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The map label for this gene is nadC [H]

Identifier: 126695546

GI number: 126695546

Start: 190858

End: 191724

Strand: Reverse

Name: nadC [H]

Synonym: P9301_02081

Alternate gene names: 126695546

Gene position: 191724-190858 (Counterclockwise)

Preceding gene: 126695547

Following gene: 126695545

Centisome position: 11.68

GC content: 29.64

Gene sequence:

>867_bases
GTGGATTTAAATACTCCAATAATAAGTAAGATCATTGATAATTGGATCGATGAAGATATAGGCAGAGGAGATCTTACAAG
TCCCTCTATTACAAAAGAAAATGGCAATGCATATTGGATTGCTAAAGAGGAGGGAATATTCTGTGGGGTTGAAATTATAA
AAGAAATTTTTAGAAAAATTGATTTAAAAATCAGTCCAAAATTTAATATCTCTGATGGAGATAAATTTGTTAAAGATCAA
AAACTCTTAGAAATATATGGACCTTCAAAAAGTTTACTCGCTAGTGAAAGGATCAGCTTAAATATAGCAATGCATTTATC
TGGAATATCAACATATACAAAGAATCTTACAGATAAATTAGAAGGCACAAATATAAAATTAGCAGATACTAGGAAAACGA
CTCCTGGCTTAAGAATATTTGAAAAATATGCTTTCAAATGCGGAGGTGGGGTGAATCATAGAATGGGATTATACGATGCT
GCTATGATCAAAGAAAATCATATAGCATGGACAGATAATCTTAAAAATGCAGTACAAAAAATTCGGCTAAATTCGCCTTT
TACAACTCATATAGTAATTGAAGCTGAGAATATCGAACAAGCAAAAGAAGCAGTATTAGCAGGAGCGGATAGTGTCTTAT
TAGATGAACTTAGTCCTGAAACAATCAAAAAAAGCGTTCAAGAATTAAGATATTTATCAATTAATAGCTTAAAAAAAGAA
GTCAATAAAAATTTGATAATAGAAGTTTCTGGAATAAACCCTCAAGAAATTAGTAAATATCTAATAAAAGGTATTGATTT
GATTTCAACAAGTTCTTCAATCACCAAAAGTAATTGGATTGATTTGAGTATGCGTTATATTAATTAA

Upstream 100 bases:

>100_bases
TAAGTTTTGTATTGGCAAATAAATTTGAGTTAAATTACATAGTGATATATAGTTGAATGTCTAACTTCAGTTTAATTTTT
ATTAATTATTTCTTAGTTTA

Downstream 100 bases:

>100_bases
TCATATAGATAAATAATTGAATAATTAATGCTAATCATTTTTAAAGAATTAACAAAACAATTTGAACAATCTCTTTTAGA
TAGTCTTGAAAAAAATGATA

Product: nicotinate-nucleotide pyrophosphorylase:quinolinate phosphoriobsyl transferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MDLNTPIISKIIDNWIDEDIGRGDLTSPSITKENGNAYWIAKEEGIFCGVEIIKEIFRKIDLKISPKFNISDGDKFVKDQ
KLLEIYGPSKSLLASERISLNIAMHLSGISTYTKNLTDKLEGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDA
AMIKENHIAWTDNLKNAVQKIRLNSPFTTHIVIEAENIEQAKEAVLAGADSVLLDELSPETIKKSVQELRYLSINSLKKE
VNKNLIIEVSGINPQEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN

Sequences:

>Translated_288_residues
MDLNTPIISKIIDNWIDEDIGRGDLTSPSITKENGNAYWIAKEEGIFCGVEIIKEIFRKIDLKISPKFNISDGDKFVKDQ
KLLEIYGPSKSLLASERISLNIAMHLSGISTYTKNLTDKLEGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDA
AMIKENHIAWTDNLKNAVQKIRLNSPFTTHIVIEAENIEQAKEAVLAGADSVLLDELSPETIKKSVQELRYLSINSLKKE
VNKNLIIEVSGINPQEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN
>Mature_288_residues
MDLNTPIISKIIDNWIDEDIGRGDLTSPSITKENGNAYWIAKEEGIFCGVEIIKEIFRKIDLKISPKFNISDGDKFVKDQ
KLLEIYGPSKSLLASERISLNIAMHLSGISTYTKNLTDKLEGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDA
AMIKENHIAWTDNLKNAVQKIRLNSPFTTHIVIEAENIEQAKEAVLAGADSVLLDELSPETIKKSVQELRYLSINSLKKE
VNKNLIIEVSGINPQEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=281, Percent_Identity=28.1138790035587, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1786299, Length=255, Percent_Identity=38.0392156862745, Blast_Score=161, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=285, Percent_Identity=32.9824561403509, Blast_Score=143, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32291; Mature: 32291

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNTPIISKIIDNWIDEDIGRGDLTSPSITKENGNAYWIAKEEGIFCGVEIIKEIFRKI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCCEECHHHHHHHHHHC
DLKISPKFNISDGDKFVKDQKLLEIYGPSKSLLASERISLNIAMHLSGISTYTKNLTDKL
CCEECCCCCCCCCHHHHHCCCEEEEECCCHHHHHHCCEEEEEEEEECCHHHHHHHHHHHC
EGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDAAMIKENHIAWTDNLKNAVQK
CCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHH
IRLNSPFTTHIVIEAENIEQAKEAVLAGADSVLLDELSPETIKKSVQELRYLSINSLKKE
HCCCCCCEEEEEEEECCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VNKNLIIEVSGINPQEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MDLNTPIISKIIDNWIDEDIGRGDLTSPSITKENGNAYWIAKEEGIFCGVEIIKEIFRKI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCCEECHHHHHHHHHHC
DLKISPKFNISDGDKFVKDQKLLEIYGPSKSLLASERISLNIAMHLSGISTYTKNLTDKL
CCEECCCCCCCCCHHHHHCCCEEEEECCCHHHHHHCCEEEEEEEEECCHHHHHHHHHHHC
EGTNIKLADTRKTTPGLRIFEKYAFKCGGGVNHRMGLYDAAMIKENHIAWTDNLKNAVQK
CCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHH
IRLNSPFTTHIVIEAENIEQAKEAVLAGADSVLLDELSPETIKKSVQELRYLSINSLKKE
HCCCCCCEEEEEEEECCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VNKNLIIEVSGINPQEISKYLIKGIDLISTSSSITKSNWIDLSMRYIN
CCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]