Click here to switch to the map view.

The map label for this gene is sufS [H]

Identifier: 126700650

GI number: 126700650

Start: 3521949

End: 3523223

Strand: Direct

Name: sufS [H]

Synonym: CD3032

Alternate gene names: 126700650

Gene position: 3521949-3523223 (Clockwise)

Preceding gene: 126700637

Following gene: 126700652

Centisome position: 82.09

GC content: 29.8

Gene sequence:

>1275_bases
ATGCAATTCATAGATGTATCTAAATACATTGAAGGTGCAAACCTTAAAGTTAAAACTAAAAATGGTGAAACTGTTAAAAG
AATATATTTTAACAACTCTGCCACTCCATTAGTTTTAAAAAACGTAATGGATAACTTAAACTGTGAGATTCCTTGGCTTA
CTTATATTAATGCTCCAGGAATAATCTCAGAAAAAAATACTTTAAAATATGAAAATGTACGCTCTACTATCCTCAAACTT
ATTGATGGAGACGAAGAAAAGGATTCTGTTATTTATGTCAAAAATGCTACAGAAGGAATAAACTTCTTAGCAAAATTTTT
TAAAGATGAAAATCCAGATAAATTTGTTATTACCACAGCAATGGAGCATATGGCTAATTACCTGCCTTTTAAAGTTAATT
TTCCTACAAAAGTTGTTGGAATTACAGAAAAAGGAGAACTTGATTTATGTCAATTAGAGAATATACTTAAAAATTATGCT
GGTAATGTATCTCTCGTTACAGTTACAGGAGCTAGTAATGTCACAGGTATAACCACTCCTATATATGAAATAGCAAGAAT
AGCTCATAAGTATGGTGCAAAGATATTGGTGGATATTGTGCAAGTAATTCAGCATAAACCTTTTTCAATGATGCCACATG
AATGTGATGAGCATATAGATTTTGTTGTTTTTAGTGCTCATAAATGTTATTCTCCACTAAATGGAGGAGCTCTGGTAGGA
CCTAAAAAATTCTTTGAAAAATTTAATCCTGTACTATATGGCTCAGGTTCCACCAAATTTGTAAATGATAACAAAATACT
ATATGCAGACATACCCCAACGTTTTGAAGCAGGATACCCAGAGTATTTTGGAACTCTTGCAATGGGAAAAGCACTGAACA
CTTTAAATAAAATTGGTCTAAACAGAATTTCAAAATACGAAAGAGAATTATTTTTATATGTTAAAGAAGAAATGAGTAAA
ATACCTAATATAATAATATATGGAGATAAATCAAATAATGTAATTATCCCAAATATATCTTTTAATATAAGTAATATGTA
TTACAAAGATGTAGCAAAATATTTAGTTGATAACTTTGGAATAGAAACTGGAGCTGGAGTAGTAGGTGCAGATATTTATG
TACAAAAATTATTAGGTATAAGTCCAAAAGAAGCATATGTCAGATTTATGAGGGAAAATCCTGTAGGTCTTGTTAGGATA
AGCTTAGGAATGTACAATACTTTTGATGAGGTGGATAGCTTTATACATGCTATTAAAACTTTGGCTTTTAAATAA

Upstream 100 bases:

>100_bases
ACCCCTTATAAAAACATAACATATATTAAACAAGCTCTTGATTAAAACTTGAGCTTTTTTAATAAAAAACAGAATAGTTT
ATTAGATAAGGGGTTTTTTT

Downstream 100 bases:

>100_bases
GTTTTTTCTATTCTTTTTTATCAATAAATAGAGAGTAGTTTTGTTTTCACAAAAAAGCAAATTATATCAACAGTCAATTT
CATTAGCAATTAGACACTCA

Product: aminotransferase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MQFIDVSKYIEGANLKVKTKNGETVKRIYFNNSATPLVLKNVMDNLNCEIPWLTYINAPGIISEKNTLKYENVRSTILKL
IDGDEEKDSVIYVKNATEGINFLAKFFKDENPDKFVITTAMEHMANYLPFKVNFPTKVVGITEKGELDLCQLENILKNYA
GNVSLVTVTGASNVTGITTPIYEIARIAHKYGAKILVDIVQVIQHKPFSMMPHECDEHIDFVVFSAHKCYSPLNGGALVG
PKKFFEKFNPVLYGSGSTKFVNDNKILYADIPQRFEAGYPEYFGTLAMGKALNTLNKIGLNRISKYERELFLYVKEEMSK
IPNIIIYGDKSNNVIIPNISFNISNMYYKDVAKYLVDNFGIETGAGVVGADIYVQKLLGISPKEAYVRFMRENPVGLVRI
SLGMYNTFDEVDSFIHAIKTLAFK

Sequences:

>Translated_424_residues
MQFIDVSKYIEGANLKVKTKNGETVKRIYFNNSATPLVLKNVMDNLNCEIPWLTYINAPGIISEKNTLKYENVRSTILKL
IDGDEEKDSVIYVKNATEGINFLAKFFKDENPDKFVITTAMEHMANYLPFKVNFPTKVVGITEKGELDLCQLENILKNYA
GNVSLVTVTGASNVTGITTPIYEIARIAHKYGAKILVDIVQVIQHKPFSMMPHECDEHIDFVVFSAHKCYSPLNGGALVG
PKKFFEKFNPVLYGSGSTKFVNDNKILYADIPQRFEAGYPEYFGTLAMGKALNTLNKIGLNRISKYERELFLYVKEEMSK
IPNIIIYGDKSNNVIIPNISFNISNMYYKDVAKYLVDNFGIETGAGVVGADIYVQKLLGISPKEAYVRFMRENPVGLVRI
SLGMYNTFDEVDSFIHAIKTLAFK
>Mature_424_residues
MQFIDVSKYIEGANLKVKTKNGETVKRIYFNNSATPLVLKNVMDNLNCEIPWLTYINAPGIISEKNTLKYENVRSTILKL
IDGDEEKDSVIYVKNATEGINFLAKFFKDENPDKFVITTAMEHMANYLPFKVNFPTKVVGITEKGELDLCQLENILKNYA
GNVSLVTVTGASNVTGITTPIYEIARIAHKYGAKILVDIVQVIQHKPFSMMPHECDEHIDFVVFSAHKCYSPLNGGALVG
PKKFFEKFNPVLYGSGSTKFVNDNKILYADIPQRFEAGYPEYFGTLAMGKALNTLNKIGLNRISKYERELFLYVKEEMSK
IPNIIIYGDKSNNVIIPNISFNISNMYYKDVAKYLVDNFGIETGAGVVGADIYVQKLLGISPKEAYVRFMRENPVGLVRI
SLGMYNTFDEVDSFIHAIKTLAFK

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787970, Length=368, Percent_Identity=30.4347826086957, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1789175, Length=361, Percent_Identity=23.8227146814404, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=403, Percent_Identity=26.0545905707196, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6319831, Length=205, Percent_Identity=28.2926829268293, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 47780; Mature: 47780

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFIDVSKYIEGANLKVKTKNGETVKRIYFNNSATPLVLKNVMDNLNCEIPWLTYINAPG
CCEECHHHHHCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCC
IISEKNTLKYENVRSTILKLIDGDEEKDSVIYVKNATEGINFLAKFFKDENPDKFVITTA
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEHHH
MEHMANYLPFKVNFPTKVVGITEKGELDLCQLENILKNYAGNVSLVTVTGASNVTGITTP
HHHHHHHCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHH
IYEIARIAHKYGAKILVDIVQVIQHKPFSMMPHECDEHIDFVVFSAHKCYSPLNGGALVG
HHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEECHHHCCCCCCCEEEC
PKKFFEKFNPVLYGSGSTKFVNDNKILYADIPQRFEAGYPEYFGTLAMGKALNTLNKIGL
HHHHHHHCCCEEECCCCCEEECCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NRISKYERELFLYVKEEMSKIPNIIIYGDKSNNVIIPNISFNISNMYYKDVAKYLVDNFG
HHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEECEEEEECHHHHHHHHHHHHHHCC
IETGAGVVGADIYVQKLLGISPKEAYVRFMRENPVGLVRISLGMYNTFDEVDSFIHAIKT
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH
LAFK
HHCC
>Mature Secondary Structure
MQFIDVSKYIEGANLKVKTKNGETVKRIYFNNSATPLVLKNVMDNLNCEIPWLTYINAPG
CCEECHHHHHCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCC
IISEKNTLKYENVRSTILKLIDGDEEKDSVIYVKNATEGINFLAKFFKDENPDKFVITTA
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEEEHHH
MEHMANYLPFKVNFPTKVVGITEKGELDLCQLENILKNYAGNVSLVTVTGASNVTGITTP
HHHHHHHCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHH
IYEIARIAHKYGAKILVDIVQVIQHKPFSMMPHECDEHIDFVVFSAHKCYSPLNGGALVG
HHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEECHHHCCCCCCCEEEC
PKKFFEKFNPVLYGSGSTKFVNDNKILYADIPQRFEAGYPEYFGTLAMGKALNTLNKIGL
HHHHHHHCCCEEECCCCCEEECCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NRISKYERELFLYVKEEMSKIPNIIIYGDKSNNVIIPNISFNISNMYYKDVAKYLVDNFG
HHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEECEEEEECHHHHHHHHHHHHHHCC
IETGAGVVGADIYVQKLLGISPKEAYVRFMRENPVGLVRISLGMYNTFDEVDSFIHAIKT
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH
LAFK
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA