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The map label for this gene is hymA [H]

Identifier: 126701028

GI number: 126701028

Start: 3983987

End: 3984484

Strand: Direct

Name: hymA [H]

Synonym: CD3405

Alternate gene names: 126701028

Gene position: 3983987-3984484 (Clockwise)

Preceding gene: 126701027

Following gene: 126701029

Centisome position: 92.86

GC content: 33.33

Gene sequence:

>498_bases
ATGTGCGATTTTATTTCACACAACAAGCAATTATTTGACGAACTAGATATATTTATTGACTCTCTTGCAACAAAGGAAGG
TGCGTTAATACAAGTTCTACATGAAGCCCAAGGTATATTTGGATATCTTCCAAAAGAAGTTCAACTTCATGTTGCTAGAA
AACTTGGAGTAGCTCCTGCAAAGGTATATGGGGTTGTTACATTCTATTCTTATTTTACTACAGAACCTGTAGGTAAGTAT
AAAATCAGTGTCTGTCTAGGAACTGTATGTTTTGTAAAAGGTGCTGACAAAATCTTAAGTGCTTTTGAAAAACAGCTTGG
CATAAAAGTTGGAGAAACTACTAGTGATTTTAAATTTTCTTTAGAAGGTTTAAGATGTTTGGGGGCATGTGGTTTAGCTC
CAGTTGTTACTGTAAATGGTAAAGTTTATGGTAAAGTGAAACCTGACCAAGTAAGCGAAATATTAGATACTTATAGAGAA
TTAGAATTGAATTGTTAA

Upstream 100 bases:

>100_bases
TTATTGTTTTGGTTTTGTTCACCCACATAATGTTGGGGTCAACTCATGGTTAATTATTTTATGAAAAATAATAACTTTAA
AAAGAAAAGGGGGATTTGTT

Downstream 100 bases:

>100_bases
GAGGGGTGAATAAATAATGCGTAAAGTAAATTCATTTGATGAATTAAAAGTTTTAGCTGATGAGCTGAAACCTAATCTTA
GCTTAAGAAAAAATTATTCT

Product: iron-only hydrogenase, electron-transferring subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MCDFISHNKQLFDELDIFIDSLATKEGALIQVLHEAQGIFGYLPKEVQLHVARKLGVAPAKVYGVVTFYSYFTTEPVGKY
KISVCLGTVCFVKGADKILSAFEKQLGIKVGETTSDFKFSLEGLRCLGACGLAPVVTVNGKVYGKVKPDQVSEILDTYRE
LELNC

Sequences:

>Translated_165_residues
MCDFISHNKQLFDELDIFIDSLATKEGALIQVLHEAQGIFGYLPKEVQLHVARKLGVAPAKVYGVVTFYSYFTTEPVGKY
KISVCLGTVCFVKGADKILSAFEKQLGIKVGETTSDFKFSLEGLRCLGACGLAPVVTVNGKVYGKVKPDQVSEILDTYRE
LELNC
>Mature_165_residues
MCDFISHNKQLFDELDIFIDSLATKEGALIQVLHEAQGIFGYLPKEVQLHVARKLGVAPAKVYGVVTFYSYFTTEPVGKY
KISVCLGTVCFVKGADKILSAFEKQLGIKVGETTSDFKFSLEGLRCLGACGLAPVVTVNGKVYGKVKPDQVSEILDTYRE
LELNC

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=132, Percent_Identity=45.4545454545455, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1788621, Length=133, Percent_Identity=34.5864661654135, Blast_Score=89, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17561328, Length=157, Percent_Identity=40.7643312101911, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18859877, Length=154, Percent_Identity=39.6103896103896, Blast_Score=116, Evalue=5e-27,
Organism=Drosophila melanogaster, GI21355353, Length=141, Percent_Identity=35.4609929078014, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18135; Mature: 18135

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCDFISHNKQLFDELDIFIDSLATKEGALIQVLHEAQGIFGYLPKEVQLHVARKLGVAPA
CCCCHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
KVYGVVTFYSYFTTEPVGKYKISVCLGTVCFVKGADKILSAFEKQLGIKVGETTSDFKFS
HHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHCCEECCCCCCHHHH
LEGLRCLGACGLAPVVTVNGKVYGKVKPDQVSEILDTYRELELNC
HHHHHHHHCCCCCEEEEECCEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MCDFISHNKQLFDELDIFIDSLATKEGALIQVLHEAQGIFGYLPKEVQLHVARKLGVAPA
CCCCHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
KVYGVVTFYSYFTTEPVGKYKISVCLGTVCFVKGADKILSAFEKQLGIKVGETTSDFKFS
HHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHCCEECCCCCCHHHH
LEGLRCLGACGLAPVVTVNGKVYGKVKPDQVSEILDTYRELELNC
HHHHHHHHCCCCCEEEEECCEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]