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The map label for this gene is ciaR [H]

Identifier: 126699294

GI number: 126699294

Start: 1961207

End: 1961878

Strand: Direct

Name: ciaR [H]

Synonym: CD1688

Alternate gene names: 126699294

Gene position: 1961207-1961878 (Clockwise)

Preceding gene: 126699293

Following gene: 126699295

Centisome position: 45.71

GC content: 25.6

Gene sequence:

>672_bases
ATGAAGGTTTTAATAGTTGAAGATAATAAGATACTTTTAGAAAGTGTAGTAGAAGAACTTAGCAAGCATTTTGAAACTGA
AAAGTGTGAAGATGGAGAAGAAGCTTTATACTTAGTAAATCAAAATATATATGATTTAGTCATTTTAGACTTAATGCTTC
CTAATATAAATGGATTTGATATCCTAAAGAAAATGAGAGTTAATAATATAGATACACCTGTACTTATATTGACAGCAAAA
GAAACATTAGATGACAAAGTAGAAGCATTTACTATAGGAGCTAATGATTATTTGACAAAACCTTTTTATATGGAAGAGTT
AGTAGCTAGGGTATACGCTATATTAAGGACTAATGGAAAAATAAAAGAAAGAAACGGATTAGAATTTAAATCTTTATATT
TAGATACACTAGAAAAAAGAGTGTATATTGAAAAAGAAGAAATAAAACTTCAAAACAAACAGTTTAACTTGCTTGAGTAT
TTTGTATTAAATAAAGGTTCAATTTTATTAAAAGAGCAGATTTATGATAGAATATGGGGAATTGATTCAGATGCGACTAT
TGAAATAGTGGAAGTATATGTAAGTAATCTAAGAAAAAAACTAAGTAAATATGGATATGATAAATATATTAAAACTAAAC
GTAAGGTAGGATATATATTCGATGATAAATAA

Upstream 100 bases:

>100_bases
AGTGGGATATACGTATGATGATATAAAAGAAAAAGCCAATGTGGATATTGACTTAAAATCTCATAAAGTTAAGATAGACA
AATAAAGGTAGGGGATACTT

Downstream 100 bases:

>100_bases
GAATGTATTTACCAGTACTAAAAATCATTTAATAAAAATGTATATTATTGTAGTAGGTAGTTTTTTAATAATCTTTTCTA
TATTTATATACTCATATTTT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKVLIVEDNKILLESVVEELSKHFETEKCEDGEEALYLVNQNIYDLVILDLMLPNINGFDILKKMRVNNIDTPVLILTAK
ETLDDKVEAFTIGANDYLTKPFYMEELVARVYAILRTNGKIKERNGLEFKSLYLDTLEKRVYIEKEEIKLQNKQFNLLEY
FVLNKGSILLKEQIYDRIWGIDSDATIEIVEVYVSNLRKKLSKYGYDKYIKTKRKVGYIFDDK

Sequences:

>Translated_223_residues
MKVLIVEDNKILLESVVEELSKHFETEKCEDGEEALYLVNQNIYDLVILDLMLPNINGFDILKKMRVNNIDTPVLILTAK
ETLDDKVEAFTIGANDYLTKPFYMEELVARVYAILRTNGKIKERNGLEFKSLYLDTLEKRVYIEKEEIKLQNKQFNLLEY
FVLNKGSILLKEQIYDRIWGIDSDATIEIVEVYVSNLRKKLSKYGYDKYIKTKRKVGYIFDDK
>Mature_223_residues
MKVLIVEDNKILLESVVEELSKHFETEKCEDGEEALYLVNQNIYDLVILDLMLPNINGFDILKKMRVNNIDTPVLILTAK
ETLDDKVEAFTIGANDYLTKPFYMEELVARVYAILRTNGKIKERNGLEFKSLYLDTLEKRVYIEKEEIKLQNKQFNLLEY
FVLNKGSILLKEQIYDRIWGIDSDATIEIVEVYVSNLRKKLSKYGYDKYIKTKRKVGYIFDDK

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=38.0090497737557, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=35.1351351351351, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=37.280701754386, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32, Blast_Score=138, Evalue=2e-34,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=36.6071428571429, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=32.4444444444444, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=30.3571428571429, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=27.5109170305677, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=33.0434782608696, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=28.7671232876712, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=28.2511210762332, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.004329004329, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=27.3913043478261, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=37.962962962963, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787229, Length=170, Percent_Identity=28.8235294117647, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=35.9223300970874, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI48994928, Length=116, Percent_Identity=34.4827586206897, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26201; Mature: 26201

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLIVEDNKILLESVVEELSKHFETEKCEDGEEALYLVNQNIYDLVILDLMLPNINGFD
CEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHH
ILKKMRVNNIDTPVLILTAKETLDDKVEAFTIGANDYLTKPFYMEELVARVYAILRTNGK
HHHHHHCCCCCCCEEEEEEHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
IKERNGLEFKSLYLDTLEKRVYIEKEEIKLQNKQFNLLEYFVLNKGSILLKEQIYDRIWG
EECCCCCHHHHHHHHHHHHHHEEEHHHHEECCCCHHHHHHEECCCCCEEHHHHHHHHHHC
IDSDATIEIVEVYVSNLRKKLSKYGYDKYIKTKRKVGYIFDDK
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MKVLIVEDNKILLESVVEELSKHFETEKCEDGEEALYLVNQNIYDLVILDLMLPNINGFD
CEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCHHH
ILKKMRVNNIDTPVLILTAKETLDDKVEAFTIGANDYLTKPFYMEELVARVYAILRTNGK
HHHHHHCCCCCCCEEEEEEHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCC
IKERNGLEFKSLYLDTLEKRVYIEKEEIKLQNKQFNLLEYFVLNKGSILLKEQIYDRIWG
EECCCCCHHHHHHHHHHHHHHEEEHHHHEECCCCHHHHHHEECCCCCEEHHHHHHHHHHC
IDSDATIEIVEVYVSNLRKKLSKYGYDKYIKTKRKVGYIFDDK
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]