAGCTTTCGGCTACGATT
AGATAGCGCAAATTCCTTCG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKTLTIIKPDDWHLHLREGLVLKNIIHFTSEYFGRAIVMPNTKVPITSIKSAISYKKSIIEALPESSKFKPLMTMYLTDE
TDKGELINGFKNNVFFAAKLYPANATTNSSHGVRKIENLYKIFESMQDSGMPLLIHGEVTDSEVDVFDREEVFIDKELSQ
ITKRFPKLKIVLEHITTSYAVNFVKENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRLALRKAATSGEKCF
FLGTDSAPHLRKWKAFCGCAGIFNSPVAIESYLTVFEEEDALDNFEKFASLNGPNFYNVPPNKEKLKLVSRPNKIKEFID
VIQEKNTVGQIKPFHAGETLQWQVEGKLI

Sequences:

>Translated_349_residues
MKTLTIIKPDDWHLHLREGLVLKNIIHFTSEYFGRAIVMPNTKVPITSIKSAISYKKSIIEALPESSKFKPLMTMYLTDE
TDKGELINGFKNNVFFAAKLYPANATTNSSHGVRKIENLYKIFESMQDSGMPLLIHGEVTDSEVDVFDREEVFIDKELSQ
ITKRFPKLKIVLEHITTSYAVNFVKENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRLALRKAATSGEKCF
FLGTDSAPHLRKWKAFCGCAGIFNSPVAIESYLTVFEEEDALDNFEKFASLNGPNFYNVPPNKEKLKLVSRPNKIKEFID
VIQEKNTVGQIKPFHAGETLQWQVEGKLI
>Mature_349_residues
MKTLTIIKPDDWHLHLREGLVLKNIIHFTSEYFGRAIVMPNTKVPITSIKSAISYKKSIIEALPESSKFKPLMTMYLTDE
TDKGELINGFKNNVFFAAKLYPANATTNSSHGVRKIENLYKIFESMQDSGMPLLIHGEVTDSEVDVFDREEVFIDKELSQ
ITKRFPKLKIVLEHITTSYAVNFVKENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRLALRKAATSGEKCF
FLGTDSAPHLRKWKAFCGCAGIFNSPVAIESYLTVFEEEDALDNFEKFASLNGPNFYNVPPNKEKLKLVSRPNKIKEFID
VIQEKNTVGQIKPFHAGETLQWQVEGKLI

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=347, Percent_Identity=49.8559077809798, Blast_Score=363, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323452, Length=359, Percent_Identity=33.7047353760446, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 39638; Mature: 39638

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLTIIKPDDWHLHLREGLVLKNIIHFTSEYFGRAIVMPNTKVPITSIKSAISYKKSII
CCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHH
EALPESSKFKPLMTMYLTDETDKGELINGFKNNVFFAAKLYPANATTNSSHGVRKIENLY
HHCCCCCCCCEEEEEEEECCCCCCHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHH
KIFESMQDSGMPLLIHGEVTDSEVDVFDREEVFIDKELSQITKRFPKLKIVLEHITTSYA
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHEEHHHHHHHHHHCCHHHHHHHHHHHHHE
VNFVKENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRLALRKAATSGEKCF
EEEEEECCCCCEECCEEEEEECCEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCEEE
FLGTDSAPHLRKWKAFCGCAGIFNSPVAIESYLTVFEEEDALDNFEKFASLNGPNFYNVP
EEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCC
PNKEKLKLVSRPNKIKEFIDVIQEKNTVGQIKPFHAGETLQWQVEGKLI
CCHHHHEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MKTLTIIKPDDWHLHLREGLVLKNIIHFTSEYFGRAIVMPNTKVPITSIKSAISYKKSII
CCEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHH
EALPESSKFKPLMTMYLTDETDKGELINGFKNNVFFAAKLYPANATTNSSHGVRKIENLY
HHCCCCCCCCEEEEEEEECCCCCCHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHH
KIFESMQDSGMPLLIHGEVTDSEVDVFDREEVFIDKELSQITKRFPKLKIVLEHITTSYA
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHEEHHHHHHHHHHCCHHHHHHHHHHHHHE
VNFVKENNIGATITPHHLHINRNAMFFGGLNSDFYCLPVAKRENNRLALRKAATSGEKCF
EEEEEECCCCCEECCEEEEEECCEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCCEEE
FLGTDSAPHLRKWKAFCGCAGIFNSPVAIESYLTVFEEEDALDNFEKFASLNGPNFYNVP
EEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCC
PNKEKLKLVSRPNKIKEFIDVIQEKNTVGQIKPFHAGETLQWQVEGKLI
CCHHHHEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA