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The map label for this gene is vanR [H]

Identifier: 126699228

GI number: 126699228

Start: 1881909

End: 1882610

Strand: Direct

Name: vanR [H]

Synonym: CD1624

Alternate gene names: 126699228

Gene position: 1881909-1882610 (Clockwise)

Preceding gene: 126699227

Following gene: 126699229

Centisome position: 43.86

GC content: 28.63

Gene sequence:

>702_bases
ATGAACGAAAATATTTTGATTGTGGATGATGAAAAAGAAATAGCAGATTTAATTGAAGTATATTTAAAAAATGAAGGTTT
TACAGTATACAAGTTTTATACAGGTAAGGAAGCTCTAGAATGTATTGAATCTAAAAATTTGGATATGGCTATTTTAGATA
TTATGCTTCCTGATATTGATGGATTTCATATTTGCCAGAAAATTCGAGAAAAATACTATTATCCTATCATTATGTTAACA
GCTAAAATTGAAGATATAGACAAGATAATGGGTTTAACCATAGGTGCTGATGATTATATAACAAAGCCATTTAACCCTTT
GGAAGTTGTTGCAAGAGTAAAGACACAATTAAGAAGATATATGCGATATAATAATTCTTATGAACAACAGTCGATAATTG
TTAATGAGTATGATATTAAAGGATTGATTATCAATAAAGAAACACATAAATGTAGTTTATTTGGGAAAGAAGTAGCATTA
ACACCGATTGAATTTTCTATTCTTTGGTATTTATGTGAACATCAAGGAAAAGTGGTTCCTTCTGAAGAATTGTTTGAAGC
TGTATGGGGAGAAAAATATCTTGATAATAATAACACAGTTATGGCTCATATAGGGCGATTACGTGAAAAAATTCATGAAC
CTTCTAAAAACCCGAAATTTATAAAAACTGTATGGGGAGTAGGTTATACAATTGAAAAGTAA

Upstream 100 bases:

>100_bases
TATAAAAATTAGTTACAAATATGCTTGTAATTATTTGATATGTAAATTTACCAATATTATAAATGATGACCTCGATAATA
AGGAGAGTGAAAAATAATCT

Downstream 100 bases:

>100_bases
AAATATTAAAGTCAATCCTGACTTTACTCAAGTGAGAAATAAAATTTTTATGAGAACAGCTTTAATGGCATTTATAGCCA
TTATTTTCATATGGATTTTA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIESKNLDMAILDIMLPDIDGFHICQKIREKYYYPIIMLT
AKIEDIDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRYMRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVAL
TPIEFSILWYLCEHQGKVVPSEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNPKFIKTVWGVGYTIEK

Sequences:

>Translated_233_residues
MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIESKNLDMAILDIMLPDIDGFHICQKIREKYYYPIIMLT
AKIEDIDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRYMRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVAL
TPIEFSILWYLCEHQGKVVPSEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNPKFIKTVWGVGYTIEK
>Mature_233_residues
MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIESKNLDMAILDIMLPDIDGFHICQKIREKYYYPIIMLT
AKIEDIDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRYMRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVAL
TPIEFSILWYLCEHQGKVVPSEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNPKFIKTVWGVGYTIEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=38.8646288209607, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1789809, Length=235, Percent_Identity=35.3191489361702, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=35.3448275862069, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=32.7433628318584, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=33.0434782608696, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=32.7433628318584, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=34.4978165938865, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1786599, Length=233, Percent_Identity=32.1888412017167, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=31.7180616740088, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1790552, Length=228, Percent_Identity=33.7719298245614, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1789402, Length=232, Percent_Identity=34.051724137931, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=32.3144104803493, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=31.0344827586207, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=31.1688311688312, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=32.4786324786325, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27217; Mature: 27217

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIESKNLDMAILDIMLPDID
CCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCC
GFHICQKIREKYYYPIIMLTAKIEDIDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRY
HHHHHHHHHHHHCCEEEEEEECHHHHHHHHCEEECCCCCCCCCCCHHHHHHHHHHHHHHH
MRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVALTPIEFSILWYLCEHQGKVVP
HHHCCCCCHHEEEEEEECEEEEEEECCCCEEEEECCEEEECCHHHHHHHHHHHCCCCCCC
SEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNPKFIKTVWGVGYTIEK
HHHHHHHHHCHHEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEECC
>Mature Secondary Structure
MNENILIVDDEKEIADLIEVYLKNEGFTVYKFYTGKEALECIESKNLDMAILDIMLPDID
CCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCC
GFHICQKIREKYYYPIIMLTAKIEDIDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRY
HHHHHHHHHHHHCCEEEEEEECHHHHHHHHCEEECCCCCCCCCCCHHHHHHHHHHHHHHH
MRYNNSYEQQSIIVNEYDIKGLIINKETHKCSLFGKEVALTPIEFSILWYLCEHQGKVVP
HHHCCCCCHHEEEEEEECEEEEEEECCCCEEEEECCEEEECCHHHHHHHHHHHCCCCCCC
SEELFEAVWGEKYLDNNNTVMAHIGRLREKIHEPSKNPKFIKTVWGVGYTIEK
HHHHHHHHHCHHEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]