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The map label for this gene is nudF [H]

Identifier: 126699374

GI number: 126699374

Start: 2042385

End: 2042993

Strand: Direct

Name: nudF [H]

Synonym: CD1765

Alternate gene names: 126699374

Gene position: 2042385-2042993 (Clockwise)

Preceding gene: 126699373

Following gene: 126699375

Centisome position: 47.61

GC content: 27.42

Gene sequence:

>609_bases
TTGAAAAAAACTATAATAAAGAATGTAAATCCAATGATTGAAAATAAGTTTATAGGACTTTTTGAAATAGAGTATAAAAA
CAAATTAGATGAAGATAAGGTTTGGATGGTAGCATCAAGAAAAAGTAGTGAGCAATTAAAAAATATTTATTTGAAGAATG
AAGAAGATAGTGTAGATGCAGTTGTAATAGTTGGGCTTCATAAAAGTAGTAAAAAATTAATTTTAATAAGACAATTTAGA
GTACCTATTAATGGATATATATACGAGTTACCAGCAGGTCTTGTTGATGAAGGAGAGTCTATAGATATTTCCGTTGAAAG
AGAACTTAGAGAAGAAACAGGACTTACTCTTTTAGAAATTAAAAAAAATAAAAGTATTGATAAAGTTTATTTATCTCCTG
GAATGAGTGATGAATCTGTTGCCTTTGTTTATTGTATATGTGATGGTGATATAACAGATGAATTTTTAGAACCAGATGAA
GAGATTGAAGCGCTTTTAATTTCGCAAGAAGATGCAAAAGAGATTTTACAAAGTAATCATAAGATAGACACAAAAGCATT
TTTGATTTTACAAATGTTTGTGAGTTTAGGAGCTAAATTATTTGAATAG

Upstream 100 bases:

>100_bases
TCCTGAAATGGAAATATAATAAGTTGTTGAATACTTGTTAAGATATTATATTTACTTAATGATGTTAAAAAGGTATTAAA
AAAGAAAGGTCGTAGTAAAT

Downstream 100 bases:

>100_bases
ATATATAGAAAAGAGGTTATATAGAAGAGTAAAATAATAAAGTTTATTTTACTTGTGTAAATTATAATCTCTTTTTTTAT
ACAATAAAGTATAATTTTGT

Product: NUDIX family hydrolase

Products: NA

Alternate protein names: ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; ASPPase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MKKTIIKNVNPMIENKFIGLFEIEYKNKLDEDKVWMVASRKSSEQLKNIYLKNEEDSVDAVVIVGLHKSSKKLILIRQFR
VPINGYIYELPAGLVDEGESIDISVERELREETGLTLLEIKKNKSIDKVYLSPGMSDESVAFVYCICDGDITDEFLEPDE
EIEALLISQEDAKEILQSNHKIDTKAFLILQMFVSLGAKLFE

Sequences:

>Translated_202_residues
MKKTIIKNVNPMIENKFIGLFEIEYKNKLDEDKVWMVASRKSSEQLKNIYLKNEEDSVDAVVIVGLHKSSKKLILIRQFR
VPINGYIYELPAGLVDEGESIDISVERELREETGLTLLEIKKNKSIDKVYLSPGMSDESVAFVYCICDGDITDEFLEPDE
EIEALLISQEDAKEILQSNHKIDTKAFLILQMFVSLGAKLFE
>Mature_202_residues
MKKTIIKNVNPMIENKFIGLFEIEYKNKLDEDKVWMVASRKSSEQLKNIYLKNEEDSVDAVVIVGLHKSSKKLILIRQFR
VPINGYIYELPAGLVDEGESIDISVERELREETGLTLLEIKKNKSIDKVYLSPGMSDESVAFVYCICDGDITDEFLEPDE
EIEALLISQEDAKEILQSNHKIDTKAFLILQMFVSLGAKLFE

Specific function: Acts on ADP-mannose and ADP-glucose as well as ADP- ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17564994, Length=162, Percent_Identity=30.8641975308642, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319587, Length=141, Percent_Identity=31.9148936170213, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004385
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: =3.6.1.13 [H]

Molecular weight: Translated: 23094; Mature: 23094

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTIIKNVNPMIENKFIGLFEIEYKNKLDEDKVWMVASRKSSEQLKNIYLKNEEDSVDA
CCCCHHCCCCCHHHCCEEEEEEEEECCCCCCCCEEEEECCCCHHHHHHEEECCCCCCCCE
VVIVGLHKSSKKLILIRQFRVPINGYIYELPAGLVDEGESIDISVERELREETGLTLLEI
EEEEEECCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHCCEEEEE
KKNKSIDKVYLSPGMSDESVAFVYCICDGDITDEFLEPDEEIEALLISQEDAKEILQSNH
ECCCCEEEEEECCCCCCCCEEEEEEEECCCCCHHHCCCCHHHHEEEECCHHHHHHHHCCC
KIDTKAFLILQMFVSLGAKLFE
CCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKTIIKNVNPMIENKFIGLFEIEYKNKLDEDKVWMVASRKSSEQLKNIYLKNEEDSVDA
CCCCHHCCCCCHHHCCEEEEEEEEECCCCCCCCEEEEECCCCHHHHHHEEECCCCCCCCE
VVIVGLHKSSKKLILIRQFRVPINGYIYELPAGLVDEGESIDISVERELREETGLTLLEI
EEEEEECCCCCEEEEEEEECCCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHCCEEEEE
KKNKSIDKVYLSPGMSDESVAFVYCICDGDITDEFLEPDEEIEALLISQEDAKEILQSNH
ECCCCEEEEEECCCCCCCCEEEEEEEECCCCCHHHCCCCHHHHEEEECCHHHHHHHHCCC
KIDTKAFLILQMFVSLGAKLFE
CCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10542272 [H]