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The map label for this gene is thrC [H]

Identifier: 126699735

GI number: 126699735

Start: 2451653

End: 2453134

Strand: Direct

Name: thrC [H]

Synonym: CD2118

Alternate gene names: 126699735

Gene position: 2451653-2453134 (Clockwise)

Preceding gene: 126699733

Following gene: 126699736

Centisome position: 57.14

GC content: 26.11

Gene sequence:

>1482_bases
ATGTATTATTCAAGTACGAGAGGCACCGAAGAAAAAGTAACTGCATCACAAGCAATAATAAAAGGAATATCAAATGATGG
TGGTCTTTATGTTCCAAGTGAATTTCCCAATGTAAAAAATGAACTTATAAATTTAGTAAATTTAACGTATTCTCAGATAG
CATTTTTTGTACTTAGTAAATTTTTATGTGATTTTACTGAAGATGAAATTAAAAATTGTATAGAAAATGCATATGATGAA
AAGTTTGATTGTAGTAGTATAGCTCCATTAAATAAAGTAAATGATACTTATTTCTTAGAACTATATCACGGTCCAACTTT
AGCATTTAAAGATATGGCACTTACTATAATGCCTCATCTTCTTAAAACATCTATAAAGAAAGATAATTTAGAGAAAGATG
TTGTGATTCTTACTGCTACATCTGGAGATACAGGTAAAGCTGCACTTGAGGGATTTAAAGATATAGATAAAATAAAGATA
ATTGTATTCTTCCCAGAAGATGGTGTAAGCCCAGTACAAAAACTTCAAATGAAAACTCAAACTGGAAAAAATACATATGT
AGTTGGTATAAAAGGAAATTTTGATGATGCACAATCAGGTGTAAAGAAGATTTTTTCTGATAAAGAATTTAATCAAAAAC
TATTGGATAATAATTATATATTATCTTCTGCAAATTCAATTAATATAGGAAGACTTCTTCCACAAGTTGCATACTATTTT
TATTCATATATGAAATTAGTTAGCAATAGTGATATAAATTTAAATGATAAAATAAATTTTGTTGTCCCAACTGGTAATTT
TGGTAATATTCTAGCTGGATATTATGCCAAACAAATGGGTCTTCCAATAAACAAATTGATATGTGCATCAAATGATAATA
ATGTTCTTTATGATTTCTTTAAAACTGGTGTATATGATAAAAATAGAACATTGAAATTAACTACTTCTCCTTCTATGGAT
ATATTAATTTCAAGTAATTTAGAACGATTACTGTTTGAAATATCAAATAGAAATACTGATATTGTAAATAAGCTTTTATC
AGACCTTAGTGATAAAGGAGTCTACAAAATAAGTGATGATATGGAAAAAAATTTAGCCTCATTCTATGGAGAATATTCAA
ATGAAGAAGAAGTTAAAAGCACGATAAACAATGTGTTTAAAAATTATAATTATTTGATAGATACTCATACTGCTGTTGCA
TACAATTGTTATGAAAAATATAAAAAAGAAACTTCTGATAACACAAAAACTGTTATTGTAAGTACTGCAAGTCCATTCAA
GTTTTCTGAAGATGTTCTAAAGTCTATAGATTGTGATTTTAAAGACCTTGATGACTTTGCTATAATTGATAGATTATCAA
GTATTTCTAAAATAGATATTCCAAAACCTATTAAAAATCTTAAAAATGCAGAAATACTACATAAAGATATTTATGAAAAA
GATGAATTAAAACTAGCTATAAAAAAATTCTTAAAGGTATAG

Upstream 100 bases:

>100_bases
TGAGGGTCTTTTTTTATTACCTAAATTCAGTTTTTAAAATATTCTGTATCTAATTTAATTAGCTAATTAAAAATTTAAAA
TATATGGAGGATTATAAAAA

Downstream 100 bases:

>100_bases
GTGATTATTATGTTAGAGATTATAGTTCCTGCAACAAGTGCTAATATAGGTCCAGGATTTGATTGTCTTGGAATTGCGTT
AAATATATACAATAAATTTT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MYYSSTRGTEEKVTASQAIIKGISNDGGLYVPSEFPNVKNELINLVNLTYSQIAFFVLSKFLCDFTEDEIKNCIENAYDE
KFDCSSIAPLNKVNDTYFLELYHGPTLAFKDMALTIMPHLLKTSIKKDNLEKDVVILTATSGDTGKAALEGFKDIDKIKI
IVFFPEDGVSPVQKLQMKTQTGKNTYVVGIKGNFDDAQSGVKKIFSDKEFNQKLLDNNYILSSANSINIGRLLPQVAYYF
YSYMKLVSNSDINLNDKINFVVPTGNFGNILAGYYAKQMGLPINKLICASNDNNVLYDFFKTGVYDKNRTLKLTTSPSMD
ILISSNLERLLFEISNRNTDIVNKLLSDLSDKGVYKISDDMEKNLASFYGEYSNEEEVKSTINNVFKNYNYLIDTHTAVA
YNCYEKYKKETSDNTKTVIVSTASPFKFSEDVLKSIDCDFKDLDDFAIIDRLSSISKIDIPKPIKNLKNAEILHKDIYEK
DELKLAIKKFLKV

Sequences:

>Translated_493_residues
MYYSSTRGTEEKVTASQAIIKGISNDGGLYVPSEFPNVKNELINLVNLTYSQIAFFVLSKFLCDFTEDEIKNCIENAYDE
KFDCSSIAPLNKVNDTYFLELYHGPTLAFKDMALTIMPHLLKTSIKKDNLEKDVVILTATSGDTGKAALEGFKDIDKIKI
IVFFPEDGVSPVQKLQMKTQTGKNTYVVGIKGNFDDAQSGVKKIFSDKEFNQKLLDNNYILSSANSINIGRLLPQVAYYF
YSYMKLVSNSDINLNDKINFVVPTGNFGNILAGYYAKQMGLPINKLICASNDNNVLYDFFKTGVYDKNRTLKLTTSPSMD
ILISSNLERLLFEISNRNTDIVNKLLSDLSDKGVYKISDDMEKNLASFYGEYSNEEEVKSTINNVFKNYNYLIDTHTAVA
YNCYEKYKKETSDNTKTVIVSTASPFKFSEDVLKSIDCDFKDLDDFAIIDRLSSISKIDIPKPIKNLKNAEILHKDIYEK
DELKLAIKKFLKV
>Mature_493_residues
MYYSSTRGTEEKVTASQAIIKGISNDGGLYVPSEFPNVKNELINLVNLTYSQIAFFVLSKFLCDFTEDEIKNCIENAYDE
KFDCSSIAPLNKVNDTYFLELYHGPTLAFKDMALTIMPHLLKTSIKKDNLEKDVVILTATSGDTGKAALEGFKDIDKIKI
IVFFPEDGVSPVQKLQMKTQTGKNTYVVGIKGNFDDAQSGVKKIFSDKEFNQKLLDNNYILSSANSINIGRLLPQVAYYF
YSYMKLVSNSDINLNDKINFVVPTGNFGNILAGYYAKQMGLPINKLICASNDNNVLYDFFKTGVYDKNRTLKLTTSPSMD
ILISSNLERLLFEISNRNTDIVNKLLSDLSDKGVYKISDDMEKNLASFYGEYSNEEEVKSTINNVFKNYNYLIDTHTAVA
YNCYEKYKKETSDNTKTVIVSTASPFKFSEDVLKSIDCDFKDLDDFAIIDRLSSISKIDIPKPIKNLKNAEILHKDIYEK
DELKLAIKKFLKV

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=444, Percent_Identity=41.6666666666667, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI149193323, Length=443, Percent_Identity=30.9255079006772, Blast_Score=234, Evalue=2e-61,
Organism=Escherichia coli, GI1786185, Length=426, Percent_Identity=31.6901408450704, Blast_Score=188, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6319901, Length=461, Percent_Identity=34.9240780911063, Blast_Score=279, Evalue=7e-76,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 55782; Mature: 55782

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYYSSTRGTEEKVTASQAIIKGISNDGGLYVPSEFPNVKNELINLVNLTYSQIAFFVLSK
CCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FLCDFTEDEIKNCIENAYDEKFDCSSIAPLNKVNDTYFLELYHGPTLAFKDMALTIMPHL
HHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
LKTSIKKDNLEKDVVILTATSGDTGKAALEGFKDIDKIKIIVFFPEDGVSPVQKLQMKTQ
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHC
TGKNTYVVGIKGNFDDAQSGVKKIFSDKEFNQKLLDNNYILSSANSINIGRLLPQVAYYF
CCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
YSYMKLVSNSDINLNDKINFVVPTGNFGNILAGYYAKQMGLPINKLICASNDNNVLYDFF
HHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHEEEECCCCCEEHHHH
KTGVYDKNRTLKLTTSPSMDILISSNLERLLFEISNRNTDIVNKLLSDLSDKGVYKISDD
HCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEECHH
MEKNLASFYGEYSNEEEVKSTINNVFKNYNYLIDTHTAVAYNCYEKYKKETSDNTKTVIV
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEE
STASPFKFSEDVLKSIDCDFKDLDDFAIIDRLSSISKIDIPKPIKNLKNAEILHKDIYEK
ECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHCCH
DELKLAIKKFLKV
HHHHHHHHHHHCC
>Mature Secondary Structure
MYYSSTRGTEEKVTASQAIIKGISNDGGLYVPSEFPNVKNELINLVNLTYSQIAFFVLSK
CCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FLCDFTEDEIKNCIENAYDEKFDCSSIAPLNKVNDTYFLELYHGPTLAFKDMALTIMPHL
HHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHH
LKTSIKKDNLEKDVVILTATSGDTGKAALEGFKDIDKIKIIVFFPEDGVSPVQKLQMKTQ
HHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHC
TGKNTYVVGIKGNFDDAQSGVKKIFSDKEFNQKLLDNNYILSSANSINIGRLLPQVAYYF
CCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
YSYMKLVSNSDINLNDKINFVVPTGNFGNILAGYYAKQMGLPINKLICASNDNNVLYDFF
HHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHEEEECCCCCEEHHHH
KTGVYDKNRTLKLTTSPSMDILISSNLERLLFEISNRNTDIVNKLLSDLSDKGVYKISDD
HCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEECHH
MEKNLASFYGEYSNEEEVKSTINNVFKNYNYLIDTHTAVAYNCYEKYKKETSDNTKTVIV
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEEE
STASPFKFSEDVLKSIDCDFKDLDDFAIIDRLSSISKIDIPKPIKNLKNAEILHKDIYEK
ECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHCCH
DELKLAIKKFLKV
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]