Click here to switch to the map view.

The map label for this gene is metA [H]

Identifier: 126699434

GI number: 126699434

Start: 2112199

End: 2113089

Strand: Direct

Name: metA [H]

Synonym: CD1826

Alternate gene names: 126699434

Gene position: 2112199-2113089 (Clockwise)

Preceding gene: 126699433

Following gene: 126699435

Centisome position: 49.23

GC content: 27.95

Gene sequence:

>891_bases
ATGGCTTTAATACTACCAAAGGGATTACCTGTTATTAATAAATTATTAGATGAAGGAATAGATGTAATTTATAAAGAAGA
TTTTAAAAAGGAATTAAAGTATGAAGAAAACATAGACACTAAGATAGCTATACTAAATCTAATGCCTATAAAGATAGATA
CAGAATTAGATTTACTAAGAAGGATAGATAAAACAGGATTCAACGTGTCTGTGGAATTTATTAAAATTTCAACAAGAGAA
AGTAAAAGAAGTTGTAATGAATATGTTAAAGAATTTTATAAAACATTTGATGAAGCCAAAGGAGAGTATTTTGATGGCTT
TATAATAACAGGAGCTCCAGTTGAACAAATGGAGTTTGAAGAAGTTGATTATTGGAATGAACTAGAAGAAATTATGGATT
ATTCTAAGAGAAAAACTAAATCTACATTATATATATGTTGGGCAGCTCAAGCAAGTCTTTACAAATACTACAATGTAAAA
AAACTTCCACTAAGTCAAAAATGTTTTGGAGTATTTAAGCATAAGGTAGATAAAGATAGTAAAATAGTAGATGGATTTGA
AAATGAATTTTTTGCTCCACATTCAAGACATACTACTGTAAATATTGAAGCTTTGAAAGAGAATAAAGAGTTGAGCATTG
TGAGTCATTCTAAAGAAGCTGGTCCCTATATAATTACAAATTCAAGAGATGTGTTCGTAATGGGTCATAGCGAGTATGAC
AAATACACTCTTGATAAAGAATATAAGAGGGATATAAATAAAGGAGATAAAATATCTATACCTCAAAATTACTATATTAA
TGATGACCCTTCAGAAGAGCCAACTGTAAAATGGAAAAAACATTCAGAATTGTTGTTTAGAAATTGGATAAAAAACTATT
TGATACAATAA

Upstream 100 bases:

>100_bases
TAAGATTATCTGTTGGAATAGAAAATGTAGAGGATTTAATAGCTGATTTAAATCAAGCTTTAAATTTCTAATATTCTAAG
AGAAAGAGAAGTGAAAAGAT

Downstream 100 bases:

>100_bases
ATTTTAAGAGTATATAAATGTTAACTAAAAAAATATAGAAATTTATAGGTATAAAGTTAATCTTAATGATACTTTATACC
TTATTTTTTTAAAATTTGAC

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MALILPKGLPVINKLLDEGIDVIYKEDFKKELKYEENIDTKIAILNLMPIKIDTELDLLRRIDKTGFNVSVEFIKISTRE
SKRSCNEYVKEFYKTFDEAKGEYFDGFIITGAPVEQMEFEEVDYWNELEEIMDYSKRKTKSTLYICWAAQASLYKYYNVK
KLPLSQKCFGVFKHKVDKDSKIVDGFENEFFAPHSRHTTVNIEALKENKELSIVSHSKEAGPYIITNSRDVFVMGHSEYD
KYTLDKEYKRDINKGDKISIPQNYYINDDPSEEPTVKWKKHSELLFRNWIKNYLIQ

Sequences:

>Translated_296_residues
MALILPKGLPVINKLLDEGIDVIYKEDFKKELKYEENIDTKIAILNLMPIKIDTELDLLRRIDKTGFNVSVEFIKISTRE
SKRSCNEYVKEFYKTFDEAKGEYFDGFIITGAPVEQMEFEEVDYWNELEEIMDYSKRKTKSTLYICWAAQASLYKYYNVK
KLPLSQKCFGVFKHKVDKDSKIVDGFENEFFAPHSRHTTVNIEALKENKELSIVSHSKEAGPYIITNSRDVFVMGHSEYD
KYTLDKEYKRDINKGDKISIPQNYYINDDPSEEPTVKWKKHSELLFRNWIKNYLIQ
>Mature_295_residues
ALILPKGLPVINKLLDEGIDVIYKEDFKKELKYEENIDTKIAILNLMPIKIDTELDLLRRIDKTGFNVSVEFIKISTRES
KRSCNEYVKEFYKTFDEAKGEYFDGFIITGAPVEQMEFEEVDYWNELEEIMDYSKRKTKSTLYICWAAQASLYKYYNVKK
LPLSQKCFGVFKHKVDKDSKIVDGFENEFFAPHSRHTTVNIEALKENKELSIVSHSKEAGPYIITNSRDVFVMGHSEYDK
YTLDKEYKRDINKGDKISIPQNYYINDDPSEEPTVKWKKHSELLFRNWIKNYLIQ

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family [H]

Homologues:

Organism=Escherichia coli, GI1790443, Length=299, Percent_Identity=34.1137123745819, Blast_Score=213, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005697
- ProDom:   PD037892 [H]

Pfam domain/function: PF04204 HTS [H]

EC number: =2.3.1.46 [H]

Molecular weight: Translated: 34923; Mature: 34792

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALILPKGLPVINKLLDEGIDVIYKEDFKKELKYEENIDTKIAILNLMPIKIDTELDLLR
CEEECCCCCHHHHHHHHCCHHEEEHHHHHHHCCCCCCCCCEEEEEEEEEEEECCHHHHHH
RIDKTGFNVSVEFIKISTRESKRSCNEYVKEFYKTFDEAKGEYFDGFIITGAPVEQMEFE
HHHCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEECCEEEECCCHHHHHHH
EVDYWNELEEIMDYSKRKTKSTLYICWAAQASLYKYYNVKKLPLSQKCFGVFKHKVDKDS
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHCCEEECCCCHHHHHHHHHHCCCCC
KIVDGFENEFFAPHSRHTTVNIEALKENKELSIVSHSKEAGPYIITNSRDVFVMGHSEYD
HHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCEEEECCCEEEEEECCCCC
KYTLDKEYKRDINKGDKISIPQNYYINDDPSEEPTVKWKKHSELLFRNWIKNYLIQ
CCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALILPKGLPVINKLLDEGIDVIYKEDFKKELKYEENIDTKIAILNLMPIKIDTELDLLR
EEECCCCCHHHHHHHHCCHHEEEHHHHHHHCCCCCCCCCEEEEEEEEEEEECCHHHHHH
RIDKTGFNVSVEFIKISTRESKRSCNEYVKEFYKTFDEAKGEYFDGFIITGAPVEQMEFE
HHHCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCEECCEEEECCCHHHHHHH
EVDYWNELEEIMDYSKRKTKSTLYICWAAQASLYKYYNVKKLPLSQKCFGVFKHKVDKDS
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHCCEEECCCCHHHHHHHHHHCCCCC
KIVDGFENEFFAPHSRHTTVNIEALKENKELSIVSHSKEAGPYIITNSRDVFVMGHSEYD
HHHCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCEEEECCCEEEEEECCCCC
KYTLDKEYKRDINKGDKISIPQNYYINDDPSEEPTVKWKKHSELLFRNWIKNYLIQ
CCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA