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The map label for this gene is murC [H]

Identifier: 126695359

GI number: 126695359

Start: 22570

End: 23916

Strand: Reverse

Name: murC [H]

Synonym: P9301_00211

Alternate gene names: 126695359

Gene position: 23916-22570 (Counterclockwise)

Preceding gene: 126695361

Following gene: 126695358

Centisome position: 1.46

GC content: 27.91

Gene sequence:

>1347_bases
ATGTCAGCATTAGCAATAGGTTTACTTAAAAAAGGTTATTCAGTTTCAGGATCTGATTTAGTTAAAAATGATGAAACCAA
TAAATTAGAGAAATTAGGTGCAGTAATCTTTAATTCTCAAGTACGACAAAATATTGAATTTATTATTTCAAAATTTACCA
ACAAATTGATTTATTTTGTTGTAAGCTCCGCGATCAAGCCAGAAAATGAAGAATTTTCGTACTGCAGAGAAAATAATTTA
TCAATAAAACATCGTTCAGAGATACTTGCAATGCTAATGCGCACTTACACTGCATTGGCGGTAGCAGGCAGCCACGGAAA
AACATCAACCAGTACATTTCTTTCAACAATACTTGAGTTATGTACACGTAATTCGTCTTCAATAACTGGAGGAATAATTC
CTATTTACAACTCTAATTGTCATTTAGATAATACAAAATACTTAGTAGCTGAAGTTGATGAATCTGATGGAACAATTAAC
AAATATAAGTCTGATATCGGAATAATTAATAACATTGATTTTGATCATTGCGATCACTTTTCTAATTTAAATGAAGTAAT
CTCTACTTTTAAAAGTTTCGCTAAAAACTCTAAAAAATTACTACTTAATTTTGATTGTGAAACGTCAAGAAATAATTTTT
ATTCTAATTGGAAGTGGTCAAACAGTACTGCTAAAAACGTTACTTATGCAATAATTCCGATTGAGATTAATTCAAAGTAT
ACAATTGGGAAATATTATGAAAATGGAAATTTTATTAGTAGTTTAAATATCCCAATTCCAGGTTTACACAATCTATCAAA
TATCACCGCAGCAATAGCTGCTTCAAGAATGATAGGAGTAGATTTTATAGAAATTAAAAAAAATATAAAATATCTAAAAC
TGCCAAAAAAAAGATTTGAATTTAGAGGCCAATTAGATGAAAGAAGTTTATATGATGATTATGCACATCACCCAAACGAA
ATAAAAGAAACGATTAAATTAGGAAGATTATTGATTCAACAAAACCATAATAAAGAATGTCAAAAAAGTAGATTAATAGC
TATATTTCAACCTCATAGATACTCTCGAGTAAAACAATTTACGAAAGAATTCGCTGAAGAATTATCAAAAGCAGATGTTA
TTTATGTAACCAGTATTTATGGAGCAGGGGAAGGAAACGAAGATAGAATAACTTCGAAAATTATCACTGATCTGATTTAT
AAAAAAAATAAAAATGTTAGTTACATAAATAATTATTATGAAGTTACGAAGAATTTTTACGAATTAACTCAAAAAGGGGA
TTTAATTTTGAATATGGGAGCTGGTGATTGTCATAATTTCTGGTCAATTTTAAATAAAAATAATTAA

Upstream 100 bases:

>100_bases
TATACCTAGAAGTTATTTTGATTTAAGTAAAAGATAAACATTGGATAAAGAATTACTATTGAAAGGTCATTTTCATTTTA
TTGGGATTGGGGGTATTGGG

Downstream 100 bases:

>100_bases
ATGGATAAATAATTTATGAAAAAAACAATTCTTTCTGAAAGCTGTAATTTAAGTAATTATACGACTATAAAAGTGGGAGG
AATAGCTGAATATTTTGCTG

Product: UDP-N-acetylmuramate-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSALAIGLLKKGYSVSGSDLVKNDETNKLEKLGAVIFNSQVRQNIEFIISKFTNKLIYFVVSSAIKPENEEFSYCRENNL
SIKHRSEILAMLMRTYTALAVAGSHGKTSTSTFLSTILELCTRNSSSITGGIIPIYNSNCHLDNTKYLVAEVDESDGTIN
KYKSDIGIINNIDFDHCDHFSNLNEVISTFKSFAKNSKKLLLNFDCETSRNNFYSNWKWSNSTAKNVTYAIIPIEINSKY
TIGKYYENGNFISSLNIPIPGLHNLSNITAAIAASRMIGVDFIEIKKNIKYLKLPKKRFEFRGQLDERSLYDDYAHHPNE
IKETIKLGRLLIQQNHNKECQKSRLIAIFQPHRYSRVKQFTKEFAEELSKADVIYVTSIYGAGEGNEDRITSKIITDLIY
KKNKNVSYINNYYEVTKNFYELTQKGDLILNMGAGDCHNFWSILNKNN

Sequences:

