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The map label for this gene is cysM [H]

Identifier: 126699198

GI number: 126699198

Start: 1849652

End: 1850560

Strand: Direct

Name: cysM [H]

Synonym: CD1594

Alternate gene names: 126699198

Gene position: 1849652-1850560 (Clockwise)

Preceding gene: 126699197

Following gene: 126699199

Centisome position: 43.11

GC content: 32.01

Gene sequence:

>909_bases
ATGTTATATAATAACGCATTAGAGTTGATAGGAAACACACCTGTAGTAAGGCTGAATAATTTAGGCTGTACTAATGGGTG
TTCTAACATATATGTAAAATTAGAAAAAGTAAATCCAGCAGGAAGTATAAAAGATAGAGCTGTTTATGAAATGTTAGAGG
GCTTAGAGCAAAGAGGAGAATTAAAAAAGGGAGATGTACTAGTTGAAGCAACTAGTGGAAATACTGGTATTGCATTATCT
ATGATAGGAAAATTAAAAGGATATGAAGTAGTAATCGTAATGCCCGAAACAATGAGCGTTGAGAGAAGAGATTTAATGAA
GGCTTATGGAGCAAATTTGGTGCTTACAGATGGTAAAGCTGGAATGGCAGGTTCCATAGAAAAAGCAAATGAACTTTTAA
AAGAAAATCCAAACTATAAAAGCCTAAAACAATTTGAAAATAAAGATAATCCAAATGCACATTATAAAACAACAGCAGTT
GAAATTATGAATGATGTCAAAGATTTAGATATATTCGTATGTGGAGTTGGAACAGGTGGTACTTTAATAGGAACTGCAAG
ATATTTAAAAGAACAAAATCCAAATATAAGAGTAATTGCACTTGAACCAAAAAAATCTCCAGCTATATCAGAAAACAAGA
CTGGACCTCATAAAATACAAGGAATAGGTGCTAACTTTGTTCCTGAAAATTATGATTCTAGTGTAGTTGATGAAGTAATA
TTAGTAGATGATGAAGATGCATTTGATACAGTTAAATTACTTGCAGCAAAAGAGGGAATTTTAGTAGGGATATCTTCTGG
AGCAAATATATTTGGTGCTATAGAGATGGCAAAAAAGTATCCAGATAAAAAGATAGTTACAGTAGCTCCAGATGGAGTTG
ATAAGTATATGTCTATGGGAATATTTTAA

Upstream 100 bases:

>100_bases
ATAAAATCCAAAAAAAGGTTGCATTATCAAAATGATAATACTATAATATATTTATCGTTATCAATTTGATAATAGATTTG
GACATATAGGAGGAAATAGT

Downstream 100 bases:

>100_bases
TAATTTTATTTGAGGGAGTGAATACTTTGTTTAAGAAAATAAATAAAGATATTGAATATATAATGAAGAATGATCCAGCA
GCTAGGTCTAAGATAGAAGT

Product: O-acetylserine sulfhydrylase

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLYNNALELIGNTPVVRLNNLGCTNGCSNIYVKLEKVNPAGSIKDRAVYEMLEGLEQRGELKKGDVLVEATSGNTGIALS
MIGKLKGYEVVIVMPETMSVERRDLMKAYGANLVLTDGKAGMAGSIEKANELLKENPNYKSLKQFENKDNPNAHYKTTAV
EIMNDVKDLDIFVCGVGTGGTLIGTARYLKEQNPNIRVIALEPKKSPAISENKTGPHKIQGIGANFVPENYDSSVVDEVI
LVDDEDAFDTVKLLAAKEGILVGISSGANIFGAIEMAKKYPDKKIVTVAPDGVDKYMSMGIF

Sequences:

