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The map label for this gene is mtaD [H]

Identifier: 126700319

GI number: 126700319

Start: 3127142

End: 3128506

Strand: Direct

Name: mtaD [H]

Synonym: CD2705

Alternate gene names: 126700319

Gene position: 3127142-3128506 (Clockwise)

Preceding gene: 126700318

Following gene: 126700325

Centisome position: 72.89

GC content: 31.06

Gene sequence:

>1365_bases
ATGTCACAATTACTTATAAAAAATGCATATCTAATTACTATGAATGCAGATAGAGAGGTATATGAAAATGGAAGCATACT
TATTGAAAATAATATTATAAAAGAGGTTGGTAAGTTTGATATTAATATTGTAGATAAAGATGCAGAGATATATGATGCTA
AAGGAAAAATACTAATGCCAGGGCTAGTCAATACGCATGTTCACTTATCTCAACAATTAGGACGTGGTCTTGCAGATGAT
GTTGTACTTTTAACTTGGCTTAGAGAGAGAATTTGGCCATACGAAAGTAGCTTCAATTATGAAGATTCCTTGATTTCATC
TACTGCATGTTGTGTTGAATTGATAAAATCTGGTGTCACTACATTTTTAGAATCTGGTGGTCAATATGTAGATGCTATGG
TTGAGGCTGTTGATAAAACTGGACTTAGAGCCTGTTTAGCTAAATCAGTTATGGATACAGGAGATGGTCTTCCTGAGGCA
TGGCAAAAAACTACTGATGAGGAAATCAATACTCAATTAGACTTATTCCATAAGTTTAATAATACATCTAATGAGAGAAT
TAAAATATGGTTTGCATTAAGAACTATTTTTAATACAACTGAAGAATTACTTGTTAGAACTAAAGAACTAGCTGATAAAT
ACAATACAGGTATACATATGCATATTGCTGAAATAGCTGATGAAATTTCATTTGTAAAGCAAAACAATGGAGTTGGAACA
GTTGAATACCTTGATAAACTAGGTGTATTAGGACCAAATCTTTTAGCTGCTCATACAGTTTGGCTTACTCATAAGGAAAT
TGATTTATTTAGATTACATGATGTAAAAGTTTCTCATGACCCAGGTTCAGCTATGAAAGTGGTTCTAGGATTTGCATCAA
TTCCTGAAATGTTAGAAAAAGGAATACCTGTTTCAATTGGTACTGATGGAGCTCCTTCAAATAATAGAATGGACCTTATG
AGGGACATGTATCTTACATCACTAATACATAAAGGAAGAACTTTAAACCCAACTGTCGTACCAGCTGAAGAAGTCTTAGA
AATGGCTACTATAAATGGAGCAAAATGTGCTTTACTAGAAAAAGAAATTGGTAGTCTTGAAGTAGGAAAAAAAGCTGATA
TGATTATTCTAAATCCAGATACAATTCATTGTTTACCAATGCATAATCCAATTGGAAATATAGTTTATTCTATGACTAGT
GAAAATGTAGACTCTACTATTTGTGATGGTAAATGGTTGATGAAGGAAAGAAAAGTATTAGTTGTAGATGAATCTGAATT
ATTAAATAAAGTTAAAAAACAAGCTTCTAAAATAAAAGATAAAGCAGAAGTTAAAATTCCATCTAAATTTAAAATTATAA
AATAA

Upstream 100 bases:

>100_bases
AATCACTTTATATGTAAATTGATTTTGCTATTAACTTTGTATAGAAAATTTATTATCATAATATATAGATATAAAAATAT
ATAGAAAAGGAGTGGTGTTT

Downstream 100 bases:

>100_bases
CATAAATTTCAATTGTTTTGTAAATATGAATATATAAATATATTTATATACATCATATATACAAAACAATTGTTTTTTTA
TTTTATATTCATTAGCATTG

Product: amidohydrolas

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSQLLIKNAYLITMNADREVYENGSILIENNIIKEVGKFDINIVDKDAEIYDAKGKILMPGLVNTHVHLSQQLGRGLADD
VVLLTWLRERIWPYESSFNYEDSLISSTACCVELIKSGVTTFLESGGQYVDAMVEAVDKTGLRACLAKSVMDTGDGLPEA
WQKTTDEEINTQLDLFHKFNNTSNERIKIWFALRTIFNTTEELLVRTKELADKYNTGIHMHIAEIADEISFVKQNNGVGT
VEYLDKLGVLGPNLLAAHTVWLTHKEIDLFRLHDVKVSHDPGSAMKVVLGFASIPEMLEKGIPVSIGTDGAPSNNRMDLM
RDMYLTSLIHKGRTLNPTVVPAEEVLEMATINGAKCALLEKEIGSLEVGKKADMIILNPDTIHCLPMHNPIGNIVYSMTS
ENVDSTICDGKWLMKERKVLVVDESELLNKVKKQASKIKDKAEVKIPSKFKIIK

Sequences:

>Translated_454_residues
MSQLLIKNAYLITMNADREVYENGSILIENNIIKEVGKFDINIVDKDAEIYDAKGKILMPGLVNTHVHLSQQLGRGLADD
VVLLTWLRERIWPYESSFNYEDSLISSTACCVELIKSGVTTFLESGGQYVDAMVEAVDKTGLRACLAKSVMDTGDGLPEA
WQKTTDEEINTQLDLFHKFNNTSNERIKIWFALRTIFNTTEELLVRTKELADKYNTGIHMHIAEIADEISFVKQNNGVGT
VEYLDKLGVLGPNLLAAHTVWLTHKEIDLFRLHDVKVSHDPGSAMKVVLGFASIPEMLEKGIPVSIGTDGAPSNNRMDLM
RDMYLTSLIHKGRTLNPTVVPAEEVLEMATINGAKCALLEKEIGSLEVGKKADMIILNPDTIHCLPMHNPIGNIVYSMTS
ENVDSTICDGKWLMKERKVLVVDESELLNKVKKQASKIKDKAEVKIPSKFKIIK
>Mature_453_residues
SQLLIKNAYLITMNADREVYENGSILIENNIIKEVGKFDINIVDKDAEIYDAKGKILMPGLVNTHVHLSQQLGRGLADDV
VLLTWLRERIWPYESSFNYEDSLISSTACCVELIKSGVTTFLESGGQYVDAMVEAVDKTGLRACLAKSVMDTGDGLPEAW
QKTTDEEINTQLDLFHKFNNTSNERIKIWFALRTIFNTTEELLVRTKELADKYNTGIHMHIAEIADEISFVKQNNGVGTV
EYLDKLGVLGPNLLAAHTVWLTHKEIDLFRLHDVKVSHDPGSAMKVVLGFASIPEMLEKGIPVSIGTDGAPSNNRMDLMR
DMYLTSLIHKGRTLNPTVVPAEEVLEMATINGAKCALLEKEIGSLEVGKKADMIILNPDTIHCLPMHNPIGNIVYSMTSE
NVDSTICDGKWLMKERKVLVVDESELLNKVKKQASKIKDKAEVKIPSKFKIIK

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=332, Percent_Identity=29.2168674698795, Blast_Score=136, Evalue=5e-32,
Organism=Escherichia coli, GI1789249, Length=371, Percent_Identity=27.4932614555256, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI87082177, Length=452, Percent_Identity=24.1150442477876, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6319963, Length=393, Percent_Identity=22.64631043257, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24643849, Length=395, Percent_Identity=24.0506329113924, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 50672; Mature: 50541

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLLIKNAYLITMNADREVYENGSILIENNIIKEVGKFDINIVDKDAEIYDAKGKILMP
CCCEEEECEEEEEECCCCHHHCCCCEEEECHHHHHHCCCEEEEEECCCEEEECCCCEECC
GLVNTHVHLSQQLGRGLADDVVLLTWLRERIWPYESSFNYEDSLISSTACCVELIKSGVT
CHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TFLESGGQYVDAMVEAVDKTGLRACLAKSVMDTGDGLPEAWQKTTDEEINTQLDLFHKFN
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHC
NTSNERIKIWFALRTIFNTTEELLVRTKELADKYNTGIHMHIAEIADEISFVKQNNGVGT
CCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCH
VEYLDKLGVLGPNLLAAHTVWLTHKEIDLFRLHDVKVSHDPGSAMKVVLGFASIPEMLEK
HHHHHHHCCCCCCHHHHEEEEEEECCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHC
GIPVSIGTDGAPSNNRMDLMRDMYLTSLIHKGRTLNPTVVPAEEVLEMATINGAKCALLE
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEH
KEIGSLEVGKKADMIILNPDTIHCLPMHNPIGNIVYSMTSENVDSTICDGKWLMKERKVL
HHCCCCCCCCCCCEEEECCCEEEEEECCCCHHHHEEEECCCCCCCHHCCCHHHHCCCCEE
VVDESELLNKVKKQASKIKDKAEVKIPSKFKIIK
EECHHHHHHHHHHHHHHCCCCCEEECCCCEEECC
>Mature Secondary Structure 
SQLLIKNAYLITMNADREVYENGSILIENNIIKEVGKFDINIVDKDAEIYDAKGKILMP
CCEEEECEEEEEECCCCHHHCCCCEEEECHHHHHHCCCEEEEEECCCEEEECCCCEECC
GLVNTHVHLSQQLGRGLADDVVLLTWLRERIWPYESSFNYEDSLISSTACCVELIKSGVT
CHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TFLESGGQYVDAMVEAVDKTGLRACLAKSVMDTGDGLPEAWQKTTDEEINTQLDLFHKFN
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHC
NTSNERIKIWFALRTIFNTTEELLVRTKELADKYNTGIHMHIAEIADEISFVKQNNGVGT
CCCCCEEEEEEEHHHHHCCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCH
VEYLDKLGVLGPNLLAAHTVWLTHKEIDLFRLHDVKVSHDPGSAMKVVLGFASIPEMLEK
HHHHHHHCCCCCCHHHHEEEEEEECCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHC
GIPVSIGTDGAPSNNRMDLMRDMYLTSLIHKGRTLNPTVVPAEEVLEMATINGAKCALLE
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEH
KEIGSLEVGKKADMIILNPDTIHCLPMHNPIGNIVYSMTSENVDSTICDGKWLMKERKVL
HHCCCCCCCCCCCEEEECCCEEEEEECCCCHHHHEEEECCCCCCCHHCCCHHHHCCCCEE
VVDESELLNKVKKQASKIKDKAEVKIPSKFKIIK
EECHHHHHHHHHHHHHHCCCCCEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA