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The map label for this gene is hymB [H]

Identifier: 126701029

GI number: 126701029

Start: 3984501

End: 3986387

Strand: Direct

Name: hymB [H]

Synonym: CD3406

Alternate gene names: 126701029

Gene position: 3984501-3986387 (Clockwise)

Preceding gene: 126701028

Following gene: 126701030

Centisome position: 92.87

GC content: 34.98

Gene sequence:

>1887_bases
ATGCGTAAAGTAAATTCATTTGATGAATTAAAAGTTTTAGCTGATGAGCTGAAACCTAATCTTAGCTTAAGAAAAAATTA
TTCTAAGGAAAATGTATTAAGAAGAGAATTACTTGTTTGTTGTGATACTGGATGTACATCTTCAAACAGTCTAGAAATAG
TTAGTGAATTAGAAAATGAAATAAAGAAATCAGGAATCCAAGATAAAGTTAGTGTTCGTTTGACAGGTTGTTTTGGTTTC
TGTGCTCAAGGTCCTATTGTAAAAGTTTATCCTGATAACGTTTTCTACGTAAAAGTTGAGCCATCTGATGCTGAAAAGAT
AGTTCAAAGCCACTTAATTAGAAATACAGTTGTCGAGGAATTATTATATGAGGAAGAATCTTTAAGTAAAAAAGTTGAAG
AACAAGAAGAAATGTCTTTCTACAAAAAACAGTTACGTATAGCTTTAAAAAATTGTGGTCTTATAGACCCAGATAGTATA
GAAGAATATATTGCCAATGATGGTTATTTAGCTCTAGGCAAATGTTTAACTTCTCTTACTCCTCAAGAAGTTATTGCAGA
GGTAAAAACTTCTGGCCTTCGTGGTAGAGGTGGTGCAGGTTTCCCTACTGGCTCTAAATGGGAAGCTGCTTCAAAAAATC
CAGCTGGTCCAACAGATAAAAAGTTTGTTGTATGTAATGCTGATGAAGGTGACCCAGGTGCATTTATGGATAGATCTGTA
CTTGAAGGTGACCCTCATAGTGTACTAGAAGCTATGGCAATATGTGGATACGCTATAGGTTCTGATACAGGATACATATA
CATAAGAGCAGAATATCCAAAATCTATAGAAAGATTAAAAGTAGCCATAGCTCAAGCTGAAAAATACGGTTTACTTGGCG
AAAATATCTTAGGCACTGGATTTAACTTTAAATTAGAATTAAAATATGGTGCAGGTGCTTTCGTTTGTGGTGAAGGTACA
GCGCTAATGCATTCAATTGAAGGTAGACGTGGTGAACCTAGAATGAAAACTTATAGTTCTTCTAAGAGTGGTCTATGGAA
ATCTCCTACTTGCTTAAATAACGTTGAGACTTTTGCTAACATACCTGCAATTATACTTAAGGGTGGAGATTGGTTTGCCA
ACTTAGGTACTGAAGATTCTAGTGGTACTAAAGTCTTTGCTCTTGGTGGAAAAGTAGAAAATGTAGGACTTGTTGAAGTT
CCAATGGGTACTACTTTAAGAGATATTGTATTTGAAATTGGTGGGGGAATCCCTGAAGGTAAGAAATTTAAGGCTGTTCA
AACAGGTGGACCATCTGGCGGATGTATACCAACTGAACATTTAGACACTCCTATAGACTTTGGTTCATTAAGTTCTATCG
GTTCAATGATGGGCTCTGGTGGTATGCTTGTTCTTGATGAATCTGACTGTATGGTAGATATAGCCAAGTTCTTCCTTGAG
TTTACTGTTGAAGAATCTTGTGGTAAATGTACACCTTGTCGTATAGGTACTACAAGATTATTAGAAATATTAACTAAAAT
TACAGAAGGTAATGGTACTCTACAAGATTTAGATGACCTAGAAAACCTTGCTGAAACTATACAAACTGCTTCATTATGTG
GTCTTGGTAAAGCTGCTCCAAACCCTGTTTTAAGTACTCTTCAATATTTCAAAGATGAGTATATAGCTCATGTTGTAGAT
AAGAAATGTCCTGCTGGTAAATGTCAGAACTTACTTTCTTACTTTATAACAGATGACTGTAAGGGTTGTACAAAATGTTC
TAGAGTGTGTCCTGCTGGTTGTATAACAGGTTCTGTTAAGGAACAACATACAATAGATACTTCTAAGTGTCTAAAATGTG
GTGCTTGTATAGATAATTGTACATTTAACGCTATAATCAAGAAATAA

Upstream 100 bases:

>100_bases
AATGGTAAAGTTTATGGTAAAGTGAAACCTGACCAAGTAAGCGAAATATTAGATACTTATAGAGAATTAGAATTGAATTG
TTAAGAGGGGTGAATAAATA

Downstream 100 bases:

