Click here to switch to the map view.

The map label for this gene is gor [H]

Identifier: 126695931

GI number: 126695931

Start: 518871

End: 520235

Strand: Direct

Name: gor [H]

Synonym: P9301_05931

Alternate gene names: 126695931

Gene position: 518871-520235 (Clockwise)

Preceding gene: 126695929

Following gene: 126695933

Centisome position: 31.6

GC content: 30.26

Gene sequence:

>1365_bases
TTGGAATTTGAATTTGATTTAATTGTTGTTGGCGCTGGATCTGGAGGACTCGCTGCGGCTAAACGTGCGGCTAGTTATGG
AGCAAAAGTCGCAATCATAGAAGCAAATCAAATAGGAGGAACTTGTGTGATAAGGGGATGTGTGCCAAAGAAATTAATGG
TTTATGCAGCCAAAAGTAAAAAAAATATGGATTCTTCTGAAGGATATGGATTAAAAAATGAAGGTATTAATTTTGAATCA
AATATTTTGTTGAAGAACGTTAGAGAGGAGGTTTCTAGATTAAGTAATTTACATAGAAATTCTTTAAAAAAGTTGAATAT
AACTATTTTTGAAGGCTTAGGAAGATTTATTACTCAAAATGAATTAGAAATTATTTGTTCAAACACAAAGAAAATTAAAA
ACAAAATAAGTTCAAAAAAAATTCTTATTTCAGTTGGAGGTAAACCAAAGAAATTAAATATTCCTGGAATAGATTTGGCA
TGGACTAGTGATGATATTTTTGAATTAGAAAAGTTTCCTAAATCATTATTAATAGTGGGAGGTGGATATATTGCTTGTGA
ATTTGCTTCTATTTTCAGAAATTTAGGTACAGAAGTAACTCAATTAATAAGAGGTAAACATTTACTTAATGGTTTTGATG
AGGATCTTTCTCTATGCCTAGAGGAATCACCTACTTTTACTGATATCAAAATAATCTCCAATGCTCAATTGAAGTCTATC
GACAGAGTAAATGGAAATTTGGAATCGACCTTAGAATCGGGGGATAAACTCCTAACTAATAATATCCTTATTGCTACAGG
AAGAGAACCAAATCTTTTGCCTTTAAATTTAGATTTTTTAAATCTAAAGATGGATGGCCAATATTTAGATGTTGATGAAC
TTAATCAAACAAGCAATGCAAATATTTTTGCAGTCGGCGATATCATAAATAAACCAAACTTAACTCCAGTAGCAATAGAA
CAAGGGAGAGTTTTTTCAGATAATTTTTTTAATGACCAAAAAAGAAAGGTAAATTATGAATATATTCCTAAGGCCGTTTT
TACTATTCCTGAAATTTCAACAGTTGGCTTAAGTGAGAAAAGAGCTAAAGAGATTTACTCTGAAAAAAATATAAAAATTT
TCAAATGCAAATTTACCCCTATGTCTAATACCTTTAAAAAGAATAAATCAAAATGTATGTTGAAGATTGTTGTTCATAAG
CTAACTGACAAAGTACTGGGATGTCATATGTTTGGAGAAACATCATCTGAGATTATTCAAATGGTATCAGTTTCATTAAA
TGCAGGAATAACAAAAAAAGATTTTGACATTACTATGGCTTTGCACCCAACTATCTCAGAAGAATTTGTGACTATGTATG
GATAA

Upstream 100 bases:

>100_bases
TTCAACTTCAAATTTATTTAAATCATCCCATGACAAAATCCCATTCATTATTTGAATTAAAGCTATAAACTAACGTTATA
ATAATTGATTAAAAAAAGTC

Downstream 100 bases:

>100_bases
TATTATGAATTAGAAAATTTTAATTTTTCTTGAACTATCAGAAACACTGTAAGTAAAGCAAAATAAATAAATAATCCTAT
CCTTAACTCAGAAAGGAAGT

Product: glutathione reductase (NADPH)

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEANQIGGTCVIRGCVPKKLMVYAAKSKKNMDSSEGYGLKNEGINFES
NILLKNVREEVSRLSNLHRNSLKKLNITIFEGLGRFITQNELEIICSNTKKIKNKISSKKILISVGGKPKKLNIPGIDLA
WTSDDIFELEKFPKSLLIVGGGYIACEFASIFRNLGTEVTQLIRGKHLLNGFDEDLSLCLEESPTFTDIKIISNAQLKSI
DRVNGNLESTLESGDKLLTNNILIATGREPNLLPLNLDFLNLKMDGQYLDVDELNQTSNANIFAVGDIINKPNLTPVAIE
QGRVFSDNFFNDQKRKVNYEYIPKAVFTIPEISTVGLSEKRAKEIYSEKNIKIFKCKFTPMSNTFKKNKSKCMLKIVVHK
LTDKVLGCHMFGETSSEIIQMVSVSLNAGITKKDFDITMALHPTISEEFVTMYG

Sequences:

>Translated_454_residues
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEANQIGGTCVIRGCVPKKLMVYAAKSKKNMDSSEGYGLKNEGINFES
NILLKNVREEVSRLSNLHRNSLKKLNITIFEGLGRFITQNELEIICSNTKKIKNKISSKKILISVGGKPKKLNIPGIDLA
WTSDDIFELEKFPKSLLIVGGGYIACEFASIFRNLGTEVTQLIRGKHLLNGFDEDLSLCLEESPTFTDIKIISNAQLKSI
DRVNGNLESTLESGDKLLTNNILIATGREPNLLPLNLDFLNLKMDGQYLDVDELNQTSNANIFAVGDIINKPNLTPVAIE
QGRVFSDNFFNDQKRKVNYEYIPKAVFTIPEISTVGLSEKRAKEIYSEKNIKIFKCKFTPMSNTFKKNKSKCMLKIVVHK
LTDKVLGCHMFGETSSEIIQMVSVSLNAGITKKDFDITMALHPTISEEFVTMYG
>Mature_454_residues
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEANQIGGTCVIRGCVPKKLMVYAAKSKKNMDSSEGYGLKNEGINFES
NILLKNVREEVSRLSNLHRNSLKKLNITIFEGLGRFITQNELEIICSNTKKIKNKISSKKILISVGGKPKKLNIPGIDLA
WTSDDIFELEKFPKSLLIVGGGYIACEFASIFRNLGTEVTQLIRGKHLLNGFDEDLSLCLEESPTFTDIKIISNAQLKSI
DRVNGNLESTLESGDKLLTNNILIATGREPNLLPLNLDFLNLKMDGQYLDVDELNQTSNANIFAVGDIINKPNLTPVAIE
QGRVFSDNFFNDQKRKVNYEYIPKAVFTIPEISTVGLSEKRAKEIYSEKNIKIFKCKFTPMSNTFKKNKSKCMLKIVVHK
LTDKVLGCHMFGETSSEIIQMVSVSLNAGITKKDFDITMALHPTISEEFVTMYG

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=36.7965367965368, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=32, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=32, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=32, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=30.6345733041575, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=32, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI291045266, Length=482, Percent_Identity=30.0829875518672, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI22035672, Length=458, Percent_Identity=29.2576419213974, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI291045268, Length=482, Percent_Identity=27.5933609958506, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI91199540, Length=465, Percent_Identity=26.4516129032258, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=35.4022988505747, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=27.7899343544858, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1786307, Length=470, Percent_Identity=27.4468085106383, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=27.1334792122538, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=36.5957446808511, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71983429, Length=458, Percent_Identity=36.6812227074236, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71983419, Length=456, Percent_Identity=36.6228070175439, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71982272, Length=484, Percent_Identity=31.6115702479339, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=26.8980477223427, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6325166, Length=469, Percent_Identity=36.4605543710021, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6325240, Length=467, Percent_Identity=23.5546038543897, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6321091, Length=467, Percent_Identity=25.4817987152034, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=32.76955602537, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=31.8565400843882, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=31.8565400843882, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=31.8565400843882, Blast_Score=230, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21358499, Length=474, Percent_Identity=27.4261603375527, Blast_Score=163, Evalue=3e-40,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50331; Mature: 50331

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEANQIGGTCVIRGCVPKKLMVYAAKSK
CCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEEEEEECCC
KNMDSSEGYGLKNEGINFESNILLKNVREEVSRLSNLHRNSLKKLNITIFEGLGRFITQN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEEEEEHHHHHHHHCCC
ELEIICSNTKKIKNKISSKKILISVGGKPKKLNIPGIDLAWTSDDIFELEKFPKSLLIVG
CEEEEECCHHHHHHHCCCCEEEEEECCCCCEECCCCEEEEECCCHHHHHHHCCCEEEEEE
GGYIACEFASIFRNLGTEVTQLIRGKHLLNGFDEDLSLCLEESPTFTDIKIISNAQLKSI
CCEEEHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCHHHHH
DRVNGNLESTLESGDKLLTNNILIATGREPNLLPLNLDFLNLKMDGQYLDVDELNQTSNA
HHHCCCHHHHHHCCCEEEECCEEEEECCCCCEEEEEEEEEEEEECCCEECHHHCCCCCCC
NIFAVGDIINKPNLTPVAIEQGRVFSDNFFNDQKRKVNYEYIPKAVFTIPEISTVGLSEK
CEEEEECCCCCCCCCEEEEECCEEECCCCCCCHHHCCCHHHCCCEEEECCCCEECCCCHH
RAKEIYSEKNIKIFKCKFTPMSNTFKKNKSKCMLKIVVHKLTDKVLGCHMFGETSSEIIQ
HHHHHHCCCCCEEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHH
MVSVSLNAGITKKDFDITMALHPTISEEFVTMYG
HHHHHHCCCCEECCCEEEEEECCCCCCCHHEECC
>Mature Secondary Structure
MEFEFDLIVVGAGSGGLAAAKRAASYGAKVAIIEANQIGGTCVIRGCVPKKLMVYAAKSK
CCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEEEEEECCC
KNMDSSEGYGLKNEGINFESNILLKNVREEVSRLSNLHRNSLKKLNITIFEGLGRFITQN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEEEEEHHHHHHHHCCC
ELEIICSNTKKIKNKISSKKILISVGGKPKKLNIPGIDLAWTSDDIFELEKFPKSLLIVG
CEEEEECCHHHHHHHCCCCEEEEEECCCCCEECCCCEEEEECCCHHHHHHHCCCEEEEEE
GGYIACEFASIFRNLGTEVTQLIRGKHLLNGFDEDLSLCLEESPTFTDIKIISNAQLKSI
CCEEEHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCHHHHH
DRVNGNLESTLESGDKLLTNNILIATGREPNLLPLNLDFLNLKMDGQYLDVDELNQTSNA
HHHCCCHHHHHHCCCEEEECCEEEEECCCCCEEEEEEEEEEEEECCCEECHHHCCCCCCC
NIFAVGDIINKPNLTPVAIEQGRVFSDNFFNDQKRKVNYEYIPKAVFTIPEISTVGLSEK
CEEEEECCCCCCCCCEEEEECCEEECCCCCCCHHHCCCHHHCCCEEEECCCCEECCCCHH
RAKEIYSEKNIKIFKCKFTPMSNTFKKNKSKCMLKIVVHKLTDKVLGCHMFGETSSEIIQ
HHHHHHCCCCCEEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHH
MVSVSLNAGITKKDFDITMALHPTISEEFVTMYG
HHHHHHCCCCEECCCEEEEEECCCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7559423; 11759840 [H]