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The map label for this gene is vncS [H]

Identifier: 126699489

GI number: 126699489

Start: 2178397

End: 2179716

Strand: Direct

Name: vncS [H]

Synonym: CD1877

Alternate gene names: 126699489

Gene position: 2178397-2179716 (Clockwise)

Preceding gene: 126699488

Following gene: 126699490

Centisome position: 50.78

GC content: 20.98

Gene sequence:

>1320_bases
ATGAAAAAATTAAAGATATTTCCAAAAATGTTCATACAAATATTTTCTGTTCTTGGAATAATAATTATATTAGTTCATTC
ATTAGTTTTTTTTATCTTTCCTAAAACATATTTGGAGACGAGAAAAGAAAAGATTCATAATATGGCAAATGAAATTTCTA
GTAATATGAATGGAAAAGAAATAAAATATATAGAACAAACTTTGGAGCTTTATTCTAAGAGTAGTGAAATAAAAGCATTT
ATAAAAGAAAAAAATAATAAGAATGAAATACAAATCAAAGATAATATAAATGTTAATTTAGAAAGTGATAGTAATTCTTT
GATAATTGAAGAAAGAGAAATAAAGCTTAATGATGGTAAAAAAACAAATCTACAATTTGTTTCTACAGCTGATATGCAAA
AAGATGCGAAAGATTTAAGCCTTAAATTTTTACCATATTCTTTATTAATATCAATTTTATTTTCTGCTATTATTTCTTTA
ATTTATGCAAAATCAATAAAAAATAATATACAAGAAATAAAAATTGTTACTGATAAAATGATGAAACTTGATAAAAAAAC
GCGTTTAAAAGTTAGCTCTAATGATGAAGTTGGAGAATTAAAACAACAAATTAATGATTTGTATTCTACTTTATTAAGAA
CAATTGACGATTTGGAATTTAAAAATAAAGAAATTTTAAAATTAGAAAAGTTAAAATATGACTTTTTTAAAGGTGCATCC
CATGAACTTAAAACTCCTCTTGCTAGTCTTAAAATAATACTGGAAAACATGAAATACAATATTGGAAAATATAAAGAAAG
AGATATTTATATTAATGAATGTATTGAAATCGTTGATAGTTTAACAAAAAATATTTCTCAAATATTATCAGTTCATTCTA
TAGAAAATTTGAATAATGATGAAGAATATTTGAAAATAAATGATACATTAGAAGACATATTAAAAAAGTATGAAATATTA
GCAAATCAAAAGAAAATAACTGTCAATAATTATATATTAGATGAGAATGTTTATATAGGAAAAACAGCTTTAAAGATTAT
TCTATCTAATTTGATTAGTAATGCGGTAAAATATACTGATGTAAATGGGGTAATTAATATTGGGATAGTTAATGATTGGT
TATATATAGAGAATTCATACGGTAACAATAAAATTTCGAATATGGATAAAATATTTGATGTTAAATTTGATTTAAATAAG
GAAAATAGTAATGGATTAGGTTTATATATTGTAAGTAATATTCTGAATAATTACAATATAGAATATAAAGCATTGCAGGA
TGAAGAATTTTTTATCTTTAAAATTAAAATATTTTCTTAA

Upstream 100 bases:

>100_bases
ATGATCGAGTAATAGATGTATATATAAAAGAACTTAGAAAAAAATTACAATTAGACTGTATAACTACTATAAGAAATGTA
GGATATAAATTGGAGAGAAA

Downstream 100 bases:

>100_bases
ACAAGATATAATTTTGCAATAGTTATTGAAAAATAGAGACTTATTATTAGCCATGGAAGTAAAGGCTTTTTTCTTATTGA
AAGTGAACAGAAAATAATTG

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: Vancomycin B-type resistance protein vanSB; Vancomycin histidine protein kinase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKKLKIFPKMFIQIFSVLGIIIILVHSLVFFIFPKTYLETRKEKIHNMANEISSNMNGKEIKYIEQTLELYSKSSEIKAF
IKEKNNKNEIQIKDNINVNLESDSNSLIIEEREIKLNDGKKTNLQFVSTADMQKDAKDLSLKFLPYSLLISILFSAIISL
IYAKSIKNNIQEIKIVTDKMMKLDKKTRLKVSSNDEVGELKQQINDLYSTLLRTIDDLEFKNKEILKLEKLKYDFFKGAS
HELKTPLASLKIILENMKYNIGKYKERDIYINECIEIVDSLTKNISQILSVHSIENLNNDEEYLKINDTLEDILKKYEIL
ANQKKITVNNYILDENVYIGKTALKIILSNLISNAVKYTDVNGVINIGIVNDWLYIENSYGNNKISNMDKIFDVKFDLNK
ENSNGLGLYIVSNILNNYNIEYKALQDEEFFIFKIKIFS

Sequences:

>Translated_439_residues
MKKLKIFPKMFIQIFSVLGIIIILVHSLVFFIFPKTYLETRKEKIHNMANEISSNMNGKEIKYIEQTLELYSKSSEIKAF
IKEKNNKNEIQIKDNINVNLESDSNSLIIEEREIKLNDGKKTNLQFVSTADMQKDAKDLSLKFLPYSLLISILFSAIISL
IYAKSIKNNIQEIKIVTDKMMKLDKKTRLKVSSNDEVGELKQQINDLYSTLLRTIDDLEFKNKEILKLEKLKYDFFKGAS
HELKTPLASLKIILENMKYNIGKYKERDIYINECIEIVDSLTKNISQILSVHSIENLNNDEEYLKINDTLEDILKKYEIL
ANQKKITVNNYILDENVYIGKTALKIILSNLISNAVKYTDVNGVINIGIVNDWLYIENSYGNNKISNMDKIFDVKFDLNK
ENSNGLGLYIVSNILNNYNIEYKALQDEEFFIFKIKIFS
>Mature_439_residues
MKKLKIFPKMFIQIFSVLGIIIILVHSLVFFIFPKTYLETRKEKIHNMANEISSNMNGKEIKYIEQTLELYSKSSEIKAF
IKEKNNKNEIQIKDNINVNLESDSNSLIIEEREIKLNDGKKTNLQFVSTADMQKDAKDLSLKFLPYSLLISILFSAIISL
IYAKSIKNNIQEIKIVTDKMMKLDKKTRLKVSSNDEVGELKQQINDLYSTLLRTIDDLEFKNKEILKLEKLKYDFFKGAS
HELKTPLASLKIILENMKYNIGKYKERDIYINECIEIVDSLTKNISQILSVHSIENLNNDEEYLKINDTLEDILKKYEIL
ANQKKITVNNYILDENVYIGKTALKIILSNLISNAVKYTDVNGVINIGIVNDWLYIENSYGNNKISNMDKIFDVKFDLNK
ENSNGLGLYIVSNILNNYNIEYKALQDEEFFIFKIKIFS

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates vanR by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=262, Percent_Identity=24.0458015267176, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51013; Mature: 51013

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLKIFPKMFIQIFSVLGIIIILVHSLVFFIFPKTYLETRKEKIHNMANEISSNMNGKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHH
IKYIEQTLELYSKSSEIKAFIKEKNNKNEIQIKDNINVNLESDSNSLIIEEREIKLNDGK
HHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCEEEEECCCCEEEEEECEEEECCCC
KTNLQFVSTADMQKDAKDLSLKFLPYSLLISILFSAIISLIYAKSIKNNIQEIKIVTDKM
CCCEEEEEECHHHCCHHHCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MKLDKKTRLKVSSNDEVGELKQQINDLYSTLLRTIDDLEFKNKEILKLEKLKYDFFKGAS
HHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
HELKTPLASLKIILENMKYNIGKYKERDIYINECIEIVDSLTKNISQILSVHSIENLNND
HHHHCHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EEYLKINDTLEDILKKYEILANQKKITVNNYILDENVYIGKTALKIILSNLISNAVKYTD
CCEEEECHHHHHHHHHHHHHCCCCEEEEEEEEEECCEEEHHHHHHHHHHHHHHHHHEEEE
VNGVINIGIVNDWLYIENSYGNNKISNMDKIFDVKFDLNKENSNGLGLYIVSNILNNYNI
CCCEEEEEEEEEEEEEECCCCCCCCCCCHHEEEEEEEECCCCCCCEEEEEHHHHHHCCCE
EYKALQDEEFFIFKIKIFS
EEEEECCCCEEEEEEEEEC
>Mature Secondary Structure
MKKLKIFPKMFIQIFSVLGIIIILVHSLVFFIFPKTYLETRKEKIHNMANEISSNMNGKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHH
IKYIEQTLELYSKSSEIKAFIKEKNNKNEIQIKDNINVNLESDSNSLIIEEREIKLNDGK
HHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEECCCEEEEECCCCEEEEEECEEEECCCC
KTNLQFVSTADMQKDAKDLSLKFLPYSLLISILFSAIISLIYAKSIKNNIQEIKIVTDKM
CCCEEEEEECHHHCCHHHCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MKLDKKTRLKVSSNDEVGELKQQINDLYSTLLRTIDDLEFKNKEILKLEKLKYDFFKGAS
HHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
HELKTPLASLKIILENMKYNIGKYKERDIYINECIEIVDSLTKNISQILSVHSIENLNND
HHHHCHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EEYLKINDTLEDILKKYEILANQKKITVNNYILDENVYIGKTALKIILSNLISNAVKYTD
CCEEEECHHHHHHHHHHHHHCCCCEEEEEEEEEECCEEEHHHHHHHHHHHHHHHHHEEEE
VNGVINIGIVNDWLYIENSYGNNKISNMDKIFDVKFDLNKENSNGLGLYIVSNILNNYNI
CCCEEEEEEEEEEEEEECCCCCCCCCCCHHEEEEEEEECCCCCCCEEEEEHHHHHHCCCE
EYKALQDEEFFIFKIKIFS
EEEEECCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]