>Translated_448_residues
MSALAIGLLKKGYSVSGSDLVKNDETNKLEKLGAVIFNSQVRQNIEFIISKFTNKLIYFVVSSAIKPENEEFSYCRENNL
SIKHRSEILAMLMRTYTALAVAGSHGKTSTSTFLSTILELCTRNSSSITGGIIPIYNSNCHLDNTKYLVAEVDESDGTIN
KYKSDIGIINNIDFDHCDHFSNLNEVISTFKSFAKNSKKLLLNFDCETSRNNFYSNWKWSNSTAKNVTYAIIPIEINSKY
TIGKYYENGNFISSLNIPIPGLHNLSNITAAIAASRMIGVDFIEIKKNIKYLKLPKKRFEFRGQLDERSLYDDYAHHPNE
IKETIKLGRLLIQQNHNKECQKSRLIAIFQPHRYSRVKQFTKEFAEELSKADVIYVTSIYGAGEGNEDRITSKIITDLIY
KKNKNVSYINNYYEVTKNFYELTQKGDLILNMGAGDCHNFWSILNKNN
>Mature_447_residues
SALAIGLLKKGYSVSGSDLVKNDETNKLEKLGAVIFNSQVRQNIEFIISKFTNKLIYFVVSSAIKPENEEFSYCRENNLS
IKHRSEILAMLMRTYTALAVAGSHGKTSTSTFLSTILELCTRNSSSITGGIIPIYNSNCHLDNTKYLVAEVDESDGTINK
YKSDIGIINNIDFDHCDHFSNLNEVISTFKSFAKNSKKLLLNFDCETSRNNFYSNWKWSNSTAKNVTYAIIPIEINSKYT
IGKYYENGNFISSLNIPIPGLHNLSNITAAIAASRMIGVDFIEIKKNIKYLKLPKKRFEFRGQLDERSLYDDYAHHPNEI
KETIKLGRLLIQQNHNKECQKSRLIAIFQPHRYSRVKQFTKEFAEELSKADVIYVTSIYGAGEGNEDRITSKIITDLIYK
KNKNVSYINNYYEVTKNFYELTQKGDLILNMGAGDCHNFWSILNKNN

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=456, Percent_Identity=27.8508771929825, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790680, Length=404, Percent_Identity=24.7524752475248, Blast_Score=112, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51080; Mature: 50948

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALAIGLLKKGYSVSGSDLVKNDETNKLEKLGAVIFNSQVRQNIEFIISKFTNKLIYFV
CCHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSSAIKPENEEFSYCRENNLSIKHRSEILAMLMRTYTALAVAGSHGKTSTSTFLSTILEL
HHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHH
CTRNSSSITGGIIPIYNSNCHLDNTKYLVAEVDESDGTINKYKSDIGIINNIDFDHCDHF
HCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHCCCCEEECCCHHHHHHH
SNLNEVISTFKSFAKNSKKLLLNFDCETSRNNFYSNWKWSNSTAKNVTYAIIPIEINSKY
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEECCCCCCCEEEEEEEEEECCEE
TIGKYYENGNFISSLNIPIPGLHNLSNITAAIAASRMIGVDFIEIKKNIKYLKLPKKRFE
EEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCEEECCHHHHH
FRGQLDERSLYDDYAHHPNEIKETIKLGRLLIQQNHNKECQKSRLIAIFQPHRYSRVKQF
HCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEECCCHHHHHHHH
TKEFAEELSKADVIYVTSIYGAGEGNEDRITSKIITDLIYKKNKNVSYINNYYEVTKNFY
HHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ELTQKGDLILNMGAGDCHNFWSILNKNN
HHHCCCCEEEECCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SALAIGLLKKGYSVSGSDLVKNDETNKLEKLGAVIFNSQVRQNIEFIISKFTNKLIYFV
CHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSSAIKPENEEFSYCRENNLSIKHRSEILAMLMRTYTALAVAGSHGKTSTSTFLSTILEL
HHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHH
CTRNSSSITGGIIPIYNSNCHLDNTKYLVAEVDESDGTINKYKSDIGIINNIDFDHCDHF
HCCCCCCCCCCEEEEECCCCCCCCCEEEEEEECCCCCCHHHHHCCCCEEECCCHHHHHHH
SNLNEVISTFKSFAKNSKKLLLNFDCETSRNNFYSNWKWSNSTAKNVTYAIIPIEINSKY
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEECCCCCCCEEEEEEEEEECCEE
TIGKYYENGNFISSLNIPIPGLHNLSNITAAIAASRMIGVDFIEIKKNIKYLKLPKKRFE
EEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCEEECCHHHHH
FRGQLDERSLYDDYAHHPNEIKETIKLGRLLIQQNHNKECQKSRLIAIFQPHRYSRVKQF
HCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEECCCHHHHHHHH
TKEFAEELSKADVIYVTSIYGAGEGNEDRITSKIITDLIYKKNKNVSYINNYYEVTKNFY
HHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ELTQKGDLILNMGAGDCHNFWSILNKNN
HHHCCCCEEEECCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]