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The map label for this gene is pyrD [H]

Identifier: 126695557

GI number: 126695557

Start: 203894

End: 205063

Strand: Reverse

Name: pyrD [H]

Synonym: P9301_02191

Alternate gene names: 126695557

Gene position: 205063-203894 (Counterclockwise)

Preceding gene: 126695558

Following gene: 126695556

Centisome position: 12.49

GC content: 30.68

Gene sequence:

>1170_bases
ATGAATGAACAGCAGGGGGTATTTAAAAATCTTTATAAAAACTTGATGACACCTATACTAAAAAATGATTCTGGAATAGA
TGCAGAATATTTAACTAATTTATCTCTTAGCCTTCTATCATTTAGTTCAAGAAAATATAATTGGCCTTTAGTTTCATCAA
TCCTAAAAAATTTAAATGAAGAATTTTCTGTAATTGATAAAAGGTTAAGTCAAAACATATGTGGAATAAATTTTTGTAAT
CCAATTGGTTTAGCTGCAGGTTTTGACAAAAATGGGAATGCTGCAAATATATGGAAAGATTTTGGTTTTGGATTTGCAGA
ACTTGGAACAGTAACTAAATTTGCTCAAAATGGCAATCCAAAACCAAGGTTATTTAGATTAGCTGAAGAAGAAGCAGCAT
TAAATAGGATGGGTTTCAATAATAATGGTGCTGAAAATCTGGTTAAAAATTTTCTTGAGCAGGGTATCGAGTTCAAAAAA
AATAGGGATAATATTTGTTTAGGGATAAATTTCGGTAAGTCTAAAATCACAAGCTTATCTCAAGCAAAAGATGATTATTT
AACTTCTCTAGAATTATTAATTCCATATTGTGATTACGCAGCAATAAACGTAAGTTCTCCAAATACTGAAGGACTAAGAA
AGTTGCAAGATCCAATACTTCTAAAAGACCTTCTTAGAGCAATTAAAAACTTACCTAATTGTCCACCATTATTTGTAAAA
ATTGCGCCAGATTTAAGCCTTAAAGATATTGAAGATATTTGCAAGTTAATAATCGAGGAAAATATAGATGGGATAATTGC
TACTAACACCAGCATAGATAGATTAGGTCTTGAAAATAGGAAGATAAGGCAAACAGGATTATTACTTTCTGAAGAAAATG
GAGGCTTAAGTGGAAAACCTTTACAAAAAAAAGCAAATCAAGTCATAAAAGATATTCGTAATATTGATAAAAATATTATT
TTAATTGGCGTTGGTGGAATCGATAGTCCTGAGTCGGCTTGGGAAAGAATTTGTTCTGGAGCATCATTAATTCAACTTTA
TACGGGATGGATATATAAGGGGCCACAATTAGTCCCCAATATACTTGAAGGAATTTTAAAGCAACTCAATATCCATCAAT
TGTCCAATATTAAAGAGGCCATTGGATCAGATTTAAAATGGGTTAAATAA

Upstream 100 bases:

>100_bases
AAATATAAAACAATATTTACTTTTTGAATGGCGTAATTGGAGATTGATTCCCAAAGATAAAAAATATTGGATAATAGAAA
AAAAAGAATTCTAATTTTTT

Downstream 100 bases:

>100_bases
AAATTAGAAAATGAATAATGAACAAATCCGAAACTAATGATTACTCAACATTAGCCATGCAAATATCAGACTTAAAGCAT
GGAGGAAATGTATATGCAAA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNEQQGVFKNLYKNLMTPILKNDSGIDAEYLTNLSLSLLSFSSRKYNWPLVSSILKNLNEEFSVIDKRLSQNICGINFCN
PIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQNGNPKPRLFRLAEEEAALNRMGFNNNGAENLVKNFLEQGIEFKK
NRDNICLGINFGKSKITSLSQAKDDYLTSLELLIPYCDYAAINVSSPNTEGLRKLQDPILLKDLLRAIKNLPNCPPLFVK
IAPDLSLKDIEDICKLIIEENIDGIIATNTSIDRLGLENRKIRQTGLLLSEENGGLSGKPLQKKANQVIKDIRNIDKNII
LIGVGGIDSPESAWERICSGASLIQLYTGWIYKGPQLVPNILEGILKQLNIHQLSNIKEAIGSDLKWVK

Sequences:

>Translated_389_residues
MNEQQGVFKNLYKNLMTPILKNDSGIDAEYLTNLSLSLLSFSSRKYNWPLVSSILKNLNEEFSVIDKRLSQNICGINFCN
PIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQNGNPKPRLFRLAEEEAALNRMGFNNNGAENLVKNFLEQGIEFKK
NRDNICLGINFGKSKITSLSQAKDDYLTSLELLIPYCDYAAINVSSPNTEGLRKLQDPILLKDLLRAIKNLPNCPPLFVK
IAPDLSLKDIEDICKLIIEENIDGIIATNTSIDRLGLENRKIRQTGLLLSEENGGLSGKPLQKKANQVIKDIRNIDKNII
LIGVGGIDSPESAWERICSGASLIQLYTGWIYKGPQLVPNILEGILKQLNIHQLSNIKEAIGSDLKWVK
>Mature_389_residues
MNEQQGVFKNLYKNLMTPILKNDSGIDAEYLTNLSLSLLSFSSRKYNWPLVSSILKNLNEEFSVIDKRLSQNICGINFCN
PIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQNGNPKPRLFRLAEEEAALNRMGFNNNGAENLVKNFLEQGIEFKK
NRDNICLGINFGKSKITSLSQAKDDYLTSLELLIPYCDYAAINVSSPNTEGLRKLQDPILLKDLLRAIKNLPNCPPLFVK
IAPDLSLKDIEDICKLIIEENIDGIIATNTSIDRLGLENRKIRQTGLLLSEENGGLSGKPLQKKANQVIKDIRNIDKNII
LIGVGGIDSPESAWERICSGASLIQLYTGWIYKGPQLVPNILEGILKQLNIHQLSNIKEAIGSDLKWVK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=331, Percent_Identity=41.3897280966767, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI119943098, Length=302, Percent_Identity=24.8344370860927, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787177, Length=303, Percent_Identity=46.5346534653465, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI87082059, Length=339, Percent_Identity=25.6637168141593, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17509475, Length=337, Percent_Identity=37.6854599406528, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI281361352, Length=334, Percent_Identity=39.5209580838323, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI17137316, Length=334, Percent_Identity=39.5209580838323, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24640763, Length=303, Percent_Identity=27.3927392739274, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18858217, Length=303, Percent_Identity=27.3927392739274, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 43239; Mature: 43239

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQQGVFKNLYKNLMTPILKNDSGIDAEYLTNLSLSLLSFSSRKYNWPLVSSILKNLNE
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EFSVIDKRLSQNICGINFCNPIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQNGNP
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
KPRLFRLAEEEAALNRMGFNNNGAENLVKNFLEQGIEFKKNRDNICLGINFGKSKITSLS
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHCCCCCCEEEEEECCHHHHHHHH
QAKDDYLTSLELLIPYCDYAAINVSSPNTEGLRKLQDPILLKDLLRAIKNLPNCPPLFVK
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEE
IAPDLSLKDIEDICKLIIEENIDGIIATNTSIDRLGLENRKIRQTGLLLSEENGGLSGKP
ECCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHCCCCCHHHHHCCEEECCCCCCCCCC
LQKKANQVIKDIRNIDKNIILIGVGGIDSPESAWERICSGASLIQLYTGWIYKGPQLVPN
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHH
ILEGILKQLNIHQLSNIKEAIGSDLKWVK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNEQQGVFKNLYKNLMTPILKNDSGIDAEYLTNLSLSLLSFSSRKYNWPLVSSILKNLNE
CCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EFSVIDKRLSQNICGINFCNPIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQNGNP
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
KPRLFRLAEEEAALNRMGFNNNGAENLVKNFLEQGIEFKKNRDNICLGINFGKSKITSLS
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHCCCCCCEEEEEECCHHHHHHHH
QAKDDYLTSLELLIPYCDYAAINVSSPNTEGLRKLQDPILLKDLLRAIKNLPNCPPLFVK
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEE
IAPDLSLKDIEDICKLIIEENIDGIIATNTSIDRLGLENRKIRQTGLLLSEENGGLSGKP
ECCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHCCCCCHHHHHCCEEECCCCCCCCCC
LQKKANQVIKDIRNIDKNIILIGVGGIDSPESAWERICSGASLIQLYTGWIYKGPQLVPN
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHH
ILEGILKQLNIHQLSNIKEAIGSDLKWVK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]