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The map label for this gene is elaC

Identifier: 126700156

GI number: 126700156

Start: 2934488

End: 2935405

Strand: Direct

Name: elaC

Synonym: CD2539

Alternate gene names: 126700156

Gene position: 2934488-2935405 (Clockwise)

Preceding gene: 126700145

Following gene: 126700158

Centisome position: 68.4

GC content: 29.63

Gene sequence:

>918_bases
ATGATAGATTTAACTTTACTTGGATGTGGTGGAAATGTACCTATGCCAAACAGATTTCTATCCTCTGTATTTATAAACTA
TAAAGGTAGAAAAATACTAATTGACTGTGGTGAAGGTACTCAGGTATCTATGAAGCTAAAAAAATGTGGCTTTAAAGATA
TAGACTTGATTTGTATAACCCATTTACATGGTGACCATATATTTGGACTTTTAGGACTTTTATCAACAATTGGGAATAGT
GGTCGTACAAGTGATTTAACTATAGTTGGTCCAGTTGGAATAGTCGATTGTATACGTTCTATGAGAAATTTAGTAGAATA
TGTACCATACACTTTAAAAATTATAGAAAACCCTCAAGGCAATTTTTCTTTAGATAATAAAGTTTTAAGAAATTTAGAAA
TTTCAACAATCAGTTTAGAACACTCTATAGAGTGTTTAGGATACAGTTTTAATTTTAGAAGAAACCCTAAATTTGATATA
GATAAGGCAACTAAAAACGAAGTTCCTAAAATATTATGGAACAAACTCCAAGAAGGTCAAAATATAGTTTTAGATTCAAA
ACAATACACTCCAGATATGGTCTTAGGAGAATTGAGAAAGGGAGTTAAGATAAGTCTTACAACCGATACAAGACCTATAG
AATCAATACCAGATTTCATAAAAGATAGTGATTTATTTATATGTGAAGCCATGTATGGTGATGATTTAGATATATCAAAA
GCTGTTAGAAACAAACATATGACTTTTAGAGAAGCTGCTAATCTTGCAAAACTTGGAAATGTCAAACAACTTTTACTGAC
TCATTTTAGTCCTTCTTTAGACATACCTAGTATGTATTTAGAAAATGCTACTAATGTTTTTGAAAATACTATTCTTGGAG
AAGATAGATTAAGCTTGCGTTTAAATTTTGATGAATAA

Upstream 100 bases:

>100_bases
AATACACATTTATTGTTATATTTAATGTTAAAATAATTATAATAGGATATCATAATAAAAACAAACAACAGATTTGTGTT
AATTTTAGAAAGGGGAAAAA

Downstream 100 bases:

>100_bases
TTTAATGGAATCCTTATTTCTAAAAATTTGGAATAAAAATTTGGAATAAAAATTTAGGAATGAATTTTACCATGATAAAA
ATAGTTTAGGTAAATTCATT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIDLTLLGCGGNVPMPNRFLSSVFINYKGRKILIDCGEGTQVSMKLKKCGFKDIDLICITHLHGDHIFGLLGLLSTIGNS
GRTSDLTIVGPVGIVDCIRSMRNLVEYVPYTLKIIENPQGNFSLDNKVLRNLEISTISLEHSIECLGYSFNFRRNPKFDI
DKATKNEVPKILWNKLQEGQNIVLDSKQYTPDMVLGELRKGVKISLTTDTRPIESIPDFIKDSDLFICEAMYGDDLDISK
AVRNKHMTFREAANLAKLGNVKQLLLTHFSPSLDIPSMYLENATNVFENTILGEDRLSLRLNFDE

Sequences:

>Translated_305_residues
MIDLTLLGCGGNVPMPNRFLSSVFINYKGRKILIDCGEGTQVSMKLKKCGFKDIDLICITHLHGDHIFGLLGLLSTIGNS
GRTSDLTIVGPVGIVDCIRSMRNLVEYVPYTLKIIENPQGNFSLDNKVLRNLEISTISLEHSIECLGYSFNFRRNPKFDI
DKATKNEVPKILWNKLQEGQNIVLDSKQYTPDMVLGELRKGVKISLTTDTRPIESIPDFIKDSDLFICEAMYGDDLDISK
AVRNKHMTFREAANLAKLGNVKQLLLTHFSPSLDIPSMYLENATNVFENTILGEDRLSLRLNFDE
>Mature_305_residues
MIDLTLLGCGGNVPMPNRFLSSVFINYKGRKILIDCGEGTQVSMKLKKCGFKDIDLICITHLHGDHIFGLLGLLSTIGNS
GRTSDLTIVGPVGIVDCIRSMRNLVEYVPYTLKIIENPQGNFSLDNKVLRNLEISTISLEHSIECLGYSFNFRRNPKFDI
DKATKNEVPKILWNKLQEGQNIVLDSKQYTPDMVLGELRKGVKISLTTDTRPIESIPDFIKDSDLFICEAMYGDDLDISK
AVRNKHMTFREAANLAKLGNVKQLLLTHFSPSLDIPSMYLENATNVFENTILGEDRLSLRLNFDE

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=329, Percent_Identity=31.306990881459, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI87082078, Length=307, Percent_Identity=31.5960912052117, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_CLOD6 (Q182M7)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001089053.1
- ProteinModelPortal:   Q182M7
- SMR:   Q182M7
- STRING:   Q182M7
- GeneID:   4913436
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD2539
- NMPDR:   fig|1496.1.peg.2114
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   WLTHFSP
- ProtClustDB:   PRK00055
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34276; Mature: 34276

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLTLLGCGGNVPMPNRFLSSVFINYKGRKILIDCGEGTQVSMKLKKCGFKDIDLICIT
CEEEEEECCCCCCCCCHHHHHHHHEECCCCEEEEECCCCCEEEEEHHHCCCCCCEEEEEE
HLHGDHIFGLLGLLSTIGNSGRTSDLTIVGPVGIVDCIRSMRNLVEYVPYTLKIIENPQG
EECCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCEEEEEEECCCC
NFSLDNKVLRNLEISTISLEHSIECLGYSFNFRRNPKFDIDKATKNEVPKILWNKLQEGQ
CCCCCHHHHHCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
NIVLDSKQYTPDMVLGELRKGVKISLTTDTRPIESIPDFIKDSDLFICEAMYGDDLDISK
EEEEECCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHH
AVRNKHMTFREAANLAKLGNVKQLLLTHFSPSLDIPSMYLENATNVFENTILGEDRLSLR
HHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
LNFDE
EECCC
>Mature Secondary Structure
MIDLTLLGCGGNVPMPNRFLSSVFINYKGRKILIDCGEGTQVSMKLKKCGFKDIDLICIT
CEEEEEECCCCCCCCCHHHHHHHHEECCCCEEEEECCCCCEEEEEHHHCCCCCCEEEEEE
HLHGDHIFGLLGLLSTIGNSGRTSDLTIVGPVGIVDCIRSMRNLVEYVPYTLKIIENPQG
EECCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCEEEEEEECCCC
NFSLDNKVLRNLEISTISLEHSIECLGYSFNFRRNPKFDIDKATKNEVPKILWNKLQEGQ
CCCCCHHHHHCCCEEEEEECCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
NIVLDSKQYTPDMVLGELRKGVKISLTTDTRPIESIPDFIKDSDLFICEAMYGDDLDISK
EEEEECCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHH
AVRNKHMTFREAANLAKLGNVKQLLLTHFSPSLDIPSMYLENATNVFENTILGEDRLSLR
HHHHHCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEE
LNFDE
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA