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The map label for this gene is cobD [H]

Identifier: 126695556

GI number: 126695556

Start: 202752

End: 203876

Strand: Reverse

Name: cobD [H]

Synonym: P9301_02181

Alternate gene names: 126695556

Gene position: 203876-202752 (Counterclockwise)

Preceding gene: 126695557

Following gene: 126695554

Centisome position: 12.42

GC content: 31.38

Gene sequence:

>1125_bases
ATGAACAAATCCGAAACTAATGATTACTCAACATTAGCCATGCAAATATCAGACTTAAAGCATGGAGGAAATGTATATGC
AAATGCAAAAAAATTAAATTTATTACCCTCTGAAATCATTGACGCAAGTGCCTCGTTAGTACCCTTTGATCCACCTCAAA
TACTAATAGATTCATTAAATGCGGGAATTAAGAATCTTGGATTTAGATATTACCCAGAGAGAAACTTGAGTGATCTGAAA
GAAATAATCGGTAAATTTCATGGGATAAATCCAGATAATATATTGCCTGGAAATGGAGCTTCTGAGCTAATAACCTGGGC
AGGTTATGAAGCATCCAAATTTGGAATAAGTTGTATTCCTTCTCCATCATTTGTTGATTATGAAAGATCTTTAAATTGTT
GGAATAGCAATTTTGTACATTGCGAATTACCAAAAAACTGGAATGATATTTTTCCTCAATCATTCCCGCTTCATCCAAAA
GGTGATGTTATTTGGATAACAAATCCACATAACCCTACCGGTCAATTATGGGAAAAGAATTCATTGGAGGAACTTGTAAA
AAAATATAAATTAGTTATCTGTGATGAAGCTTTCTTATCGATAACACCTAATGGAGACAAAGAATCTTTAATACCATTAA
CCCAAAGATTTGATAATTTATTAGTCTTGAGAAGCTTGACTAAAATCTTCAATATTCCTGGTCTTAGATTAGGTTACGTT
ATTGGTTCATCGAAAAAACTTAAGCAATGGGAAATAAAAAGAGATCCTTGGCCTTTAAATTCATTTGCTATTAAAGCCGG
AATTGATCTACTAAGTAATAAGAAATTCTATGAACAATGGACAAAACAGATTCACAGCTGGATAAATATTGAAAAAAAGA
GAGTATTTGAAAAATTATCAAAAATAGAGAGTCTTAAAGTTCATAACTCTTCAACCAACTTTTTTTTAGTAGAAAGTAAA
ACATCCTTGTCGCCAAATATCAAATACTTAGAAAATAAGGGAATATTGCTTAGAGAATGCACTTCATTTAGATTTCTTGA
CGAAAAGTGGGCAAGAATAAGTTTGCAGAACAGCAAAAATAACACTCTTTTATGTGAAGAAATTCAGAATTCCTTCAAAA
AATAA

Upstream 100 bases:

>100_bases
AAGGAATTTTAAAGCAACTCAATATCCATCAATTGTCCAATATTAAAGAGGCCATTGGATCAGATTTAAAATGGGTTAAA
TAAAAATTAGAAAATGAATA

Downstream 100 bases:

>100_bases
TTAATAAATTTTTTAATCTCAATTTTAGATTTTATTTTTTTATTATTTTCCATATTCTTCTTCATGAGATCTAATATTTC
ATAATGATTTTTTCCCTTTT

Product: aminotransferases class-I

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MNKSETNDYSTLAMQISDLKHGGNVYANAKKLNLLPSEIIDASASLVPFDPPQILIDSLNAGIKNLGFRYYPERNLSDLK
EIIGKFHGINPDNILPGNGASELITWAGYEASKFGISCIPSPSFVDYERSLNCWNSNFVHCELPKNWNDIFPQSFPLHPK
GDVIWITNPHNPTGQLWEKNSLEELVKKYKLVICDEAFLSITPNGDKESLIPLTQRFDNLLVLRSLTKIFNIPGLRLGYV
IGSSKKLKQWEIKRDPWPLNSFAIKAGIDLLSNKKFYEQWTKQIHSWINIEKKRVFEKLSKIESLKVHNSSTNFFLVESK
TSLSPNIKYLENKGILLRECTSFRFLDEKWARISLQNSKNNTLLCEEIQNSFKK

Sequences:

>Translated_374_residues
MNKSETNDYSTLAMQISDLKHGGNVYANAKKLNLLPSEIIDASASLVPFDPPQILIDSLNAGIKNLGFRYYPERNLSDLK
EIIGKFHGINPDNILPGNGASELITWAGYEASKFGISCIPSPSFVDYERSLNCWNSNFVHCELPKNWNDIFPQSFPLHPK
GDVIWITNPHNPTGQLWEKNSLEELVKKYKLVICDEAFLSITPNGDKESLIPLTQRFDNLLVLRSLTKIFNIPGLRLGYV
IGSSKKLKQWEIKRDPWPLNSFAIKAGIDLLSNKKFYEQWTKQIHSWINIEKKRVFEKLSKIESLKVHNSSTNFFLVESK
TSLSPNIKYLENKGILLRECTSFRFLDEKWARISLQNSKNNTLLCEEIQNSFKK
>Mature_374_residues
MNKSETNDYSTLAMQISDLKHGGNVYANAKKLNLLPSEIIDASASLVPFDPPQILIDSLNAGIKNLGFRYYPERNLSDLK
EIIGKFHGINPDNILPGNGASELITWAGYEASKFGISCIPSPSFVDYERSLNCWNSNFVHCELPKNWNDIFPQSFPLHPK
GDVIWITNPHNPTGQLWEKNSLEELVKKYKLVICDEAFLSITPNGDKESLIPLTQRFDNLLVLRSLTKIFNIPGLRLGYV
IGSSKKLKQWEIKRDPWPLNSFAIKAGIDLLSNKKFYEQWTKQIHSWINIEKKRVFEKLSKIESLKVHNSSTNFFLVESK
TSLSPNIKYLENKGILLRECTSFRFLDEKWARISLQNSKNNTLLCEEIQNSFKK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=277, Percent_Identity=27.0758122743682, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 42812; Mature: 42812

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSETNDYSTLAMQISDLKHGGNVYANAKKLNLLPSEIIDASASLVPFDPPQILIDSLN
CCCCCCCCHHHHEEEHHHHCCCCCEEECCHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHH
AGIKNLGFRYYPERNLSDLKEIIGKFHGINPDNILPGNGASELITWAGYEASKFGISCIP
CCHHHCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEECCCCCCCCCCEECC
SPSFVDYERSLNCWNSNFVHCELPKNWNDIFPQSFPLHPKGDVIWITNPHNPTGQLWEKN
CCCCCCHHHCCCCCCCCEEEEECCCCCHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
SLEELVKKYKLVICDEAFLSITPNGDKESLIPLTQRFDNLLVLRSLTKIFNIPGLRLGYV
CHHHHHHHHEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
IGSSKKLKQWEIKRDPWPLNSFAIKAGIDLLSNKKFYEQWTKQIHSWINIEKKRVFEKLS
ECCCCCCCEEECCCCCCCCCCCHHHHCHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHH
KIESLKVHNSSTNFFLVESKTSLSPNIKYLENKGILLRECTSFRFLDEKWARISLQNSKN
HHHHEEEECCCCCEEEEECCCCCCCCCEEECCCCEEEEHHHCHHHHHCHHHEEEEECCCC
NTLLCEEIQNSFKK
CCEEHHHHHHHHCC
>Mature Secondary Structure
MNKSETNDYSTLAMQISDLKHGGNVYANAKKLNLLPSEIIDASASLVPFDPPQILIDSLN
CCCCCCCCHHHHEEEHHHHCCCCCEEECCHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHH
AGIKNLGFRYYPERNLSDLKEIIGKFHGINPDNILPGNGASELITWAGYEASKFGISCIP
CCHHHCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHEEECCCCCCCCCCEECC
SPSFVDYERSLNCWNSNFVHCELPKNWNDIFPQSFPLHPKGDVIWITNPHNPTGQLWEKN
CCCCCCHHHCCCCCCCCEEEEECCCCCHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
SLEELVKKYKLVICDEAFLSITPNGDKESLIPLTQRFDNLLVLRSLTKIFNIPGLRLGYV
CHHHHHHHHEEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
IGSSKKLKQWEIKRDPWPLNSFAIKAGIDLLSNKKFYEQWTKQIHSWINIEKKRVFEKLS
ECCCCCCCEEECCCCCCCCCCCHHHHCHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHH
KIESLKVHNSSTNFFLVESKTSLSPNIKYLENKGILLRECTSFRFLDEKWARISLQNSKN
HHHHEEEECCCCCEEEEECCCCCCCCCEEECCCCEEEEHHHCHHHHHCHHHEEEEECCCC
NTLLCEEIQNSFKK
CCEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]