>100_bases
CTTATTTGGAGGAGGAATAACAATGAGTTTAGTTAATTTAACTATTAATGGCAAACACGTTTCAGCACCTAGTGGAACTT
CTATCTTAGATGCTGCGAAA

Product: iron-only hydrogenase, electron-transferring subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MRKVNSFDELKVLADELKPNLSLRKNYSKENVLRRELLVCCDTGCTSSNSLEIVSELENEIKKSGIQDKVSVRLTGCFGF
CAQGPIVKVYPDNVFYVKVEPSDAEKIVQSHLIRNTVVEELLYEEESLSKKVEEQEEMSFYKKQLRIALKNCGLIDPDSI
EEYIANDGYLALGKCLTSLTPQEVIAEVKTSGLRGRGGAGFPTGSKWEAASKNPAGPTDKKFVVCNADEGDPGAFMDRSV
LEGDPHSVLEAMAICGYAIGSDTGYIYIRAEYPKSIERLKVAIAQAEKYGLLGENILGTGFNFKLELKYGAGAFVCGEGT
ALMHSIEGRRGEPRMKTYSSSKSGLWKSPTCLNNVETFANIPAIILKGGDWFANLGTEDSSGTKVFALGGKVENVGLVEV
PMGTTLRDIVFEIGGGIPEGKKFKAVQTGGPSGGCIPTEHLDTPIDFGSLSSIGSMMGSGGMLVLDESDCMVDIAKFFLE
FTVEESCGKCTPCRIGTTRLLEILTKITEGNGTLQDLDDLENLAETIQTASLCGLGKAAPNPVLSTLQYFKDEYIAHVVD
KKCPAGKCQNLLSYFITDDCKGCTKCSRVCPAGCITGSVKEQHTIDTSKCLKCGACIDNCTFNAIIKK

Sequences:

>Translated_628_residues
MRKVNSFDELKVLADELKPNLSLRKNYSKENVLRRELLVCCDTGCTSSNSLEIVSELENEIKKSGIQDKVSVRLTGCFGF
CAQGPIVKVYPDNVFYVKVEPSDAEKIVQSHLIRNTVVEELLYEEESLSKKVEEQEEMSFYKKQLRIALKNCGLIDPDSI
EEYIANDGYLALGKCLTSLTPQEVIAEVKTSGLRGRGGAGFPTGSKWEAASKNPAGPTDKKFVVCNADEGDPGAFMDRSV
LEGDPHSVLEAMAICGYAIGSDTGYIYIRAEYPKSIERLKVAIAQAEKYGLLGENILGTGFNFKLELKYGAGAFVCGEGT
ALMHSIEGRRGEPRMKTYSSSKSGLWKSPTCLNNVETFANIPAIILKGGDWFANLGTEDSSGTKVFALGGKVENVGLVEV
PMGTTLRDIVFEIGGGIPEGKKFKAVQTGGPSGGCIPTEHLDTPIDFGSLSSIGSMMGSGGMLVLDESDCMVDIAKFFLE
FTVEESCGKCTPCRIGTTRLLEILTKITEGNGTLQDLDDLENLAETIQTASLCGLGKAAPNPVLSTLQYFKDEYIAHVVD
KKCPAGKCQNLLSYFITDDCKGCTKCSRVCPAGCITGSVKEQHTIDTSKCLKCGACIDNCTFNAIIKK
>Mature_628_residues
MRKVNSFDELKVLADELKPNLSLRKNYSKENVLRRELLVCCDTGCTSSNSLEIVSELENEIKKSGIQDKVSVRLTGCFGF
CAQGPIVKVYPDNVFYVKVEPSDAEKIVQSHLIRNTVVEELLYEEESLSKKVEEQEEMSFYKKQLRIALKNCGLIDPDSI
EEYIANDGYLALGKCLTSLTPQEVIAEVKTSGLRGRGGAGFPTGSKWEAASKNPAGPTDKKFVVCNADEGDPGAFMDRSV
LEGDPHSVLEAMAICGYAIGSDTGYIYIRAEYPKSIERLKVAIAQAEKYGLLGENILGTGFNFKLELKYGAGAFVCGEGT
ALMHSIEGRRGEPRMKTYSSSKSGLWKSPTCLNNVETFANIPAIILKGGDWFANLGTEDSSGTKVFALGGKVENVGLVEV
PMGTTLRDIVFEIGGGIPEGKKFKAVQTGGPSGGCIPTEHLDTPIDFGSLSSIGSMMGSGGMLVLDESDCMVDIAKFFLE
FTVEESCGKCTPCRIGTTRLLEILTKITEGNGTLQDLDDLENLAETIQTASLCGLGKAAPNPVLSTLQYFKDEYIAHVVD
KKCPAGKCQNLLSYFITDDCKGCTKCSRVCPAGCITGSVKEQHTIDTSKCLKCGACIDNCTFNAIIKK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=377, Percent_Identity=39.7877984084881, Blast_Score=280, Evalue=4e-75,
Organism=Homo sapiens, GI260656005, Length=377, Percent_Identity=39.7877984084881, Blast_Score=279, Evalue=5e-75,
Organism=Escherichia coli, GI1788620, Length=404, Percent_Identity=41.0891089108911, Blast_Score=335, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI17531727, Length=375, Percent_Identity=40.8, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI45550452, Length=370, Percent_Identity=39.4594594594595, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI19920794, Length=372, Percent_Identity=38.7096774193548, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24653819, Length=373, Percent_Identity=31.3672922252011, Blast_Score=199, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24653817, Length=333, Percent_Identity=30.03003003003, Blast_Score=171, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 67905; Mature: 67905

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00645 COMPLEX1_51K_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKVNSFDELKVLADELKPNLSLRKNYSKENVLRRELLVCCDTGCTSSNSLEIVSELENE
CCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
IKKSGIQDKVSVRLTGCFGFCAQGPIVKVYPDNVFYVKVEPSDAEKIVQSHLIRNTVVEE
HHHCCCCCEEEEEEEEEEHHHCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
LLYEEESLSKKVEEQEEMSFYKKQLRIALKNCGLIDPDSIEEYIANDGYLALGKCLTSLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHCCC
PQEVIAEVKTSGLRGRGGAGFPTGSKWEAASKNPAGPTDKKFVVCNADEGDPGAFMDRSV
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHCCHH
LEGDPHSVLEAMAICGYAIGSDTGYIYIRAEYPKSIERLKVAIAQAEKYGLLGENILGTG
HCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
FNFKLELKYGAGAFVCGEGTALMHSIEGRRGEPRMKTYSSSKSGLWKSPTCLNNVETFAN
CCEEEEEEECCCEEEECCCHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHC
IPAIILKGGDWFANLGTEDSSGTKVFALGGKVENVGLVEVPMGTTLRDIVFEIGGGIPEG
CCEEEEECCCEEEECCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCCCC
KKFKAVQTGGPSGGCIPTEHLDTPIDFGSLSSIGSMMGSGGMLVLDESDCMVDIAKFFLE
CCEEEEECCCCCCCCCCHHCCCCCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
FTVEESCGKCTPCRIGTTRLLEILTKITEGNGTLQDLDDLENLAETIQTASLCGLGKAAP
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
NPVLSTLQYFKDEYIAHVVDKKCPAGKCQNLLSYFITDDCKGCTKCSRVCPAGCITGSVK
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHCCCCCC
EQHTIDTSKCLKCGACIDNCTFNAIIKK
HHHCCCHHHHHHHCCHHHCCCCCCEECC
>Mature Secondary Structure
MRKVNSFDELKVLADELKPNLSLRKNYSKENVLRRELLVCCDTGCTSSNSLEIVSELENE
CCCCCCHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
IKKSGIQDKVSVRLTGCFGFCAQGPIVKVYPDNVFYVKVEPSDAEKIVQSHLIRNTVVEE
HHHCCCCCEEEEEEEEEEHHHCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
LLYEEESLSKKVEEQEEMSFYKKQLRIALKNCGLIDPDSIEEYIANDGYLALGKCLTSLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHCCC
PQEVIAEVKTSGLRGRGGAGFPTGSKWEAASKNPAGPTDKKFVVCNADEGDPGAFMDRSV
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHCCHH
LEGDPHSVLEAMAICGYAIGSDTGYIYIRAEYPKSIERLKVAIAQAEKYGLLGENILGTG
HCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
FNFKLELKYGAGAFVCGEGTALMHSIEGRRGEPRMKTYSSSKSGLWKSPTCLNNVETFAN
CCEEEEEEECCCEEEECCCHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHC
IPAIILKGGDWFANLGTEDSSGTKVFALGGKVENVGLVEVPMGTTLRDIVFEIGGGIPEG
CCEEEEECCCEEEECCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHCCCCCCC
KKFKAVQTGGPSGGCIPTEHLDTPIDFGSLSSIGSMMGSGGMLVLDESDCMVDIAKFFLE
CCEEEEECCCCCCCCCCHHCCCCCCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
FTVEESCGKCTPCRIGTTRLLEILTKITEGNGTLQDLDDLENLAETIQTASLCGLGKAAP
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
NPVLSTLQYFKDEYIAHVVDKKCPAGKCQNLLSYFITDDCKGCTKCSRVCPAGCITGSVK
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHCCCCCC
EQHTIDTSKCLKCGACIDNCTFNAIIKK
HHHCCCHHHHHHHCCHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]