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The map label for this gene is thrB [H]

Identifier: 126699736

GI number: 126699736

Start: 2453135

End: 2454037

Strand: Direct

Name: thrB [H]

Synonym: CD2119

Alternate gene names: 126699736

Gene position: 2453135-2454037 (Clockwise)

Preceding gene: 126699735

Following gene: 126699737

Centisome position: 57.18

GC content: 29.46

Gene sequence:

>903_bases
GTGATTATTATGTTAGAGATTATAGTTCCTGCAACAAGTGCTAATATAGGTCCAGGATTTGATTGTCTTGGAATTGCGTT
AAATATATACAATAAATTTTATGTTGAAGAAATTGAAAGTGGTCTTGAAATAGAAGGTTGTGAAGATGCTTACAAAAACG
AAAATAACTTAGTTTATACATCTATGAAGTACTTTTTTGATAGAGTTAAACCAGAAAAAATACCTGCTGGTATCAAAATA
AAAATCCAAAGTGAAGTACCTATATGTAGAGGTCTTGGCAGTAGTGCCTCTTGTATAGTAGCTGGAGTTATAGCTGCAAA
TGCTCTATCAGGTGCTAATTTAGATAAAAATCAATTACTAAATATAGCTTCAGAAATAGAAGGTCACCCAGATAATGTTG
CTCCTGCTATTTTAGGAAATATGATTGTATCTGTTACTGATAATGAGAATATACATTATGATATTATAAAAATTCCTGAA
GAACTTAAATTTTGTGCAATGATACCTAATTTTAAGTTATCAACAGAAAAAGCTAGAGGTGTTTTACCAAAGGAAATACC
ATATTCTGATGGGGTATTCAATGTTAGTAGAGTTGCTTTACTAATATCTGCCTTACTAAACAAAAACTTTGACCTACTTA
AAGTAGCTTGTCAAGACAAATTGCATCAAGATTATAGAGGAACTCTAATTGAGAACTACAATGATATTGTTGAAAAATCT
GAACAATTAAATAGTATTGGAGTATTTTTAAGTGGAGCTGGACCTACTATAATGTCTTTAATAAAAGAAAATGATGATAG
TTTTGTGGATAATATGAAAAATTACCTACAAAAACTAAAATCTGATTGGGAAATAAAAGAGTTATGTTGCGATTCTAATG
GAGCTGTTTTAAATATAATATAA

Upstream 100 bases:

>100_bases
AAAACCTATTAAAAATCTTAAAAATGCAGAAATACTACATAAAGATATTTATGAAAAAGATGAATTAAAACTAGCTATAA
AAAAATTCTTAAAGGTATAG

Downstream 100 bases:

>100_bases
TTATCGTCTTCTATACAAAATATAACTACTCTTTTATTATAATTTGTAGTATAATAATTAGGACTAGGTAATAATATTAA
GTATTATAATCTAGTTCTTT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MIIMLEIIVPATSANIGPGFDCLGIALNIYNKFYVEEIESGLEIEGCEDAYKNENNLVYTSMKYFFDRVKPEKIPAGIKI
KIQSEVPICRGLGSSASCIVAGVIAANALSGANLDKNQLLNIASEIEGHPDNVAPAILGNMIVSVTDNENIHYDIIKIPE
ELKFCAMIPNFKLSTEKARGVLPKEIPYSDGVFNVSRVALLISALLNKNFDLLKVACQDKLHQDYRGTLIENYNDIVEKS
EQLNSIGVFLSGAGPTIMSLIKENDDSFVDNMKNYLQKLKSDWEIKELCCDSNGAVLNII

Sequences:

>Translated_300_residues
MIIMLEIIVPATSANIGPGFDCLGIALNIYNKFYVEEIESGLEIEGCEDAYKNENNLVYTSMKYFFDRVKPEKIPAGIKI
KIQSEVPICRGLGSSASCIVAGVIAANALSGANLDKNQLLNIASEIEGHPDNVAPAILGNMIVSVTDNENIHYDIIKIPE
ELKFCAMIPNFKLSTEKARGVLPKEIPYSDGVFNVSRVALLISALLNKNFDLLKVACQDKLHQDYRGTLIENYNDIVEKS
EQLNSIGVFLSGAGPTIMSLIKENDDSFVDNMKNYLQKLKSDWEIKELCCDSNGAVLNII
>Mature_300_residues
MIIMLEIIVPATSANIGPGFDCLGIALNIYNKFYVEEIESGLEIEGCEDAYKNENNLVYTSMKYFFDRVKPEKIPAGIKI
KIQSEVPICRGLGSSASCIVAGVIAANALSGANLDKNQLLNIASEIEGHPDNVAPAILGNMIVSVTDNENIHYDIIKIPE
ELKFCAMIPNFKLSTEKARGVLPKEIPYSDGVFNVSRVALLISALLNKNFDLLKVACQDKLHQDYRGTLIENYNDIVEKS
EQLNSIGVFLSGAGPTIMSLIKENDDSFVDNMKNYLQKLKSDWEIKELCCDSNGAVLNII

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=314, Percent_Identity=28.343949044586, Blast_Score=114, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6321814, Length=350, Percent_Identity=32.2857142857143, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33028; Mature: 33028

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIMLEIIVPATSANIGPGFDCLGIALNIYNKFYVEEIESGLEIEGCEDAYKNENNLVYT
CEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEE
SMKYFFDRVKPEKIPAGIKIKIQSEVPICRGLGSSASCIVAGVIAANALSGANLDKNQLL
HHHHHHHHCCCCCCCCCEEEEEECCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHH
NIASEIEGHPDNVAPAILGNMIVSVTDNENIHYDIIKIPEELKFCAMIPNFKLSTEKARG
HHHHHCCCCCCCHHHHHHCCEEEEEECCCCEEEEEEECCCHHHHHHCCCCCEECCHHHCC
VLPKEIPYSDGVFNVSRVALLISALLNKNFDLLKVACQDKLHQDYRGTLIENYNDIVEKS
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
EQLNSIGVFLSGAGPTIMSLIKENDDSFVDNMKNYLQKLKSDWEIKELCCDSNGAVLNII
HHHCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEC
>Mature Secondary Structure
MIIMLEIIVPATSANIGPGFDCLGIALNIYNKFYVEEIESGLEIEGCEDAYKNENNLVYT
CEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEE
SMKYFFDRVKPEKIPAGIKIKIQSEVPICRGLGSSASCIVAGVIAANALSGANLDKNQLL
HHHHHHHHCCCCCCCCCEEEEEECCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHH
NIASEIEGHPDNVAPAILGNMIVSVTDNENIHYDIIKIPEELKFCAMIPNFKLSTEKARG
HHHHHCCCCCCCHHHHHHCCEEEEEECCCCEEEEEEECCCHHHHHHCCCCCEECCHHHCC
VLPKEIPYSDGVFNVSRVALLISALLNKNFDLLKVACQDKLHQDYRGTLIENYNDIVEKS
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
EQLNSIGVFLSGAGPTIMSLIKENDDSFVDNMKNYLQKLKSDWEIKELCCDSNGAVLNII
HHHCCEEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA