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The map label for this gene is comEC [H]

Identifier: 126699539

GI number: 126699539

Start: 2228308

End: 2229465

Strand: Direct

Name: comEC [H]

Synonym: CD1930

Alternate gene names: 126699539

Gene position: 2228308-2229465 (Clockwise)

Preceding gene: 126699538

Following gene: 126699559

Centisome position: 51.94

GC content: 29.27

Gene sequence:

>1158_bases
GTGATAGAAATAAGTATAAAAAATAAAAAAAATTCTAAAATTAAAACTTTGATACTTTTATTGATAGTATCTATATCGAT
TTATTTAACTGGTTGTACTACATCAGATAATGGAAATAATCAATCAAATAATAATGATTCTTTGTCTAGTAGTATATCAA
GTGATAAGAATGTAAAAATTCATTTTATTGACACTGGAAATAGTGATGCAATATTGATTCAAGATGGTAAAACTTTTACA
TTGATAGATGGGGGAGATAATGATGATGAGGGATTAATGGTAGATTACCTAAACAATCAAGGTGTAAAAGATATTAAATA
TCTTATAGCTACCCATTCTCATGCAGACCATTTAGGTGGACTTGATTCTGTTGTCAAAAACTTTAATATAGAAAATGTTT
TTGTATCGAATGGTTCAGCAGAAACAAAGAGTTATAGGGACTTTATAAATGCTTTAGCAAATAAGGGTTTATCCCCAAGT
GTACCGCTTGAAAATAATAAGTTCTATTTAGAAGATTCTTATTTTGAAGTTCTAAATACAAATGGGGGAGATACTACTAA
TGAACAATCTCTAGTCCTTGTATATACTAATGGGAATGATAAAGTTTTATTTACAGGTGATGCTGAAGAAGGTACCGAAA
AAGAAATACTACCTAAGCTTGAGAAAGTAGACCTTTTAAAAGTAGCTCATCATGGTTCTCGTAGTAGTTCATCTCAAGAG
TTTTTAGATAAAGTAAATCCTGAATATGCGGTTCTTTTAGTAGGCAAGGGTAATTCATATGGTCATCCACATCAGGAGAC
AATGAATAAATTAAAAAAAATGGGAGTAAAAGTACATAGAAGTGATGAGTGTTCAGATATAATATTTGAATCAACAGGTG
ATGGAGTATTTACAAGTTGTAAAGATGGAAGTTATAATAAAGGCGTTAGAGAAGATGGAAACTCTGGAAAATCAAACAGT
AATACAAGTAAAAATGATTCTTTTAAAAATAAACAAAATACATCCAATTCAGAAGAAATAGTGTATTTTACTCCAAAAGG
TAAGAGTTATCACTCTACAAAAAATTGTAGTGGGCTTTCAAGAAGTAAAAAAATATTATCAGGCACAATTGCAGAAAGTA
AGAAAAATGACCCATGTGATATATGTTATGGAAAATAA

Upstream 100 bases:

>100_bases
GTACTATAATCTATTATTTAAAATATTATGTAAAAAAATATCATAAAAACGCATATCATGTTATAATTACTAGAGTATTA
TGAATATGGAGGCGTAGTTT

Downstream 100 bases:

>100_bases
CAAAAAAACAACCAATTTATCTATAAAGCTTCTGAACTTTAAATCATTTAAAAAATAAAATAAATGCATAAAAAAATAAG
CTATAATCAATAGATAACAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MIEISIKNKKNSKIKTLILLLIVSISIYLTGCTTSDNGNNQSNNNDSLSSSISSDKNVKIHFIDTGNSDAILIQDGKTFT
LIDGGDNDDEGLMVDYLNNQGVKDIKYLIATHSHADHLGGLDSVVKNFNIENVFVSNGSAETKSYRDFINALANKGLSPS
VPLENNKFYLEDSYFEVLNTNGGDTTNEQSLVLVYTNGNDKVLFTGDAEEGTEKEILPKLEKVDLLKVAHHGSRSSSSQE
FLDKVNPEYAVLLVGKGNSYGHPHQETMNKLKKMGVKVHRSDECSDIIFESTGDGVFTSCKDGSYNKGVREDGNSGKSNS
NTSKNDSFKNKQNTSNSEEIVYFTPKGKSYHSTKNCSGLSRSKKILSGTIAESKKNDPCDICYGK

Sequences:

>Translated_385_residues
MIEISIKNKKNSKIKTLILLLIVSISIYLTGCTTSDNGNNQSNNNDSLSSSISSDKNVKIHFIDTGNSDAILIQDGKTFT
LIDGGDNDDEGLMVDYLNNQGVKDIKYLIATHSHADHLGGLDSVVKNFNIENVFVSNGSAETKSYRDFINALANKGLSPS
VPLENNKFYLEDSYFEVLNTNGGDTTNEQSLVLVYTNGNDKVLFTGDAEEGTEKEILPKLEKVDLLKVAHHGSRSSSSQE
FLDKVNPEYAVLLVGKGNSYGHPHQETMNKLKKMGVKVHRSDECSDIIFESTGDGVFTSCKDGSYNKGVREDGNSGKSNS
NTSKNDSFKNKQNTSNSEEIVYFTPKGKSYHSTKNCSGLSRSKKILSGTIAESKKNDPCDICYGK
>Mature_385_residues
MIEISIKNKKNSKIKTLILLLIVSISIYLTGCTTSDNGNNQSNNNDSLSSSISSDKNVKIHFIDTGNSDAILIQDGKTFT
LIDGGDNDDEGLMVDYLNNQGVKDIKYLIATHSHADHLGGLDSVVKNFNIENVFVSNGSAETKSYRDFINALANKGLSPS
VPLENNKFYLEDSYFEVLNTNGGDTTNEQSLVLVYTNGNDKVLFTGDAEEGTEKEILPKLEKVDLLKVAHHGSRSSSSQE
FLDKVNPEYAVLLVGKGNSYGHPHQETMNKLKKMGVKVHRSDECSDIIFESTGDGVFTSCKDGSYNKGVREDGNSGKSNS
NTSKNDSFKNKQNTSNSEEIVYFTPKGKSYHSTKNCSGLSRSKKILSGTIAESKKNDPCDICYGK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 42124; Mature: 42124

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEISIKNKKNSKIKTLILLLIVSISIYLTGCTTSDNGNNQSNNNDSLSSSISSDKNVKI
CEEEEECCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCEEE
HFIDTGNSDAILIQDGKTFTLIDGGDNDDEGLMVDYLNNQGVKDIKYLIATHSHADHLGG
EEEECCCCCEEEEECCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHCCC
LDSVVKNFNIENVFVSNGSAETKSYRDFINALANKGLSPSVPLENNKFYLEDSYFEVLNT
HHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEEC
NGGDTTNEQSLVLVYTNGNDKVLFTGDAEEGTEKEILPKLEKVDLLKVAHHGSRSSSSQE
CCCCCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
FLDKVNPEYAVLLVGKGNSYGHPHQETMNKLKKMGVKVHRSDECSDIIFESTGDGVFTSC
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEECCCCCCEEEEECCCCCEEEEC
KDGSYNKGVREDGNSGKSNSNTSKNDSFKNKQNTSNSEEIVYFTPKGKSYHSTKNCSGLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCH
RSKKILSGTIAESKKNDPCDICYGK
HHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MIEISIKNKKNSKIKTLILLLIVSISIYLTGCTTSDNGNNQSNNNDSLSSSISSDKNVKI
CEEEEECCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCHHHHHCCCCCCEEE
HFIDTGNSDAILIQDGKTFTLIDGGDNDDEGLMVDYLNNQGVKDIKYLIATHSHADHLGG
EEEECCCCCEEEEECCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHCCC
LDSVVKNFNIENVFVSNGSAETKSYRDFINALANKGLSPSVPLENNKFYLEDSYFEVLNT
HHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEEC
NGGDTTNEQSLVLVYTNGNDKVLFTGDAEEGTEKEILPKLEKVDLLKVAHHGSRSSSSQE
CCCCCCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHH
FLDKVNPEYAVLLVGKGNSYGHPHQETMNKLKKMGVKVHRSDECSDIIFESTGDGVFTSC
HHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCEEEECCCCCCEEEEECCCCCEEEEC
KDGSYNKGVREDGNSGKSNSNTSKNDSFKNKQNTSNSEEIVYFTPKGKSYHSTKNCSGLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCH
RSKKILSGTIAESKKNDPCDICYGK
HHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]