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The map label for this gene is vncR [H]

Identifier: 126699488

GI number: 126699488

Start: 2177747

End: 2178400

Strand: Direct

Name: vncR [H]

Synonym: CD1876

Alternate gene names: 126699488

Gene position: 2177747-2178400 (Clockwise)

Preceding gene: 126699487

Following gene: 126699489

Centisome position: 50.76

GC content: 26.91

Gene sequence:

>654_bases
ATGAAAATATTAACTGTTGAAGATGATAATATGATAAGAGAGGGAATAAGTGAATATCTTTCAGAATTTGGATATACTGT
TATTCAAGCTAAAGATGGAAGAGAAGCCTTGTCAAAATTTAATAGCGATATAAATTTGGTTATCTTAGACATTCAGATAC
CTTTTATAAATGGTTTAGAAGTGTTGAAAGAAATTAGAAAGAAAAGCAATTTACCAATTCTAATCTTGACTGCATTTAGT
GATGAAGAATATAAAATTGATGCATTTACTAATTTAGTAGACGGATATGTAGAAAAGCCATTTTCATTGCCGGTCTTAAA
GGCTAGAATAGATTCTTTAATTAAGAAGAATTATGGACATTTAGAGAAGTTTGAATATAAGGATCTATCGGTTAATTTTA
ATAGCTATACAGCTAAAATAAATGGTGAAGAAATAGATGTAAATGCAAAAGAACTAGAAGTATTAAAATGTTTATTGGAT
AATAATGGACAAGTGTTAACAAGAATGCAAATTATTGATTATGTATGGAAAGATAGCGAAGAAACTCCTTATGATCGAGT
AATAGATGTATATATAAAAGAACTTAGAAAAAAATTACAATTAGACTGTATAACTACTATAAGAAATGTAGGATATAAAT
TGGAGAGAAAATGA

Upstream 100 bases:

>100_bases
TAAAATTTTCGGTGCTTTTTAGCACCAAAAATTTTTTGGCTTTTAAATATCAAATAATATGCTGTATAATATAAGTGTAT
AGGCTTAAGTGGAGGTATAT

Downstream 100 bases:

>100_bases
AAAAATTAAAGATATTTCCAAAAATGTTCATACAAATATTTTCTGTTCTTGGAATAATAATTATATTAGTTCATTCATTA
GTTTTTTTTATCTTTCCTAA

Product: two-component system response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MKILTVEDDNMIREGISEYLSEFGYTVIQAKDGREALSKFNSDINLVILDIQIPFINGLEVLKEIRKKSNLPILILTAFS
DEEYKIDAFTNLVDGYVEKPFSLPVLKARIDSLIKKNYGHLEKFEYKDLSVNFNSYTAKINGEEIDVNAKELEVLKCLLD
NNGQVLTRMQIIDYVWKDSEETPYDRVIDVYIKELRKKLQLDCITTIRNVGYKLERK

Sequences:

>Translated_217_residues
MKILTVEDDNMIREGISEYLSEFGYTVIQAKDGREALSKFNSDINLVILDIQIPFINGLEVLKEIRKKSNLPILILTAFS
DEEYKIDAFTNLVDGYVEKPFSLPVLKARIDSLIKKNYGHLEKFEYKDLSVNFNSYTAKINGEEIDVNAKELEVLKCLLD
NNGQVLTRMQIIDYVWKDSEETPYDRVIDVYIKELRKKLQLDCITTIRNVGYKLERK
>Mature_217_residues
MKILTVEDDNMIREGISEYLSEFGYTVIQAKDGREALSKFNSDINLVILDIQIPFINGLEVLKEIRKKSNLPILILTAFS
DEEYKIDAFTNLVDGYVEKPFSLPVLKARIDSLIKKNYGHLEKFEYKDLSVNFNSYTAKINGEEIDVNAKELEVLKCLLD
NNGQVLTRMQIIDYVWKDSEETPYDRVIDVYIKELRKKLQLDCITTIRNVGYKLERK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=33.0357142857143, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=32.7354260089686, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=27.8761061946903, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=30.6306306306306, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=28.8288288288288, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=29.1479820627803, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=31.4159292035398, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=29.0178571428571, Blast_Score=98, Evalue=3e-22,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30.4347826086957, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=30.2222222222222, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=26.8722466960352, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=35.5371900826446, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788550, Length=105, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25199; Mature: 25199

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILTVEDDNMIREGISEYLSEFGYTVIQAKDGREALSKFNSDINLVILDIQIPFINGLE
CEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCEEEEEEEEECCCCHHH
VLKEIRKKSNLPILILTAFSDEEYKIDAFTNLVDGYVEKPFSLPVLKARIDSLIKKNYGH
HHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
LEKFEYKDLSVNFNSYTAKINGEEIDVNAKELEVLKCLLDNNGQVLTRMQIIDYVWKDSE
CHHCCCCEEEEEECCEEEEECCCEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCC
ETPYDRVIDVYIKELRKKLQLDCITTIRNVGYKLERK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MKILTVEDDNMIREGISEYLSEFGYTVIQAKDGREALSKFNSDINLVILDIQIPFINGLE
CEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCEEEEEEEEECCCCHHH
VLKEIRKKSNLPILILTAFSDEEYKIDAFTNLVDGYVEKPFSLPVLKARIDSLIKKNYGH
HHHHHHHHCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
LEKFEYKDLSVNFNSYTAKINGEEIDVNAKELEVLKCLLDNNGQVLTRMQIIDYVWKDSE
CHHCCCCEEEEEECCEEEEECCCEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCC
ETPYDRVIDVYIKELRKKLQLDCITTIRNVGYKLERK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]