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The map label for this gene is thlA2 [H]

Identifier: 126700290

GI number: 126700290

Start: 3092064

End: 3093242

Strand: Direct

Name: thlA2 [H]

Synonym: CD2676

Alternate gene names: 126700290

Gene position: 3092064-3093242 (Clockwise)

Preceding gene: 126700288

Following gene: 126700291

Centisome position: 72.07

GC content: 35.79

Gene sequence:

>1179_bases
ATGAAAGATGTAGTAATCGTATCAGCAGTCAGAACACCTATAGGAAGTTTTGGAGGTGTATTTAAAAATACTTCAGCTGT
TCAACTTGGAACTATCGCTGTTAAAGAAGCGATATCACGTGTAGGACTTAATTTATCTGAAATAGATGAAGTAATAATTG
GAAATGTTCTTCAAACAGGGCTTGGACAGAATGTTGCTAGACAAATTGCTATAAATGCAGGTATACCAAATTCTGTTCCA
AGCTACACAGTAAATAAATTATGTGGTTCAGGGCTTAAAAGTGTCCAGCTAGCTGCCCAATCAATCACATCTGGTGAAAA
TGATGTGGTAATTGCAGGTGGTACTGAAAATATGAGTCAAGCTCCTTATATCGTTCCAACTGCTCGCTTTGGTAGTAAAA
TGGGTAACATAACCATGGTAGATAGTATGCTAACAGATGGCCTTATTGATGCTTTCAATCAGTATCATATGGGAATAACT
GCAGAAAATATTGCAACTAAATTTGAATTTACTAGAGAAATGCAAGATAAATTGGCATTAGAAAGTCAAAATAAGGCTGA
GAATGCTATAAAAAACAACCGCTTTAAAGAAGAAATCGTTCCAGTAGATGTTTTAATACGTCGAGGAAAAATAGAAACTA
TTGATAAAGATGAATATCCTAAATTAGGTATGACATTTGAAGGTTTATCTAAACTTAAACCTGCATTCAAAAAAGATGGT
ACTGTAACAGCTGGAAATGCCTCAGGTATTAATGATGGTGCGGCTATGTTAATACTAATGAGCCAACAAAAAGCAGACGA
ACTAGGTATTAGACCACTTGCTAAAATAAAATCCTATGCTTCAGCTGGTGTTGAACCTGAAGTCATGGGTACTGGTCCAA
TCCCTGCAACTAGAAAAGCACTGAAAAAAGCTGGACTTAGCATCAATGATATAGACTTAATAGAAGCAAATGAAGCGTTT
GCTGCCCAAGCATTAGCTGTTAAAAATGAACTTCAAATAGATTCATCAAAGTTAAATGTTAATGGTGGTGCAATAGCATT
AGGACATCCAATAGGAGCAAGTGGAGCTAGAATACTTGTTACCTTAATTTATGAAATGCAAAAACGTAAAGTTGAAACTG
GACTTGCAACACTTTGTATTGGTGGTGGTCAAGGAATATCAATGGTGGTTTCACGATAG

Upstream 100 bases:

>100_bases
AAAAACAAGCTTGTATTAAAAAAGTACTTTATTATAGTGTTCCCTAATTTCTTTATTCAGAAAATTTTTAATTATCATTC
AAGAAAGGTAACTATTAGAT

Downstream 100 bases:

>100_bases
GAGGAAATATGAATAAAATAGTTAGCATTGATGAAGCTCTATCTCATGTAAAAGATGGAGATACAATAATGGTTGGTGGA
TTCATGGCCAATGGTTCACC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKDVVIVSAVRTPIGSFGGVFKNTSAVQLGTIAVKEAISRVGLNLSEIDEVIIGNVLQTGLGQNVARQIAINAGIPNSVP
SYTVNKLCGSGLKSVQLAAQSITSGENDVVIAGGTENMSQAPYIVPTARFGSKMGNITMVDSMLTDGLIDAFNQYHMGIT
AENIATKFEFTREMQDKLALESQNKAENAIKNNRFKEEIVPVDVLIRRGKIETIDKDEYPKLGMTFEGLSKLKPAFKKDG
TVTAGNASGINDGAAMLILMSQQKADELGIRPLAKIKSYASAGVEPEVMGTGPIPATRKALKKAGLSINDIDLIEANEAF
AAQALAVKNELQIDSSKLNVNGGAIALGHPIGASGARILVTLIYEMQKRKVETGLATLCIGGGQGISMVVSR

Sequences:

>Translated_392_residues
MKDVVIVSAVRTPIGSFGGVFKNTSAVQLGTIAVKEAISRVGLNLSEIDEVIIGNVLQTGLGQNVARQIAINAGIPNSVP
SYTVNKLCGSGLKSVQLAAQSITSGENDVVIAGGTENMSQAPYIVPTARFGSKMGNITMVDSMLTDGLIDAFNQYHMGIT
AENIATKFEFTREMQDKLALESQNKAENAIKNNRFKEEIVPVDVLIRRGKIETIDKDEYPKLGMTFEGLSKLKPAFKKDG
TVTAGNASGINDGAAMLILMSQQKADELGIRPLAKIKSYASAGVEPEVMGTGPIPATRKALKKAGLSINDIDLIEANEAF
AAQALAVKNELQIDSSKLNVNGGAIALGHPIGASGARILVTLIYEMQKRKVETGLATLCIGGGQGISMVVSR
>Mature_392_residues
MKDVVIVSAVRTPIGSFGGVFKNTSAVQLGTIAVKEAISRVGLNLSEIDEVIIGNVLQTGLGQNVARQIAINAGIPNSVP
SYTVNKLCGSGLKSVQLAAQSITSGENDVVIAGGTENMSQAPYIVPTARFGSKMGNITMVDSMLTDGLIDAFNQYHMGIT
AENIATKFEFTREMQDKLALESQNKAENAIKNNRFKEEIVPVDVLIRRGKIETIDKDEYPKLGMTFEGLSKLKPAFKKDG
TVTAGNASGINDGAAMLILMSQQKADELGIRPLAKIKSYASAGVEPEVMGTGPIPATRKALKKAGLSINDIDLIEANEAF
AAQALAVKNELQIDSSKLNVNGGAIALGHPIGASGARILVTLIYEMQKRKVETGLATLCIGGGQGISMVVSR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=52.4296675191816, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI167614485, Length=391, Percent_Identity=45.7800511508951, Blast_Score=357, Evalue=9e-99,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=42.7480916030534, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=42.4242424242424, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=32.3943661971831, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=30.2564102564103, Blast_Score=152, Evalue=4e-37,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=54.8469387755102, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=60.0508905852417, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=44, Blast_Score=323, Evalue=9e-90,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=42, Blast_Score=291, Evalue=3e-80,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=32.2738386308068, Blast_Score=198, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=45.9183673469388, Blast_Score=353, Evalue=8e-98,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=43.0025445292621, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=39.7959183673469, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=32.0843091334895, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=33.502538071066, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=45.959595959596, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=38.7341772151899, Blast_Score=232, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=52.8061224489796, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=43.9897698209719, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=43.4782608695652, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=30.7511737089202, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41376; Mature: 41376

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVVIVSAVRTPIGSFGGVFKNTSAVQLGTIAVKEAISRVGLNLSEIDEVIIGNVLQTG
CCCEEEEEEHHCCCHHHCCHHCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
LGQNVARQIAINAGIPNSVPSYTVNKLCGSGLKSVQLAAQSITSGENDVVIAGGTENMSQ
CCHHHHHHEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCC
APYIVPTARFGSKMGNITMVDSMLTDGLIDAFNQYHMGITAENIATKFEFTREMQDKLAL
CCEEEEEHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHH
ESQNKAENAIKNNRFKEEIVPVDVLIRRGKIETIDKDEYPKLGMTFEGLSKLKPAFKKDG
CCCHHHHHHHHCCCHHHHHCCHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHCHHHHCCC
TVTAGNASGINDGAAMLILMSQQKADELGIRPLAKIKSYASAGVEPEVMGTGPIPATRKA
CEEECCCCCCCCCEEEEEEECCCCHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHH
LKKAGLSINDIDLIEANEAFAAQALAVKNELQIDSSKLNVNGGAIALGHPIGASGARILV
HHHCCCCCCCEEEEECCHHHHHHHHHHHHHHEECCCEEEECCCEEEECCCCCCCCHHHHH
TLIYEMQKRKVETGLATLCIGGGQGISMVVSR
HHHHHHHHHHHHCCEEEEEECCCCCCEEEECC
>Mature Secondary Structure
MKDVVIVSAVRTPIGSFGGVFKNTSAVQLGTIAVKEAISRVGLNLSEIDEVIIGNVLQTG
CCCEEEEEEHHCCCHHHCCHHCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
LGQNVARQIAINAGIPNSVPSYTVNKLCGSGLKSVQLAAQSITSGENDVVIAGGTENMSQ
CCHHHHHHEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCCCCCC
APYIVPTARFGSKMGNITMVDSMLTDGLIDAFNQYHMGITAENIATKFEFTREMQDKLAL
CCEEEEEHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHH
ESQNKAENAIKNNRFKEEIVPVDVLIRRGKIETIDKDEYPKLGMTFEGLSKLKPAFKKDG
CCCHHHHHHHHCCCHHHHHCCHHHHEECCCCCCCCCCCCCCCCCCHHHHHHHCHHHHCCC
TVTAGNASGINDGAAMLILMSQQKADELGIRPLAKIKSYASAGVEPEVMGTGPIPATRKA
CEEECCCCCCCCCEEEEEEECCCCHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHH
LKKAGLSINDIDLIEANEAFAAQALAVKNELQIDSSKLNVNGGAIALGHPIGASGARILV
HHHCCCCCCCEEEEECCHHHHHHHHHHHHHHEECCCEEEECCCEEEECCCCCCCCHHHHH
TLIYEMQKRKVETGLATLCIGGGQGISMVVSR
HHHHHHHHHHHHCCEEEEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]