Click here to switch to the map view.

The map label for this gene is codB [H]

Identifier: 126699323

GI number: 126699323

Start: 1990110

End: 1991399

Strand: Direct

Name: codB [H]

Synonym: CD1716

Alternate gene names: 126699323

Gene position: 1990110-1991399 (Clockwise)

Preceding gene: 126699322

Following gene: 126699324

Centisome position: 46.39

GC content: 31.47

Gene sequence:

>1290_bases
ATGGAAGAAGAAAAAATTAACTATGCTCTGGAACAGATTCCAGAGAATCAAAAACGTGGTTGGGTAGCTATGTTTTCAGT
TTTAGTAGCAATAGGTGTAGATTTATCATCTGTTATTTTAGGCGCTGAGTTGGCACAGAGTATGCCAATGAAACAAGCAA
TATTGTCAGTAATTGTTGGTTCATTTTTTTCTGCAATTTTGTATACTACATGCTCTTTGGTTGGTTCATCTACAAGTTTA
TCTACATCTATGATAACAAAGTATGTATTTGGAGAAGCTGGAGCAAAAATATTTTCTCTAGTTATAGGGGTTTCTCTATT
AGGTTGGTTTGGAGTTCAAGTAGGTTTCTTTGCTCAAAATGCACAGATAATAATAAAAGATATATTTAATTTAGATGTCA
GTATGCAGATTTTAAGCCTAATAGGTGGTCTCTTGATGATGAGTACTGCAATTTATGGATATAAGGCAATGGAGAAGTTG
AGTGTGTATTCAGTACCATTTTTATTAGTTCTTATGATGCTAACTATATTCTTAGCTTTTAGAGCAAATGGAATTTCAGT
TGATGATAATATGAAATCTACTATGACATTTGCAGGTGGAGTTTCTCTGTCAATGAGTATAATAATAGTTGGTGCAATTG
TATCTCCTGATATAAGTCGTTGGGCTAAAAGTAGAAGAGACTGTGCTCTTTCAAGCTTTTTGGGAATACAATTTGGAAAT
GCTTTTATGATAATAGTTTCGATAGTATTAGTAAAATGTATGGGAACTTCAGATATTATGAGAATTTTTATTACATTAGG
AATTGCTATACCAGGTATAATAGTACTTACATTAGCACAATGGACTACAAATACAAGTAATGTATATTCAGCATCATTAA
GCATAGCTCTTGTACTTAAGAAGGCTCCTGAGAAAGTATTAACTATAGTCCTTGGTATTATAGCGACATTATTGGCTGTA
TTTGGAATATATGAAGGTTTTATAGGATTTTTAAATTTACTTGGAATTGTAATTGCACCTGTTGGTGGTGTATATACAGC
AGAATATTACATAGTAAAGCAAGAACTTAAAGGCTTTGATAAAGGAGTATTATATAAACCAATAGTTAAACGTTCAATAG
TGTCTTGGATAATTGGTATATTAATAACTTACCTTTCAACATATGGATTTATAACTCTTACTACTATAGCACCTTTAGAT
GGTTTTATAGCAGGGTTTGTAGTACAATCTATTATTGGAAAAGTGCTTTGTTCAACAAAAAATAAGCAAGAAATAGACAA
AGCAGTATAA

Upstream 100 bases:

>100_bases
ATGAAAATTATAAAAATATGATAGTTAATAAATTTATAAATTAGAAAATTGTAAAATATGCTAAGGTCAGTAGTTTTACG
ATTTAAATGGAGGGATGAAA

Downstream 100 bases:

>100_bases
AGAAATTTGTTTATAAAGTATAAAATAAATTAGAAATATGAGGAGAAAGTAACATGAGATTTTTAACAGAAGAAAGTGTA
GATAAAATAGCAGTTGGTGC

Product: permease

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MEEEKINYALEQIPENQKRGWVAMFSVLVAIGVDLSSVILGAELAQSMPMKQAILSVIVGSFFSAILYTTCSLVGSSTSL
STSMITKYVFGEAGAKIFSLVIGVSLLGWFGVQVGFFAQNAQIIIKDIFNLDVSMQILSLIGGLLMMSTAIYGYKAMEKL
SVYSVPFLLVLMMLTIFLAFRANGISVDDNMKSTMTFAGGVSLSMSIIIVGAIVSPDISRWAKSRRDCALSSFLGIQFGN
AFMIIVSIVLVKCMGTSDIMRIFITLGIAIPGIIVLTLAQWTTNTSNVYSASLSIALVLKKAPEKVLTIVLGIIATLLAV
FGIYEGFIGFLNLLGIVIAPVGGVYTAEYYIVKQELKGFDKGVLYKPIVKRSIVSWIIGILITYLSTYGFITLTTIAPLD
GFIAGFVVQSIIGKVLCSTKNKQEIDKAV

Sequences:

>Translated_429_residues
MEEEKINYALEQIPENQKRGWVAMFSVLVAIGVDLSSVILGAELAQSMPMKQAILSVIVGSFFSAILYTTCSLVGSSTSL
STSMITKYVFGEAGAKIFSLVIGVSLLGWFGVQVGFFAQNAQIIIKDIFNLDVSMQILSLIGGLLMMSTAIYGYKAMEKL
SVYSVPFLLVLMMLTIFLAFRANGISVDDNMKSTMTFAGGVSLSMSIIIVGAIVSPDISRWAKSRRDCALSSFLGIQFGN
AFMIIVSIVLVKCMGTSDIMRIFITLGIAIPGIIVLTLAQWTTNTSNVYSASLSIALVLKKAPEKVLTIVLGIIATLLAV
FGIYEGFIGFLNLLGIVIAPVGGVYTAEYYIVKQELKGFDKGVLYKPIVKRSIVSWIIGILITYLSTYGFITLTTIAPLD
GFIAGFVVQSIIGKVLCSTKNKQEIDKAV
>Mature_429_residues
MEEEKINYALEQIPENQKRGWVAMFSVLVAIGVDLSSVILGAELAQSMPMKQAILSVIVGSFFSAILYTTCSLVGSSTSL
STSMITKYVFGEAGAKIFSLVIGVSLLGWFGVQVGFFAQNAQIIIKDIFNLDVSMQILSLIGGLLMMSTAIYGYKAMEKL
SVYSVPFLLVLMMLTIFLAFRANGISVDDNMKSTMTFAGGVSLSMSIIIVGAIVSPDISRWAKSRRDCALSSFLGIQFGN
AFMIIVSIVLVKCMGTSDIMRIFITLGIAIPGIIVLTLAQWTTNTSNVYSASLSIALVLKKAPEKVLTIVLGIIATLLAV
FGIYEGFIGFLNLLGIVIAPVGGVYTAEYYIVKQELKGFDKGVLYKPIVKRSIVSWIIGILITYLSTYGFITLTTIAPLD
GFIAGFVVQSIIGKVLCSTKNKQEIDKAV

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=364, Percent_Identity=28.021978021978, Blast_Score=139, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 46292; Mature: 46292

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHCC
>Mature Secondary Structure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CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]