>Translated_302_residues
MLYNNALELIGNTPVVRLNNLGCTNGCSNIYVKLEKVNPAGSIKDRAVYEMLEGLEQRGELKKGDVLVEATSGNTGIALS
MIGKLKGYEVVIVMPETMSVERRDLMKAYGANLVLTDGKAGMAGSIEKANELLKENPNYKSLKQFENKDNPNAHYKTTAV
EIMNDVKDLDIFVCGVGTGGTLIGTARYLKEQNPNIRVIALEPKKSPAISENKTGPHKIQGIGANFVPENYDSSVVDEVI
LVDDEDAFDTVKLLAAKEGILVGISSGANIFGAIEMAKKYPDKKIVTVAPDGVDKYMSMGIF
>Mature_302_residues
MLYNNALELIGNTPVVRLNNLGCTNGCSNIYVKLEKVNPAGSIKDRAVYEMLEGLEQRGELKKGDVLVEATSGNTGIALS
MIGKLKGYEVVIVMPETMSVERRDLMKAYGANLVLTDGKAGMAGSIEKANELLKENPNYKSLKQFENKDNPNAHYKTTAV
EIMNDVKDLDIFVCGVGTGGTLIGTARYLKEQNPNIRVIALEPKKSPAISENKTGPHKIQGIGANFVPENYDSSVVDEVI
LVDDEDAFDTVKLLAAKEGILVGISSGANIFGAIEMAKKYPDKKIVTVAPDGVDKYMSMGIF

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=303, Percent_Identity=39.2739273927393, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI295821200, Length=303, Percent_Identity=39.2739273927393, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI4557415, Length=303, Percent_Identity=39.2739273927393, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI11345492, Length=284, Percent_Identity=26.056338028169, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI2367138, Length=296, Percent_Identity=43.5810810810811, Blast_Score=247, Evalue=8e-67,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=47.5409836065574, Blast_Score=239, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=44.4805194805195, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17535051, Length=300, Percent_Identity=45.3333333333333, Blast_Score=250, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=45.2145214521452, Blast_Score=250, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI115535073, Length=304, Percent_Identity=46.3815789473684, Blast_Score=236, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17561720, Length=308, Percent_Identity=42.5324675324675, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=44.6009389671362, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=36.5079365079365, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=314, Percent_Identity=35.3503184713376, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17561716, Length=119, Percent_Identity=42.8571428571429, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=37.1428571428571, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321449, Length=323, Percent_Identity=33.4365325077399, Blast_Score=139, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24643623, Length=305, Percent_Identity=39.344262295082, Blast_Score=197, Evalue=8e-51,
Organism=Drosophila melanogaster, GI20129101, Length=305, Percent_Identity=39.344262295082, Blast_Score=197, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32666; Mature: 32666

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYNNALELIGNTPVVRLNNLGCTNGCSNIYVKLEKVNPAGSIKDRAVYEMLEGLEQRGE
CCCCCHHHHHCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
LKKGDVLVEATSGNTGIALSMIGKLKGYEVVIVMPETMSVERRDLMKAYGANLVLTDGKA
CCCCCEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCC
GMAGSIEKANELLKENPNYKSLKQFENKDNPNAHYKTTAVEIMNDVKDLDIFVCGVGTGG
CCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCEEEEEECCCCC
TLIGTARYLKEQNPNIRVIALEPKKSPAISENKTGPHKIQGIGANFVPENYDSSVVDEVI
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHCEEE
LVDDEDAFDTVKLLAAKEGILVGISSGANIFGAIEMAKKYPDKKIVTVAPDGVDKYMSMG
EECCCCHHHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHCCCCEEEEECCCCHHHHHHHC
IF
CC
>Mature Secondary Structure
MLYNNALELIGNTPVVRLNNLGCTNGCSNIYVKLEKVNPAGSIKDRAVYEMLEGLEQRGE
CCCCCHHHHHCCCCEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
LKKGDVLVEATSGNTGIALSMIGKLKGYEVVIVMPETMSVERRDLMKAYGANLVLTDGKA
CCCCCEEEEECCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCCC
GMAGSIEKANELLKENPNYKSLKQFENKDNPNAHYKTTAVEIMNDVKDLDIFVCGVGTGG
CCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCEEEEEECCCCC
TLIGTARYLKEQNPNIRVIALEPKKSPAISENKTGPHKIQGIGANFVPENYDSSVVDEVI
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHCEEE
LVDDEDAFDTVKLLAAKEGILVGISSGANIFGAIEMAKKYPDKKIVTVAPDGVDKYMSMG
EECCCCHHHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHCCCCEEEEECCCCHHHHHHHC
IF
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9034314; 10688204 [H]