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The map label for this gene is tcyP [H]

Identifier: 126700158

GI number: 126700158

Start: 2937222

End: 2938610

Strand: Direct

Name: tcyP [H]

Synonym: CD2541

Alternate gene names: 126700158

Gene position: 2937222-2938610 (Clockwise)

Preceding gene: 126700156

Following gene: 126700170

Centisome position: 68.46

GC content: 30.31

Gene sequence:

>1389_bases
TTGGAAAGTTCATTTTTATCACAATTTCTTATGATTACAGATTTTAAAACAATTTTTTTCATAATATTACTTCTAGGTAC
GTTCTTTATTGTTAGACAATTTGAAAAGAAAAAAATAAAATTTTCATTGAGAACAATATATGCTACAGTACTAGGACTCA
TATTGGGAATCATAATACAAGCTTTTGCTGGTTTTCCTAATGATACAACTCAAGTCACTTGGCTACAAGAAGTAAGTAAG
TGGTATAGCCTATTTGGTTCTGGATTTATGGACTTATTAAAAATGTTAGTAGTACCTTTAGTTTTCTTATCCATTATAAA
AGTAATTATAAATATGAAAGATAACAATCTTGGAACTCTGACATTTAAATCTTTAGGTATGCTTCTTGCTACTACTGCTA
TAGCTGCAATTGTTGGAATTATCGTTGCAAATATAATGAAGTTAGGTGTAGGAGCTAATATGCCTACTTTAGTTGAAAAT
CAAGAACTTAAAGAAATAAACTCTCTTGTGGATACTTTAAGAGGATTACTACCATCTAATCCTGTAATGGCTATGGCAAA
TGGAAATATTGTAGCTACAATAATATTTGCTACATTTATAGCTACCTCAATAAAGAGATTAAGTAAAAAACATTTTGAGA
CAATAAAACCATTTATAGATTTTATAGAAGCATCTTACAAAATAATTGTAAGTGTGTCTATGACTGTTATTAAATTTATG
CCTTATGCTGTGGTTGCTCTGCTTGCAAATACAATAACTTCACAAGGTATTAGTTCAATAGTATCTGTTTTACAGTTTAT
AGTAGCTCTTTATATATCAGTTGCAATATTATTTATTATACATTTAATTTTTATAACTTTAAATGGTCTAAATCCCATTA
CTTATATAAAAAATTCAACTGAAGCTTTACTTCTGGCATTTACTTCACGTTCTAGTTTAGGAACATTGCCTGTAACGATA
GAAAGTCTAGTACAAAATCACGGAGTTGATGAGGGTGTATCAAGCTTTACAGCAAGTTTAGGTGCAAATATGGGTATGAA
TGGTTGTGCAGGTATATATCCTGCTTTAATGGCTGTAACACTTGCCAATATGGCTGGAGTAAACATGGATATGAGCTTTT
ATGTTATGTTGTTAATTGTTATAACAATTAGTTCATTTGGAATAGCTGGGCTTCCAGGAACTGCTACAATGGCCGTTTCA
GTTGTTATCTCTGGAGTTGGTCTTGGTTCTTATTTTCCATTAGTTGGTGGTATACTTGCAATAGACCCTATACTAGATAT
GGGACGTACTATGATAAATGTTAATGGTGCTATGGTATCATCAATTACTGTAGGAAAATCACTTGGAAAAATAGATAAAG
AAGTATTTAGTAAAAAAAATATTTCTTAG

Upstream 100 bases:

>100_bases
CTCTATTTAAGTAAATTGTGATATAATATTGACATTTTTTTAATATATTGATATCATTTAAACTTAGAAAAATTTATTTT
TAAATAAAAGGAGAAAAATA

Downstream 100 bases:

>100_bases
AATAACACTCAAAATAAATGGCTAACTTTTTACCAGTTAGCCATTTATTTTATCAGAAAACTTTTTTAGAAATTTACTCA
CAAAACGGAAAAAATTCTTT

Product: sodium:dicarboxylate symporter family protein

Products: NA

Alternate protein names: Transporter of cystine tcyP [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MESSFLSQFLMITDFKTIFFIILLLGTFFIVRQFEKKKIKFSLRTIYATVLGLILGIIIQAFAGFPNDTTQVTWLQEVSK
WYSLFGSGFMDLLKMLVVPLVFLSIIKVIINMKDNNLGTLTFKSLGMLLATTAIAAIVGIIVANIMKLGVGANMPTLVEN
QELKEINSLVDTLRGLLPSNPVMAMANGNIVATIIFATFIATSIKRLSKKHFETIKPFIDFIEASYKIIVSVSMTVIKFM
PYAVVALLANTITSQGISSIVSVLQFIVALYISVAILFIIHLIFITLNGLNPITYIKNSTEALLLAFTSRSSLGTLPVTI
ESLVQNHGVDEGVSSFTASLGANMGMNGCAGIYPALMAVTLANMAGVNMDMSFYVMLLIVITISSFGIAGLPGTATMAVS
VVISGVGLGSYFPLVGGILAIDPILDMGRTMINVNGAMVSSITVGKSLGKIDKEVFSKKNIS

Sequences:

>Translated_462_residues
MESSFLSQFLMITDFKTIFFIILLLGTFFIVRQFEKKKIKFSLRTIYATVLGLILGIIIQAFAGFPNDTTQVTWLQEVSK
WYSLFGSGFMDLLKMLVVPLVFLSIIKVIINMKDNNLGTLTFKSLGMLLATTAIAAIVGIIVANIMKLGVGANMPTLVEN
QELKEINSLVDTLRGLLPSNPVMAMANGNIVATIIFATFIATSIKRLSKKHFETIKPFIDFIEASYKIIVSVSMTVIKFM
PYAVVALLANTITSQGISSIVSVLQFIVALYISVAILFIIHLIFITLNGLNPITYIKNSTEALLLAFTSRSSLGTLPVTI
ESLVQNHGVDEGVSSFTASLGANMGMNGCAGIYPALMAVTLANMAGVNMDMSFYVMLLIVITISSFGIAGLPGTATMAVS
VVISGVGLGSYFPLVGGILAIDPILDMGRTMINVNGAMVSSITVGKSLGKIDKEVFSKKNIS
>Mature_462_residues
MESSFLSQFLMITDFKTIFFIILLLGTFFIVRQFEKKKIKFSLRTIYATVLGLILGIIIQAFAGFPNDTTQVTWLQEVSK
WYSLFGSGFMDLLKMLVVPLVFLSIIKVIINMKDNNLGTLTFKSLGMLLATTAIAAIVGIIVANIMKLGVGANMPTLVEN
QELKEINSLVDTLRGLLPSNPVMAMANGNIVATIIFATFIATSIKRLSKKHFETIKPFIDFIEASYKIIVSVSMTVIKFM
PYAVVALLANTITSQGISSIVSVLQFIVALYISVAILFIIHLIFITLNGLNPITYIKNSTEALLLAFTSRSSLGTLPVTI
ESLVQNHGVDEGVSSFTASLGANMGMNGCAGIYPALMAVTLANMAGVNMDMSFYVMLLIVITISSFGIAGLPGTATMAVS
VVISGVGLGSYFPLVGGILAIDPILDMGRTMINVNGAMVSSITVGKSLGKIDKEVFSKKNIS

Specific function: Mediates uptake of L-cystine, the oxidized form of L- cysteine [H]

COG id: COG1823

COG function: function code R; Predicted Na+/dicarboxylate symporter

Gene ontology:

Cell location: Membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=411, Percent_Identity=23.3576642335766, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI21314632, Length=418, Percent_Identity=26.3157894736842, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI66773030, Length=450, Percent_Identity=24.4444444444444, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI194239697, Length=224, Percent_Identity=28.125, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI169790839, Length=457, Percent_Identity=24.0700218818381, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI4827012, Length=371, Percent_Identity=25.6064690026954, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI5032093, Length=377, Percent_Identity=25.4641909814324, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI223468564, Length=252, Percent_Identity=26.1904761904762, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI223468566, Length=262, Percent_Identity=27.0992366412214, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI301601644, Length=123, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI262359914, Length=394, Percent_Identity=23.0964467005076, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788024, Length=458, Percent_Identity=30.7860262008734, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1790514, Length=434, Percent_Identity=27.8801843317972, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789947, Length=390, Percent_Identity=25.1282051282051, Blast_Score=118, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71983106, Length=464, Percent_Identity=24.5689655172414, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71983099, Length=464, Percent_Identity=24.5689655172414, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI193206505, Length=456, Percent_Identity=25.6578947368421, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71996953, Length=457, Percent_Identity=24.2888402625821, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17537407, Length=430, Percent_Identity=24.1860465116279, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI193206654, Length=460, Percent_Identity=22.3913043478261, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583025, Length=454, Percent_Identity=25.9911894273128, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17137668, Length=454, Percent_Identity=25.9911894273128, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24583023, Length=454, Percent_Identity=25.9911894273128, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 49748; Mature: 49748

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA