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The map label for this gene is ciaH [H]

Identifier: 126699295

GI number: 126699295

Start: 1961868

End: 1963100

Strand: Direct

Name: ciaH [H]

Synonym: CD1689

Alternate gene names: 126699295

Gene position: 1961868-1963100 (Clockwise)

Preceding gene: 126699294

Following gene: 126699296

Centisome position: 45.73

GC content: 26.03

Gene sequence:

>1233_bases
ATGATAAATAAGAATGTATTTACCAGTACTAAAAATCATTTAATAAAAATGTATATTATTGTAGTAGGTAGTTTTTTAAT
AATCTTTTCTATATTTATATACTCATATTTTAGGGGACTTACATATAGTGGAATTGATAGTGAGATAAATGATGAACTTG
AATATATAGTCTCTCAATTTAAAAGAACTTCATTTTTGAACCCAATAAGACTGAAAGATCCTAAAGATATGGTGTATGTA
TATGAAGATGGAAGGATAAGTTACTATACTCAAAATGAATATTTTGATGAGTTACTTCCAGATAGAAGACTAGATAAAAA
AAATTCGTTTTTTAAATACACAGAAAATGGATATACTTTTAGAGAATTAAATGTAGATGTAGGTAGATACCAAATACAGA
TAATTAGAAATATAGATTCTGAGATGAATTCTTTGAGACAGCTTACATCTGTTCTTATAATTGGAATATTAATTTCTGTA
ATAATTACTTACTTTGTGGCTGTATATCTCACTAGAAAAGCTTTAATTCCAATAGAAACAGCATGGAAAAATCAAGCTAA
GTTTATACAAGATGCTTCTCATGAATTAAGAACACCAATAACAATAGTTTCATCAAAATTAGAAAGTATGTTAAAATCCC
CAGAAAGTACAGTAAATGATGAAGTTGAAACAATAGCTACTGCAATGAAGGAAACTAGAAGACTTAAAAAAATGATAACT
GATTTATTGTCTCTTACTAAAGAGGACTCTATTGTTAAAGTTAATTTAGAAGAAATAGATTTAGAAAAGTTATTGGAAGA
AATATCAGAAGACTATATTGACATTGCTGAGTTTCAGGAAAAAAGATTCGTGTTTAATTCTAAACTGAAGAATAAAGTTA
TAATAACAGATAAAAATAAATTAAGACAACTTATATTAATTTTCATTGATAATGCCTTTAAGTATACAAAATTGGGTGAT
GAGATAGCATTAGAATTGAAAGAAGATATAGAGGATGAGGTAACTTTACTTATAAGTGATACTGGTATAGGCATAAAAAA
AGAAGAGATACCTCTTATATTTGATAGATTTTTTAGAAGTGAAAATGTAAGAAATAAAGATTTAGAAGGTTCTGGAATAG
GACTTTCAATAGCTCGCATGATTAGTTTAAACTTATCTATTGATATAAATGTAACTTCTGATGTAGATATTGGAACTACA
TTTGAATTGTCAATACCAAAAAAGTTAAAATAA

Upstream 100 bases:

>100_bases
GAAATAGTGGAAGTATATGTAAGTAATCTAAGAAAAAAACTAAGTAAATATGGATATGATAAATATATTAAAACTAAACG
TAAGGTAGGATATATATTCG

Downstream 100 bases:

>100_bases
TAAAAATATAAAAAATTGTTTTTAGAAATGAAGAATGGGTATACTAATTAGTATAAAATATAAAAAGACCTTATAAAAGT
AAATTTATATTTATAAATTT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MINKNVFTSTKNHLIKMYIIVVGSFLIIFSIFIYSYFRGLTYSGIDSEINDELEYIVSQFKRTSFLNPIRLKDPKDMVYV
YEDGRISYYTQNEYFDELLPDRRLDKKNSFFKYTENGYTFRELNVDVGRYQIQIIRNIDSEMNSLRQLTSVLIIGILISV
IITYFVAVYLTRKALIPIETAWKNQAKFIQDASHELRTPITIVSSKLESMLKSPESTVNDEVETIATAMKETRRLKKMIT
DLLSLTKEDSIVKVNLEEIDLEKLLEEISEDYIDIAEFQEKRFVFNSKLKNKVIITDKNKLRQLILIFIDNAFKYTKLGD
EIALELKEDIEDEVTLLISDTGIGIKKEEIPLIFDRFFRSENVRNKDLEGSGIGLSIARMISLNLSIDINVTSDVDIGTT
FELSIPKKLK

Sequences:

>Translated_410_residues
MINKNVFTSTKNHLIKMYIIVVGSFLIIFSIFIYSYFRGLTYSGIDSEINDELEYIVSQFKRTSFLNPIRLKDPKDMVYV
YEDGRISYYTQNEYFDELLPDRRLDKKNSFFKYTENGYTFRELNVDVGRYQIQIIRNIDSEMNSLRQLTSVLIIGILISV
IITYFVAVYLTRKALIPIETAWKNQAKFIQDASHELRTPITIVSSKLESMLKSPESTVNDEVETIATAMKETRRLKKMIT
DLLSLTKEDSIVKVNLEEIDLEKLLEEISEDYIDIAEFQEKRFVFNSKLKNKVIITDKNKLRQLILIFIDNAFKYTKLGD
EIALELKEDIEDEVTLLISDTGIGIKKEEIPLIFDRFFRSENVRNKDLEGSGIGLSIARMISLNLSIDINVTSDVDIGTT
FELSIPKKLK
>Mature_410_residues
MINKNVFTSTKNHLIKMYIIVVGSFLIIFSIFIYSYFRGLTYSGIDSEINDELEYIVSQFKRTSFLNPIRLKDPKDMVYV
YEDGRISYYTQNEYFDELLPDRRLDKKNSFFKYTENGYTFRELNVDVGRYQIQIIRNIDSEMNSLRQLTSVLIIGILISV
IITYFVAVYLTRKALIPIETAWKNQAKFIQDASHELRTPITIVSSKLESMLKSPESTVNDEVETIATAMKETRRLKKMIT
DLLSLTKEDSIVKVNLEEIDLEKLLEEISEDYIDIAEFQEKRFVFNSKLKNKVIITDKNKLRQLILIFIDNAFKYTKLGD
EIALELKEDIEDEVTLLISDTGIGIKKEEIPLIFDRFFRSENVRNKDLEGSGIGLSIARMISLNLSIDINVTSDVDIGTT
FELSIPKKLK

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=28, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1786783, Length=231, Percent_Identity=29.8701298701299, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=29.3103448275862, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=29.9145299145299, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788393, Length=206, Percent_Identity=28.1553398058252, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=25.9911894273128, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1790346, Length=194, Percent_Identity=28.3505154639175, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1790436, Length=262, Percent_Identity=26.3358778625954, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=25.3275109170306, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788279, Length=198, Percent_Identity=28.2828282828283, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47585; Mature: 47585

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINKNVFTSTKNHLIKMYIIVVGSFLIIFSIFIYSYFRGLTYSGIDSEINDELEYIVSQF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KRTSFLNPIRLKDPKDMVYVYEDGRISYYTQNEYFDELLPDRRLDKKNSFFKYTENGYTF
HHHHCCCCCCCCCCCCEEEEEECCEEEEEECHHHHHHHCCCCCCCCCCCCEEECCCCEEE
RELNVDVGRYQIQIIRNIDSEMNSLRQLTSVLIIGILISVIITYFVAVYLTRKALIPIET
EEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AWKNQAKFIQDASHELRTPITIVSSKLESMLKSPESTVNDEVETIATAMKETRRLKKMIT
HHCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DLLSLTKEDSIVKVNLEEIDLEKLLEEISEDYIDIAEFQEKRFVFNSKLKNKVIITDKNK
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHH
LRQLILIFIDNAFKYTKLGDEIALELKEDIEDEVTLLISDTGIGIKKEEIPLIFDRFFRS
HHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCC
ENVRNKDLEGSGIGLSIARMISLNLSIDINVTSDVDIGTTFELSIPKKLK
CCCCCCCCCCCCCCHHEEHHEEEEEEEEEEECCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MINKNVFTSTKNHLIKMYIIVVGSFLIIFSIFIYSYFRGLTYSGIDSEINDELEYIVSQF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KRTSFLNPIRLKDPKDMVYVYEDGRISYYTQNEYFDELLPDRRLDKKNSFFKYTENGYTF
HHHHCCCCCCCCCCCCEEEEEECCEEEEEECHHHHHHHCCCCCCCCCCCCEEECCCCEEE
RELNVDVGRYQIQIIRNIDSEMNSLRQLTSVLIIGILISVIITYFVAVYLTRKALIPIET
EEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
AWKNQAKFIQDASHELRTPITIVSSKLESMLKSPESTVNDEVETIATAMKETRRLKKMIT
HHCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DLLSLTKEDSIVKVNLEEIDLEKLLEEISEDYIDIAEFQEKRFVFNSKLKNKVIITDKNK
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHH
LRQLILIFIDNAFKYTKLGDEIALELKEDIEDEVTLLISDTGIGIKKEEIPLIFDRFFRS
HHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCC
ENVRNKDLEGSGIGLSIARMISLNLSIDINVTSDVDIGTTFELSIPKKLK
CCCCCCCCCCCCCCHHEEHHEEEEEEEEEEECCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]