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The map label for this gene is dnaA

Identifier: 126695929

GI number: 126695929

Start: 516187

End: 517581

Strand: Direct

Name: dnaA

Synonym: P9301_05911

Alternate gene names: 126695929

Gene position: 516187-517581 (Clockwise)

Preceding gene: 126695926

Following gene: 126695931

Centisome position: 31.44

GC content: 34.34

Gene sequence:

>1395_bases
TTGCAAACAATTAATCCTATTTGGGCGGAAGTTCAACAATCACTGAAAAAAACTTTAAGTAAGCCTTCATTTGAGACATG
GATAAGGCCTGCTAAATTTAATTGTTTTGAAAATGGCTTATTGACTTTAATCGCTCCAAATACATTTTCCAGTGATTGGT
TAAGAAAGAATTATTGTCAAACTATCGAAAAGGCTGCAAAAGAAATATGCGGCCATGATGTAAAAGTTGTTTTTAAATCT
GAAAAAAATATAAGCAGAGATTCAACAAATAAAGAGAACCTAGATGATCAGATTGTGAATCATAAAACAAAATCATTTCC
TAATAATAGTCAAGAAATTTCTTCAAAAAATAGATCCAAAAATCCCAACGGTCTAAATTTACGTTACGTCTTTAAAAGAT
TTGTTGTAGGTCCAAATAGTAGGTTGGCTCATGCAGCGGCTTTAGCAGTTGCCGAATCACCCGGGAGAGAATTTAATCCC
TTATTTATTTGTGGTGGAGTAGGTCTCGGTAAAACTCATTTAATGCAAGCAATAGGCCATTATCGAGTAGAAATAGATCC
AGAGGCAAAAGTTAAATATGTATCTACAGAAACTTTTACTAATGACGTTATTAGTGGTATTAGAAGAGACGGAATGACAG
CTATTCGAGATAAATATAGAAATGTAGATTTGATTTTAATAGACGATATACAGTTCTTAGAAGGCAAAGAGTATACACAG
GAAGAATTTTTTCATACTTTTAACGCTCTTCACGAATCAGGAAGTCAAATAGTAATCGCTAGTGATAGACCTCCAAATCA
ATTGTCTGGAATTCAGGAGAGATTAATTTCTAGGTTCTCGATGGGCATGACTGCAGATATTCAACCACCTGACCTTGAGA
CAAGGACAGCAATCCTTCAAAAAAAGGCAGAACAAGAAAGTATGAGTCTACCAAGAGATTTAATTCAATTTATAGCAGGA
AGATTCACTTCGAATATTCGAGAATTGGAAGGAGCATTTACTAGAGCTGTTGCATTTGCATCAATAACAGGCTTGCCAAT
GACAGTTCAATCAATTGCTCCAATGCTTGATCCGAATAGTGTTGGAGTAGTTGTCAGTCCAAAACAAGTTATTAATAAAG
TGTCAGATTTCTTTAAAGTTTCTACTGATGAATTGATTAGCTCAAGTAGGAGAAAACCAGTAAGTCAAGCTAGGCAAATA
GGTATGTATCTTATGCGACATGGAACGGATTTAAGCCTACCAAGAATTGGAGATGAGTTTGGGGGCAAAGACCATACAAC
GGTTATGTATGCTATTGAACAAGTTGAAAAAAAATTGTCTATTGATCCTAATATTGCAAGTCAAGTTCAAAAAATAAGGG
ATTTGCTTCAAATAGATTCAAGAAAAAATTTATAG

Upstream 100 bases:

>100_bases
TCATGGTTTGTTAAGTAATTTTAAATTTGTCGTGATCTTGTGATTTGATAATGGCCAATTATTAAATTCCAACTAGATTA
ATAATCTAGAGAATAAAATT

Downstream 100 bases:

>100_bases
TTTTACTTTAACTAGAGATAAAATTTCTAGGATCTTGATCATATCTATGCCTGAAAGGTATATTATCTATTTCATTAATA
TTACTAAGCGATTCAATTTT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MQTINPIWAEVQQSLKKTLSKPSFETWIRPAKFNCFENGLLTLIAPNTFSSDWLRKNYCQTIEKAAKEICGHDVKVVFKS
EKNISRDSTNKENLDDQIVNHKTKSFPNNSQEISSKNRSKNPNGLNLRYVFKRFVVGPNSRLAHAAALAVAESPGREFNP
LFICGGVGLGKTHLMQAIGHYRVEIDPEAKVKYVSTETFTNDVISGIRRDGMTAIRDKYRNVDLILIDDIQFLEGKEYTQ
EEFFHTFNALHESGSQIVIASDRPPNQLSGIQERLISRFSMGMTADIQPPDLETRTAILQKKAEQESMSLPRDLIQFIAG
RFTSNIRELEGAFTRAVAFASITGLPMTVQSIAPMLDPNSVGVVVSPKQVINKVSDFFKVSTDELISSSRRKPVSQARQI
GMYLMRHGTDLSLPRIGDEFGGKDHTTVMYAIEQVEKKLSIDPNIASQVQKIRDLLQIDSRKNL

Sequences:

>Translated_464_residues
MQTINPIWAEVQQSLKKTLSKPSFETWIRPAKFNCFENGLLTLIAPNTFSSDWLRKNYCQTIEKAAKEICGHDVKVVFKS
EKNISRDSTNKENLDDQIVNHKTKSFPNNSQEISSKNRSKNPNGLNLRYVFKRFVVGPNSRLAHAAALAVAESPGREFNP
LFICGGVGLGKTHLMQAIGHYRVEIDPEAKVKYVSTETFTNDVISGIRRDGMTAIRDKYRNVDLILIDDIQFLEGKEYTQ
EEFFHTFNALHESGSQIVIASDRPPNQLSGIQERLISRFSMGMTADIQPPDLETRTAILQKKAEQESMSLPRDLIQFIAG
RFTSNIRELEGAFTRAVAFASITGLPMTVQSIAPMLDPNSVGVVVSPKQVINKVSDFFKVSTDELISSSRRKPVSQARQI
GMYLMRHGTDLSLPRIGDEFGGKDHTTVMYAIEQVEKKLSIDPNIASQVQKIRDLLQIDSRKNL
>Mature_464_residues
MQTINPIWAEVQQSLKKTLSKPSFETWIRPAKFNCFENGLLTLIAPNTFSSDWLRKNYCQTIEKAAKEICGHDVKVVFKS
EKNISRDSTNKENLDDQIVNHKTKSFPNNSQEISSKNRSKNPNGLNLRYVFKRFVVGPNSRLAHAAALAVAESPGREFNP
LFICGGVGLGKTHLMQAIGHYRVEIDPEAKVKYVSTETFTNDVISGIRRDGMTAIRDKYRNVDLILIDDIQFLEGKEYTQ
EEFFHTFNALHESGSQIVIASDRPPNQLSGIQERLISRFSMGMTADIQPPDLETRTAILQKKAEQESMSLPRDLIQFIAG
RFTSNIRELEGAFTRAVAFASITGLPMTVQSIAPMLDPNSVGVVVSPKQVINKVSDFFKVSTDELISSSRRKPVSQARQI
GMYLMRHGTDLSLPRIGDEFGGKDHTTVMYAIEQVEKKLSIDPNIASQVQKIRDLLQIDSRKNL

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=444, Percent_Identity=36.7117117117117, Blast_Score=311, Evalue=7e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_PROM0 (A3PBT9)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090815.1
- ProteinModelPortal:   A3PBT9
- STRING:   A3PBT9
- GeneID:   4911592
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_05911
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   DEVAFLI
- ProtClustDB:   PRK00149
- BioCyc:   PMAR167546:P9301ORF_0605-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 52167; Mature: 52167

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTINPIWAEVQQSLKKTLSKPSFETWIRPAKFNCFENGLLTLIAPNTFSSDWLRKNYCQ
CCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHCCCCEEEEECCCCCHHHHHHHHHH
TIEKAAKEICGHDVKVVFKSEKNISRDSTNKENLDDQIVNHKTKSFPNNSQEISSKNRSK
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCC
NPNGLNLRYVFKRFVVGPNSRLAHAAALAVAESPGREFNPLFICGGVGLGKTHLMQAIGH
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHC
YRVEIDPEAKVKYVSTETFTNDVISGIRRDGMTAIRDKYRNVDLILIDDIQFLEGKEYTQ
EEEEECCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCHHHCCCCHHH
EEFFHTFNALHESGSQIVIASDRPPNQLSGIQERLISRFSMGMTADIQPPDLETRTAILQ
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
KKAEQESMSLPRDLIQFIAGRFTSNIRELEGAFTRAVAFASITGLPMTVQSIAPMLDPNS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCCCC
VGVVVSPKQVINKVSDFFKVSTDELISSSRRKPVSQARQIGMYLMRHGTDLSLPRIGDEF
CEEEECHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHH
GGKDHTTVMYAIEQVEKKLSIDPNIASQVQKIRDLLQIDSRKNL
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQTINPIWAEVQQSLKKTLSKPSFETWIRPAKFNCFENGLLTLIAPNTFSSDWLRKNYCQ
CCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHCCCCEEEEECCCCCHHHHHHHHHH
TIEKAAKEICGHDVKVVFKSEKNISRDSTNKENLDDQIVNHKTKSFPNNSQEISSKNRSK
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCC
NPNGLNLRYVFKRFVVGPNSRLAHAAALAVAESPGREFNPLFICGGVGLGKTHLMQAIGH
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHC
YRVEIDPEAKVKYVSTETFTNDVISGIRRDGMTAIRDKYRNVDLILIDDIQFLEGKEYTQ
EEEEECCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCCHHHCCCCHHH
EEFFHTFNALHESGSQIVIASDRPPNQLSGIQERLISRFSMGMTADIQPPDLETRTAILQ
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
KKAEQESMSLPRDLIQFIAGRFTSNIRELEGAFTRAVAFASITGLPMTVQSIAPMLDPNS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCCCC
VGVVVSPKQVINKVSDFFKVSTDELISSSRRKPVSQARQIGMYLMRHGTDLSLPRIGDEF
CEEEECHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHH
GGKDHTTVMYAIEQVEKKLSIDPNIASQVQKIRDLLQIDSRKNL
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA